Day: February 19, 2021

Application of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Intermediate 4 (1mmol) and the intermediate 7 (1mmol) were dissolved in ethanol to the glass flask, then HCl solution was added as a catalyst refluxed at 80C for 15-18h. After the TLC monitoring reaction was completed, the mixture was vacuum filtered and concentrated. Finally, the above crude product can be isolated and purified by column chromatography (Hexane/EtOAc=8:1) to obtain target compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17635-45-9, SDS of cas: 17635-45-9

The title compound was prepared according to Scheme 7. To a stirred solution of 4- (i//-pyrazol-l~yl)anilme (CAS Number 17635-45-9, 0.5 g, 3.140 mmol) in chloroform (25 mL) was added K2CO3 (1.3 g, 9.422 mmol) at ambient temperature and the reaction mixture was cooled to 0-5 ¡ãC. Thiophosgene (0.73 g, 6.281 mmol) was added the reaction mixture at 0-5 ¡ãC. The resulting reaction mixture was stirred at ambient temperature for 3 h and then poured into water (15 mL). Tire obtained mixture was neutralized by NaHCCb and extracted with EtOAc (2 x 100 mL). The combined organic phase was dried over NaiSOg filtered and concentrated under reduced pressure yielding l-(4-isothiocyanatophenyl)-lii-pyrazole (compound 20.2; 0.56 g, 2.785 mmol). LCMS: Method A, 3.379 min MS: ES+ 202.1 (M+l).

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Related Products of 39806-90-1,Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound was prepared according to the reported procedures in 90% yield.5 6 To a solution of 4-iodo-1-methyl-1 H-pyrazole (10.0 g, 48.1 mmol) in DCM (192 ml) was added triflic acid (17.08 ml, 192 mmol) and the resulting mixture was stirred at room temperature for 5 min. mCPBA (12.44 g, 72.1 mmol) followed by mesitylene (6.36 g, 52.9 mmol) was then added (in this order). The reaction vessel was sealed and submitted to a 60C oil bath with stirring for 30 min. The reaction mixture was then allowed to reach rt after which it was concentrated in vacuo followed by precipitation by addition of Et20 (100 mL). The mixture was stirred at 0 C for additional 30 min. The solid was collected by filtration and washed with Et20. LCMS m/z 327.3. 1H NMR (400 MHz, DMSO -c/6) d 9.78 (s, 1 H), 8.55 (s, 1 H), 8.06 (s, 1 H), 7.16 (s, 2H), 3.89 (s, 3H), 2.64 (s, 6H), 2.26 (s, 3H). 13C NMR (101 MHz, DMSO-c/e) d 143.02, 142.90, 140.86, 137.02, 129.59, 124.58, 120.80 (q, J = 322.3 Hz), 79.06, 39.43, 26.43, 20.56. 19F NMR (376 MHz, DMSO-c/e) d -77.76.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-methyl-1H-pyrazole, its application will become more common.

Reference of 500011-84-7, These common heterocyclic compound, 500011-84-7, name is 3-Bromo-1-(dimethylsulfamoyl)pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: Preparation of 3-bromo-lff-pyrazole; To 3-bromo-pyrazole-l-sulfonic acid dimethylamide (21.3 g) was slowly added trifluoroacetic acid (30 mL) and stirred at room temperature for 2 h. Hexane was added and the formed precipitate was filtered off and washed with hexane. The filtrate was diluted with MTB-ether, washed with sat. NaHC03-solution, water and brine, dried over MgSO4 and concentrated in vacuum to afford 10.7 g of a colorless oil containing 80% of the title compound of the formulaBrH The residue was used for the next step without further purification .1H-NMR (CDCl3, TMS) 8 (ppm) : 6.37 (IH, d, J = 3 Hz), 7.55 (IH, d, J = 3 Hz), 12.6 (IH, br s).

The synthetic route of 500011-84-7 has been constantly updated, and we look forward to future research findings.

Reference of 852227-86-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852227-86-2 as follows.

Example 42 3-Bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-2-(2,5-dimethyl-2H-pyrazol-3-ylmethoxy)-N,N-dimethyl-benzenesulfonamide A mixture of the compound described in example 41a (153 mg), potassium carbonate (125 mg), and 5-chloromethyl-1,3-dimethyl-1H-pyrazole (55 mg) in DMF (1.4 ml) was heated at 60 C. for 3 h. The mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC (Method B), then purified by chromatography on aluminum oxide using ethyl acetate as eluent.Yield: 51 mg. MS-ESI: [M+H]+=616.2/618.2; anal. HPLC: Rt=18.40 min. (method 2)

According to the analysis of related databases, 852227-86-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

