Day: January 26, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92534-69-5, name is 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid

1-Methyl-4-nitroimidazole-5-carboxylic acid (or 1-methyl-4-nitropyrazole-5-carboxylic acid) (0.51 g, 3 mM, dry tetrahydrofuran (90 mL) and triethylamine (0.6 mL) were cooled to -10C. A solution of ethyl chloroformate (0.36 mL) in dry tetrahydrofuran (10 mL) was added to the resulting mixture and was stirred for further 30 min. The mixture of 2-(6-methoxy-1-methyl-9H-carbazol-2-yl)ethylamine 5 (0.75 g, 3 mM), tetrahydrofuran (90 mL) and triethylamine (0.6 mL) was added dropwise at -10C. The resulting mixture was left for 24 h to reach room temperature with stirring and evaporation under reduced pressure afforded a residue which was put into water (100 mL), alkalized with sodium hydrogen carbonate, and extracted with methylene chloride. The extract was dried over magnesium sulfate. After evaporation of the solvent, the solid residue was purified by column chromatography on silica gel and eluted with chloroform : methanol (9 : 1).

The synthetic route of 92534-69-5 has been constantly updated, and we look forward to future research findings.

Related Products of 5932-27-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5932-27-4 name is Ethyl 1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of E15 (200 mg, 0.45 mmol), K2C03 (188 mg, 1.36 mmol), ethyl lH-pyrazole-3- carboxylate (317 mg, 2.27 mmol) and DMF (2 mL) were was stirred at 25 ¡ãC for 12 hours. TLC showed the reaction was finished. The mixture was diluted with EtOAc (20 mL), washed with brine (30mL*3), and the organic layer was dried over anhydrous Na2S04, and then concentrated to give crude product. It was purified by column chromatography (petroleum ether: ethyl acetate = 4:1) to give the 92 (96 mg, 44.4 percent) as a white solid. 1H NMR (92): (400 MHz, CDC13) delta 7.42 (d, J=2.4 Hz, 1H), 6.86 (d, J=2.4 Hz, 1H), 5.05-4.95 (m, 2H), 4.39 (q, J=7.2Hz, 2H), 4.20-4.10 (m, 1H), 3.49-3.39 (m, 2H), 3.28 (s, 3H) ,2.60-2.55 (m, 1H), 2.22 -1.91 (m, 3H), 1.75-1.50 (m, 6H), 1.45-1.10 (m, 15H), 1.05-0.92 (m, 1H), 0.90-0.84 (m, 1H), 0.70 (s, 3H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Computed Properties of C4H7N3

4,6-Dichloro-lH-pyrrolo[2,3-b]pyridine-3-carbonitrile (0.1 18g), 1-methyl-lH- pyrazo 1-3 -amine (0.027g), sodium tert-butoxide (0.269g), tris(dibenzylideneacetone)dipalladium(0) (0.026 g) and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos, 0.035g) were added to a microwave vial, followed by dry DMF (5 mL). The reaction mixture was flushed with N2 for -lOmin, and then heated to 80 ¡ãC with microwaves for 1 h. The reaction mixture was subjected to silica-gel flash column chromatography [dichloromethane-methanol (2-3percent)]. The eluted material, obtained as a yellow solid (0.055 g, 78percent) was identified as 4-chloro-6-[(l-methyl-lH-pyrazol-3- yl)amino]-lH-pyrrolo[2,3-b]pyridine-3-carbonitrile. LC-MS (Method A) (m/z) 273 (M+H+); tR = 2.11

The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives

The complex 2 was synthesized by modification of Xie et al method [17]. Complex 2 was prepared by carrying out the reaction of 1, 10-phenanthroline, CoCl2¡¤6H2O and 1H-pyrazole-3,5-dicarboxylic acid (in the presence of KOH) in 2:1:1M ratio. The product was isolated by evaporation of reaction mixture after the completion of reaction which was monitored on TLC. Single crystals suitable for X-ray crystallography were obtained at room temperature. [Co(phen)2L], 2: Yield: 76%, m.p.>300C; CCDC: 1817080, anal. Calc. for [C29H18CoN6O4] (%): C, 60.74; H, 3.16; N, 14.66; Found: C, 60.68; H, 3.23; N, 14.23. UV-vis (1¡Á10-4 M, DMSO, lambdamax nm): 261 (pi-pi*), 330 (n-pi*), 573 (d-d). FT-IR (KBr pallet, upsilonmax/cm-1):1689, 1647 nu(C=O), 1572 nu(C=N), 1519 nu(C=C), 594 nu(Co-N), 426 nu(Co-O).

