Day: February 8, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H4N4

Following the procedure described in Example 1 wherein 2-propanol was used as the solvent instead OF ETHANOL, 91 percent OF THE product was obtained with m. p. 184-187 ¡ãC.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16617-46-2.

Adding a certain compound to certain chemical reactions, such as: 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36650-74-5, SDS of cas: 36650-74-5

Reference Production Example 7-2 1-(hydroxymethyl)-3-cyano-1H-pyrazole The mixture of 0.86 g of 3-cyano-1H-pyrazole and 0.55 g of paraformaldehyde was stirred at 130 C for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. After the mixture was filtered, the filterate was concentrated under reduced pressure to obtain 0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole. 1H-NMR(DMSO-d6,TMS,delta(ppm)):5.54(2H,s),6.70(1H,d),7.72(1H,d)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-3-carbonitrile, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 84547-86-4, name is 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84547-86-4, Safety of 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid

To a solution of 4-bromo-1-methyl-1H-pyrazole-3-carboxylic acid (450 mg,2.2 mmol)in DCM (10 mL)was added oxalyl dichloride (0.37 mL,4.39 mmol)and DMF (0.016 mL,0.22mmol). The mixture was stirred at room temperature for 2 hand concentrated in vacuo to give 4-bromo-1-methyl-1H-pyrazole-3-carbonyl chloride (500 mg,crude)as a white solid which was10 dissolved in DCM (15 mL). 3-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-8-amine (350 mg,1.56mmol)and N,N-diisopropylethylamine (1.09 mL,6.24 mmol)were added. The reaction mixturewas stirred at room temperature for 16 h. The reaction was washed with water (5 mL). Theorganic layer was dried over anhydrou Na2S04,filtered and concentrated in vacuo. The cruderesidue was purified by silica gel column chromatography (DCM/MeOH = 20: 1)to give the title15 compound (400 mg,62%)as a yellow solid. 1HNMR (400 MHz,DMSO-d6)8 10.55 (s,1H),9.28 (s,1H),8.33 (s,1H),8.17 (s,1H),8.08- 8.06 (m,2H),7.77- 7.71 (m,2H),7.69- 7.64 (m,1H),4.01 (s,3H),3.92 (s,3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2075-45-8, name is 4-Bromo-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 2075-45-8

To a solution of 466 4-bromo-1H-pyrazole 51b (146 mg, 1 mmol) in 20 dichloromethane was added successively with 153 triethylamine (303 mg, 3 mmol) and 467 di-tert-butyl dicarbonate (327 mg, 1.5 mmol), and the mixture was stirred at room temperature for 3 h. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate=100/1 to 10/1) to give the target 468 product tert-butyl 4-bromo-1H-pyrazole-1-carboxylate 51c (150 mg, white solid). Yield: 61%. MS m/z (ESI): 247[M+1]

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 52867-42-2,Some common heterocyclic compound, 52867-42-2, name is Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 25-[5-(4-Fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide a) Methyl 5-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylate; To a solution of [5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-yl]-methanol (290 mg, 1.4 mmol) in THF (30 mL) was added 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (218 mg, 1.4 mmol) and triphenylphosphine (477 mg, 1.82 mmol) at ambient temperature under an argon atmosphere. Then diethyl azodicarboxylate (641 muL, 3.5 mmol) was added and the reaction mixture was stirred for 16 h at room temperature. Concentration and purification by chromatography (silica, 20 to 50% ethyl acetate in heptane) afforded the title compound (483 mg, 100%) as a white solid. MS: m/e=346.2 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-methyl-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, its application will become more common.

Some common heterocyclic compound, 100784-27-8, name is Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8ClN3O4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate

To a mixture of 7.0 g of 3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide, 5.3 g of anhydrous potassium carbonate and 50 ml of dry acetone there was added 2.8 g of n-butyl isocyanate at room temperature, and the mixture was refluxed for 3 hours. After the reaction, acetone was evaporated under reduced pressure and the residue was dissolved in ice-water. After separation of a trace of water insolubles, the filtrate was made acidic with hydrochloric acid and the crystals formed were filtered, washed with water and dried to give 5.2 g of N-(n-butylcarbamoyl)-3-chloro-4-methoxycarbonyl-1-methlpyrazole-5-sulfonamide. (0065) Into a mixture of 120 ml of dry toluene and the product obtained from the above procedure, 4.2 g of phosgene was passed under reflux. Then, the reaction mixture was further refluxed for 1.5 hours. After completion of the reaction, evaporation under reduced pressure to obtain crude 3-chloro-4-ethoxycarbonyl-1-methylpyrazole-5-sulfonyl isocyanate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 100784-27-8, its application will become more common.

