Month: January 2021

Electric Literature of 15366-34-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15366-34-4 name is Methyl 1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 4: To a mixture of methyl 1H-pyrazole-5-carboxylate (3.15 g, 25.0 mmol), cyclopropylboronic acid (4.30 g, 50.0 mmol), sodium carbonate (5.30 g, 50.0 mmol), and dichloroethane (125 mL) at 70 C was added a heated suspension of copper(II) acetate (4.55 g, 25.0 mmol), 1,10-phenanthroline (4.50 g, 25.0 mmol), and dichloroethane (31 mL). The reaction mixture was then stirred vigorously under air at 70 C for 4 hours. The reaction mixture was cooled and filtered through Celite. The solvent was removed and the residue purified by silica gel chromatography (0 to 100% EtOAc in hexanes) to afford the desired product as a pale green

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 1145-01-3

A solution of ethyl 3,5-diphenyl-1-hydropyrazole (0.20 mmol ), tert-butyl alpha-diazoacetoacetate ( 0.25 mmol) was added in a 25 mL Schrocker tube at room temperature,[Cp * RhCl2] 2 (0¡¤01 mmol), AgSbF6 (0.04 mmol) and tetrahydrofuran (2.00 mL) were added and argon was bubbled through argon for 2 minutes. Tighten the lid. Stir at 60 C for 24 hours. The reaction was stopped and concentrated under reduced pressure to give a crude product. The column was finally rinsed with a mixture of petroleum ether and ethyl acetate and subjected to rapid column chromatography (silica gel column) to give the corresponding nitrogen-containing fused heterocyclic compound (60 mg of white solid, 84% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27258-33-9 as follows. category: pyrazoles-derivatives

Example 4; Influence of the ligand Using the optimal conditions [Example 2] which leads to 85-87% ee with the ligand sd499, a ligand screening with a variety of N,O-ligands was carried out. The results are given in the following table. The best results were obtained with the ligands sd311b (91% ee) and commercially available (S)-2-piperidinyl-1,1,2-triphenylethanol at 5 mol% scale. As the latter one is known to be a somewhat slower ligand than the paracyclophane-based ligands and the derivatives of sd499, we repeated the experiment with 10 mol% of (S)-2-piperidinyl-1,1,2-triphenylethanol. This experiment gave 93% ee. The ligand is available in both enantiomeric forms.

According to the analysis of related databases, 27258-33-9, the application of this compound in the production field has become more and more popular.

Application of 139756-02-8, These common heterocyclic compound, 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

We intended to synthesize compounds based on 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one scaffold by using microwave assisted protocol (Scheme 1). In this direction we started the studies for optimization of synthesis of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 3a. The optimization studies were initiated by screening of different oxidizing agents as depicted in Table1, see Supplementary data using DMSO:Water in 1:1 proportion to see the conversion in desired product. Amongst all oxidants, the best result was observed with K2S2O8, in equivalence studies for catalyst, 3eq. of catalyst has given maximum yields (Table1, see Supplementary data). Therefore, all reactions were conducted using this condition after optimization of catalyst. However, oxone has also given the product 3a with minor yields. After screening of the catalyst we started study of selectivity for solvent that could affect the formation of 5-(2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 3a. The solvent screening was carried out to find out the best conversion, the mixture of DMSO:H2O in 1:1 proportion has given the best results with excellent yields (Table2, see Supplementary data). The microwave protocols were optimized for this reaction as mentioned in Table 3, see Supplementary data; the reactions carried under different microwave Watt powers have given varied results. Wherein, entry 3(b) (Table3, see Supplementary data) was found to be the best condition for maximum conversion. A series of compounds based on 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one scaffold was synthesized using these optimized conditions, wherein, all kind of substrates with diversity around aryl ring were chosen for conversion and in all cases products obtained in good to excellent yields (Table1).

Statistics shows that 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide is playing an increasingly important role. we look forward to future research findings about 139756-02-8.

Adding a certain compound to certain chemical reactions, such as: 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4149-06-8, COA of Formula: C9H9N3O

General procedure: The mixture of isatin (1 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one (1 mmol), 1,2-diarylethan-1-one, 2,3-dihydroinden-1-one (1 mmol) or 3,4-dihydronaphthalen-1(2H)-one (1 mmol), H2O (6 mL), HOAc (2 mL) was put in a reaction flask under 90 C about 5-7 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be isolated out at same time. Then, compound 4 was recrystallized from DMF, however, the pure products of 6 and 8 were filtered from water, dried, without further recrystallization.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, and friends who are interested can also refer to it.

