Day: March 5, 2021

Adding a certain compound to certain chemical reactions, such as: 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 113100-53-1, HPLC of Formula: C6H5F3N2O2

(1500 mg, 7.5 mmol) and SOCl2 (3500 mg, 30 mmol) was refluxedfor 4 h. After the reaction is completed, the excess of SOCl2 wasevaporated to give 4 as a yellow liquid that was used withoutfurther purification.

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Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.

Into a 50-mL round-bottom flask, was placed 23.2 (100 mg, 0.27 mmol, 1.00 eq.), n-BuOH (10 mL), 1-(oxan-4-yl)-1H-pyrazol-4-amine (90 mg, 0.54 mmol, 2.01 eq.), and hydrogen chloride in dioxane (1 mL, 4 M). The resulting solution was stirred for 30 h at 110 C in an oil bath. The resulting mixture was concentrated in vacuo. The resulting solution was diluted with H20. The pH value of the solution was adjusted to 10 with sodium carbonate. The solids were collected by filtration. The crude product was purified by Flash- Prep-HPLC with the following conditions (IntelFlash-1): Column, C18; mobile phase, ACN_Water=0: l increasing to ACN_Water=l :0 within 15 min; Detector, UV 254 nm. This resulted in 15.6 mg (12%) of I-24 as a brown solid. LC-MS: (ESI, m/z): [M+H+]= 505.3. 1H NMR: {4d-MeOD, ppm) 7.889 (1H, s), 7.590 (1H, s), 7.055-7.065 (1H, m), 6.050-6.060 (1H, m), 4.302-4.408 (1H, m), 4.054-4.171 (3H, m), 3.941-3.974 (3H, s), 3.528-3.615 (2H, m), 2.722-2.755 (4H, m), 2.539-2.607 (1H, m), 2.279-2.321 (2H, m), 2.047-2.174 (6H, m), 1.300- 1.700 (8H, m), 0.350 (4H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 78703-53-4, name is 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid

General procedure: To a solution of 2,5-dimethyl-1,3-thiazole-4-carboxylic acid (107mg, 0.681mmol) in THF (5mL) was added thionyl chloride (118muL, 1.36mmol) and two drops of DMF. The mixture was stirred at room temperature for 2h and concentrated under reduced pressure. The residue was dissolved in DMA (6mL), and 27b (200mg, 0.619mmol) was added to the solution at 0C. The mixture was stirred at room temperature for 2h. The mixture was diluted with saturated aqueous sodium hydrogen carbonate and extracted with AcOEt. The extract was washed with saturated aqueous sodium hydrogen carbonate, brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residual solid was recrystallized from EtOH to give 29a (248mg, 87%) as white crystals: mp 239-240C; 1H NMR (DMSO-d6) delta 0.78-0.86 (4H, m), 2.04 (1H, br s), 2.23-2.28 (3H, m), 2.65 (3H, s), 2.70 (3H, s), 6.82 (1H, dd, J=8.3, 2.7Hz), 7.27 (1H, d, J=8.7Hz), 7.50 (1H, dd, J=9.5, 2.3Hz), 7.66 (1H, d, J=2.7Hz), 7.69-7.75 (1H, m), 8.82 (1H, dd, J=2.3, 0.8Hz), 9.66 (1H, s), 11.02 (1H, s); Anal. Calcd for C23H22N6O3S: C, 59.73; H, 4.79; N, 18.17. Found: C, 59.48; H, 4.80; N, 18.00.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 114474-28-1, name is 4-(1H-Pyrazol-4-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

[0100] A mixture of 2,4-dichloro-5,7-dihydrofuro[3,4-d]pyrimidine (300 mg, 1.57 mmol), 4-(lH-pyrazol-4-yl)aniline (250 mg, 1.57 mmol), and diisopropylethylamine (0.55 mL, 3.14 mmol) in DMF (3.14 mL) was heated at 100 C for 5 h. TLC showed the reaction was complete. The mixture was then diluted with water. The resulted yellow precipitate was filtered and washed with water and dried in vacuo to provide 480 mg (97%) title compound which was used directly for next step reaction without further purification.

According to the analysis of related databases, 114474-28-1, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3N3O4

Preparation of the Resin (ii):30 g of Rink resin (PolymerLab; 0.99 mmol/g) is swollen in 150 ml of DMF. After stirring for 10 minutes, the DMF is filtered off and replaced with 150 ml of a solution of piperidine in DMF (50/50, v/v). The mixture is stirred for 1 hour and then filtered. The resin is washed successively with five times 150 ml of DMF, twice 150 ml of methanol and three times 150 ml of DMF. Next, a solution of 14.1 g of 4-nitro-3-pyrazolecarboxylic acid (90 mmol, 3 eq.) and 13.8 g of HOBt (90 mmol, 3 eq.) in 150 ml of DMF is added to the resin, immediately followed by 13.8 ml of DIC (90 mmol; 3 eq.). The mixture is stirred for 16 hours at room temperature. The solution is filtered and the resin is washed successively with five times 150 ml of DMF, twice 150 ml of methanol, three times 150 ml of DMF and then with 150 ml of a 1 M SnCl2 solution (33 g in 150 ml). The mixture is stirred at room temperature for 24 hours and is then filtered, and the resin is washed with five times 150 ml of DMF, twice 150 ml of methanol, three times 150 ml of DCM and twice 150 ml of ethyl ether. After drying under vacuum, 31 g of intermediate resin (ii) are isolated.

