Category: 10199-53-8

Synthesis and biological activities of 3-substituted-6- pyrazolyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles was written by An, Yue;Yao, Mingxing;Zhou, Xiaoxia;Liu, Mingyang. And the article was included in Yingyong Huaxue in 2014.Synthetic Route of C11H10N2O2 This article mentions the following:

The three kinds of 1-methyl-5-substituted-pyrazole-3-carboxylic acid were obtained by 5-substituted-1H-pyrazole-3-Et formate based on methylation and hydrolysis of the ester. Then the six kinds of 3-substituted-4-amino-5-mercapto-1,2,4-triazole were obtained using the substituted carboxylic acid by a series of reaction. Finally, eighteen novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles compounds were synthesized by phosphorus chloride treatment of the above two obtained intermediate. The structures of all new compounds were characterized by IR, ¹H NMR, ¹³C NMR and elemental analyses. The preliminary test shows that all the compounds display plant growth regulator activity and antibacterial activity. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Synthetic Route of C11H10N2O2).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 鎺矯).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Synthetic Route of C11H10N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus was written by Eissa, Ibrahim H.;Mohammad, Haroon;Qassem, Omar A.;Younis, Waleed;Abdelghany, Tamer M.;Elshafeey, Ahmed;Abd Rabo Moustafa, Mahmoud M.;Seleem, Mohamed N.;Mayhoub, Abdelrahman S.. And the article was included in European Journal of Medicinal Chemistry in 2017.Synthetic Route of C11H10N2O2 This article mentions the following:

A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound that carries an aminoguanidine functionality from one side and a Bu moiety on the other ring, several analogs were prepared Considering the pharmacokinetic parameters as a key factor in structural optimization, the structure-activity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analog I as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of I was confirmed in vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Synthetic Route of C11H10N2O2).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Synthetic Route of C11H10N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of Free-Wilson models in spectroscopy. Reevaluation of the Tensmeyer additivity system in the proton NMR of pyrazoles was written by Cativiela, C.;Garcia, J. I.;Elguero, J.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1987.Electric Literature of C11H10N2O2 This article mentions the following:

Modified coefficients of the Tensmeyer additivity system are used to calculate ¹H NMR chem. shifts δ(4-H) of the proton at the 4-position of 1,3,5-substituted pyrazoles. The coefficients were reevaluated by using a more accurate math. procedure. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Electric Literature of C11H10N2O2).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Electric Literature of C11H10N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Lanthanide pyrazolecarboxylates for OLEDs and bioimaging was written by Utochnikova, Valentina V.;Latipov, Egor V.;Dalinger, Alexander I.;Nelyubina, Yulia V.;Vashchenko, Andrey A.;Hoffmann, Michael;Kalyakina, Alena S.;Vatsadze, Sergey Z.;Schepers, Ute;Brase, Stefan;Kuzmina, Natalia P.. And the article was included in Journal of Luminescence in 2018.Reference of 10199-53-8 This article mentions the following:

Novel materials based on lanthanide complexes with six pyrazolecarboxylates were obtained. They possess high solubility due to the purposeful introduction of the nitrogen heteroatom in α-position to the carboxy-group, and their luminescence quantum yields reach 100%. High absorption and non-toxicity allowed their successful use for bioimaging in cellulo. While the special approach to electron transport enhancement allowed using them as OLED emission materials. In the experiment, the researchers used many compounds, for example, 1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8Reference of 10199-53-8).

1-Methyl-5-phenyl-1H-pyrazole-3-carboxylic acid (cas: 10199-53-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Reference of 10199-53-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics