Month: January 2021

Application of 5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

Into a 50 mL round bottom flask containing a solution of 4-nitro-7H-pyrrazole-3-carboxalic acid (5.0 g, 32 mmol) in methanol (50 mL) was added concentrated sulfuric acid (1 mL) at 0 C. The resulting slurry was stirred at reflux temperature overnight. The solvents were evaporated under reduced pressure and the residual mass was dissolved in ethyl acetate and washed with water and brine solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to yield methyl 4-nitro-7H-pyrazole-3-carboxylate as a solid which was taken to next step without further purification. 1Eta NMR (CD3OD 300 MHz): delta 8.59 (s, 1H), 3.93 (s, 3H). MS calc’d [M-H]+ 170.0, found 170.1.

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.

Synthetic Route of 25016-20-0,Some common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2,3-dichlorophenyl)(5-aminoindol-1-yl)methanone (40 mg, 0.13 mmol, 1.0 equiv.), 1-A-1H-pyrazole-3-carboxylic acid (17 mg, 0.134 mmol, 1.05 equiv.), HATU (54 mg, 0.14 mmol, 1.1 equiv.),DIPEA (18 mg, 0.14 mmol, 1.1 equiv.) was dissolved in an appropriate amount of DCM and stirred at room temperature for 6 to 8 hours. The TLC monitors the reaction in real time. anti-After completion, the reaction solution was diluted with 2N HCl, and extracted with three portions of ethyl acetate. The organic phase was combined and then dissolved with water and saturated NaHCO3.Wash with liquid, saturated NaCl solution, and dry the organic layer with anhydrous NaSO4.Distilled under reduced pressure to obtain a crude product,Purified by silica gel column to obtain N-(1-(2,3-Dichlorobenzoyl)porphyrin-5-yl)-1-methyl-1H-pyrazole-3-carboxamide (40 mg, yield: 73.9%).

The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-20-0, Quality Control of 1-Methyl-1H-pyrazole-3-carboxylic acid

Step 3: To solution of step 2 intermediate (6.0 g, 47.6 mmol) in CH2CI2 (50 mL) were added oxalyl chloride (6.12 mL, 71.4 mmol) and catalytic amount of DMF (0.5 mL) at 0C. The RM was stirred at rt for 2 h. The RM was concentrated under reduced pressure and residue was diluted with CH2CI2. NH3 gas was passed through RM at 0C for 30 min. After that the RM was concentrated under reduced pressure and residue was suspended in THF (50 ml) and filtered. The filtrate was concentrated under reduced pressure to yield the desired compound (3.5 g, 59%). LC-MS (Method 3): m/z [M+H]+ = 126 (MW calc. = 125.13); R, = 0.76 min.

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These common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H5IN2

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

The synthetic route of 4-Iodo-1-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 132712-71-1

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

The synthetic route of 132712-71-1 has been constantly updated, and we look forward to future research findings.

Application of 116008-52-7,Some common heterocyclic compound, 116008-52-7, name is 4-Amino-1H-pyrazole-3-carboxylic acid, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Amino acid 4 (2 g, 0.0157 mol) wassuspended in absolute EtOH (20 ml). SOCl2 (1.17 ml,1.92 g, 0.0161 mol) was added dropwise to the suspension.The mixture was heated under reflux for 12 h untilhomogenization. A cherry-colored solution formed. Thesolvent was evaporated to dryness under reduced pressureon the rotary evaporator. The solid residue was dried in avacuum desiccator to constant weight. Yield 3.0 g (99%),pink solid, mp 114-115C. 1H NMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 10.22 (4, br. s, NH, +NH3);8.03 (1H, s, -3 pyrazole); 4.28 (2, q, J = 7.0,OCH2H3); 1.30 (3, t, J = 7.1, OCH2H3). 13C NMRspectrum (101 MHz, DMSO-d6), delta, ppm: 160.5; 133.7;127.3; 116.6; 60.8; 14.1. Found, m/z: 178.05868 [M+Na]+.C6H9N3NaO2. Calculated, m/z: 178.05870.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Amino-1H-pyrazole-3-carboxylic acid, its application will become more common.

