Day: March 9, 2021

Application of 1453-58-3,Some common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) 1-Benzenesulfonyl-3-methylpyrazole. A mixture of 3-methylpyrazole (5 g, 60.9 mmol), benzenesulfonyl chloride (8.55 mL, 67 mmol) and triethylamine (9.3 mL, 67 mmol) in acetonitrile was heated at reflux for 2 h, allowed to cool and concentrated. EtOAc (300 mL) was added and the solution was filtered and concentrated to provide a solid residue which was crystallised from EtOAc to give the title compound as an off-white powder (Yield:7.92 g, 58 percent).1H-NMR (DMSO-d6): delta 8.35 (d, 1 H), 7.97-7.94 (m, 2H), 7.78 (tt, 1 H), 7.66 (t, 2H),6.43 (d, 1 H), 2.17 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methylpyrazole, its application will become more common.

Reference of 3528-45-8, These common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: Synthesis of 3-(4-methoxybenzyl)-9-(methylsulfanyl)-6,7-dihydro-3H- pyrazolo[4′,3′:5,6]pyrido[4,3-f]quinazoline. To a mixture of (E)-6- ((dimethylamino)methylene)-2-(methylthio)-7,8-dihydroquinazolin-5(6H)-one (8 g, 32 mmol) and l-(4-methoxybenzyl)-lH-pyrazol-5 -amine (7.2 g, 35 mmol) was added trifluoroacetic acid (3 mL). The reaction mixture was heated at 100 0C for 16 hours. The reaction was cooled to room temperature and diluted with a 1 : 1 mixture of methanol and isopropanol (40 mL). The mixture was stirred for 30 minutes and filtered. The solid obtained was then further purified using flash column chromatography (SiO2, gradient from 100% chloroform to 2% EtOAc in chloroform) to give the desired product (3.0 g, 24%) as a yellow solid. 1H NMR (CDCl3, 400MHz): delta 9.52 (s, IH), 7.98 (s, IH), 7.82 (s, IH), 7.40 (d, J = 8.0 Hz, 2H), 6.82 (d, J = 8.0 Hz, 2H), 5.64 (s, 2H), 3.78 (s, 3H), 3.16 (t, J = 6.0 Hz, 2H), 3.10 (t, J = 6.2 Hz, 2H), 2.65 (s, 3H); LCMS [M+H]: 390.

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 92933-47-6

General procedure: To a solution of HATU (104 mg, 0.27 mmol) and 3-isopropylpyrazole-5-carboxylic acid (36 mg, 0.22 mmol) in DMF (14 mL) was then added diisopropylethylamine (0.055 mL, 0.31 mmol). The reaction solution was stirred at room temperature for 2 h. 2-(Benzylamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile (75 mg, 0.21 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. The resulting residue was purified by column chromatography on silica gel (EtOAc/hexane = 2:1) to give title compound as a white solid (33 mg, 37%).

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H7FN4

5-Amino-i -(4-fluorophenyl)-i H-pyrazole-4-car- boxamide (Step 1, 900 mg, 4.45 mmol) was added dropwise to sulfuric acid (10 mE) at 0 C. The resulting solution was stirred for 2 hat 25 C. The pH of the solution was adjusted to 8 by the addition of sodium carbonate (10% aqueous). The resulting mixture was extracted with dichloromethane (4×50 mE) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to provide 5-amino-i -(4-fluorophenyl)- 1H-pyrazole-4-car- boxamide which was used in Step 3 without further purification. ECMS: (ESI) mlz 221 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51516-70-2, its application will become more common.

Electric Literature of 49633-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49633-25-2, name is 3-Isopropylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1-(4-Bromo-phenyl)-3-isopropyl-1H-pyrazole 3-Isopropylpyrazole (588 mg, 5.43 mmol), 1-bromo-4-iodobenzene (15.11 g, 53.4 mmol), cesium carbonate (5.22 g, 16.0 mmol), copper(I)iodide (1.02 g, 5.34 mmol) and N,N’-dimethylethylenediamine (570 uL, 5.34 mmol) are combined in dry N,N-dimethylformamide (100 mL) and heated at 100 C. for 3 hours under a nitrogen atmosphere. The mixture is cooled, poured into water and extracted with diethyl ether. The organic phase is dried and the solvent removed. The residue is purified by flash chromatography (30% dichloromethane in cyclohexane) to give the title compound (Yield 1.37 g) LC (METHOD 5): tR=1.47 min; Mass spectrum (ES+): m/z=265/267 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Isopropylpyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 39806-90-1, These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To solution of Weinreb amide 10c (8.00 g, 15.4 mmol, 1.0 equiv.) in THF (180 mL) is added 4-iodo-1-methylpyrazole (12.8 g, 61.6 mmol, 4.0 equiv.). The solution is cooled to -78 C, a solution of tert-butyllithium (1.7 M in pentane, 37 mL, 4. equiv.) is added dropwise and the reaction is stirred for 45 min. The reaction mixture is poured into aqueous NH4Cl (saturated) and extracted with EtOAc. After isolation of organic phase, silica is added and the solid residue is purified by chromatography using MeOH in DCM to give the desired product 12b. (6.20 g, 74%)

