Month: January 2021

Electric Literature of 139755-99-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139755-99-0, name is 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

Step 4: Synthesis of I -methyl-4-nitro-3 -propyl- 1 H-pyrazole-5-carboxylic acid:- Dissolve 1-methyl-3-propyl-1H-pyrazole-5-carboxylic acid (13.0 gm 7.7 m.ml) in 20 mlof conc.H2S04 and heated at 50 C. After that nitric mixture (9 ml) was added slowly over an 1 hour after the addition mixture was stirred at 50 C for 7 hours and then cooled to room temperature before being poured onto ice. Filteration of the precipitate gave the nitropyrazole as a white solid; Yield 88%. 1H NMR (400 MHz, CDC13) 6 4.10 (s, 3H) 2.50 (t, J=7.6Hz, 3H) 1.70 (m 2H) 1.02(t, J=7.6Hz, 3H) ppm ESI {M + Na] :236.07

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference of 5334-40-7, A common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 18 Methyl 4-nitro-1H-pyrazole-3-carboxylate To a solution of 4-nitro-1H-pyrazole-3-carboxylic acid (10.0 g, 63.7 mmol) in methanol (100 mL), thionyl chloride (5.1 mL, 70.0 mmol) was added dropwise at 0 C., and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure, and the obtained residue was dissolved in ethyl acetate. This solution was washed with saturated aqueous sodium hydrogencarbonate solution, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (9.9 g, yield 91%). 1H-NMR (CDCl3): delta 4.06 (3H, s), 8.51 (1H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 129768-28-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 129768-28-1, name is 5-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A. Preparation ofN-( cis-4-fluoro-4-( 3-fluoro-5-( trifluoromethyl)phenylsulfonyl) cyclohexyl)-3 -(trifluoromethyl)- lH-pyrazole-5-carboxamide (200)[00296] Cis-4-fluoro-4-(3-fluoro-5-(trifluoromethyl)phenylsulfonyl)cyclohexanamine hydrochloride (124) (500 mg, 1.32 mmol), 3-trifluoromethyl-lH- pyrazole-5-carboxylic acid (199) (238 mg, 1.32 mmol), HATU (668 mg, 1.8 mmol), and TEA (740 mu, 5.3 mmol) were stirred in DCM (15 mL) at room temperature for 16 hours. The reaction was diluted with DCM, washed sequentially with NH4C1 saturated solution and Na2HC03 saturated solution, dried (Na2S04), and concentrated in vacuo. The residue purified by automated flash chromatography (20% EtOAc/PE) to give N-(cis-4-fluoro-4-(3-fluoro-5-(trifluoromethyl)phenylsulfonyl) cyclohexyl)-3- (trifluoromethyl)-lH-pyrazole-5-carboxamide (200) (530 mg, 82%).

The synthetic route of 5-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 288-13-1, The chemical industry reduces the impact on the environment during synthesis 288-13-1, name is 1H-Pyrazole, I believe this compound will play a more active role in future production and life.

General procedure: General procedure: iodobenzene (1.0mmol), pyrazole (1.5 mmol), LiOH (2.0 mmol), TBAB(0.2 mmol), active Cu (0.1 mmol) and 2 mL H2O were added to a 10 mL flask. The mixture was heated in an oil bath at 120?. When the reaction completed, the resulting mixture was cooled to room temperature and the product was extracted by ethyl acetate (10 mL¡Á3). The combine dextracts were washed by brine (15 mL) , dried over MgSO4 and evaporated under reduced pressure. Further purification by silica gel column chromatography (5:1 petroleum ether/ethylacetate) give 1-phenyl-1H-pyrazole (2a, 0.126 g, 88%) as a Colorless liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 138786-86-4, The chemical industry reduces the impact on the environment during synthesis 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.

3,4-dihydropyran (8.21 ml, 90 mmol) was added drop wise to a solution of 4-nitro- lH-pyrazole-3-carboxylic acid methyl ester (10 g, 60 mmol) in chloroform (200 ml) at O0C. The reaction mixture was stirred for 45 min before being allowed to warm to 250C. After 1 h Et2O (100 ml) was added and this mixture was washed sequentially with sat. aq. NaHCO3 (250 ml), water (2 x 250 ml), and brine (250 ml). The organics were dried (Na2SO4) and evaporated in vacuo to give 4-nitro-l-(tetrahydro-pyran-2- yl)-lH-pyrazole-3-carboxylic acid methyl ester as a yellow oil (16.99g, impure). A portion of this protected pyrazole (9.66 g, 37.88 mmol) was combined with hydrazine hydrate (9.97 ml, 200 mmol) and ethanol (150 ml) and stirred at 250C under N2. After Ih the mixture was evaporated in vacuo to give a crude orange oil. This was partitioned between EtOAc (4 x 150 ml) and brine (150 ml). The organic layer was dried (Na2SO4) and evaporated in vacuo to give 4-nitro-l-(tetrahydro-pyran-2-yl)- lH-pyrazole-3-carboxylic acid hydrazide as a yellow foam (8.45 g, 87%). (LC/MS (acidic method): Rt 1.56, [M+H]+256).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-nitro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 34334-96-8, name is 3-Methyl-5-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34334-96-8, COA of Formula: C4H5N3O2