Related Products of 612511-81-6, These common heterocyclic compound, 612511-81-6, name is (1-Methyl-1H-pyrazol-3-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 9-bromo-l,6-dichloro-benzo[c][l,6]naphthyridine (0.10 g, 0.31 mMol) in anhydrous CH3CN (4.0 mL) was added C-(I -methyl- lH-pyrazol-3-yl)-methylamine (0.040 g 0.36 mMol) and anhydrous Et3N (0.22 mL, 1.6 mMol). The reaction mixture was heated in a sealed tube at 12O0C. After 3 hours the solvent was removed and the solid obtained was re-dissolved in EtOAc (10 mL). The EtOAc layer was washed with water (2 x 5 mL), brine (1 x 10 mL), and dried over MgSO4. The filtrate was concentrated and the resulting residue was purified using preparative HPLC to afford 9-bromo- 1 -chloro-N- [( 1 -methyl- 1 //-pyrazol-3 – yl)methyl]benzo[c]-l,6-naphthyridin-6-amine. 1H NMR (400 MHz, DMSO-d6) deltal 1.34 (br d, IH), 10.11 (d, IH), 8.61 (t, IH), 8.32 (d, IH), 7.75-7.73 (dd, IH), 7.55 (d, IH), 7.37 (t, IH), 6.40 (d, IH), 6.18 (d, IH), 4.74 (d, 2H), 3.77 (s, 3H). LRMS calculated for C17H14BrClN5 [M+H]+, 404.0; found 403.9.

The synthetic route of 612511-81-6 has been constantly updated, and we look forward to future research findings.

Application of 330792-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of tert-butyl 3-(tosyloxy)piperidine- 1 -carboxylate (355 mg, 1.0 mmol) and 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (276 mg, 1.0 mmol) in 5 mL of DMF is added Cs2CO3 (650 mg, 2.0 mmol). The mixture is stirred at RT for 16 hours, 75 C for 3 hours and 60C for 16 hours. The mixture is concentrated washed with brine (100 mL x 3) and dried over Na2504. The material is concentrated and purified by chromatography column on silica gel (eluted with petroleum ether/ethyl actate = 3/1) to afford 60 mg (13%) of tert-butyl 3- (5 -amino-4-cyano-3 -(4-phenoxyphenyl)- 1H-pyrazol- 1 -yl)piperidine- 1 -carboxylate as a yellow

The synthetic route of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 179692-08-1, name is Ethyl 4-iodo-1H-pyrazole-5-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 179692-08-1, Formula: C6H7IN2O2

To a solution of ethyl 4-iodo-1H-pyrazol-3-formate (4.2 g, 15.8 mmol, 1.0 eq.) and potassium carbonate (4.37 g, 31.6 mmol, 2.0 eq.) in acetonitrile (45 mL) was added p-methoxybenzyl chloride (3.09 g, 19.7 mmol, 1.25 eq.) under stirring at room temperature. The reaction liquid was protected with nitrogen gas and stirred overnight at 60C. The reaction liquid was cooled to room temperature and insoluble substances were filtered. The filter cake was washed with ethyl acetate. The filtrate was concentrated in vacuo and separated by column chromatography on silica gel column to give ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazol-5-formate (C1, 1.94 g, 32% yield) and ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazol-3-formate (C2, 2.90 g, 47% yield). C1: 1H NMR (400MHz, CDCl3) delta 7.61 (s, 1H), 7.21 (d, J = 8.4 Hz, 2H), 6.82 (d, J = 8.4 Hz, 2H), 5.70 (s, 2H), 4.37 (q, J = 7.2 Hz, 2H), 3.77 (s, 3H), 1.40 (t, J = 7.2Hz, 3H). m/z=409[M+Na]+. C2: 1H NMR (400MHz, CDCl3) delta 7.36 (s, 1H), 7.22 (d, J = 8.8 Hz, 2H), 6.90 (d, J = 8.4 Hz, 2H), 5.31 (s, 2H), 4.44 (q, J = 7.2 Hz, 2H), 3.81 (s, 3H), 1.43 (t, J = 7.2Hz, 3H). m/z=409[M+Na]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-iodo-1H-pyrazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 330792-70-6,Some common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0110] Under nitrogen atmosphere, a mixture of toluene (8.0 v), AcOH (0.5 v), BG-8 (1.2 eq.) and BG-4 (66.9 Kg 1.0 eq.) was heated to 95C and stirred until the reaction was completed. The mixture was cooled, concentrated and precipitated from methanol. The mixture was centrifuged and the cake was washed with methanol. The cake was dried under vacuum. This gave 107.8 Kg of product.1H NMR (DMSO-de) delta 8.78 (d, J= 4.6 Hz, 1H), 8.15-8.07 (m, 2H), 7.51-7.41 (m, 2H), 7.34 (d, J= 4.6 Hz, 1H), 7.27-7.19 (m, 3H), 7.17-7.10 (m, 2H), 4.24-4.02 (m, 2H), 3.81-3.69 (m, 1H), 3.12-3.82 (m, 2H), 2.15-2.04 (m, 2H), 1.76-1.60 (m, 2H), 1.43 (s, 9H).

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.