Month: December 2020

Related Products of 42027-81-6, The chemical industry reduces the impact on the environment during synthesis 42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, I believe this compound will play a more active role in future production and life.

[0215j A solution of 2-(4-nitro-1H-pyrazol-1-yl)ethanol (2.00 g, 12.73 mmol), 3,4- dihydro-2H-pyran (1.60 g, 19.10 mmol) and p-toluenesulfonic acid (87 mg, 0.51 mmol) in THF (20 mL) was stirred at room temperature for 2 h. Then the mixture was diluted with EtOAc (150 mL), washed with sat. aqueous sodium carbonate (50 mL) and water 60 mL. The organic phase was dried (Na2SO4), filtered and concentrated to give crude product 4-nitro- 1 -(2-((tetrahydro- 2H-pyran-2-yl)oxy)ethyl)-1H-pyrazole as colorless oil (2.00 g, yield: 67%). ESI-MS (M+H) :242.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 67-51-6

3,5-Dimethyl-1H-pyrazole, 78.5 g (0.818 mol), was dissolved in 700 mL of water heated to 70C, and 517 g (3.271 mol) of potassium permanganate was added to the hot solution, maintaining the temperature no higher than 90C. The mixture was cooled to room temperature, the precipitate of MnO2 was filtered off and washed with water, and the filtrate was acidified with aqueous HCl to pH 2 and left overnight. The precipitate was filtered off and washed with water. Yield 41.75 g (33%), white crystals, mp 257-258C. 1H NMR spectrum: delta 7.07 ppm, s (1H, 4-H). 5-Methyl-1H-pyrazole-3-carboxylic acid (2). The aqueous filtrate obtained after separation of diacid 1, was neutralized to pH 5-6, and the precipitate of 2 was filtered off and washed with water. Yield 18.1 g (18%), white crystals, mp 210-211C. 1H NMR spectrum, delta, ppm: 2.25 s (3H, CH3), 6.42 s (1H, 4-H).

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1222174-92-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1222174-92-6, name is Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of intermediate 2a (515 mg), 2,5-dimethoxyphenylboronic acid (642 mg) and Pd(dppf)CI2-CH2CI2 ( 05 mg) in a mixture of THF (15 mL) and sodium carbonate solution (2 M, 3 mL) was heated in a microwave (Biotage) to 100 C for 1.5 h. The mixture was chilled, the layers separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by chromatography (Interchim cartridge 50SiHP / 25 g, Cy / EtOAc) to yield the desired compound (77% yield). LC-MS (Method 2): m/z [M+H]+ = 277.1 (MW calc. = 276.29); R, = 0.62 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1904-31-0

4-Chloro-6-[(1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (0.118 g), 1-methyl-1H-pyrazol-3-amine (0.027 g), sodium tert-butoxide (0.269 g), tris(dibenzylideneacetone)dipalladium(0) (0.026 g) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos, 0.035 g) were added to a microwave vial, followed by dry DMF (5 mL). The reaction mixture was flushed with N2 for ?10 min, and then heated to 80¡ã C. with microwaves for 1 h. The reaction mixture was subjected to silica-gel flash column chromatography [dichloromethane-methanol (2-3percent)]. The eluted material, obtained as a yellow solid (0.055 g, 78percent) was identified as 4-chloro-6-[(1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile. LC-MS (Method A) (m/z) 273 (M+H+); tR=2.11.

The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 3524-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a 50 mL single-mouth flask,Salicylaldehyde (1 mmol) was added in sequence,Ethyl cyanoacetate (1 mmol) and 3-methyl-1-phenyl-5-aminopyrazole (1 mmol),Triethylamine (0.1 mmol) and ethanol (8 mL),The reaction was stirred under reflux for 8 h.After the reaction is over,Cool to room temperature.Rotate the solvent under reduced pressure,Get a rough product,The crude product was recrystallized from 95% ethanol.5-amino-1-methyl-3-phenylcoumarin[4,3-d]pyrazolo[3,4-b]pyridine-6(3H)-one (Ia):Yield 63%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1,3-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-13-1, name is 1H-Pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 1H-Pyrazole

A solution of lH-pyrazole (30 g, 440 mmol) in tetrahydrofuran (500 mL) was treated with sodium hydride (26 g, 648 mmol, 60%) at 0 C, and then stirred for 1 h at 0 C. N,N-Dimethylsulfamoyl chloride (95 g, 661 mmol) was added dropwise at 0 C. The resulting solution was stirred for additional 2 h at room temperature and then quenched by water. The resulting solution was extracted with dichloromethane and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/petroleum ether (1/6) to afford to N,N-dimethyl-lH-pyrazole-l -sulfonamide ( 58 g, 75%) as colorless oil. LCMS (ESI): M+H+ = 175.0.

The synthetic route of 288-13-1 has been constantly updated, and we look forward to future research findings.