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 5203-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 9 (4 mmol), dissolved in dry dichloromethane( 60 mL), and DCC (4.8 mmol) were mixed together and stirred at room temperature for 1 h. Then 1,3-dimethyl-1H-pyrazol-5-ol (4 mmol) and DMAP (0.4 mmol) were added to the above solution,and stirred for a further 24-36 h at room temperature. After adding dichloromethane (30 mL), the resultant mixture was washed sequentially with 2 N hydrochloric acid (100 mL), saturated NaHCO3 and saturated brine and dried over anhydrous sodium sulfate.The residue solution was evaporated in vacuum and purified by silica gel column chromatography using gradient elution of ethyl acetate/hexane (V/V = 1/2) to obtain the desired intermediate 10.

The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6825-71-4, name is Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate

Sodium ethoxide (33.2g) at room temperatureEthanol solution (500mL)3,5-Diamino-1H-pyrazole-4-carboxylic acid ethyl ester (20.8 g) was added in sequence.1,3-Dimethylpyrimidine-2,4(1H,3H)-dione (17.0 g).After the completion of heating to 90 C reaction12 hours.After the reaction is completed,The pH was adjusted to pH 7 with 1N hydrochloric acid at room temperature.Collect solids,Ethanol wash,Dry to give the title compound (18.4 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 31108-57-3,Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of II-C7 (245 mg, 0.6 mmol) and lH-pyrazole-4-carbonitrile (53.6 mg, 0.6 mmol) in acetone (5 mL) was added K2C03 (158 mg, 1.12 mmol). The reaction mixture was stirred at 20 C for 16 hrs. The reaction mixture was extracted with EtOAc (3 x 30 mL). The combined organic layer was washed with saturated brine (30 mL), dried over Na2S04, filtered and concentrated to give the product. The product was purified by flash column (0-30% of EtOAc in PE) to give II-C8 (39.5 mg, 16%) as a solid. (2671) 1H NMR (400 MHz, CDCl3) dH 7.85 (s, 1H), 7.81 (s, 1H), 4.95 (dd, J= 18.0, 44.8 Hz, 2H), 2.58 (t, J= 8.4 Hz, 1H), 2.25-2.15 (m, 1H), 2.08-1.99 (m, 1H), 1.82-1.60 (m, 9H), 1.45-1.15 (m, 13H), 1.05-0.79 (m, 7H), 0.66 (s, 3H); ELSD purity, 99%; MS ESI calcd. for (2672) C27H4ON302 [M+H]+ 438, found 438.

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

Reference of 25016-20-0,Some common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of methyl 1-methyl-1H-pyrazole-3-carboxylate To a solution of 1-methyl-1H-pyrazole-3-carboxylic acid (504 mg, 4 mmol) in MeOH (5 mL) was added SOCl2 (1.4 mL, 20 mmol) at 0 C. The mixture was stirred at r.t overnight then concentrated under reduced pressure. The residue was dissolved in EtOAc, washed with satd. aq. NaHCO3 and concentrated to afford methyl 1-methyl-1H-pyrazole-3-carboxylate. LC-MS: m/z 141 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazole-3-carboxylic acid, its application will become more common.

Reference of 35691-93-1,Some common heterocyclic compound, 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, molecular formula is C8H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

step 1 – To a solution of 3,5-dimethyl-lff-pyrazole-4-carboxylic acid ethyl ester (0.2 g, 1.19 mmol) in DMF (10 mL) cooled to O0C was added sequentially NaH (60% in mineral oil, 72 mg, 1.78 mmol) and S-chloro-?-trifluoromethyl-pyridazine (0.22 g, 1.21 mmol; Tetrahedron 1999 55:15067-15070). The resulting mixture was stirred at RT for 3 h then partitioned between EtOAc and saturated aqueous NH4Cl. The layers were separated and the aqueous layer was extracted twice with EtOAc. The combined extracts were dried (Na2SO4), filtered and evaporated. The residue was purified via Si?2 chromatography eluting with hexane/EtOAc to afford 0.228 g (62%) of 118a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, its application will become more common.

Some common heterocyclic compound, 16209-00-0, name is 4-(1H-Pyrazol-1-yl)benzoic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 16209-00-0

To a suspension of 4-(pyrazol-1-yl)benzoic acid (1.56 g) in dichloromethane (25 ml) was added oxalyl chloride (1.04 g) and one drop of dimethylformamide. The mixture was stirred at room temperature for 18 hours to yield a clear solution. The volatile material was removed under reduced pressure to afford 4-(pyrazol-1-yl)benzoyl chloride as a pale yellow solid (1.58 g), which was utilized without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16209-00-0, its application will become more common.