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 86477-09-0, name is Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 86477-09-0

Add 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid ethyl ester (3.10 g, 17.2 mmol) and 30 mL of water to a 100 mL vial and cool to 0 C.Add sodium hydroxide solid (4.8 g, 86.0 mmol), stir to dissolve,Transfer to room temperature for 3 h, TLC detection reaction is completed,Wash once with 30 mL of DCM, adjust the pH of the aqueous phase to about 5 with concentrated hydrochloric acid.A white solid is precipitated and suction filtered to obtain a part of the product.The filtrate was extracted 3 times with 50 mL of EA, and the organic phases were combined and dried over anhydrous sodium sulfate.Filtered, concentrated,A total of 1.7g of light yellow solid, a yield of 65%,

The synthetic route of Ethyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate has been constantly updated, and we look forward to future research findings.

Synthetic Route of 35277-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35277-02-2, name is 4-Fluoro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step D: 4-fluoro-lH-pyrazole-l-carboxamidine hydrochloride (28-e) To 4-fluoro-lH-pyrazole, 28-d, (2g, 23mmol) and cyanamide (0.97g, 23mmol) in dioxane (5mL) was added 4N HC1 in dioxane (15mL). The mixture was gently refluxed with stirring for 2h under nitrogen. During the course of the reaction the product crystallizes. After cooling to room temperature, 10 mL of anhydrous ether was added and the mixture was allowed to stand for 30min. The white solid was collected by filtration, washed with anhydrous ether and dried to constant weight in vacuuo providing the product, 28-e, (3g, 80%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4149-06-8 as follows. Recommanded Product: 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one

General procedure: The mixture of isatin (1 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one (1 mmol), 1,2-diarylethan-1-one, 2,3-dihydroinden-1-one (1 mmol) or 3,4-dihydronaphthalen-1(2H)-one (1 mmol), H2O (6 mL), HOAc (2 mL) was put in a reaction flask under 90 C about 5-7 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be isolated out at same time. Then, compound 4 was recrystallized from DMF, however, the pure products of 6 and 8 were filtered from water, dried, without further recrystallization.

According to the analysis of related databases, 4149-06-8, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 5071-61-4

General procedure: To a solution of compound 15 (1.0 mmol) in dichloromethane (20 ml) was added EDCI¡¤HCl (1.2 mmol) and HOBt (0.1 mmol). Then added corresponding hetroaromatic acids 10a-i, 14a-i and 12a-d (1.0 mmol) and the reaction mixture was stirred at room temperature for 10 h. The reaction was monitored by TLC. After completion of reaction, water was added to reaction mixture and extracted with dichloromethane (2 ¡Á 30 ml). The solvent was evaporated under reduced pressure to afford the crude product which was further purified by column chromatography on silica gel using ethyl acetate and hexane as solvent system to obtain the pure products as solids.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5071-61-4, its application will become more common.

Application of 39806-90-1,Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-iodo-l-methyl-lH-pyrazole (23.31 mg, 0.112 mmol) in anhydrous DMSO (5 ml) was added intermediate 19.6-1 (20 mg, 0.075 mmol), (Irans)-N 1.N2-dimethylcycloheane- 1, 2-diamine (2.125 mg, 0.015 mmol), potassium phosphate (47.6 mg, 0.224 mmol) and Cul (1.423 mg, 7.47 pmol). The resulting mixture was stirred at 90C under N2 protection for 12 hours. After filtration and concentration, the crude product was purified by pre-HPLC (TFA) to give example 19.7-1, (R,R or S,S)-5-chloro-6-(3-fluoro-l-methylpiperidin-4-yl)-l-(l-methyl-lH-pyrazol-4-yl)- lH-indazole, TFA salt. MS (ESI) m/z calc?d for C17H20CIFN5 [M+H]+ 348, found 348. NMR (400 MHz, CD3OD) d 8.12-8.25 (m, 2H), 7.96 (s, 1H), 7.88 (br s, 1H), 7.67 (s, 1H), 7.63-7.67 (m, 1H), 5.22-5.48 (m, 1H), 5.22-5.48 (m, 1H), 4.00 (s, 3H), 3.92 (br s, 1H), 3.82 (m, 1H), 3.60 (br s, 1H), 3.16-3.30 (m, 2H), 3.03 (s, 3H), 2.27 (br s, 1H), 2.02-2.20 (m, 1H). LRRK2 IC50 3.9 nM.

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.