Related Products of 56426-35-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56426-35-8 name is Methyl 5-phenyl-1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 96 (320mg, 1.S8mmol) was dissolved in THF/water (l5mL, 1:1), lithiumhydroxide monohydrate (146mg, 3.48mmol) was added and the reaction mixture wasstirred for 2h. The THF was removed in vacuo and the aqueous solution was acidified to pH 1 with 1M aq HC1. The precipitate was collected by filtration to give the title0 . + +compound (232mg, 78/o) as a yellow solid. LCMS: ES 189.0 [IVIH]

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-phenyl-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 5-Iodo-1-methyl-1H-pyrazole

General procedure: A solution of 3-bromopyridine (0.38 g, 2.40 mmol), 2-cyclohex-1-en-1-yl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.50 g, 2.40 mmol), tetrakis(triphenylphosphine)palladium (0) (0.14 g, 0.12 mmol) and cesium carbonate (1.72 g, 5.29 mmol) in 1,4-dioxane (8.0 mL) and water (4.0 mL) was stirred at 90 C. for 4 hours. After allowing to cool, the reaction solution was subjected to extraction with ethyl acetate (50 mL), and the organic layer was dried over anhydrous sodium sulfate. After vacuum concentration, the residue was purified with column chromatography (hexane/ethyl acetate=2:1) to yield the title compound (347.3 mg, 99%) as a colorless oil. The reaction and aftertreatment were conducted in the same manner as in Example 39a by using 5-iodo-1-methyl-1H-pyrazole (1.90 g, 9.14 mmol), 2-(4,4-difluorocyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.00 g, 4.10 mmol), tetrakis(triphenylphosphine)palladium (0) (240 mg, 0.208 mmol), cesium carbonate (2.70 g, 8.29 mmol), 1,4-dioxane (10 mL) and water (5 mL), to yield the title compound (767 mg, 94%) as a colorless oil. 1H-NMR (500 MHz, CDCl3) delta ppm: 2.13-2.22 (2H, m), 2.56-2.60 (2H, m), 2.73 (2H, t, J=14.2 Hz), 3.86 (3H, s), 5.73 (1H, brs), 6.14 (1H, d, J=2.0 Hz), 7.42 (1H, d, J=2.0 Hz)

The synthetic route of 34091-51-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69843-13-6, name is 1-Methyl-1H-pyrazol-4-amine, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazol-4-amine

Example 4.082- [ [5-Fluoro-2- [(l-methylpyrazol-4-yl)aminol -4-pyridyll amino I -N-methyl-benzamide A mixture of l-methylpyrazol-4-amine (41.7 mg, 0.43 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (41.4 mg, 0.07 mmol), bis(dibenzylideneacetone)palladium (32.7 mg, 0.057 mmol), sodium tert-butoxide (51.5 mg, 0.54 mmol), and 2-[(2-chloro-5-fluoropyridin-4-yl)amino]-N-methylbenzamide (100 mg, 0.36 mmol) was suspended in dioxane (3 mL). The mixture was heated at 150C for 30 minutes in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated. The residue was purified by preparative HPLC and fractions containing product were combined and evaporated to afford example 4.08 (51.2 mg, 42% yield); 1H NMR spectrum: (300 MHz, DMSO) delta 2.78 (3H, d), 3.77 (3H, s), 6.66 – 6.68 (IH, m), 7.07 – 7.10 (IH, m), 7.31 (IH, s), 7.47 – 7.56 (2H, m), 7.69 – 7.72 (IH, m), 7.84 (IH, s), 7.91 – 7.92 (IH, m), 8.51 (IH, s), 8.64 (IH, q), 10.08 (IH, d); Mass spectrum: m/z (ESI+) (M+H)+ = 341.04.

The synthetic route of 69843-13-6 has been constantly updated, and we look forward to future research findings.

Related Products of 31230-17-8, A common heterocyclic compound, 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 19; feri-Butyl 3-amino- -methyl-1 H-pyrazole-1 -car boxy late; Sodium hydride (60percent dispersion in mineral oil, 0.81 g, 33.96 mmol) was added slowly to a stirred suspension of 5-methyl-1 H-pyrazol-3-amine (3.00 g, 30.90 mmol) in tetrahydrofuran (150 mL) at 0 ¡ãC. The mixture was stirred for 30 minutes, then di-tert- butyl dicarbonate (7.40 g, 33.96 mmol) was added to the reaction. The mixture was stirred and warmed to room temperature. After 2 hours, saturated aqueous sodium hydrogencarbonate solution was added to the reaction and the mixture was extracted with chloroform. The organic layer was washed with brine, dried (Na2S04) and evaporated. Followed by purification of the crude product by flash chromatography (2.44 g, 40percent).LRMS (m/z): 198 (M+1 )+.1 H NMR (400 MHz, METHANOL-^) delta ppm 1.61 (s, 9 H) 2.10 (s, 3 H) 4.85 (s, 2 H) 5.24 (s, 1 H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.