Day: February 18, 2021

Related Products of 57012-20-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Preparation of 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) A mixture of compound 14 (3 grams, 23.8 mmol) and pyridinium dichromate (13.4 grams, 35.7 mmol) in dichloromethane (100 mL) was stirred at 25 C. under nitrogen atmosphere for 16 hours. The reaction mixture was then filtered. The filtrate was collected, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude thus obtained was passed through the silica gel to afford the desired compound 2,5-dimethyl-2H-pyrazole-3-carbaldehyde (15) 1 gram as a brown solid. Yield: 34%; 1H NMR (200 MHz, CDCl3): delta 9.8 (s, H), 6.6(s, H), 4.1 (s, 3H), 2.3 (s, 3H). Mass (CI method, i-butane): 125 (M+1, 100%); IR: numax (KBr, cm-1): 1688.

The chemical industry reduces the impact on the environment during synthesis (1,3-Dimethyl-1H-pyrazol-5-yl)methanol. I believe this compound will play a more active role in future production and life.

These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5-Cyclopropyl-1H-pyrazol-3-amine

To a mixture of 110a (2.38 g, 7.00 mmol), 5-cyclopropyl-lH-pyrazol-3-amine (905 mg, 7.35 mmol), in 1,4-dioxane (40 mL) in a 100 mL single-neck round-bottomed flask was added cesium carbonate (6.84 g, 21.0 mmol). The mixture was purged with nitrogen for 30min. Tris(dibenzylideneacetone)dipalladium(0) (641 mg, 0.700 mmol) and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (688 mg, 1.19 mmol) were then added. The flask was connected to a nitrogen-purged condenser and the mixture was refluxed for 6 h under nitrogen. The mixture was cooled to room temperature and filtered. The filter cake was suspended in ethyl acetate (30 mL) and water (10 mL) and filtered through Celite. The layers were separated. The combined organic layers were dried with anhydrous magnesium sulfate. The drying agent was removed by filtration. The filtrate was concentrated under reduced pressure. The residue was purified on silica eluted with a gradient 0 to 50% ethyl acetate in heptane to afford 6-chloro-4-(5-cyclopropyl-lH-pyrazol-3-ylamino)-2-((2- (trimethylsilyl)ethoxy)methyl)pyridazin-3(2H)-one (111a) (1.58 g, 59%).

The synthetic route of 5-Cyclopropyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Reference of 1018446-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018446-95-1 name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) tert-butyl 4-[({4-[(2-chlorophenoxy)methyl]pyridin-2-yl}carbonyl)amino]-1H-pyrazole-1-carboxylate To a solution of 4-[(2-chlorophenoxy)methyl]pyridine-2-carboxylic acid (2.64 g) obtained in Example 119(2) in tetrahydrofuran (50 mL) was added oxalyl chloride (1 mL) at room temperature, and then N,N-dimethylformamide (1 drop) was added. The mixture was stirred at room temperature for 40 min and tetrahydrofuran was evaporated under reduced pressure. The residue was dissolved in N,N-dimethylacetamide (50 mL). This solution was added dropwise to a solution of tert-butyl 4-amino-1H-pyrazole-1-carboxylate (2.01 g) synthesised in the above-mentioned (1a) in N,N-dimethylacetamide (50 mL), which was placed in advance in a different pear shape flask. The mixture was stirred at room temperature for 3 hr. Water was added, and the precipitated solid was collected by filtration and washed with water and hexane to give a gray solid (3.73 g, 87%). 1H NMR (300 MHz, DMSO-d6) delta ppm 1.60 (s, 9H) 5.45 (s, 2H) 6.97-7.06 (m, 1H) 7.19-7.25 (m, 1H) 7.28-7.37 (m, 1H) 7.50 (dd, J=1.51, 7.91 Hz, 1H) 7.73 (dd, J=1.60, 4.99 Hz, 1H) 8.15 (s, 1H) 8.24 (d, J=0.75 Hz, 1H) 8.58 (s, 1H) 8.77 (d, J=4.90 Hz, 1H) 11.28 (s, 1H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, and friends who are interested can also refer to it.

Synthetic Route of 27258-33-9,Some common heterocyclic compound, 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4; Influence of the ligand Using the optimal conditions [Example 2] which leads to 85-87% ee with the ligand sd499, a ligand screening with a variety of N,O-ligands was carried out. The results are given in the following table. The best results were obtained with the ligands sd311b (91% ee) and commercially available (S)-2-piperidinyl-1,1,2-triphenylethanol at 5 mol% scale. As the latter one is known to be a somewhat slower ligand than the paracyclophane-based ligands and the derivatives of sd499, we repeated the experiment with 10 mol% of (S)-2-piperidinyl-1,1,2-triphenylethanol. This experiment gave 93% ee. The ligand is available in both enantiomeric forms.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-5-carbaldehyde, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Quality Control of 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Benzimidazole (248 mg, 2.1 mmol) was added to tetrazine 1a (270 mg, 1 mmol) in acetonitrile (5 mL), the mixture was stirred for 3 h with heating to 75 C. Then, after hot filtration, the substance was washed with hot acetonitrile on the filter. The yield was 299 mg (95%). A red powder, m.p. 332-334 C. Found (%): C, 60.74; H, 3.41; N, 35.42. C16H10N8. Calculated (%): C, 61.14; H, 3.21; N, 35.65. 1H NMR (DMSO-d6), delta: 7.48-7.55, 7.56-7.62, 7.91-7.97, 8.45-8.52 (both m, 2 H each, H(4), H(5), H(6), H(7) in benzimidazolyls); 9.43 (both s, 2 H each, H(2) in benzimidazolyls). 13C NMR (DMSO-d6), delta: it was technically impossible to register 13C NMR spectrum because of the poor solubility of compound 1d.