Electric Literature of 20154-03-4,Some common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Preparation of 1-(4-nitro-ph 1H-pyrazole1 -fluoro-4-nitro benzene (4.14 g, 29.4 mmol) was added slowly to a solution of 3- trifluoromethylpyrazole (2 g, 14.7 mmol) and anhydrous potassium carbonate (6 g, 44.1 mmol) in D F at room temperature.The reaction mixture was then heated at 110C overnight then cooled to RT. The reaction mixture was diluted with water then extracted with ethyl acetate (2 x). The combined organic layers were washed with water and brine, then dried over sodium sulfate, filtered and concentrated to give the title compound as a beige solid (3.3 g, 87.4%). TLC: Ethylacetate/Hexane (3/7): Rf : 0.85. 1H N R (CDCI3; 400 MHz): delta 8.38 (dd, J = 9.1 Hz, 2H), 8.10 (d, J = 2.4 Hz, 1 H), 7.94 (dd, J = 9.1 Hz, 2H), 6.83 (d, J = 2.5 Hz, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)-1H-pyrazole, its application will become more common.

Related Products of 162758-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 162758-35-2 name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of carboxylic acid in CH2Cl2 (0.1 M) at rt. was added (COCl)2(3 eq) and a catalytic amount of DMF (1 drop). The mixture was then stirred for 1 h and concentratedin vacuo. The resultant crude acid chloride was dissolved in CH2Cl2 then DIPEA (6 eq) and the amine(1.5 eq) were added. The mixture was stirred at rt. for a further 16 h, washed with H2O three times,dried over Mg2SO4, filtered, and concentrated in vacuo. The resultant crude oil was then purified byflash chromatography to give the amide product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, and friends who are interested can also refer to it.

Reference of 154471-65-5,Some common heterocyclic compound, 154471-65-5, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 3.8 g (25.3 mmol) l-methyl-3-(trifluoromethyl)- lH-pyrazole (2) in dichloromethane (75 ml) was added 3.42 ml (26 mmol) of ethyltriflate. After heating the mixture to reflux for 6 hours the low boiling components were removed under reduced pressure to yield 2.4 g (29 %) of the ionic liquid 5 as amber coloured oil

The synthetic route of 154471-65-5 has been constantly updated, and we look forward to future research findings.

Related Products of 175137-46-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

17/18D. trans-Methyl 2-(4-(5-cyclopropyl-lH-pyrazol-3-ylamino)pyrrolo[l,2-f][l,2,4]triazin-2-yl)cyclopentanecarboxylate. trans-Methyl 2-(4-oxo-3,4-dihydropyrrolo[l,2-f][l,2,4]triazin-2- yl)cyclopentanecarboxylate hydrochloride (450 mg, 1.51 mmol) was dissolved in POCl3 (10 mL, 107 mmol) and heated to 85 0C for 1.5 h, then at 100 0C for an additional 4.5 h. The reaction was cooled to rt and concentrated in vacuo, co- evaporating with toluene several times. NMP (6 mL) was added to the residue, and the reaction was heated to 80 0C before a solution of 5-cyclopropyl-lH-pyrazol-3- amine (922 mg, 7.49 mmol) dissolved in NMP (6 mL) was slowly injected. The reaction was stirred overnight at 80 0C, then cooled to rt. EtOAc (250 mL) was added, and the reaction was washed with water (2 x 150 mL) and brine (150 mL). The organic layer was dried (MgSO4), filtered, and concentrated in vacuo. The compound was purified by silica gel flash chromatography (0-40% 90: 10: 1 [CH2Cl2ZMeOHZcOnC NH4OH]ZCH2Cl2), followed by trituration with 1: 1 CH2Cl2ZHeX to give 17/18D (260 mg, 50%). 17/18D had an analytical HPLC retention time = 2.15 min (Waters XBridge 4.6 x 50 mm, 5-95% aqueous acetonitrile over 5 min containing 10 mM ammonium acetate) and a LCZMS M+ + 1 = 367.

The chemical industry reduces the impact on the environment during synthesis 5-Cyclopropyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Synthetic Route of 1621-91-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1621-91-6, name is 1H-Pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

b) Methyl 1H-pyrazole-3-carboxylate 1H-Pyrazole-3-carboxylic acid (15 g, 133.8 mmol) was dissolved in MeOH (250 ml). Concentrated H2SO4 (30 ml) was added to the solution. The resulting mixture was refluxed for 12 h and concentrated. The residue obtained was quenched by saturated aqueous solution of NaHCO3 and extracted with EtOAc. The organic layer was concentrated. Yield 12.05 g. 1H-NMR (400 MHz; CDCl3): delta 3.98 (s, 3H), 6.86 (d, 1H), 7.85 (d, 1H), 11.9 (bs, 1H).

The synthetic route of 1H-Pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.