Day: February 18, 2021

Adding a certain compound to certain chemical reactions, such as: 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 578008-32-9, HPLC of Formula: C9H15N3O2

A reaction vessel was charged with 6-chloro-N-[(l¡ê)-l-(5-fluoropyrimidm-2-yl)emyl]pyrazm-2- amine (Intermediate 9, 118 mg, 0.47 mmol), tert-butyl 3-amino-5-methyl-lH-pyrazole-l- carboxylate (Intermediate 10, 103 mg, 0.52 mmol), Cs2CO3 (459 mg, 1.14 mmol), Xantphos (14 mg, 0.024 mmol) and Pd2(dba)3 (7 mg, 0.012 mmol) and purged with nitrogen for 10 minutes. Dioxane (0.15 M) was then added to the tube and the reaction mixture was purged with nitrogen for another 10 minutes. The reaction mixture was heated at 1000C overnight. The reaction mixture was filtered through a plug of diatomaceous earth, diluted with EtOAc, washed with nuaetaCO3(aq) and brine, and dried (Na2SO4). The solvent was removed in vacuo to give a yellow residue (181 mg), which was purified with a Gilson column (10-35% MeCN/H2O, 15 min). The title compound was collected as a yellow solid (18.9 mg). LCMS: [M+H]+ 315. 1H NMR (300 MHz5 DMSO-d6) delta: 9.69 (s, 1 H) 8.94 (s, 2 H) 7.77 (br.s, 1 H) 7.53 (s, 1 H) 7.43 (s, 1 H) 6.03 (s, 1 H) 5.68 (s, 1 H) 5.24 (m, 1 H) 2.27 (s, 3 H) 1.60 (d, 3 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C10H15N3O2

Synthesis of 244-A. To a solution of tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)- carboxylate (1.40 g, 6.70 mmol) in DCM (10 mL) was added TFA (3 mL) dropwise under ice bath. Then the solution was stirred at room temperature 1 h. The solvent was removed in vacuo to give 244- A as a crude product

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1280210-79-8.

Some common heterocyclic compound, 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, molecular formula is C15H17N5O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C15H17N5O2

Step 6. (+/-)-(4-(1 -(2-Cyano- 1 -(2,2,5,5 -d4-cyclopentyl)ethyl)- 1 H-pyrazol-4- yl)-7H-pyrrolol2,3-dlpyrimidin-7-yl)methyl pivalate ((+/-)38). To a solution of 37 (400 mg, 1.34 mmol, preparation described in Lin, Q. et al. Org. Lett., 2009, 1], 1999-2002) in acetonitrile (10 mL) was added 36 (418 mg, 3.34 mmol) followed by DBU (421 tL, 2.81 mmol). The reaction stirred at room temperature for 15 hours then was concentrated under reduced vacuum. The resulting crude mixture was diluted with water and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed with iN HC1, dried (Na2SO4), filtered and concentrated underreduced pressure. Purification via normal phase column chromatography (Si02, 0-60% ethyl acetate/hexanes) followed by reverse phase column chromatography (C 18, 5-70% acetonitrile/water containing 0.1% formic acid) afforded (+/-)38 (68 mg, 12%) as a white foam. 1H NMR (DMSO-d6, 400 MHz) oe 8.84 (s, 1H), 8.79 (s, 1H),8.40 (s, 1H), 7.74 (d, J= 3.8 Hz, 1H), 7.12 (d, J- 3.8 Hz, lH), 6.24 (s, 2H), 4.54 (td, J= 9.7, 4.3 Hz, 1H), 3.30-3.15 (m, 2H), 2.39 (d, J 9.8 Hz, 1H), 1.68- 1.36 (m, 4H), 1.08 (s, 9H); MS (ESI) 425.3 [(M + H)j.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1146629-77-7, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 151049-87-5, name is 3-Bromo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C4H5BrN2

Example 0734 0734-1 A mixture of 5-bromo-2-methylpyridine (258 mg), bis(pinacolato)diboron (396 mg), potassium acetate (282 mg), (1,1′-bis(diphenylphosphino)ferrocene)palladium(II) dichloride-dichloromethane adduct (49 mg), and 1,4-dioxane (5 mL) was stirred at 100 C. for 2.5 hours. 3-Bromo-1-methyl-1H-pyrazole (200 mg), sodium carbonate (254 mg), bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) (42 mg), and water (0.5 mL) were added thereto, followed by stirring at 100 C. for 6 hours. The reaction mixture was cooled to room temperature, the solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate, NH silica), thereby obtaining 2-methyl-5-(1-methyl-1H-pyrazol-3-yl)pyridine (190 mg) as yellow oily substance. MS m/z (M+H): 174.

The synthetic route of 151049-87-5 has been constantly updated, and we look forward to future research findings.