Electric Literature of 1260243-04-6,Some common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-amino-1H-pyrazole-4-carboxylic acid ester (1.0 g, 6.45 mmol) was dissolved in methanol (200 mL) and the solution purged with nitrogen. Formaldehyde (37% by weight, 4.5 mL, 21.18 mmol) was added followed by 10% Pd/C (1.0 g). The reaction mixture was shaked on a Parr hydrogenator at 10 psi for 18hrs. The reaction mixture was filtered through celite to remove the catalyst and the residue washed with methanol (200 mL) and water (20 mL). The combined filtrates were evaporated in vacuo. The crude residue was triturated with methanol/diethyl ether and the filtrate concentrated to afford a colourless oil identified as the title compound (1.1 g, 6.00 mmol, 93% yield). [MH]+= 183.7

The synthetic route of 1260243-04-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1260243-04-6, HPLC of Formula: C6H9N3O2

General procedure: A mixture of ethyl-5-amino-1H-pyrazole-4-carboxylate 1 (1.0 mmol), an appropriate aldehyde 2 (1.0 mmol) and aterminal alkyne 3 (1.0 mmol) in acetic acid (5 mL) was stirred at 25 C for 10 min. The mixture was then stirred at 60 C under ultrasound using a laboratory ultrasonic bath SONOREX SUPER RK 510H model producing irradiationof 35 kHz for 30 min in the presence of air. The increase of bath temperature beyond 60 C due to the prolonged ultrasound irradiation was controlled by adding cold water time to time. After completion of the reaction the mixture was cooled to room temperature, poured into ethyl acetate (25 mL) and washed with brine solution (2 x 15 mL) followed by 10% NaHCO3 solution (2 x 15 mL). The organiclayer was collected, dried over anhydrous Na2SO4, filteredand concentrated under low vacuum. The residue isolatedwas purified by column chromatography over silica gel using3-8% petroleum ether-EtOAc to give the desired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-amino-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.

Related Products of 1260243-04-6, A common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of ethyl 5-amino- 1H-pyrazole-4-carboxylate (1.0 g, 6.493 mmol) in AcOH (15 mL) was added 1,1,1-trifluoropentane-2,4-dione (1.0 g, 6.493 mmol) at 110 ¡ãC. The mixture was stirred for 2 hours and concentrated in vacuo. The residue was dissolved in EA(100 mL). The organic solution was washed with 10percent NaHCO3 solution (50 mL), dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo to afford ethyl 7-methyl- 5 -(trifluoromethyl)pyrazolo [1,5-al pyrimidine-3 -carboxylate (1.8 g, 100percent) as a yellow solid.LC-MS m/z: 274.0 [M+Hf?. tR= 1.71 mm.

The synthetic route of 1260243-04-6 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H7F3N2O2

Example 119: Preparation of l-(prop-2-yl)-3-trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester and 2-(prop-2-yl)-3-trifluoromethyl-2H-pyrazole-4-carboxylic acid ethyl ester3-Trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester (2.5 g, 1.2 mmol) was dissolved in acetonitrile (25 ml) and stirred at room temperature. To the solution was added 2-iodopropane (1.8 ml, 1.8 mmol), followed by potassium carbonate (2.488 g, 1.8 mmol). The reaction mixture was heated to reflux and stirred for 6.5 hours. The reaction mixture was stored at room temperature for 16 hours. The reaction mixture was poured into water and extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate and concentrated to give l-(prop-2-yl)-3- trifluoromethyl-lH-pyrazole-4-carboxylic acid ethyl ester (isomer A) and 2-(prop-2-yl)- 3-trifluoromethyl-2H-pyrazole-4-carboxylic acid ethyl ester (isomer B) (9:1 mixture) as a yellow oil which was purified by column chromatography on silica gel (eluent: 0-10% ethyl acetate in hexane). Isomer A was obtained as a white solid (1.724 g, 57% yield). 1H-NMR (400 MHz, CDCl3): 1.35 (t, 3H, Me), 1.55 (d, 6H, Me), 4.3 (q, 2H, CH2), 4.55 (m, IH, CH), 8.0 (s, IH, CH) ppm.

The synthetic route of Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.