Day: February 3, 2021

Related Products of 13788-84-6, These common heterocyclic compound, 13788-84-6, name is 3-Methyl-4-phenyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen-purged glove box, (oxybis(2,1-phenylene))bis(diphenylphosphine) (1.0 g, 1.85 mmol) and toluene (30 mL) were added to a glass jar, equipped with a PTFE-coated stir bar. While stirring, mesitylcopper(I) (0.31 g, 1.70 mmol) was added. After a few minutes, 3-methyl-4-phenyl-1H-pyrazole (0.30 g, 1.90) was added, and the resulting mixture was heated at 90C for 3 hours. The mixture was then cooled to 60C, and stirred overnight. After cooling to room temperature, the solid that had formed was collected by filtration. The isolated solid was rinsed with toluene, followed by hexanes, and dried at 70C, under vacuum, to afford the title compound (0.66 g). Crystals were grown by slow evaporation of dichloromethane, and characterized by single crystal X-Ray crystallography, supporting the above molecular structure.

The synthetic route of 13788-84-6 has been constantly updated, and we look forward to future research findings.

Application of 2075-45-8, A common heterocyclic compound, 2075-45-8, name is 4-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: Synthesis of 4-bromo-1-ethyl-1H-pyrazole (4) To a stirred solution of NaH (34.0 g, 0.85 mol; 60% in mineral oil) in THF (400 mL) was added a solution of 4-bromo-1H-pyrazole (50 g, 0.34 mol) in THF (100 mL) at 0 C. under inert atmosphere. The reaction mixture was warmed to RT and maintained at same temperature for 1 h. The reaction mixture was cooled again to 0 C. and added EtI (63.67 g, 0.408 mol) slowly for 5 min. The resultant solution was allowed to warm to RT and then stirred for 16 h. After completion of the reaction (monitored by TLC), the reaction mixture was quenched with ice-cold water (100 mL) and extracted with EtOAc (3*250 mL). The combined organic extracts were dried over Na2SO4, filtered and concentrated under reduced pressure to obtain the crude. The crude was purified (silica gel chromatography; 4-6% EtOAc/Hexanes) to afford compound 4 (43 g, 72%) as a pale yellow liquid. 1H NMR (500 MHz, CDCl3): delta 7.45 (s, 1H), 7.41 (s, 1H), 4.15 (q, J=7.5 Hz, 2H), 1.47 (t, J=7.5 Hz, 3H); MS (ESI): m/z 175.0 (M+H+).

The synthetic route of 2075-45-8 has been constantly updated, and we look forward to future research findings.

Application of 16617-46-2, A common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, molecular formula is C4H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-amino-lH-pyrazole-4-carbonitrile (500 mg, 4.63 mmol) in n- BuOH (1 mL) was added ethyl 3-(l -methyl- lH-indazol-5-yl)-3-oxopropanoate (1.7 g, 6.90 mmol), p-TsOH (40 mg, 0.23 mmol) with stirring for 1 h at 130¡ãC. The product was collected by filtration and washed with methanol (3 x 5 ml) to afford 5- (l-methyl-lH-indazol-5-yl)-7-oxo-4H,7H-pyrazolo[l,5-a]pyrimidine-3-carbonitrile as a light yellow solid (1 g, 74percent). LCMS (ES, m/z): [M+H]+ 291.0; *H NMR (300 MHz, DMSO) delta 8.40 (s, 1H), 8.25 (s, 1H), 8.20 (s, 1H), 8.01 (d, / = 9.00 Hz, 1H), 7.76 (d, / = 9.00 Hz, 1H), 6.28 (s, 1H), 4.12 (s, 3H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 35344-95-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35344-95-7 as follows.

