Category: 15953-73-8

Carbon-13 NMR chemical shifts of N-unsubstituted and N-methylpyrazole derivatives was written by Cabildo, Pilar;Claramunt, Rosa Maria. And the article was included in Organic Magnetic Resonance in 1984.Electric Literature of C5H7ClN2 This article mentions the following:

¹³C shielding data for 100 derivatives of pyrazole are reported. These include Me, Et, Pr, tert-Bu, Ph, hydroxymethyl, carboxyl, ethoxycarbonyl, cyano, amino, hydrazino, nitro, azido, chloro, bromo and iodo groups as substituents on the ring carbon atoms. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Electric Literature of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Electric Literature of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Cu_1.5PMo₁₂O₄₀-catalyzed condensation cyclization for the synthesis of substituted pyrazoles was written by Yang, Guo-Ping;He, Xing;Yu, Bing;Hu, Chang-Wen. And the article was included in Applied Organometallic Chemistry in 2018.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3-diketones in the presence of Cu₁.₅PMo₁₂O₄₀ (0.33 mol%) under mild conditions (r.t.-60°, 10-30 min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5-mmol scale. This solvent-free and halogen-free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Michael addition of α-nitroacetate to α, β-unsaturated pyrazolamide catalyzed by triethylamine was written by Liu, Yingying;He, Qian;Chen, Feng;Li, Xuefeng. And the article was included in Shandong Huagong in 2018.Recommanded Product: 15953-73-8 This article mentions the following:

An efficient Michael addition of α-nitroacetate to α, β-unsaturated pyrazolamide was developed in the presence of triethylamine. Synthetically useful yields (50% ∼ 88%) have been achieved with various α, β-unsaturated pyrazolamides. The structures of adducts have been clearly confirmed by ¹H-NMR, ¹³C-NMR and HRMS anal. Adducts resulting from this protocol are useful synthetic intermediates for further synthetic modification. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The Reactivity Trends in Electrochemical Chlorination and Bromination of N-Substituted and N-Unsubstituted Pyrazoles* was written by Lyalin, B. V.;Petrosyan, V. A.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2014.Application of 15953-73-8 This article mentions the following:

The authors’ study of electrochem. chlorination and bromination of pyrazoles decorated with electron-withdrawing and electron-donating groups showed that the product yield and composition depended on the substitution at the N-1 atom. The authors showed for the 1st time the significant differences in halogenation reactivity patterns of N-unsubstituted and N-alkylpyrazoles. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Transition metal azolates from metallocenes. Part 1: Dimetallic and trimetallic cyclopentadienylnickel pyrazolates, synthesis and structural studies was written by Rettig, Steven J.;Storr, Alan;Summers, David A.;Thompson, Robert C.;Trotter, James. And the article was included in Canadian Journal of Chemistry in 1997.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The reactions of nickelocene with pyrazoles in benzene solution gave either dimeric compounds, [CpNi(μ-pz)]₂, (room temperature conditions) or trimetallic complexes, [CpNi(μ-pz)₂]₂Ni, (elevated temperature conditions). Both dimeric and trimetallic species were obtained as red crystalline materials and x-ray structural studies are reported for representative samples of each type. Structural features are interpreted and compared with similar, previously reported, Ni pyrazolate structures. Crystals of [CpNi(3,5-diMepz)]₂ (C₂₀H₂₄N₄Ni₂), are orthorhombic, a 15.204(1), b 17.967(2), c 6.9786(9) Å, Z = 4, space group Ama2; those of [CpNi(4-NO₂-3,5-diMepz)]₂ (C₂₀H₂₂N₆Ni₂O₂), are orthorhombic, a 17.145(3), b 17.738(1), c 7.006(1) Å, Z = 4, space group P2₁2₁2₁; those of [CpNi(3,5-F₆diMepz)]₂ (C₂₀H₁₂F₁₂N₄Ni₂), are orthorhombic, a 18.7134(8), b 15.619(2), c 7.7263(9) Å, Z = 4, space group Pnma; those of [CpNi(3,5-diMepz)₂]₂Ni (C₃₀H₃₈N₈Ni₃), are triclinic, a 10.078(2), b 16.134(2), c 9.992(1) Å, α 91.586(10), β 111.050(9), γ 86.95(1)°, Z = 2, space group P1; and those of [CpNi(4-Cl-3,5-diMepz)₂]₂Ni (C₃₀H₃₄Cl₄N₈Ni₃), are monoclinic, a 10.2201(7), b 16.174(1), c 10.7207(9) Å, β 108.193(5)°, Z = 2, space group P2₁la. The structures were solved by direct (dimetallic species) or Patterson (trimetallic complexes) methods and were refined by full-matrix least-squares procedures to R = 0.035, 0.032, 0.058, 0.032, and 0.033 (R_w = 0.021, 0.026, 0.053, 0.028, and 0.032) for 1157, 1894, 1642, 4499, and 2113 reflections with I ≥ 3σ(F²), resp. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The pyrolytic rearrangement of 1-alkynoyl-3-methylpyrazoles: synthesis of pyrazolo[1,5-a]pyridin-5-ols and related compounds was written by Brown, Roger F. C.;Eastwood, Frank W.;Fallon, Gary D.;Lee, Swee Choo;McGeary, Ross P.. And the article was included in Australian Journal of Chemistry in 1994.COA of Formula: C5H7ClN2 This article mentions the following:

Flash vacuum pyrolysis of 1-(2-alkynoyl)-3-methylpyrazoles (e.g., I; R = H, Me, Ph) at 650°/0.03 mm forms pyrazolo[1,5-a]pyridin-5-ols (e.g., II), often in high yield, which may bear substituents at C2, C3 or C7. In the absence of a 3-Me group in the precursor, N-ethynylpyrazoles are formed in low yield. The formation of both types of product is interpreted as involving 3-(N-pyrazolyl)propadienones formed by N1 → N2 migration of the N-alkynoyl group with inversion of the three-carbon chain. The fused-ring structure of 2-methylpyrazolo[1,5-a]pyridin-5-ol was established by x-ray crystallog. of the O-benzoyl derivative In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8COA of Formula: C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.COA of Formula: C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

N,N-dimethylformamide catalyzed electrophilic/nucleophilic chlorination of pyrazoles was written by Liu, Yuanyuan;Li, Yi;Zhang, Zhenglin;Xu, Guanghui;Li, Jie;Gao, Shang. And the article was included in Nanjing Gongye Daxue Xuebao, Ziran Kexueban in 2014.Category: pyrazoles-derivatives This article mentions the following:

With N,N-Dimethylformamide (DMF) as a catalyst, 1-phenyl-5-(p-tolyl)-1H-pyrazol-3-ol (1a) was heated to reflux in thionyl chloride (SOCl₂) and 4-chloro-1-phenyl-5-(p-tolyl)-1H-pyrazol-3-ol (2a) was obtained in the yield of 83%. High performance liquid chromatog. (HPLC) anal. of the reaction mixture revealed that the optimized conditions were n(1a) : n(DMF) of 10:1, and refluxing in SOCl₂ for 4 h. During the column chromatog. purification, elemental sulfur was isolated. The DMF-catalyzed electrophilic/nucleophilic chlorination mechanism was proposed, and pyrazole substrates 1b-1h were prepared to explore the scope of the mechanism. The structures of chlorinated products 2b-2h were characterized by NMR hydrogen spectrum (¹H NMR), NMR carbon spectrum (¹³C NMR), and elemental anal. The structure of 2d was also determined by single-crystal X-ray diffraction anal. This chlorination reaction was simple to be operated and had good functionality tolerance. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Category: pyrazoles-derivatives).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics