Day: February 23, 2021

Synthetic Route of 852227-86-2, These common heterocyclic compound, 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

D-15 D-16Step 4. A mixture of D-15 (210 mg, 0.78 mmol) and cesium carbonate (765 mg, 2.35 mmol) in DMF (25 mL) was heated to 60C with stirring then a solution of 5-(chloromethyl)-1 ,3-dimethyl-1 H-pyrazole (1 13 mg, 0.78 mmol) in DMF(10 mL) was added drop wise. The reaction mixture was stirred for 1 hour at 60C. The solids were removed by filtration and the solvent was removed under reduced pressure. Crude D-16 was used as such in the next step.LC-MS: Anal. Calcd. For CisHasNeOs: 376.22; found 377 [M+H]+

The synthetic route of 852227-86-2 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 37622-90-5, These common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 25 Step A: TERT-BUTYL 4- [ (METHYLSULFONYL) oxy] PIPERIDINE-L-CARBOXYLATE (3.62g, 13. OMMOL) was combined with ethyl 4-pyrazolecarboxylate (2. 0G, 14mmol) in 50ML OF DMF. The mixture was cooled to 0C, and sodium hydride (467mg, 19. 5MMOL) was added. The reaction mixture was then heated at 50C for 10h. Afterwards, it was diluted with diethyl ether (LOOML), washed with water (5 x 100mL) and brine (1 x 100ML), dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification by MPLC (silica gel, 5-100% EtOAc/hexanes) afforded the desired product. ESI-MS calculated for CL6H25N304 : 323.39, FOUND 346 (M+NA).

Statistics shows that Ethyl 4-pyrazolecarboxylate is playing an increasingly important role. we look forward to future research findings about 37622-90-5.

These common heterocyclic compound, 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 285984-25-0

b. Lambda/-(5-fert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-2-chloro-acetamide; A solution of 5-ferf-butyl-2-p-tolyl-2/-/-pyrazol-3-ylamine (886 mg, 3.86 mmol), pyridine (465 muL, 5.80 mmol) and chloroacetyl chloride (462 mul_, 5.80 mmol) in DCM (5 ml_) was stirred at RT for 2 h. The reaction mixture was diluted with aq. sat. sodium bicarbonate and DCM and the resulting aqueous layer was extracted twice with DCM. The combined organic layers were dried (MgSO4) and concentrated in vacuo to afford the title compound (1.17g, 100%) as a yellow solid. LCMS (Method 5): Rt 4.41 min, m/z 306 [MH+].

The synthetic route of 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine has been constantly updated, and we look forward to future research findings.

Related Products of 3528-45-8,Some common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, molecular formula is C11H13N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an ice-cooled solution of 2-(4-methoxy-benzyl)-2H-pyrazol-3-ylamine (406 mg, 2.0 mmol, 1.0 eq.) in DCM (5 mL), DIPEA (0.52 ml, 3.0 mmol, 1.5 eq.) was added. A solution of bromoacetyl bromide (0.19 ml, 2.2 mmol, 1.1 eq.) in DCM (2 mL) was added dropwise. The cooling bath was removed and the brown solution was stirred at r.t. for 1.5 hours. The solution was diluted with AcOEt (75 mL), washed with sat. aq. NaHCO3 soln. (1¡Á40 mL), with sat. aq. NaCl soln. (1¡Á40 mL), dried over MgSO4, and concentrated in vacuo. The residue was purified by CC (SiO2, AcOEt/Hept 1:1 to 6:4) to give the desired bromide as a beige solid.LC-MS (A): tR=2.60 min; [M-H]+=322.3.

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

A solution of the pyrazole 3,5-dicarboxylicacid (1.60 mmol, 0.25 g) in thionyl chloride (4 mL) was heated underreflux for 2 h. Excess solvent was then distilled off and the crude 23dried under vacuum. A solution of the crude pyrazole diacylchloride 23,triethylamine (4.8 mmol, 0.67 mL) and DMAP (0.32 mmol, 0.039 g) inanhydrous dichloromethane (13 mL) was cooled in an ice bath and theamine 24 (3.28 mmol, 0.782 g) was added slowly as a solution indichloromethane (3 mL). The reaction mixture was allowed to gradually warm up to room temperatureand stirred overnight. The mixture was then washed with 10percent hydrochloric acid and water, and theorganic layer separated. The aqueous layer was further extracted two more times with dichloromethane.Combined organics were dried with anhydrous sodium sulfate, filtered, concentrated and purified by flashcolumn chromatography to furnish the title compound a white solid in 85percent yield.