2-((3,5-dicyano-4-ethyl-6-(piperazin-1-yl)pyridin-2-yl)thio)-2-phenylacetamide trifluoroacetic acid (synthesis described in example 176 step 2, 215 mg, 0.413 mmol) was dissolved in dichloromethane (15 mL) and DIEA (0.144 mL, 0.826 mmol). Acetic acid (0.047 mL, 0.826 mmol) was added followed by 1H-pyrazole-4-carbaldehyde (79 mg, 0.826 mmol) The reaction was stirred for 30 minutes and sodium triacetoxyborohydride (350 mg, 1.652 mmol) was added. The reaction was stirred at 25 ¡ãC for 18Hous. The DCM solution was washed with water, a solution of saturated sodium bicarbonate, and then water. The DCM solution was dried then evaporated and the resulting solid was triturated with ethyl acetate to give after filtration pure product. The solid was dried in vacuum oven overnight to afford 2-((6-(4-((1H-pyrazol-4-yl)methyl)piperazin-1-yl)-3,5- dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide (75 mg, 0.149 mmol, 36percent yield) LCMS m/z = 487.2 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.20 (t, J=7.60 Hz, 3 H) 2.44 (br. s., 4 H) 2.75 (d, J=7.60 Hz, 2 H) 3.44 (s, 2 H) 3.86 (d, J=4.82 Hz, 4 H) 5.52 (s, 1 H) 7.28 – 7.44 (m, 4 H) 7.46 – 7.61 (m, 5 H) 7.91 (s, 1 H).

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151049-87-5 as follows. SDS of cas: 151049-87-5

Dissolve YC042 (100mg, 0.4mmol) and 1-methyl-3-bromo-1H-pyrazole (129mg, 0.8mmol) in DME, add 1.6mL of 2M sodium carbonate aqueous solution, evacuate and introduce nitrogen, and add catalyst Pd (dppf) 2Cl2-CH2Cl2 (16mg). After vacuuming again, nitrogen was passed through, refluxed at 95 C overnight, diluted with water, extracted with ethyl acetate, and the organic phase was dried over anhydrous sodium sulfate. YC043 (24 mg).

According to the analysis of related databases, 151049-87-5, the application of this compound in the production field has become more and more popular.

Synthetic Route of 70951-85-8,Some common heterocyclic compound, 70951-85-8, name is 4-Bromo-1-(tert-butyl)-1H-pyrazole, molecular formula is C7H11BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred mixture of 4-bromo-1-tert-butyl-pyrazole 3.1 (50 g) in 230 mL THF was added dropwise 2.5M N-butyllithium (100 mL, hexane) under argon atmosphere below -60 00, then the mixture was stirred at this temperature for 5 mm, before 2-lsopropoxy-4,4,5,5- tetramethyl-1 ,3,2-dioxaborolane (52 mL) were added dropwise below -60 00 The reaction mixture was allowed to reach ambient temperature. The mixture was cooled with an ice bath and diluted with aqueous phosphate buffer and water and neutralized with 2M aqueous hydrochloric acid. The organic solvent was removed by destillation and the residue was extracted with DCM. The combined organic extracts were washed with saturated brine, dried over sodium sulfate, filtered and concentrated in vacuo to yield 1-tert-butyl-4-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyrazole (44.26 g) as solid.Analysis: HPLC-MS: R1 = 0.904 mm (method F), M+H = 251

The synthetic route of 70951-85-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine

A solution of 5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine (0.5 g, 3.26 mmol) in EtOAc (10 mL) was treated with aqueous NaOH (1M, 5.87 mmol), followed by 2,2,2-trichloroethyl chloroformate (0.54 mL, 3.92 mmol) and the reaction mixture was stirred at RT for 1 h. The mixture was partitioned between EtOAc (10 mL) and water (2 x 10 mL). The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by FCC, using 0-100% EtOAc in cyclohexane to afford the title compound as a pale orange gum (0.915 g, 86%). LCMS (Method 3): Rt 3.88 min, m/z 328/330 [MH ].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 133261-11-7,Some common heterocyclic compound, 133261-11-7, name is Ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate, molecular formula is C10H14N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 3-cyclopropyl-4-iodo-1-methyl-1H-pyrazole-5-carboxylate A solution of 500 mg (2.57 mmol) of ethyl-3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate (prepared from ethyl-3-cyclopropyl-1H-pyrazole-5-carboxylate in accordance with Bioorg. Med. Chem. Lett. 1996, 6, 1819-1824) in 5 ml of acetonitrile is admixed with 706 mg (1.28 mmol) of ammonium cerium(IV) nitrate and 392 mg (1.53 mmol) of iodine and heated under reflux for three hours and afterstirred overnight at room temperature. The reaction mixture is diluted with water and ethyl acetate, and the organic phase is washed with saturated sodium thiosulphate solution, dried over sodium sulphate, filtered and concentrated by evaporation in vacuo. Chromatographic purification gives 506 mg of ethyl-3-cyclopropyl-4-iodo-1-methyl-1H-pyrazole-5-carboxylate (66%). 1H-NMR (400 MHz, d6-DMSO): delta=4.34 (m, 2H), 3.98 (s, 3H), 1.82 (m, 1H), 1.36 (m, 3H), 0.89 (m, 2H), 0.75 (m, 2H) ppm. HPLC-MS: log P=3.56; mass (m/z)=321 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-cyclopropyl-1-methyl-1H-pyrazole-5-carboxylate, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-13-1, name is 1H-Pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C3H4N2

