Month: January 2021

Electric Literature of 3524-32-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Example i.27; Preparation of (2,5-DimethyI-2H-pyrazol-3-yl)-(4′-fluoro-biphenyI-4-yl)-amine (Compound 36).A 20-mL scintillation vial was charged with 4′-bromo-4-fluoro-biphenyl (251.1 mg, 1 mmol), 3-amino-2,5-dimethyl pyrazole (111.1 mg, 1 mmol), sodium tert-butoxide (134.5 mg, 1.4 mmol), tris(dibenzylideneacetone)dipalladium(0) (45.8 mg, 0.05 mmol), BINuAP (62.3 mg, 0.1 mmol) and toluene (2 mL) under nitrogen atmosphere. The reaction mixture was heated at 800C for 48 hours. It was then allowed to cool to room temperature, taken up in ether/ethyl acetate, filtered and concentrated. The crude material was subjected to column chromatography on silica gel (Biotage, eluent hexanes/ethyl acetate 70/30) to afford Compound 36 as a yellow solid. LCMS m/z (%) = 282 (M+H, 100). 5

The chemical industry reduces the impact on the environment during synthesis 5-Amino-1,3-dimethylpyrazole. I believe this compound will play a more active role in future production and life.

Application of 27258-33-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To 2-methylpyrazole-3-carbaldehyde (55 mg, 0.50 mmol), benzyl 2-aminoacetate tosylate (186 mg, 0.550 mmol), acetic acid (1 mL), and dichloromethane (1.5 mL) were added, followed by stirring at room temperature. Sodium triacetoxyborohydride (159 mg, 0.750 mmol) was added thereto, followed by stirring at room temperature overnight. The reaction liquid was diluted with dichloromethane, and saturated aqueous sodium hydrogen carbonate was added thereto. After extraction with dichloromethane, the organic layer was washed with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazole-5-carbaldehyde. I believe this compound will play a more active role in future production and life.

Reference of 473528-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 473528-88-0, name is 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

4-Bromo-2-methyl-2H-pyrazole-3-carbaldehyde (1.00 g; 5.29 mmol) is dissolved in 5.0 ml of anhydrous THF and cooled down to -78 C. Phenylmagnesium chloride 2 mol/l (6.61 ml; 13.2 mmol) is added and the reaction mixture is stirred for 1 hour. It is warmed up to 0 C. and is quenched carefully with water, then extracted with DCM. The organic layers are pooled, dried over MgSO4 and purified by using reversed phase chromatography under basic conditions. Yield: 82% (1.16 g; 4.35 mmol);HPLC-MS: (M+H)+= 267; tRet=1.59 min; method FECBM3ESI.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-methyl-1H-pyrazole-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Application of 37622-90-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of ethyl-1H pyrazole carboxylate (5.0 g, 3.7mmol) in DMF (50 mL), Cs2CO3 (23 g, 71.35mmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-1-carboxylate (9.9 g, 35.6 mmol) were added at 5 C and reaction mixture was stirred at 90 C overnight. The completion of the reaction was confirmed by TLC. The reaction mixture was poured into ice cold water. The resulting solid was filtered, washed with water (50 mL) and dried under reduced pressure. It was used in the next step without any further purification. Yield: 87% (10 g, off white solid). 1H NMR (400 MHz, DMSO-d6 : delta 8.39 (s, 1 H), 7.87 (s, 1 H), 4.45-4.39 (m, 1 H), 4.21 (q, J = 7.2 Hz, 2H), 4.05-4.02 (m, 2H), 2.01 -1.98 (m, 2H), 1.85-1.78 (m, 2H), 1.42 (s, 9H), 1.26 (t, J = 7.2 Hz, 3H). LCMS: (Method A) 222.0 (M-Boc), Rt. 2.77 min, 92.86% (Max).

