Day: March 1, 2021

Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 2075-46-9

Compound Ia (15.0 g, 133 mmol) was added to a suspension of palladium on carbon 10% (7.0 g, 6.65 mmol) in ethanol (100 mL). The mixture was shaken for 3 hours under hydrogen pressure (40 psi) at room temperature. The catalyst was removed by filtration through a pad of Celite and the solvent was evaporated. Compound Ib was obtained as a burgundy oil (10.5 g, 126 mmol, 95%) which was used in the following step without purification; GC/MS: m/z = 83 (100%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2075-46-9, its application will become more common.

Synthetic Route of 20154-03-4, These common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 10 g (73.5 mmol) 3 -(trifluoromethyl)- 1H- pyrazole (3) in DMSO (150 ml) were added 9.9 g of potassium tert.-butoxide portion wise. After stirring for 5 minutes drop wise addition of 12 ml of iodoethane followed by stirring overnight were conducted. Water was added afterwards and the pH value was adjusted to 3 by using IN HC1. The mixture was diluted with MTBE and extracted two more times with MTBE. The combined organic phase was washed with Na2S203-solution, water and brine yielding 8 g (67 percent) of the ionic liquid 8.

The synthetic route of 20154-03-4 has been constantly updated, and we look forward to future research findings.

Application of 84547-86-4, A common heterocyclic compound, 84547-86-4, name is 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step D: Preparation of (4-Bromo-l-methyl-lH-pyrazoI-3-yl)-{4-[2-(2,4-difluoro- phenyl)-ethyl]-piperazin-l-yl}-methanone (Compound 84).In a heavy-walled sealed tube, 4-bromo-l -methyl- lH-pyrazole-3-carboxylic acid (0.0194 g, 0.0583 mmol), l-(2,4-difluorophenethyl)piperazine (0.0145 g, 0.0641 mmol), 0-(7- azabenzotriazol-l-yO-N^/V^/V^/V-tetramethyluronium hexafluorophosphate (0.0244 g, 0.0641 mmol), and triethylamine (0.0162 mL, 0.117 mmol) were combined in TEtaF (0.5 mL). The reaction mixture was heated at 100 0C for 10 min under microwave irradiation. The reaction mixture was concentrated and then purified by RP-EtaPLC. The best fractions were lyophilized to afford the TFA salt of the title compound (0.015 g) as a yellow solid. 1H NuMR (DMS0-<4 400 MHz) delta 2.90-3.80 (m, 10H), 3.87 (s, 3H), 4.18-4.40 (bs, IH), 4.45-4.69 (bs, IH), 7.07-7.16 (m, IH), 7.23-7.33 (m, IH), 7.39-7.47 (m, IH), 8.09 (s, IH). Exact mass calculated for C17H19BrF2N4O: 412.1; Found: LCMS m/z (%) = 413.1 (M+HT 79Br, 100%), 415.1 (M+H+ 81Br, 98%). The synthetic route of 84547-86-4 has been constantly updated, and we look forward to future research findings.

Application of 31108-57-3, A common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of VI (150 mg, 0.351 mmol) and K2C03 (96.9 mg, 0.702 mmol) in acetone (5 mL) was added lH-pyrazole-4-carbonitrile (48.9 mg, 0.526 mmol) at 25C. The reaction mixture was stirred at the 25C for 16 h. The reaction mixture was quenched by water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic layer was dried over Na2SC>4, filtered and concentrated in vacuum to give crude product (50 mg) which was triturated with MeCN (5 mL) to give Compound 47 (41 mg, 27%) as a solid. (0758) 1H NMR (400MHz, DMSO-d6) delta 8.31 (s, 1H), 8.05 (s, 1H), 5.87 (d, J= 18.2 Hz, 1H), 5.22 (d, J= 18.2 Hz, 1H), 4.92-4.88 (m, 1H), 3.88 (s, 1H), 3.56-3.49 (m, 1H), 2.86-2.76 (m, 1H), 1.96- 1.92 (m, 1H), 1.73-1.58 (m, 4H), 1.57-1.44 (m, 1H), 1.42-1.22 (m, 7H), 1.19-1.11 (m, 5H), 1.07 (s, 3H), 0.92-0.77 (m, 2H), 0.70 (s, 3H), 0.54 (s, 3H) LCMS Rt = 0.980 min in 2 min chromatography, 30-90 AB, purity 100%, MS ESI calcd. For C26H37N303Na+ [M+Na]+ 462, found 462.

