Day: February 5, 2021

Application of 175137-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175137-46-9 name is 5-Cyclopropyl-1H-pyrazol-3-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 172-Chloro-N-(5-cvclopropyl-lH-pyrazol-3-yl)-5-nitropyrimidin-4-amine; A mixture of 2,4-dichloro-5-nitropyrimidine (2 g) and S-cyclopropyl-lH-pyrazol-S-amine (2 g) in acetonitrile (20 mL) with diisopropylethylamine (2 mL) was stirred at room temperature for 24 hours, The resulting mixture was concentrated, and the resulting residue was separated by silica gel column (etaexane/Ethyl acetate) to afford 2.1 g desired product. MS (electrospray): 281 (M+l) for Ci0H9ClN6O2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Cyclopropyl-1H-pyrazol-3-amine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 28466-26-4, name is 4-Aminopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 28466-26-4, COA of Formula: C3H5N3

10055] A 250-mL 3-neck flask was charged with iH-pyrazol-4-amine (5 g, 60.2 mmol) and dichloromethane (50 mL). The resulting suspension was cooled to 5 C. and triethylamine (9.i3 g, 90.0 mmol) was added, followed by acetic anhydride (7.37 g, 72.2 mmol) at <20 C. The reaction was stirred at room temperature for i 8 hours, at which point thin layer chromatography (Eluent: ethyl acetate) analysis indicated that the reaction was incomplete. Additional triethylamine (4.57 g, 45.0 mmol) and acetic anhydride (3.70 g, 36.0 mmol) were added and the reaction was heated at 30 C. for an additional 3 hours to give a dark solution, at which point thin layer chromatography analysis indicated that only a trace of starting material remained. The reaction mixture was purified by flash column chromatography using ethyl acetate as eluent. The fractions containing pure product were combined and concentrated to dryness to afford an off-white solid. The solid was dried under vacuum at room temperature for i 8 hours (5.55 g, 55%):10056] ?H NMR (400 MHz, DMSO-d5) oe iO.30 (s, iH),8.39 (d, J=0.7 Hz, iH), 7.83 (d, J=0.7 Hz, iH), 2.60 (s, 3H),2.03 (s, 3H); ElMS mlz i67 ([M]j. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Aminopyrazole, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 304903-10-4, name is 1-Ethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H8N2O

General procedure: Corresponding aryl-carbaldehyde (1.0 eq.) and l-(triphenyl-phosphanylidene)propan-2-one (1.2 eq.) were dissolved in DCM. The mixture was stirred at r.t for 1-168 hours. The solvent was evaporated. The residue was purified by flash chromatography (hexane:EEO) to give the appropriate (¡ê)-4-(aryl)but-3-en-2-one.

According to the analysis of related databases, 304903-10-4, the application of this compound in the production field has become more and more popular.

Synthetic Route of 10250-63-2, These common heterocyclic compound, 10250-63-2, name is Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ester [[10250-63-2]] (1.7 g, 7.4 mmol) and aqueous 1 M KOH (10 mmol) in [ETOH] (20 mL) is stirred for 6 h. The reaction mixture is concentrated, and the residue is partitioned between cold aqueous 1 M HCl and EtOAc. The EtOAc solution is separated. The aqueous solution is further extracted with EtOAc. The combined EtOAc extracts are dried and concentrated to give [10250-64-3] as a powder: MS (ESI-) m/z 185.5.

Statistics shows that Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate is playing an increasingly important role. we look forward to future research findings about 10250-63-2.

Reference of 56984-32-8, A common heterocyclic compound, 56984-32-8, name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H9ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 11; [Show Image] Compound 6 was reacted with various benzylalcohols to give Compounds A-21, A-22, A-23 and A-24 via Mitsunobu reaction.

The synthetic route of 56984-32-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3920-50-1, name is Pyrazole-3-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H4N2O

To a 100 ml three-necked flask, 1.25 g (18 mmol) of hydroxylamine hydrochloride, 1.47 g (18 mmol) of sodium acetate and 40 ml of ethanol were added, and 0.96 g (10 mmol) of 3-formalpyrazole was added thereto with stirring, and the mixture was heated to 50 C for 2 h. After completion of the reaction, a milky white turbid liquid was obtained, which was cooled to room temperature, filtered, and the filtrate was evaporated to give an oily viscous solid, which was dissolved in 50 ml of water.Extract 50 times with 50 ml of ethyl acetate.The organic phase was dried over anhydrous sodium sulfate and filtered.The filtrate was evaporated to dryness to a pale yellow viscous solid, 0.96 g.The yield was 86.8%.