The synthetic route of Ethyl 4-pyrazolecarboxylate has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-39-4, Recommanded Product: 5334-39-4

Added 3-bromooxetane (451 ul, 5.901 mmol) to a mixture of 3-methyl-4-nitro-1 H-pyrazole (500 mg, 3.934 mmol) and cesium carbonate (2.564 g, 7.868 mmol) in DMF (5 mL) and stirred at 70 C for 6 d. Added ether (50ml_) and filtered off the residues. Removed the solvent from the filtrate in vacuo and purified the residue by flash chromatography using dichloromethane/ethyl acetate (3/7) to give the titled compound (589 mg, 82%). LCMS (Method 1 ) Rt 1.865 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Reference of 1904-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 3: Preparation of 5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine To a solution of 2-chloro-5-fluoro-4-(3-nitrophenoxy)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine (483 mg, 1.1 mmol), in 1,4-dioxane (12 mL) was added 1-methyl-1H-pyrazol-3-amine (128 mg, 1.32 mmol), Cs2CO3 (717 mg, 2.2 mmol), Xantphos (66 mg, 0.11 mmol) and Pd2(dba)3 (101 mg, 0.11 mmol). The reaction vial was flushed with nitrogen, capped, stirred and heated at 140¡ã C. in a microwave reactor for 45 min. After removing the reaction solvent, the residue was partitioned in EtOAc (120 mL) and water (20 mL). The organic layer was separated, washed with water (20 mL) and brine (10 mL), dried over Na2SO4 and evaporated. Purification via flash chromatography with a gradient of 0percent-50percent EtOAc in heptanes afforded the title compound (523 mg, 95percent yield) as a thick oil. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.62 (s, 1H) 8.28-8.32 (m, 1H) 8.26 (d, J=8.06 Hz, 1H) 7.90-7.95 (m, 1H) 7.81-7.88 (m, 1H) 7.45 (br. s., 1H) 7.32 (d, J=2.27 Hz, 1H) 5.52 (s, 2H) 3.74 (s, 3H) 3.55-3.66 (m, 2H) 0.94 (t, J=8.18 Hz, 2H) 0.00 (s, 9H). m/z (APCI+) for C22H26FN7O4Si 500.1 (M+H)+.

The synthetic route of 1-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(Furan-2-yl)-1H-pyrazol-3-amine

A solution of 3-amino-5-(2-furyl)pyrazole (162 mg, 1.09 mmol) and DIPEA (0.19 mL, 1.09 mmol) in THF (5 mL) was added dropwise to a solution of cyanuric chloride (200 mg, 1.09 mmol) in THF (16.0 mL) at 0 0C. The reaction mixture was stirred at 0 C to room temperature for 2 hours. Then, 1-metyl piperazine (0.12 mL, 1.09 mmol) and DlPEA (0.19 mL, 1.30 mmol) were added to the mixture. The mixture was allowed to stir at room temperature for 3 hours. The solids were filtered off to give compound 11 as white solid (1 10 mg, 14 %). %). 1H NMR (400 MHz, DMSOd6) delta 12.92 (s, IH, NH), 10.38 (s, IH, NH), 7.76 (s, IH, Ar-H), 6.816.61 (m, 3H, Ar-H), 3.77-3.72 (m, 4H, 2CH2), 2.38-2.35 (m, 4H, 2CH2), 2.21 (2, 3H, CH3); ESI-MS: calculated for (C15Hi7ClN8O) 360, found 361 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 4149-06-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4149-06-8, name is 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of alpha,beta-unsaturated ketone 1, or 4 (1.0 mmol), 3-amino-1-phenyl-1H-pyrazol-5(4H)-one 2 (1.0 mmol), p-TSAxH2O (0.3mmol), MeCN (4mL), H2O (4mL) was put in a reaction flask under 80 C about 1-3 h (monitored by TLC). After completion, the reaction mixture was cooled to room temperature and the products would be precipitated out at same time. Then, it was filtered, washed thoroughly with MeCN. The products were recrystallized from DMF.