In a three-necked round bottom flask, 186 g of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester (VII) was added.(0.91 mol), 900 ml of ethanol, and a solution of sodium hydroxide 44 g, (1.1 mol) dissolved in 900 ml of water, heated to 50C to 80C, and incubated for 3 hours, the reaction of the starting material was complete by TLC, and the ethanol was concentrated under reduced pressure to remove ethanol Add 100ml of toluene to extract, recover toluene in organic phase, cool the water phase to room temperature, adjust the PH value to 1-2 with 31% hydrochloric acid, cool to about 10C for 0.5 hours, filter and dry to obtain product 3- (Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid 6 (DFPA) 152 g, yield 95%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 78208-72-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78208-72-7, name is Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

5-isopropyl-1H-pyrazol-3-carboxylic acid ethyl ester (18.9 g, 104 mmol) and 1M NaOH solution (260 mL, 259 mmol) were dissolved in 1,4-dioxane (300 mL), the reaction was heated to 50¡ã C. under nitrogen and stirred for 3 h. The reaction mixture was cooled, adjusted to pH 2 using concentrated hydrochloric acid and the solvent was removed under reduced pressure. The residual solid was azeotroped with toluene (2.x.30 mL), dissolved in ethyl acetate (500 mL) and washed with water. The aqueous phase was removed, extracted with ethyl acetate (2.x.200 mL) and the combined organic extracts were dried over MgSO4. The solvent was removed under reduced pressure and the residue was azeotroped with dichloromethane (2.x.50 mL) to give the title product (14.7 g) as a white solid; 1H NMR (400 MHz, DMSO-D6): delta 12.50-13.30 (bs, 2H), 6.42 (s, 1H), 2.84-2.94 (quin, 1H), 1.15-1.19 (d, 6H) ppm; LRMS (electrospray): m/z [M-H]+ 153.

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate. I believe this compound will play a more active role in future production and life.

Electric Literature of 35277-02-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 2-ch loro-N-(2 ,4-d imethoxybenzyl )-5-nitrobenzenesulfonam ide (5.00 g, 11.6 mmol) in acetonitrile (135 mL) were added 4-fluoro-1H-pyrazole (1.50 g, 17.4 mmol) and powdered potassium carbonate (4.82 g, 34.9 mmol) and it was stirred overnight at10000. The reaction mixture was concentrated in vacuo and the residue was extracted with dichioromethane and water. The organic phase was washed with brine and dried over sodium sulfate. Concentration in vacuo led to the crude title compound (5.54 g, quant., app. 85 % purity) that was used without further purification in the next step.LC-MS (Method A): Rt = 1.23 mm; MS (ESIpos): mlz = 437 [M+H]1HNMR (400MHz, DMSO-d6) oe [ppm]: 3.48 (s, 3H), 3.62 (s, 3H), 4.13 (s, 2H), 6.15 (d,1H), 6.28 (dd, 1H), 7.09 (d, 1H), 7.81 (d, 1H), 8.00-8.10 (m, 2H), 8.23 (d, 1H), 8.43 (dd,H), 8.59 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Example P5: Preparation of 1 -Methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert- butyl-2-vinylphenyl)amide; 197 mg (1 ,01 mmol) 1 -methyl-3-trifIuoromethyl-1 H-pyrazole-4-carboxyIic acid and 135 mg(1 ,07 mmol) oxalylic acid chloride are dissolved in 8 ml methylenechloride. The solution is stirred for 3 hours at room temperature in the presence of a catalytic amount of dimethylformamide (DMF). After this the solution is slowly added to a solution consisting of180 mg (1 ,01 mmol) 3-tert-butyl-2-vinyl-phenylamine, 155 mg (1 ,52 mmol) triethylamine and7 ml methylenechloride. The resulting reaction mixture is then stirred at room temperature for 16 hours. After removal of the solvent in a water jet vacuum, the residue is purified by flash chromatography over silicagel (eluent: hexane/ethylacetate 2:1). This gives 0,27 g 1- methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert-butyl-2-vinylphenyl)amide in the form of a colourless solid (m.p. 118-119C; 76% of theory).

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1,3-Dimethyl-1H-pyrazol-5-ol

At room temperature, 1,3-dimethyl-1H-pyrazole-5-ol (1.12 g, 0.01 mol) and (1.58 g, 0.02 mol) pyridine were sequentially dissolved in 20 ml of dichloromethane. The low temperature bath was cooled to 0 C. To the above mixture was added dropwise a solution of 3,7-dichloroquinoline-8-acyl chloride (2.73 g, 0.0105 mol) in dichloromethane (10 ml),The dropping rate was 5 drops / 30 seconds. After the addition was complete, the mixture naturally rose to room temperature and reacted for 4 hours. To the reaction mixture was added 10 ml of a saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with dichloromethane (3 * 15 ml). The organic layers were combined,Wash with water (1 * 15ml), saturated brine, and dry over anhydrous magnesium sulfate. desolvate under reduced pressure to obtain 2.52 g of product with a yield of 75%

The synthetic route of 5203-77-0 has been constantly updated, and we look forward to future research findings.