Day: March 8, 2021

Adding a certain compound to certain chemical reactions, such as: 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1904-31-0, Safety of 1-Methyl-1H-pyrazol-3-amine

Boc2O (134.83 g, 617.79 mmol, 1 .00 Eq) was added to a solution of compound 14-1 (60.00 g, 617.79 mmol, 1 .00 Eq) and NaOH (27.18 g, 679.57 mmol, 1 .10 Eq) in THF/H2O (1 :1 ) (1200 ml_) at 25C in portions. The mixture was stirred for 4 h, extracted with EtOAc (800 ml_), dried and concentrated to give compound 14-2 (89.00 g, 451 .25 mmol, 73.04% yield) as a white solid. LCMS m/z 142[M-55]+. 1 H NMR (400MHz, CDCI3) delta ppm 8.01 (s, 1 H), 7.21 -7.20 (d, J=2Hz, 1 H), 6.44 (s, 1 H), 3.81 (s, 3H), 1 .51 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 28466-26-4, These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (2S,3R,4R)- I -acetyl-2-cyclopropyl-3-methyl-4-((6-methylpyridin-2-yl)amino)- 1,2,3,4- tetrahydroquinoline-6-carboxylic acid (for a preparation see Example 247, 50 mg, 0.132 mmol) andHATU (90 mg, 0.198 mmol) in N,N-dimethylformamide (DMF)(1 mL)was added IH-pyrazol-4-amine (13 mg, 0.158 mmol) followed by DIPEA (0.097 mL, 0.553 mmol). The reaction mixture was stirred at rt for 90 mm, then purified directly by MDAP (HpH). The solvent was evaporated in vacuo to give the product (8 mg). LCMS (2 mm High pH): Rt = 0.88 mi [MH] = 445.

Statistics shows that 4-Aminopyrazole is playing an increasingly important role. we look forward to future research findings about 28466-26-4.

These common heterocyclic compound, 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (1H-Pyrazol-4-yl)methanol

(lH-Pyrazol-4-yl)-methanol (0.55 g, 5.61 mmol) and imidazole (0.953 g, 14.00 mmol) are placed in an oven-dried flask under an atmosphere of argon. Dry DMF (2.2 mL) is added followed by tert-butyldiphenylsilyl chloride (1.85 g, 6.73 mmol). The reaction mixture is stirred at room temperature. The reaction is shown to be complete by TLC after 18 hours. The reaction mixture is partitioned between dichloromethane (50 mL) and water (50 mL). The organic layer is washed with water (20 mL) and brine (20 mL), dried over MgSO 4, filtered and the solvent is removed in vacuo. The title compound is obtained after purification by flash column chromatography (silica, ethyl acetate / isohexane 1:8). 1H nmr (CDCU 400 MHz); 7.70(m, 4H), 7.50(m, 2H), 7.40(m, 6H), 4.75(s, 2H), 1.10(s, 9H).

The synthetic route of (1H-Pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Electric Literature of 5932-30-9, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound ethyl 1H-indole-2-carboxylate (0.1g, 0.53 mmol) was added to a solution of 6h (0.29 g, 2.6 mmol) in EtOH (10 mL) at ambient temperature. The reaction was refluxed for 6 h and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to yield the target product 1. (yield: 77%). 1H NMR (400 MHz, DMSO-d6) delta 11.74 (s, 1H), 11.44 (s, 1H), 7.66 (t, J = 6.3 Hz, 2H), 7.45 (d, J = 8.3 Hz, 1H), 7.35 – 7.11 (m, 2H), 7.06 (t, J = 7.6 Hz, 1H), 2.28 (s, 1H), 1.87 – 1.60 (m, 3H), 1.38 – 1.21 (m, 7H). 13C NMR (400 MHz, DMSO-d6) delta 157.90, 130.67, 127.46, 124.06, 122.10, 112.79, 103.54, 30.22, 29.13, 28.12. HRMS(ESI) m/z calculated for C16H19N3O [M+Na]+:292.1426, found 292.1420.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Diethyl 3,5-pyrazoledicarboxylate

General procedure: n-Butyltriphenylphosphonium peroxodisulfate (0.5 mmol) was added in small portions to a solution of pyrazole (1 mmol) and iodine (0.6 mmol) in CH3CN/H2O (10 : 2 mL) in a 50 mL round-bottome flask equipped with a magnetic stirrer. The reaction mixture was stirred at ambient temperature for the appropriate time (see table). Upon completion of the reaction, as indicated by TLC, the reaction mixture was poured into an aqueous sodium thiosulfate solution (1 M) and extracted with diethyl ether (3 ¡Á 15 mL). The combined organic layers were dried over MgSO4. The solvent was concentrated in vacuo, the resulting product was purified on silica gel using column chromategraphy (diethyl ether : n-hexane = 1 : 4) to afford the pure compound.

According to the analysis of related databases, 37687-24-4, the application of this compound in the production field has become more and more popular.

Reference of 175137-46-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 175137-46-9 as follows.

