Day: January 14, 2021

Application of 2075-45-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2075-45-8 as follows.

4-Bromo-lH-pyrazole (3674 mg, 25 mmol, 1.0 eq),CuI (95 mg, 0.5 mmol, 0.02 eq) and K2CO3 (7256 mg, 52.5 mmol, 2.1 eq) were added to a dry pressure tube equipped with a magnetic stirring bar. (570 mg, 5 mmol, 0.2 eq), 1-iodo-3-methoxybenzene (3.57 mL, 30 mmol, 1.2 eq) and solvent dioxane ) Was added in a nitrogen-filled glove box. The mixture was bubbled with nitrogen for 5 minutes. The tube was sealed prior to removal from the glove box.The mixture was stirred in an oil bath100At temperatureAnd stirred for 2 days.The mixture was then cooled to room temperature, filtered and washed with ethyl acetate. The filtrate was concentrated and the residue was purified by column chromatographyPurification via column chromatography on silica gel using ethyl acetate (20: 1-15: 1) gave 4.09 g of the desired product 4-bromo-1- (3-methoxyphenyl) Pyrazole 3 in 65% yield.

According to the analysis of related databases, 2075-45-8, the application of this compound in the production field has become more and more popular.

326827-21-8, name is 3-Amino-5-cyclobutyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-Amino-5-cyclobutyl-1H-pyrazole

Example 271: Preparation of 6-((4-((5-cydobutyl-lH-pyrazol-3-yl)amino)-5- (trifluorometh l) rimidin-2-yl)amino)-3,4-dihydroquinoli -2(lH)-one.6-((4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroquinolin-2(lH)-one (0.060 g, 0.175 mmol), 5-cyclobutyl-lH-pyrazol-3-amine (0.024 g, 0.175 mmol) and N-ethyl-N- isopropylpropan-2-amine (0.034 ml, 0.193 mmol) were mixed in DMF (2 ml). The mixture was microwaved at 130 C for 30 min and then concentrated. 14 mg of product was recovered after automated reverse phase chromatography (water- 10% THF in MeCN). MS calcd for[C2iH2oF3N70+H]+: 444.18 found 444.15.

The synthetic route of 326827-21-8 has been constantly updated, and we look forward to future research findings.

Related Products of 14884-01-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14884-01-6, name is 4-Methoxy-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of Al (150 mg, 0.339 mmol) in acetone (3 mL) was added 4-methoxy-lH- pyrazole (49.8 mg, 0.508 mmol), followed by K2CO3 (93.7 mg, 0.678 mmol). The resulting reaction mixture was stirred at 40C for 16 hrs. To the mixture was added water (10 mL) and extracted with EtOAc (3 x 8 mL). The combined organic phase was concentrated to give a residue, which was purified by preparative HPLC to give compound 37 (10 mg, 7%), [381] 37: 1H NMR (400 MHz, CDCI3) delta 7.28 (s, IH), 7.09 (s, IH), 4.87-4.75 (m, 2H), 3.76 (s, 3H), 3.47-3.31 (m, 2H), 3.28 (s, 3H), 2.56 (t, = 8.8 Hz, IH), 2.17-2.01 (m, 4H), 1.71-1.42 (m, 8H), 1.41-0.92 (m, 12H), 0.91-0.84 (m, 2H), 0.69 (s, 3H). LCMS Rt = 1.256 min in 2 min chromatography, MS ESI calcd. for C27H43N204 [M+H]+ 459, found 459.

The synthetic route of 4-Methoxy-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1353100-91-0, name is Ethyl 3-bromo-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Product Details of 1353100-91-0

To a solution of NaH (275 mg, 6.86 mmol, 60% purity) in THF (5 mL) was added dropwise a solution of ethyl 3-bromo-lH-pyrazole-4-carboxylate (1.0 g, 4.57 mmol) in THF (10 mL) at 0 C. After addition, the mixture was stirred at this temperature for lh, and then Mel (2.93 g, 20.64 mmol, 1.29 mL) was added dropwise at 0 C. The resulting mixture was stirred at 25 C for 19h. The reaction mixture was quenched by addition sat. H4CI (5 mL), and then diluted with H20 (10 mL) and extracted with EtOAc (20 mL x 2). The combined organic layers were washed with brine (15 mL x 2), dried over Na2S04, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, Petroleum ether/Ethyl acetate = 8/1 to 5: 1) to give the Compound 142A (120 mg, yield: 11.27%) was obtained as a yellow oil and Compound 142B (370.00 mg, yield: 34.74%) was obtained as a white solid. (1387) [0574] 1H NMR (400MHz, CDC13) (142A) delta 7.93 (s, 1H), 4.42 – 4.21 (m, 2H), 3.97 – 3.82 (m, 3H), 1.36 (t, J = 7.2 Hz, 3H) (1388) [0575] 1H NMR (400MHz, CDC13) (142B) delta 7.83 (s, 1H), 4.30 (q, J = 7.0 Hz, 2H), 3.94 – 3.86 (m, 3H), 1.41 – 1.28 (m, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 287922-71-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 4-bromo-1-methyl-1H-pyrazole-3-carbonitrile (29-b) (60.8 mg, 0.327 mmol) , 4, 4, 4′, 4′, 5, 5, 5′, 5′-octamethyl-2, 2′-bi (1, 3, 2-dioxaborolane) (29-c) (91.0 mg, 0.360 mmol) , PdCl2(dppf) (47.9 mg, 0.065 mmol) and potassium acetate (64.2 mg, 0.654 mmol) in 1, 4-dioxane (3 ml) was stirred for 3 h at 80 . Then (R) -4-chloro-2- (4- (cyclopropanecarbonyl) -3-methylpiperazin-1-yl) pyrimidine-5-carbonitrile (29-a) (100 mg, 0.327 mmol) , potassium carbonate (90.1 mg, 0.654 mmol) and water (0.5 ml) were added and the resulting mixture was stirred for 5 h at 80 . The mixture was cooled, water (10 mL) was added and the mixture was extracted with ethyl acetate (3 x20 mL) . The combined organic fractions were washed with brine (3 x20 mL) , dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purified by preparative-TLC, eluting with ethyl acetate: petroleum ether =1: 2 to give compound 6-13. MS (ESI) Calc?d for (C19H21N8O) [M+H]+, 377; found, 377.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, other downstream synthetic routes, hurry up and to see.

Related Products of 89202-89-1,Some common heterocyclic compound, 89202-89-1, name is 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 203 Production of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1,4-dimethyl-1H-pyrazole-3-carboxamide To a suspension of 1,4-dimethyl-1H-pyrazole-3-carboxylic acid (151 mg, 1.08 mmol) in tetrahydrofuran (2.0 mL) were added N,N-dimethylformamide (1 drop) and thionyl chloride (0.08 mL, 1.1 mmol), and the mixture was stirred at room temperature for 50 min. The reaction mixture was concentrated under reduced pressure and dissolved in N,N-dimethylacetamide (2.0 mL). On the other hand, to a solution of N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide (327 mg, 1.0 mmol) in N,N-dimethylacetamide (6.0 mL) was added dropwise the above-mentioned solution under ice-cooling, and the mixture was stirred at room temperature for 2 hr. Under ice-cooling, aqueous sodium hydrogencarbonate solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtrated. The solvent was evaporated under reduced pressure, and the residue was purified by basic silica gel column chromatography (ethyl acetate/hexane=80/20?100/0) and recrystallized from tetrahydrofuran/ethanol to give the title compound (283 mg, 63%) as pale-yellow crystals. 1H-NMR (DMSO-d6, 300 MHz) delta 0.75-0.85 (4H, m), 1.85-2.00 (1H, m), 2.21 (3H, s), 3.89 (3H, s), 7.05-7.15 (2H, m), 7.38 (1H, t, J=9.6 Hz), 7.65 (1H, s), 7.90-8.00 (2H, m), 8.03 (1H, d, J=9.6 Hz), 9.40 (1H, s), 11.06 (1H, s).

The synthetic route of 89202-89-1 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 1-Methyl-1H-pyrazole-5-carboxylic acid

(a) 1-Methyl-4-nitro-1H-pyrazole-5-carboxylic acid A quantity comprising 69.0 gm (0.547 mol) of 1-methyl-1H-pyrazole-5-carboxylic acid of m.p.: 227-228 C. (R. Huttel and M. E. Schon, Liebigs Ann. Chem 625, 55 [1959]) was added in small portions to a mixture of 200 ml of concentrated sulfuric acid and 60 ml of 90% fuming nitric acid under stirring. The temperature of the mixture rose from 75 C. at the beginning to a maximum temperature of 95 C. After the exothermal reaction was finished, heating was continued for 30 minutes up to 95 C. The cold mixture was stirred into 300 gm of cracked ice, and the resulting ice-cold suspension was filtered off by suction filtration. The filtration residue was washed with water, and after recrystallization from ethyl acetate, 44.0 gm (47% of theory) of pale yellow crystals were obtained. M.p.: 169-170 C. (decomp.).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 4149-06-8, These common heterocyclic compound, 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The mixture of alpha,beta-unsaturated ketone 1, or 4 (1.0 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one 2 (1.0 mmol), p-TSAxH2O (0.3mmol), MeCN (4mL), H2O (4mL) was put in a reaction flask under 80 C about 1-3 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be precipitated out at same time. Then, it was filtered, washed thoroughly with MeCN. The products were recrystallized from DMF.

The synthetic route of 4149-06-8 has been constantly updated, and we look forward to future research findings.

Electric Literature of 67-51-6,Some common heterocyclic compound, 67-51-6, name is 3,5-Dimethyl-1H-pyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

15.6 g (0.088 mol) of the above intermediate crude product was dissolved in 500 mL of acetone and 17.6 g (0.132 mol) of NIS was added.The reaction solution was placed in ultrasonic wave for 8 h, the temperature should not exceed 25-30 .The reaction solution was filtered and the filtrate was concentrated and the resulting residue was passed through a short silica gel column,Dichloromethane as eluent. And concentrated under reduced pressure to give an orange liquid (16.85 g)Is a crude product of 4-iodo-3,5-dimethyl-lH-pyrazole.

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71229-85-1, Product Details of 71229-85-1

In a RBF previously equipped with a magnetic stirrer and nitrogen balloon was taken 4- bromo-1 -ethyl-1 H-pyrazole (2.15 g, 12.33 mmol) in THF (15 ml) and the mixture was cooled at -78 C. n-BuLi (2.5 M in THF, 22.4 ml, 13.56 mmol) was added drop-wise to the reaction mixture and it was stirred at same temperature for 2 h. 5-nitro-2- phenoxybenzaldehyde (commercially available, 3.0 g 12.33 mmol) was dissolved in THF (5 ml) and the solution was added drop-wise in to reaction mixture at -78 C. The reaction mixture was stirred at -78 C for 2 h and then allowed to reach room temperature and stirred for 12 h. The reaction mixture was quenched with ammonium chloride solution (50 ml) and extracted with EtOAc (2 x 100 ml). The combined organic layer was washed with brine (100 ml) and dried over sodium sulphate and the solvent removed under reduced pressure to obtain 2 g of the crude title compound that that was used in the next step without further purification. MS (ES+) m/z 340 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-ethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.