Day: December 25, 2020

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 5334-40-7

To a mixture of 4-nitro-1H-pyrazole-3-carboxylic acid (6.50 g, 41.4 mmol) and N,N-dimethylformamide (100 mL), isopropylamine (4.7 mL, 55 mmol), HOBt (6.71 g, 50 mmol) and (3-dimethylaminopropyl)ethylcarbodiimide hydrochloride (9.52 g, 50 mmol) were added, and the mixture was stirred at room temperature for 16 hr. 5percent Aqueous solution of citric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with 5percent aqueous solution of citric acid, 5percent sodium hydrogencarbonate aqueous solution, brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (5.72 g, yield 70percent). 1H-NMR (DMSO-d6, 200 MHz) :delta 1.14(6H,d, J=6.6 Hz), 3.91-4.17(1H, m), 8.45-8.65(1H, brm), 8.76(1H, brs).

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 211738-66-8, name is Methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 211738-66-8

To a solution of methyl 4-bromo- 1 -methyl- 1 H-pyrazole-3-carboxylate (p71 , 270. mg, 1.23 mmol) in DMF (8 mL), Cul (23.6 mg, 0.12 mmol) and Pd(Ph3)4 (142.4 mg, 0.12 mmol) were added and the mixture was degassed with nitrogen for 20min before adding tributyl(2-pyrimidinyl)stannane (0.5 mL, 1 .51 mmol). The reaction was stirred at 1 10 C for 4hrs. Reaction was cooled to RT and diluted with EtOAC and 1 M KF aq. solution. Phases were stirred at RT for 1 h and then separated. Organic layer was dried and solvent was removed under reduced pressure. Crude material was purified by FC on N H column (eluting from Cy to 60%EtOAc) to afford methyl 1 -methyl-4-(pyrimidin-2-yl)-1 H- pyrazole-3-carboxylate (p74, 90 mg, y= 33% yield) as white solid. MS (/T7/z): 219.0 [MH]+

The synthetic route of 211738-66-8 has been constantly updated, and we look forward to future research findings.

Application of 28466-26-4, These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: N,N-Diisopropylethylamine (3.0-4.0 eq) was added to 8-methoxyquinoline-3-carboxylic acid (1.0 eq) in solvent (dichloromethane, tetrahydrofuran,or N,N-dimethylformamide, 0.05 to 0.2 M) at room temperature. Then, 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V)(1.0-1.5 eq) was added and the reaction mixture was stirred for five minutes. Then, amine (1.0 – 2.0 eq) was added and the reaction mixture was stirred for one to sixteen hours. 10% Aqueous citric acid was added and the reaction mixture was extracted with dichloromethane, washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered,and concentrated. The resulting residue was purified by RP HPLC or silica gel chromatography to give the quinoline-3-carboxamide (1%-95% yield).

The synthetic route of 28466-26-4 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55864-87-4, name is Ethyl 4-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H7N3O4

a) A mixture of ethyl 4-NITRO-LH-PYRAZOLE-3-CARBOXYLATE (0. 685 g, 3.7 mmol) and 2- chloro-N- (3-fluorophenyl) acetamide (0.694 g, 3.7 mmol) and potassium carbonate (0.613 g, 4.44 mmol) in dimethyl formamide (10 ml) was stirred at room temperature for 20 hours. The mixture was evaporated and the residue was purified by silica gel chromatography eluting with a 8 to 10% mixture of ethyl acetate in dichloromethane to give ethyl 1- {2- [ (3- fluorophenyl) AMINO]-2-OXOETHYL}-4-NITRO-LH-PYRAZOLE-3-CARBOXYLATE (0.920 g, 74% yield): H-NMR (DMSO d6 TFA): 9.02 (s, 1H), 7.57 (d, 1H), 7.39 (q, 1H), 7.32 (d, 1H), 6.93 (t, 1H), 5.24 (s, 2H), 4.38 (q, 2H), 1.31 (t, 3H); MS (+ ve ESI): 337.17 (M+H) +.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 49633-25-2,Some common heterocyclic compound, 49633-25-2, name is 3-Isopropylpyrazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under a nitrogen atmosphere, a mixture of methyl 4-((1-(4-bromo-2-methylphenyl)-4,4,4-trifluorobutyl)amino)benzoate (racemate) (400 mg), 3-isopropylpyrazole (154 mg), copper(I) iodide (212 mg), trans-N,N’-dimethylcyclohexane-1,2-diamine (0.352 mL), potassium carbonate (385 mg) and toluene (1.8 mL) was stirred at 110C overnight, water was added at room temperature, and the insoluble material was filtered off through celite. The filtrate was extracted with ethyl acetate, and the extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (316.2 mg). MS (ESI+) : [M+H]+460.2.

The synthetic route of 49633-25-2 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 13745-17-0, name is 4-Bromo-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4-Bromo-1H-pyrazole-3-carboxylic acid

NaH (60% dispersion in mineral oil, 11.3 g, 282 mmol, 3.0 eq) was added in portions to a mixture of 4-bromo-1H-pyrazole-3-carboxylic acid (18 g, 94.2 mmol, 1.0 eq) in) anhydrous DMF (200 mL) at 0 C under argon protection. Once addition of NaH was complete, the mixture was stirred for an additional 30 min at 0C and 1h at RT. The mixture was re-cooled to 0C and then MeI (24 mL, 377 mmol, 4.0 eq) was added. The reaction mixture was diluted with EtOAc and washed with Sat’d NaHCO3, brine and dried over Na2SO4. The organic layers were concentrated to provide the crude as solid that was used without further purification. 1H NMR (400 MHz, CDCl3) delta 7.87 (s, 1H), 3.96 (s, 3H), 3.88 (s, 3H).