A solution of 4-chloro-2-methylsulfanyl-5, 8-dihydro-6H-pyrido [3, 4-d] pyrimidine-7- carboxylic acid benzyl ester (Method 147; 5.0 g, 14.0 mmol), triethylamine (4.3 g, 43 mmol), and5-cyclopropyl-lH-pyrazol-3-ylamine (2.6 g, 21 mmol) in NMP (30ml) was heated at 110 C for 48 hours. After cooling to25 C, the reaction was diluted with H20 (30 ml), extracted with MTBE (4 x 50 ml). The combined organic layer was dried overMgS04, concentrated, and purified by column chromatography (DCM:MeOH = 50 :1) to give the title compound (2.5 g, 40%). MS: Calcd.: 436; Found: [M+H] + 437.

According to the analysis of related databases, 175137-46-9, the application of this compound in the production field has become more and more popular.

Related Products of 129768-30-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129768-30-5, name is Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of ethyl 3-(trifluoromethyl)-li/-pyrazole-5-carboxylate (1.00 g, 4.80 mmol) in l,2-dichloroethane (40 mL) were added cyclopropylboronic acid (0.825 g, 9.61 mmol) and sodium carbonate (1.02 g, 9.61 mmol). The reaction mixture was warmed to 70 C and 2,2′- bipyridine (0.750 g, 4.80 mmol) and copper(II) acetate (0.873 g, 4.80 mmol) were added and the reaction mixture was allowed to stir for 18 h at 70 C. The reaction mixture was cooled to ambient temperature and diluted with a saturated aqueous solution of sodium bicarbonate and extracted with ethyl acetate (2 x). The combined organic extracts were washed with a saturated aqueous solution of sodium chloride and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with a gradient of hexanes: ethyl acetate – 95:5 to 50:50 to afford the title compound. MS: m/z = 249.1 [M+H]

The synthetic route of Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Reference of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred suspension of 4-(trifluoromethyl)-1H-pyrazole (0.4 g, 2.93 mmol) in dry DMF (8 mL), Cs2CO3 (1.91 g, 5.87mmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-1-carboxylate (obtained as described in Step 1 of Intermediate 10, 1.23 g, 5.87 mmol) were added at 0 C. The reaction mixture was stirred at 80 C overnight, and the reaction mixture was diluted with water (10 mL). The product was extracted with EtOAc (2 x 10 mL). The combined organic layer was dried over anhydrous Na2S04 and concentrated under vacuum. The crude product was purified by flash chromatography on silica gel (230-400 mesh) to afford the title compound. Yield: 73% (0.69 g, pale brown solid). 1H NMR (400 MHz, DMSO-d6): delta 8.71 (s, 1 H), 7.90 (s, 1 H), 4.44 (q, J = 7.6 Hz, 1 H), 4.04-4.06 (m, 2H), 3.10-2.69 (m, 2H), 2.02-2.08 (d, 2H), 1.84-1.75 (m, 2H), 1.42 (s, 9H). LCMS: (Method A) 264.2 (M-56), Rt. 4.82 min, 91.18% (Max).

The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Reference of 139756-02-8, These common heterocyclic compound, 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of Bh, Step 7: 4-amino-i -methyl-3-propyl- 1 H-pyrazole-5-carboxamide (1 eq) and 4-chlorobenzaldehyde (1.1 eq) were suspended in ethanol 5 ml and the mixtureheated at 70 C for 1.5 hours after conformation of forming of imine by TLC. Added CuCl2 (3 eq) and the reaction mixture heated at 75 C under 02 for 1 hours. After completion of the reaction, the ethanol was removed under vacuum. Then workup with ethyl acetate and water. Separate the organic layer and Water layer re-extracted with 2x 25 ml ethyl acetate. The combined organic layers are washed with brine solution,concentrated under vacuum. The residue was purified by column chromatography on silica the desired product Bh as a white solid; yield 90%. ?H NMR (200 MHz CDC13):6; 1 l.51(s 1H), 8.l(d J=8.6Hz 2H), 7.49(d J8.611z 2H), 4.3(s 31-I), 2.93(t J=7.5Hz 2H), 1.96(m 2H), 1.03(t J= 7.5Hz 3H). MASS: ES [M + H] . 303.09; Elemental anal. calcd. for C15H,5C1N4O ; C, 59.51; H, 4.99; Cl, 11.71; N, 18.51; 0, 5.28; found C,59.44; H, 5.01; Cl, 11.72; N, 18.53; 0, 5.30

The synthetic route of 139756-02-8 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27258-32-8, SDS of cas: 27258-32-8

To a solution of 1-methyl-1H-pyrazole-3-carbaldehyde (150 g, 1.36 mol) in DMF (1000 mL) was added NBS (240 g, 1.35 mol). The resulting solution was stirred for 2 h at 50¡ã C. and then was quenched by the addition of ice water (2000 mL). The reaction mixture was cooled to ?10¡ã C. with an ice/salt bath, and the solids were collected by filtration to provide the desired product as a white solid (200 g, 78percent). 1H NMR (300 MHz, CDCl3): delta 9.90 (d, J=0.7 Hz, 1H), 7.46 (s, 1H), 3.96 (s, 3H) ppm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.