According to the analysis of related databases, 3920-50-1, the application of this compound in the production field has become more and more popular.

Synthetic Route of 4522-35-4,Some common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, molecular formula is C3H3IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 15 5-(3-Iodo-lH-pyrazol-l -yl)-2-(trifluorometyl)pyridine To a solution of 3-iodopyrazole (0.588 g, 3.03 mmol) in DMSO (15.0 mL) was added sodium hydride (60% in oil, 0.145 g, 3.64 mmol) and stirred for 0.5 h before 5-fluoro- 2-(trifluoromethyl)pyridines added. The reaction mixture was stirred at 90 C overnight. The reaction was quenched by the addition of water and extracted with EtOAc. The combined organic extracts were washed with water and brine, dried over MgS04 and concentrated in vacuo. The crude mixture was purified by passing through the silica gel funnel with CH2C12 to give 5-(3-iodo-lH-pyrazol-l -yl)-2- (trifiuorometyl)pyridine, as a yellow solid. LCMS calc. = 339.95; found = 339.89 (M+H)+. 1H NMR (500 MHz, CDC13): delta 9.03 (d, J= 2.3 Hz, 1 H); 8.24 (dd, J= 8.4, 2.1 Hz, 1 H); 7.86 (d, J= 2.5 Hz, 1 H); 7.80 (d, J= 8.5 Hz, 1 H); 6.73 (d, J = 2.6 Hz, 1 H).

The synthetic route of 4522-35-4 has been constantly updated, and we look forward to future research findings.

Related Products of 57999-06-1, A common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of ethyl-2-benzyl-3-oxo-butanoate ( 100 rng, 454.01 muetaiotaomicron, 96.15 mu^, 1.00 eq) and 4-phenyl-lH-pyrazol-5-amine (80 mg, 499.41 wmol, 1.10 eq) in EtOH (5 mL) was added H3PQ4 (98 mg, 454.01 iotaetaomicron, 50.00 ,uL, 85% v/v, 1 .00 eq). Then the reaction mixture was stirred at 100 C for 16 h. LC-MS indicated the desired product was detected. Water ( 10 mL) was added and the mixture was stirred at 5 C for 1 h. Then the mixture was filtered and the filter cake was dried in vacuo to give 6-benzyl-5-methyl-3-phenyl- pyrazolo[l,5-a]pyrimidin-7-ol (65.3 mg, 195.92 mutaueta, 43% yield) as a white solid. NMR (400 MHz, DMSO-ifc) delta 1 1.79 (brs, I I I ). 8.12 (s, 1H), 7.57 (d, J = 7.6, 2H), 7.46 (t, 2H), 7.34-7.26 (m, 6H), 3.89 (s, 2H), 2.39 (s, 3H); I3C NMR (100 MHz, DMSQ-tfc) delta 157.4, 148.7, 142,6, 140.8, 137.3, 131.3, 129,3, 128.8, 128.4, 127.9, 126,9, 126.3, 106.0, 104 ,4, 30.5, 1 7.6, LC-MS (ESI): m/z 316.0 ( i } .

The synthetic route of 57999-06-1 has been constantly updated, and we look forward to future research findings.

89202-89-1, name is 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H8N2O2

Intermediate 971 ,4-Dimethyl-1 H-pyrazole-3-carbonyl chloride Thionyl chloride (4 ml) was added to 1 ,4-dimethyl-1 H-pyrazole-3-carboxylic acid (0.5g) and the reaction was heated at 800C for 2h. Further thionyl chloride (2ml) was added and the reaction was heated at 800C for 1 h. The reaction was evaporated, then azeotroped with toluene to give title compound, 511 mg. 1H NMR (CDCI3) delta 7.3 (s, 1 H), delta 4 (s, 3H), delta 2.2 (s, 3H).

The synthetic route of 89202-89-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of S-cyclopropyl-lH-pyrazol-S -amine (1.9g, 16.0 mmol) in CH3CN (20 ml) was added dropwise to a solution of 2,6-dichloro-5-fluoronicotinonitrile (3.0g, 16.0 mmol) and triethylamine (2.1g, 20.0 mmol) in CH3CN (80 ml) at 25 C. The resulting solution was then heated to 82 C for 18 hrs, and then cooled to 25 C, at which point the product precipitated from solution. The resulting solid was filtered, and washed with CH3CN (100 ml) to give the title compound (3.2g, 73%). MS: Calcd.: 277; Found: [M+H]+ 278.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.