The synthetic route of 4-Bromo-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Related Products of 54605-72-0, The chemical industry reduces the impact on the environment during synthesis 54605-72-0, name is 1-Phenylpyrazole-4-carboxaldehyde, I believe this compound will play a more active role in future production and life.

A solution of 1-phenyl-1H-pyrazole-4-carbaldehyde (5.0 g, 29.0 mmol), (R)-2-methyl-2-propanesulfinamide (3.51 g, 29.0 mmol) and Ti(OiPr)4 (47.7 g, 50 mL, 0.168 mol) in THF (50 mL) was stirred with heating on a water bath at 50 C for 20 h. The resulting mixture was poured into water (250 mL) with stirring for 15 min, then filtered, and the precipitate was washed twice with DCM. The filtrate was diluted with water (200 mL) and extracted with DCM (50 mL * 3). The combined extracts were dried over K2CO3, filtered through the pad of silica gel and evaporated under reduced pressure, and crystallized from iPr2O/n-hexane to afford pure 2d 6.78 g (85%). Rf: 0.5 (EtOAc/n-hexane, 1:1) = -98.7 (c 1, CHCl3). Mp 67.5-68.5 C (iPr2O/n-hexane). 1H NMR (400 MHz, CDCl3): delta 8.58 (s, 1H, CH=N), 8.34 (s, 1H, CHpyr), 8.13 (s, 1H, CHpyr), 7.72 (d, J = 7.9 Hz, 2H, Ph), 7.51-7.47 (m, 2H, Ph), 7.38-7.34 (m, 1H, Ph), 1.26 (s, 9H, tBu) ppm. 13C NMR (100 MHz, CDCl3): delta 154.21, 141.15, 139.33, 129.63 2C, 128.62, 127.59, 121.38, 119.56 2C, 57.56, 22.51 3C ppm. MS (70 eV, EI): m/z (%) = 276 (27) [MH]+, 220 (14), 219 (91), 218 (11), 172 (21), 171 (100), 170 (24), 145 (12), 144 (52), 77 (11). C14H17N3OS (275.4): calcd C 61.06, H 6.22, N 15.26, S 11.64; found C 60.93, H 6.19, N 15.25, S 11.64.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenylpyrazole-4-carboxaldehyde, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C5H4N2O4

A mixture of LaCl3¡¤7H2O (0.187g, 0.5mmol), H3pdc (0.175g, 1.0mmol), NaOH (0.041g, 1.0mmol) and H2O (5mL) was placed in a 23mL Teflon-lined Parr acid digestion bomb and heated for two days at 180¡ãC under autogenous pressure. Upon cooling to room temperature, solution was separated from the solid phase, and after filtration precipitate washed with water and acetone, respectively. The product was dried at ambient temperature. The colorless crystals of 1 were obtained with high yield and the synthesized single crystals suited for X-ray diffraction analysis. Yield ca. 86percent (based on La). Initial pH was 2.50; final pH was 1.88. Crystalline 1 is insoluble in water and common solvents and stable in air. Anal. Calc. for C15H15La2N6O18: C, 21.29; H, 1.78; N, 9.93. Found: C, 21.18; H, 2.18; N, 9.67percent. IR data (KBr pellet, cm?1): 3410(m), 3160(m), 1593(vs), 1458(m), 1352(vs), 1311(vs), 1017(s), 837(w), 783(s), 629(w).

The synthetic route of 3112-31-0 has been constantly updated, and we look forward to future research findings.

Reference of 42098-25-9,Some common heterocyclic compound, 42098-25-9, name is 5-Chloro-1-methyl-4-nitro-1H-pyrazole, molecular formula is C4H4ClN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A. tert-Butyl 4-(1-methyl-4-nitro-1H-pyrazol-5-yl)-1,4-diazepane-1-carboxylate A mixture of 5-chloro-1-methyl-4-nitro-1H-pyrazole (0.403 g, 2.50 mmol) (prepared as described for Intermediate 1, Step A and B), tert-butyl 1,4-diazepane-1-carboxylate (0.500 g, 2.50 mmol) and DIPEA (0.791 mL, 4.54 mmol) in EtOH (2 mL) was heated under microwave irradiation at 130 C. for 1 h. The mixture was concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel using CombiFlash apparatus eluting with EtOAc/hexane (50-100%). The purification afforded 0.572 g (70.4% yield) of the sub-title compound as a yellow oil. LCMS calc. for C14H23N5O4Na (M+Na)+: m/z=348.2. found: 348.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloro-1-methyl-4-nitro-1H-pyrazole, its application will become more common.

Reference of 31230-17-8,Some common heterocyclic compound, 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of compound C (1.0 g, 2.94 mmol)and 3-amino-5- methylpyrazole (314 mg, 3.23 mmol) in dimethylformamide (6 ml) was treated with diisopropylethylamine (0.614 ml, 3.53 mmol) and sodium iodide (530 mg, 3.53 mmol). The mixture was stirred under nitrogen at 85 ¡ã for 4 hours, cooled to room temperature and diluted with ethyl acetate. The solution was washed with water (x 4), dried over magnesium sulphate and concentrated to 5 ml to afford, upon crystallization and harvesting of colourless crystals, the title compound D (920 mg, 78percent). 1H-NMR DMSO-d6, delta 0.80-0.87 (4H, m), 1.77-1.85 (IH, m), 1.92 (IH, s), 5.24 (IH, br s), 6.47 (IH, br s), 7.55 (2H, d), 7.70-7.80 (2H, m), 10.24 (IH, s), 10.47 (IH, s), 11.92 (IH, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-pyrazol-3-amine, its application will become more common.