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 181585-93-3, name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 181585-93-3

Step 12: Preparati -Methyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester A 100-mL single-neck round-bottomed flask was charged with methyl 5-nitro-lH-pyrazole-3- carboxylate (3.89 g, 22.7 mmol), anhydrous DMF (30 ml) , potassium carbonate (6.28 g, 45.5 mmol). Mel (4.19 g, 1.85 ml, 29.6 mmol) was added and the reaction mixture was stirred at room temperature for 18h. The mixture was then diluted with water (150 mL) and extracted with DCM (3 x 75mL). The combined organic layers were dried over MgS04 and concentrated under vacuum. The crude material was purified by flash chromatography (silica gel, AnaLogix system, SF40-240g column, 10% to 50% EtOAc in hexanes) to give the desired product as mixture of isomers (3.75 g). M+ = 185.0 m/e

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, Product Details of 175137-46-9

To a solution of 2,6-dichloro-3-nitropyridine (0.67 g, 3.2 mmol) and DIEA (0.46 ml, 2.65 mmol) in EtOH (20 ml) was added a S-cyclopropyl-l/f-pyrazol-S-amine (0.26 g, 2.12 mmol) solution in EtOH (5 ml) drop wise at 0 0C. After addition, the reaction mixture was stirred at 25 0C for 24 hours. The solvent was removed under reduced pressure and the resulted residue was purified by column chromatography (hexane : EtOAc = 5 : 1) to give the title compound as a yellow solid (0.58 g, 98%). NMR (400 MHz) 12.36 (s, IH), 10.20 (s, IH), EPO 8.54 (d, J= 8.4 Hz, IH)5 7.01 (d, J= 8.4 Hz, IH), 6.39 (d, J= 1.6 Hz, IH), 1.94 (m, IH), 0.96 (m,2 H), 0.71 (m, 2H). MS: Calcd.: 279; Found: [M+H]+ 280.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 79080-39-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 79080-39-0 name is 1-Methyl-1H-pyrazole-3-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 5-methyl-3-(1-methylpyrazol-3-yl)-1,2,4-oxadiazole (72): To a suspension of hydroxylamine hydrochloride (351 mg, 5.05 mmol) in 4 ml EtOH was added 1.86 ml 21% wt sodium ethoxide in ethanol. The resulting mixture was stirred for 10 min at r.t. before addition of 3-cyano-1-methylpyrazole (70) (535 mg, 5 mmol). The resulting suspension was heated overnight at 90 C. After cooling down, the reaction mixture was diluted with EA then washed with brine. Org. phase was concentrated to dryness to give 506 mg crude intermediate 71. A mixture of the above crude intermediate 71, trifluoromethanesulfonic acid Ytterbium (III) salt (22 mg, 1% mol) and trimethyl orthoacetate (550 mul, 1.2 eq.) in 5 ml EtOH was heated at 85 C. for 2 h. After cooling down to r.t., fine needles formed. After filtration and wash with MeOH 166 mg intermediate 71 was recovered as pale yellow needles. The filtrate was concentrated, subjected to silica gel column purification using 0-100% B (A: hexane; B: EA) to furnish 230 mg 5-methyl-3-(1-methylpyrazol-3-yl)-1,2,4-oxadiazole (72) as white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-3-carbonitrile, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2075-46-9, name is 4-Nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2075-46-9

The 4-amino-l/i-pyrazole used as a starting material was prepared as follows :-A mixture of 4-nitro-l/J-pyrazole (0.7 g), platinum oxide (0.05 g), ethyl acetate (5 ml) and ethanol (15 ml) was stirred under 3 atmospheres pressure of hydrogen for 2 hours. The catalyst was removed by filtration and the filtrate was evaporated. There was thus obtained the required starting material (0.5 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.