Reference of 718632-46-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 718632-46-3 name is 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 2-(l,3-dioxo-l,3-dihydro-isoindol-2-ylmethyl)-benzoic acid (1.35 g, 4.8 mmol) in dry dichloromethane (30 mL), at 0 C, under stirring, was added oxalyl chloride (2.1 mL, 24 mmol) and dry N,N-dimethylformamide (35 microL). The mixture was allowed to warm to room temperature, stirred for 1.5 hours then evaporated to dryness. The residue was diluted with dry toluene and evaporated again. The crude acyl chloride thus obtained (yellow solid) was dissolved in dry tetrahydrofuran (20 mL) and treated with N,N-diisopropylethylamine (2.5 mL, 15 mmol) and with a solution of 3- amino-6,6-dimethyl-4H,6H-pyrrolo[3,4-c]pyrazole-2,5-dicarboxylic acid 5-tert-butyl ester 2-ethyl ester (1.3 g, 4 mmol) in 15 mL of dry tetrahydrofuran. The mixture was stirred at room temperature for 2 days then evaporated to dryness. The residue was dissolved in dichloromethane, washed with IN HCl, water, saturated solution of NaHCC>3, brine, dried over sodium sulfate and evaporated to dryness. The crude was purified by flash chromatography on silica gel using dichloromethane/methanol 98.5:1.5 as the eluant affording the title compound as white solid (1.5 g).IH-NMR (400 MHz), delta (ppm, DMSOtZ6): 10.63 (bs, IH), 7.91-7.83 (m, 4H), 7.71 (m, IH), 7.58-7.46 (m, 2H), 7.37 (m, IH), 5.07 (s, 2H), 4.53 (bs, 2H), 4.43 (m, 2H), 1.63 (bs, 6H), 1.50 (s, 9H), 1.37 (m, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2075-45-8, name is 4-Bromo-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Bromo-1H-pyrazole

Step A: 4-Bromo-1-cyclopropyl-1H-pyrazole 4-Bromo-1H-pyrazole (1.76 g, 12 mmol) is dissolved in anhydrous dimethylformamide (15 mL). Cyclopropyl bromide (2.9 mL, 36 mmol) and caesium carbonate (7.8 g, 24 mmol) are successively added thereto. The reaction mixture is heated for 15 hours at 160 C. in a sealed flask. At the end of the reaction, the solvent is evaporated off in vacuo and the residue is purified by chromatography over silica gel using heptane and dichloromethane as eluants to yield the expected compound.

According to the analysis of related databases, 2075-45-8, the application of this compound in the production field has become more and more popular.

Reference of 4149-06-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4149-06-8 name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 3-amino-1-phenyl-2-pyrazolin-5-one 1 (0.35 g, 2 mmol), dimedone 2 (0.28 g, 2 mmol), aldehyde 3 (0.28 mg, 2 mmol) and Cell-LA-TEA+/Fe3O4 nanocatalyst (0.03 g, 0.09 mol%) in H2O/EtOH (3:2) was subjected to ultrasonic irradiation (ultrasonic bath, room temperature). The progress of the reaction was controlled by TLC (hexane/ethyl acetate, 2:3). After reaction completion, the nanocatalyst was separated magnetically from the reaction mixture and used for subsequent cycles after washing with ethanol. By cooling the reaction solution, the solid product was collected, separated and recrystallized from methanol to get the pure product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, and friends who are interested can also refer to it.

Related Products of 34334-96-8,Some common heterocyclic compound, 34334-96-8, name is 3-Methyl-5-nitro-1H-pyrazole, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add acetonitrile (56 mL) to a mixture of 5-methyi-3-nitro-1H-pyrazoie (3.0 g, 22 mniol), potassium carbonate (6.2 g, 2.0 eq), and I -bromo-3-methoxypropane (3.8 g, 1.1 eq). Stir at 65 C overnight. Cool to EtOAc (50 mE) and filter. Concentrate the filtrate in vacuo. Subject the residue to normal phase chromatography, eluting with 35% EtOAc in hexanes, to give the title compound (3.3 g, 70%). MS (ES) ,n/z 200 (M-fH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyl-5-nitro-1H-pyrazole, its application will become more common.

Electric Literature of 143426-52-2, The chemical industry reduces the impact on the environment during synthesis 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.

4 mmol of the compound IIIb was dissolved in 20 mL of acetonitrile, and intermediate 77 mmol and 8 mmol ofcesium carbonatewere added thereto at room temperature.After heating, the reaction was refluxed for 13 hours.The reaction was stopped, the reaction solution was rotary evaporated to dryness under reduced pressure, the resulting residue was purified by columnseparation and purification to give the title compound analysis Ib

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Application of 1260243-04-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred mixture of 3.2 G (20 MMOL) of ethyl 5-amino-1 H-PYRAZOLE-4-CARBOXYLATE in 95 mL of CH212 AT-10¡ãC, 24 mL of isoamyl nitrite (180 MMOL) were added during 30 minutes. The mixture was stirred two hours at 100¡ãC and, after cooling, it was concentrated under reduced pressure (first 10 mmHg then 0.1 mmHg). The residue was dissolved in ethyl acetate and the resulting solution washed with NA2S205, HCI (1N) and water. Organic phase was separated, dried over Na2SO4, filtered and concentrated under reduced pressure to give a brown solid that was purified by column chromatography, eluting with 30percent ethyl acetate in hexane to give 4.11 G (75percent) of the title compound as a yellow solid. 1 H-NMR (DMSOD6), diagnostic signals (ppm): 13.71 (s, 1H), 8.25 (s, 1H), 4.19 (q, 2H), 1.26 (t, 3H) [M+H] + =267

The synthetic route of Ethyl 5-amino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.