25016-11-9, Name is 1-Methyl-1H-pyrazole-4-carbaldehyde, 25016-11-9, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Preparation Example 6 N-[3-(4-t-Butylphenyl)-2-methylpropyl]-N,1-dimethyl-1H-pyrazol-4-ylmethylamine (I-17) Route B-2: After suspending 200 mg (3.2 mmol) of sodium cyanoborohydride in 2 ml of absolute methanol, 380 mg (1.7 mmol) of 3-(4-t-butylphenyl)-N,2-dimethylpropylamine (IV-1) was added thereto. Subsequently, to this was added a solution of 170 mg (1.6 mmol) 4-formyl-1-methylpyrazole/2 ml absolute methanol by portions, the pH was adjusted to 7 with acetic acid, and then stirring was conducted at room temperature for 8 h. Methanol was removed under reduced pressure, water was added and extraction with ethyl acetate was done. The ethyl acetate layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue was purified with a silica gel (Silica gel 60, 230-400 mesh, Merck Co.) column (eluent composition: n-Hex/AcOEt=1/1) to afford 340 mg of the desired compound (I-17) as an oil. The yield was 70.1%.
Statistics shows that 1-Methyl-1H-pyrazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 25016-11-9.