General procedure: Complex 2 (0.05 mmol) was added to a 5 mL of a sealed tube containing the aryl iodide or bromide (0.5 mmol), 1H-pyrazole (0.75 mmol), NaOH (1 mmol), and DMSO (1 mL). The mixture was stirred at 100 C for 12 h. After being cooled to room temperature, the mixture was quenched with 10 mL H2O and extracted with EtOAc(3 ¡Á 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure.The residue was purified by flash column chromatography on silicagel with PE/EtOAc (from 10:1 to 5:1) as the eluent to afford the pure products. All N-aryl pyrazoles reported here are known products and were characterised by 1H NMR, and GC-MS.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-13-1.

Application of 1126-00-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1126-00-7, name is 1-Phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Example A: 1-Phenylpyrazole-5-carbaldehyd; Experimental procedure:; Under N2-atmosphere a solution of n-butyllithium in heptane (2.61 M, 5.3 mL, 13.9 mmol) is slowly added to a cooled (- 78 C) solution of 1-phenyl-1H-pyrazole (2.0 g, 13.9 mmol) in abs. THF (60 mL). The reaction mixture was stirred for 2 h at -78 C. Subsequently a Solution of abs. DMF (1.1 mL, 13.9 mmol) in abs. THF (8 mL) is slowly added at -78 C. This mixture was stirred for 1 h at -78 C, before it was slowly heated to room temperature and was stirred for a further 18 h. Then it was hydrolysed with water (10 mL) and subsequently extracted three times with CH2Cl2. The organic phases were dried (Na2SO4), filtered and the solvent was removed under vacuum. The crude product (2.48 g) was purified using flash-chromatography (?= 6 cm, h = 12 cm, n-hexane:ethylacetate = 8:2, 30 mL, Rf = 0.24). Yellow Oil, that crystalized in the cold to a yellow solid, melting point: 31 C, Yield: 2.15 g (90%) C10H8N2O (172.2) MS (EI): m/z (rel.Int) = 172 [M+, 100], 144 [M – CO, 69]. IR (neat): nu (cm-1) = 3063 (C-H aromat.), 2923 (C-H aliphat.), 2854 (C-H), 1683 (C=O), 1596, 1517, 1499 (C=C), 763, 694 (C-H). 1H-NMR (CDCl3): delta (ppm) = 7.11 (d, J = 2.1 Hz, 1H, Pyrazole-4-CH), 7.46 – 7.56 (m, 5H, Phenyl-CH), 7.76 (d, J = 2.0 Hz, 1H, Pyrazole-3-CH), 9.88 (s, 1 H, CHO). 13C-NMR (CDCl3): delta (ppm) = 112.5 (1 C, Pyrazole-4-CH), 125.8 (2 C, Phenyl-CH, ortho), 129.4 (1 C, Phenyl-CH, para), 129.6 (2 C, Phenyl-CH, meta), 139.0 (1 C, Phenyl-C, quartaer), 140.3 (1 C, Pyrazole-5-C), 140.7 (1 C, Pyrazole-3-CH), 180.2 (1 C, CHO).

The chemical industry reduces the impact on the environment during synthesis 1-Phenylpyrazole. I believe this compound will play a more active role in future production and life.