The synthetic route of 30169-25-6 has been constantly updated, and we look forward to future research findings.

Related Products of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 81945-73-5, name is 1H-Pyrazol-1-ol, This compound has unique chemical properties. The synthetic route is as follows., name: 1H-Pyrazol-1-ol

1. N-2-[4-(1,1-Dimethylethoxy)phenoxy]ethoxypyrazole A solution of 12.7 g (0.15 mol) of N-hydroxypyrazole in 20 ml of DMF was added dropwise to a suspension of 4.95 g (1.1 eq.) of NaH (80% dispersion in mineral oil) in 40 ml of DMF at RT, and the mixture was heated at 70 C. for 1 h. A solution of 40.95 g (0.15 mol) of 2-[4-(1,1-dimethylethoxy)phenoxy]ethyl bromide in 100 ml of DMF was added and the mixture was then heated at 125 C. for 15 h. The solvent was then stripped off in a rotary evaporator, the residue was taken up in ethyl acetate, and the solution was washed twice each with 5% strength NaOH solution and water. Drying and removal of the solvent under reduced pressured resulted in 38.4 g (93%) of the required compound as a pale oil which was employed without further purification in the next stage. 1 H-NMR (250 MHz, CDCl3): delta=7.38 (d, 1H); 7.28 (d, 1H); 6.93 (d, 2H); 6.83 (d, 2H); 6.17 (t, 1H); 4.63 (m, 2H); 4.17 (m, 2H); 1.30 (s, 9H) ppm

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 81945-73-5.

Reference of 105486-72-4, These common heterocyclic compound, 105486-72-4, name is Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 5-bromo-l-methylpyrazole-4-carboxylate (1.0 g, 4.29 mmol), 3- nitrophenylboronic acid (859 mg, 5.15 mmol), sodium carbonate (909 mg, 8.58 mmol dissolved in 4.3 mL water), and bis(triphenylphosphine)palladium(II) dichloride (151 mg, 0.21 mmol) in DME (43 mL) was heated to 90 C overnight. After this time, General Work-up Procedure 1 was followed, and the crude residue was purified by Chromatography A to afford the title compound (710 mg, 60 % yield).

The synthetic route of 105486-72-4 has been constantly updated, and we look forward to future research findings.

Reference of 2075-46-9, These common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of 3-chloro-1H-pyrazol-4-amine hydrochloride Into a 2 L three-necked round bottom flask affixed with an overhead stirrer, a temperature probe, an addition funnel, and a nitrogen inlet were added ethanol (600 mL) and 4-nitro-1H-pyrazole (50.6 g, 447 mmol). To this solution was added, in one portion, conc. HCl (368 mL) (note: rapid exotherm from 15 C. to 39 C.) and the resulting mixture was purged with nitrogen for 5 minutes. Palladium on alumina (5% w/w) (2.6 g, Alfa, black solid) was added to the mixture and stirred at room temperature while triethylsilane (208 g, 1789 mmol) was added drop-wise over 4 h. The reaction, which started to slowly exotherm from 35 C. to 55 C. over 2.0 h, was stirred for a total of 16 h and vacuum filtered through a plug of Celite to give a biphasic mixture. The mixture was transferred to a separatory funnel, the bottom aqueous layer was collected and rotary evaporated (60 C., 50 mmHg) to dryness with the aid of acetonitrile (3*350 mL). The resulting yellow solid was suspended in acetonitrile (150 mL) and allowed to stand for 2 h at room temperature followed by 1 h at 0 C. in the refrigerator. The solids were filtered and washed with acetonitrile (100 mL) to afford the titled compound 3-chloro-1H-pyrazol-4-amine hydrochloride (84 g, 97% yield, 80% purity) as a white solid: mp 190-193 C.; 1H NMR (400 MHz, DMSO-d6) delta 10.46-10.24 (bs, 2H), 8.03 (s, 0.54H), 7.75 (s, 0.46H), 5.95 (bs, 1H)); 13C-NMR (101 MHz, DMSO) delta 128.24, 125.97, 116.71.

Statistics shows that 4-Nitro-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 2075-46-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

Step c: NaH (33.08 g (19.85, 60percent), 1.5 eq) was washed with hexane, dry DMF (500 ml) was added drop wise under N2 atmosphere and stirred well. A solution of 3-(trifluoromethyl)- 1 H-pyrazole (75 g, 550 mmol) in DMF (125 ml) was added drop wise under N2 atmosphere. Then a solution of 4-methoxylbenzyl chloride (86.3 g, 550 mmol, 1 eq) in DMF (125 ml) was added drop wise and the overall reaction mixture was allowed to stir for 12 h at room temperature. On completion of the reaction, reaction contents were poured into ice water (500 ml) and the product was extracted with ethyl acetate (2 * 400 ml). The ethyl acetate layer was washed with 2N HCI (2x200ml). Then the contents were dried over sodium sulfate and concentrated under reduced pressure. Obtained crude was purified by silica gel column chromatography with 10percent ethyl acetate/Hexane to yield the required product as a brown colored liquid (98 g, 70percent yield).

According to the analysis of related databases, 20154-03-4, the application of this compound in the production field has become more and more popular.