Add acetonitrile (75 rnL) to a mixture of (2.0 g, 15rnmoi). potassium carbonate (4.1 g, 2.0 eq), and 1-chioro-2-propanol (3.8 mL, 3.0 eq).Stir at 85 C overnight. Cool to rt. Filter and rinse the solids with EtOAc. Concentrate the filtrate in vacuo to provide a residue. Subject the residue to normal phase chromatography, eluting with 50% EtOAc in hexanes, to give the title compound (2.0 g, 65%). MS (ES) ,n/z 186 (M+1-1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-5-nitro-1H-pyrazole, and friends who are interested can also refer to it.

These common heterocyclic compound, 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one

Step 1 : Synthesis of 4-bromo-l-methyl-5-(trifluoromethyl)-2,3-dihydro-lH-pyrazol- 3-one: [01064] To a stirred solution of l-methyl-5-(trifluoromethyl)-lH-pyrazol-3-ol (2g, 12.0 mmol) in ethanol (15 mL) was added bromine (0.74 mL, 14.5 mmol). The resulting solution was stirred at room temperature overnight. After which time, the reaction was concentrated in vacuo and the residue was basified (pH 8) with a saturated aqueous solution of sodium hydrogen carbonate (20 mL). The product was extracted with DCM (5×15 mL) and the combined organics were washed with brine (20 mL). The aqueous phase was back-extracted with DCM (2×5 mL). The combined organics were dried over MgS04, filtered and concentrated in vacuo to afford the title compound as an off white solid (2.48 g, 83% yield), which was used directly in the next step without purification. LC-MS 99%, 1.69 min (3 minute LC-MS method), m/z=244.80, 246.85, XH NMR (500 MHz, Methanol-d4) delta 3.81 (d, J = 1.1 Hz, 3H).

The synthetic route of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1820-80-0, name is 1H-Pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1H-Pyrazol-3-amine

To a stirred suspension of 118 (2.00g, 24.O7mmol) in concentrated HC1 (32mL) was added a solution ofNaNO2 (3.32g. 48.i4mmoi) in water (5mL) over 5 minutes at 0C. To the resulting orange reaction mixture was added a solution of KI (9.99g, 60 iSmmol) in water (l0mL) over 10 minutes. The reaction mixture was stirred at 0C for 30 minutes and then kept at 28C for another 2 hours, TLC showed the reaction was complete, then, solvent THF (3OmL) was added,followed by water (3OmL). The aqueous mixture was extracted with EtOAc (3 x8OmL) and the combined organic extracts were washed with Na2S2O3 (2 x4OmL), dried over Na2SO4, filtered and concentrated in vacuum to afford product 180 (200 g, crude), the crude product was used directly for the next step without purification.LCMS: m/z, i94.9M+H)??.

According to the analysis of related databases, 1820-80-0, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 930-36-9, name is 1-Methylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 930-36-9

A solution of POCl3 (2.61 mL, 28 mmol) in DMF (2.16 mL, 28 mmol)was stirred at 8 C for 2 h, and the resultant viscous solution waswarmed to 80 C. To this solution was added N-methylpyrazole (1 g,12 mmol), and it was stirred at 80 C for 1 h, at 100 C for 3 h, and at115 C for 1 h. The solution was then cooled to room temperature andquenched by addition of 60 mL of ice-cold water. The reaction mixturewas stirred for 24 h and then neutralized to pH 7 using 1 N NaOH andextracted with chloroform (3¡Á30 mL). The combined organic layerwas washed with brine (30 mL) and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo. The residue was purified bycolumn chromatography to afford 5 (0.68 g, 50%), Rf=0.2 Hex/EA7:3. 1H NMR (400 MHz, CDCl3) delta 9.80 (s, 1H), 7.91 (s, 1H), 7.89 (s, 1H),3.93 (s, 3H). MS (ESI) m/z 110.8 [M+H]+. HRMS calcd for C5H6N2O[M+H]+ 111.0558, found 111.0556.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 368870-03-5, These common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The corresponding acid (0.20 mmol), O-(1H-benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (0.24 mmol) and N-ethyldiisopropylamine (0.40 mmol) were mixed in DMF (1 mL) and stirred for 5 min under N2 atmosphere. Thereafter the amine component (0.20 mmol) was added and the inert atmosphere was restored. The mixture was stirred at room temperature for 16 hours then concentrated in vacuo and purified by column chromatography to furnish the amide product.

Statistics shows that (4-(1H-Pyrazol-1-yl)phenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 368870-03-5.