According to the analysis of related databases, 3112-31-0, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 110860-60-1

50.0 parts of a compound represented by the above formula (1) was added to 220 parts of isopropanol and heated to 45 C. to be completely dissolved. To this solution was added dropwise 27.0 parts of concentrated hydrochloric acid over 20 minutes.After the addition is complete, the reaction solution is cooled to 5 C.The resulting powder was filtered off. Is it enough with isopropanolAfter washing, it was dried at 50 C. for 3 hours to obtain 50.0 parts (yield 81.0%) of the hydrochloride of the compound represented by the formula (1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5932-34-3, name is Ethyl 4-bromo-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Ethyl 4-bromo-1H-pyrazole-3-carboxylate

A) ethyl 4-bromo-1-(2,6-difluorobenzyl)-1H-pyrazole-3-carboxylate A solution of ethyl 4-bromo-1H-pyrazole-3-carboxylate (2.07 g) in THF (10 mL) was added to a solution of sodium hydride (60%, 0.454 g) in THF (10 mL) at 0C, and the mixture was stirred at 0C for 5 min. To the reaction mixture was added dropwise 2-(bromomethyl)-1,3-difluorobenzene (2.152 g) at 0C, and the mixture was gradually warmed to room temperature, and stirred overnight at room temperature. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (3.16 g). MS: [M+H]+ 345.1.

According to the analysis of related databases, 5932-34-3, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 1H-Pyrazole-4-carbonitrile

To a suspension of TEA (35.2 mg, 0.348 mmol) and lH-pyrazole-4-carbon (12.9 mg, 0.139 mmol) in DMF (5 mL) was added Jl (50 mg, 0.116 mmol) at 25C under N2. The mixture was stirred at 25C for 16 h. The mixture was concentrated to give a light yellow soild. The solid was purified by pre-HPLC (Column:YMC-Actus Triart CI 8 100*30mm*5um; Condition: water(0.05%HCl)-ACN; Gradient 53%-83%B; Gradient Time(min):9.5) to afford Compound 26 (22 mg, 43% ) as a solid. *H NMR (400 MHz, CDC13) delta 7.85 (s, 1H), 7.81 (s, 1H), 5.05-4.87 (m, 2H), 3.88-3.82 (m, 1H), 2.70-2.58 (m, 1H), 2.28-2.15 (m, 1H), 2.05-1.56 (m, 7H), 1.48-1.15 (m, 17H), 0.76 (s, 3H), 0.66 (s, 3H). (0615) LCMS Rt = 0.828 min in 1.5 min chromatography, 5-95 AB, purity 100 %, MS ESI calcd. for C26H34N3O [M+H-2H20]+ 404, found 404.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 138786-86-4, A common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, molecular formula is C5H5N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) Metallic sodium(6.71 g) was added carefully and slowly to thoroughly dried methanol(830 mL) and the solution was ice-cooled after the fragment of metallic sodium was completely dissolved. Compound(1)(43.61 g) was added to the solution, then methyl iodide(43.64 mL) was added and the mixture was stirred at 60-70C for 4 hours. The reaction solution was concentrated under reduced pressure, chloroform was added to the residue and the mixture was washed with a saturated aqueous sodium bicarbonate solution and brine, dried and the solvent was distilled away. The residue was purified with a silica gel column chromatography(hexane/ethyl acetate=4/1 to 1/1) to give Compound(2)(17.0 g) as a yellow oily substance and Compound(3)(26.8 g) as a colorless powder. Compound(2): APCI-MS(m/e):186[M+H]+, 1HNMR(500MHZ/DMSO-d6 )delta(ppm):3.95(s,3H),4.00(s,3H),8.37(s,1H). Compound(3): APCI-MS(m/e):186[M+H]+, 1HNMR(500MHZ/DMSO-d6 )delta(ppm):3.94(s,3H),4.00(s,3H),8.95(s,1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 948570-75-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To 17a (1 g, 7.8 mmol) in EtOH (20 mL) was added 10% Pd/C50 mg. The reaction mixture was stirred for 3 h under hydrogen at roomtemperature. The mixture was then filtered with Celite, and the filtratewas concentrated and dried under vacuum to yield 0.74 g (97%) of 18aas a white solid. MS (ESI) m/z 98 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.