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4054-67-5 as follows. name: 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

A mixture of H4L (0.05 mmol, 0.023 g), bpz (0.10 mmol, 0.020 g), Co(NO3)26H2O (0.15 mmol, 0.044 g) and 6mL of acetonitrile/H2O (v/v 1:1) was stirred for 30 min and then transferred and sealed in a 25mL Teflon-lined reactor and heated to 120 C for 72 h, and then cooled toroom temperature at a rate of 5 C/h. Red block crystals of 1 were obtained in 58% yield based on cobalt. Calcd (%) for C34H30N4O11Co2, C,51.79; H, 3.84; N, 7.11. Found C, 51.35; H, 3.49; N, 7.01. IR: 3393(vs);3176(m); 2933(m); 2355(m); 1605(v); 1524(m); 1443(v); 1261(m);1128(v); 1037(m); 774(m); 733(m).

According to the analysis of related databases, 4054-67-5, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 100114-57-6 as follows. SDS of cas: 100114-57-6

EXAMPLE 5 [4-(3-Cyclopropyl-pyrazol-1-yl)-2-trifluoromethy-phenyl]-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone In the manner of Example 2, employing (4-fluoro-2-trifluoromethyl-phenyl)-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (1.42 g), 60% sodium hydride in oil (0.20 g), 3-cyclopropylpyrazole (0.43 g) and dimethylformamide (50 ml), the product (1.22 g) was obtained as a crystalline solid, m.p. 163-164 C.

According to the analysis of related databases, 100114-57-6, the application of this compound in the production field has become more and more popular.

131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H2ClF3N2

To a solution of 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-one (500 mg, 1.59 mmol) in acetonitrile (10 mL) was added 5-chloro-3-(trifluoromethyl)-lH-pyrazole (327 mg, 1.92 mmol), potassium iodide (133 mg, 0.80 mmol), and potassium carbonate (442 mg, 3.20 mmol) The resulting solution was stirred for 2 h at 80 C and cooled. The solid was filtered off and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/petroleum ether (1/9) to afford 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-one as a brown solid ( 300 mg, 60%). LCMS (ESI): M+H+ = 448.0.

The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1904-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-Bromopyridine (1 ) (1 .0g, 6.3mmol), 1 -methyl-1 H-pyrazol-3-amine (2) (0.79g, 8.2mmol), Xantphos (0.37g, 0.63mmol), and Cs2C03 (4.1 g, 12.6mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was then degassed with N2(g), and placed under vacuum for 10min. Pd2(dba)3 (0.29g, 0.31 mmol) was added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralized water (200ml_), and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 : 1 ) to provide N-(1 -methyl-1 H-pyrazol-3- yl)pyridin-2-amine (3) as a yellow solid (0.75g, 68percent). LCMS (ES): Found 175.2 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 155377-19-8, The chemical industry reduces the impact on the environment during synthesis 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

Ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1.50 g, 7.21 mmol) was dissolved in dry THF (50 mL) and the resulting solution cooled to -78 oC. To the resulting solution was added, 2 M solution of LAH (6.01 mL, 14.41 mmol) in THF over 30 min by keeping the temperature <10 C. The reaction mixture was allowed to come to ambient temperature, stirred for 4 h and was cooled again with to -10 oC. The reaction was quenched with the addition of 1:1 THF:water (50 mL) mixture with cooling (maintaining the temperature <20 C), followed by 5M HCl to neutralise to pH 6. The reaction mixture was diluted with EtOAc (100 mL), stirred for 30 min and left to settle for 1 h. The resulting solid was removed by filtration through Celite and washed with EtOAc. The filtered organic layer was washed with brine, dried over MgSO4 and evaporated under reduced pressure. The crude product was triturated with ether (2 x 25 mL) to obtain Intermediate 89A (0.60 g, 50.10%).1H NMR (400 MHz, DMSO-d6) delta ppm 4.44 (s, 2 H), 5.02 (s, 1 H), 7.83 (s, 1 H), 13.73 (br. s., 1 H). LCMS (Method-H): retention time 0.54 min, [M- H] 165.0. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile

Under nitrogen protection,5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.0 g, 3.6 mmol),Ethyl 2-(1-benzylpiperidin-4-ylidene)acetate (1.1 g, 4.3 mmol)A mixture of K2CO3 (745 mg, 5.4 mmol) in DMF (20 mL) was heated to 80[deg.] C. and stirred for 16 hours.Then, the reaction was quenched with water (20 mL), extracted with EA (20 mL¡Á3), the organic phases were combined, dried over Na 2 SO 4 , concentrated, and purified on a tannin extract column, eluting with 30percent EA in PE.A yellow solid product was obtained (950 mg, 54.9percent).

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.