The chemical industry reduces the impact on the environment during synthesis 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate

To 4,6-dichloropyrimidine (674 mg, 4.52 mmol) in dimethylformamide (3.4 ml) under an atmosphere of argon was added tert-butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate (946 mg, 4.52 mmol) and cesium carbonate (1.47 g, 4.52 mmol) and the reaction stirred overnight at room temperature. The reaction was poured onto water (25 ml) and stirred for 60 minutes. The precipitate was filtered and purified by HPLC (Method 20) to yield 748 mg (100% purity, 51 % yield) of the desired product. LC-MS (Method 10): Rt = 2.10 min; MS (ESIpos): m/z = 322 [M+H]+1H-NMR (600 MHz, dimethylsulfoxide-d6) delta [ppm]: 1.466 (16.00), 4.400 (1.20), 4.427 (1.38), 4.456 (1.47), 4.477 (1.29), 7.884 (0.67), 7.903 (0.79), 8.467 (0.69), 8.493 (0.62), 8.925 (1.44).

According to the analysis of related databases, 1280210-79-8, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-09-5, name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H8N2O

151. (+)-2- 3,4-trans)-l-gi,3-dimethyl-lH-pyrazol-5-yl)methyl)-4- methylpyrrolidin-3-yl)-7-ftetrahydro-2H-pyran-4-yl)imidazo[5,l- 1 [l,2,41triazin- 4(3H)-one [1110] To a stirred solution of (-)-2-((3,4-trans)-4-methylpyrrolidin-3-yl)-7- (tetrahydro-2H-pyran-4-yl)imidazo[5,l- J[l,2,4]triazin-4(3H)-one (80 mg, 0.26 mmol) in MeOH (10 mL) was added l,3-dimethyl-lH-pyrazole-5-carbaldehyde (39.2 mg, 0.31 mmol) at room temperature and stirred for 2 h under argon atmosphere. To the resulting solution was added NaCNBH3 (49.9 mg, 0.74 mmol) and stirring was continued for another 8 h at room temperature. The volatiles were evaporated under reduced pressure. The residue was diluted with water and extracted with CH2CI2 (2 x 20 mL). Combined organic layer was dried over sodium sulphate, filtered and concentrated in vacuo to obtain the crude product. The crude material was purified by silica gel column chromatography to afford (+)-2-((3,4-trans)-l-((l,3-dimethyl-lH- pyrazol-5-yl)methyl)-4-methylpyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4- yl)imidazo[5,l- J[l,2,4]triazin-4(3H)-one (40 mg, 37%) as an off-white solid; 1H- NMR (DMSO-d6, 400 MHz): delta 11.65 (bs, 1H), 7.62 (s, 1H), 5.89 (s, 1H), 3.96-3.91 (m, 2H), 3.67 (s, 3H), 3.59 (s, 2H), 3.50-3.47 (m, 2H), 3.41-3.39 (m, 1H), 2.94-2.85 (m, 2H), 2.81-2.79 (m, 2H), 2.65-2.61 (m, 1H), 2.25-2.24 (m, 1H), 2.14 (s, 3H), 1.89- 1.82 (m, 4H), 1.09 (d, 3H); Mass (ESI): 412.3 [M++l]; LC-MS: 98.59%; 412 (M++l); (column; X-bridge C-18, (50×3.0 mm, 3.5mu); RT 1.74 min. 0.05% TFA in water: ACN; 0.8 ml/min); UPLC (purity): 99.67%; (column; Acquity BEH C-18, 50×2.1 mm, 1.7mu; RT 1.18 min. 0.025% TFA (Aq): ACN; 0.50 ml/min.; Chiral HPLC: 98.34%, R,= 11.21 min (Chiralpak IA, 250 x 4.6mm, 5mu; mobile phase (A) 0.1% DEA in n-Hexane (B) DCM:MeOH (80:20) (A: B : 80:20); flow Rate: 1.00 mL/min); Optical rotation [a]D2: + 21.85 (c = 0.25, DCM); TLC: 5% MeOH/DCM (Rf: 0.5).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-09-5.