Category: 15953-73-8

Substitution in the pyrazole series. Halogen derivatives of 3,5-dimethylpyrazole was written by Morgan, G. T.;Ackerman, Isidore. And the article was included in Journal of the Chemical Society, Transactions in 1923.Name: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The diazo derivatives have been studied as a means of preparing the substitution derivatives of 3,5-dimethylpyrazole (I), but the results showed that the yields were less than by direct halogenation. Iodination occurs much more readily than in the C₆H₆ series. The 4-NO₂ derivative is best prepared by adding 6 cc. HNO₃ (d. 1.42) to 10 cc. concentrated H₂SO₄ containing 5 g. I at 0鎺? adding 20 cc. additional H₂SO₄, allowing to stand overnight and then heating 3-4 hrs. at 100鎺? The reduction to the 4-NH₂ derivative is best carried out in moist Et₂O with Al-Hg, the yield being 85%. Benzylidene derivative, m. 139-40鎺? o-Nitrobenzylidene derivative, greenish yellow turning reddish brown on exposure to light and air, m. 101鎺? m-isomer, light yellow, m. 236鎺? p-isomer, golden yellow, m. 198鎺? Aqueous HCHO gives the complex [HOCH₂N.N:CMe.C(N:CH₂):CMe]_x, does not m. 300鎺? The diazonium chloride condenses with 灏?diketones and 灏?keto esters in the presence of aqueous AcONa. 4-Azoacetylacetone derivative, golden yellow, m. 184鎺?(decomposition). 4-Azobenzoylacetone derivative, light yellow, m. 169-70鎺?(decomposition). Et 3,5-dimethylpyrazole-4-azoacetoacetate, orange-yellow, m. 157鎺? These derivatives gave red Na salts which developed intense red colors with FeCl₃. 4-Iodo-3,5-dimethylpyrazole (II), m. 137鎺? is obtained in 60% yield from boiling aqueous KI and the diazonium chloride, or in quant. yield by heating I, I in KI, AcONa and H₂O. Ac derivative, m. 62.5-3.5鎺? Bz derivative, m. 82鎺? Chloroaurate, orange-yellow, m. 174鎺? Chloroplatinate, light orange, m. 215-20鎺? Dichloride, yellow, m. 85-88鎺? by passing dry Cl into II in CHCl₃; it is very volatile at the ordinary temperature and the vapor is lachrymatory. The action of dilute aqueous NaOH is complicated and destructive and an iodoso derivative could not be isolated. Dibromide, brick-red, m. 78-81鎺? this also is volatile and lachrymatory. Iodochloride hydrochloride, yellow, m. 111鎺?(decomposition), from ICl.HCl and I in concentrated HCl; it is hydrolyzed by H₂O, liberates I from KI and S from aqueous Na₂S₂O₃, 10% NaOH decomposes it quant. into II. Dilute EtOH transforms it into the HCl salt of II, m. 195鎺? II with alk. KMnO₄ gives 4-iodopyrazolecarboxylic acid, amorphous, decompose above 70鎺? Ag salt; and 4-iodo-3-(5)-methylpyrazole, m. 185-7鎺? chloroaurate, orange-yellow; chloroplatinate, orangeyellow. With neutral KMnO₄ the product is 4-iodo-3-(5)-methylpyrazolecarboxylic acid, amorphous, m. 237鎺?Ag salt. 4-Bromo-3,5-dimethylpyrazole, m. 118鎺?chloroaurate, orange-red, m. 126-8鎺? Ac derivative, m. 38鎺? Bz derivative, m. 48-9鎺? Perbromide, by adding Br to I in concentrated HCl, orange-red, m. 142-4鎺? On warming with EtOH, the HBr salt, m. 174鎺? results. 4-Chloro-3,5-dimethylpyrazole, m. 95鎺? results by passing Cl into aqueous I. It is less basic than the Br or I derivatives and does not yield Ac or Bz derivatives I, warmed with fuming H₂SO₄ (20% SO₃) on the H₂O bath for 6 hrs., gives the 4-SO₃H acid, containing 1.5 H₂O, m. 287-8鎺? the H₂O is lost at 115鎺? Chloride, m. 100鎺? In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Name: 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Name: 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

N-Arylation of pyrazoles with activated aryl ethers was written by Chiriac, Constantin I.;Toma, Ovidiu;Chiriac, Florentina;Lupu, Viorel;Ropot, Radu;Truscan, Ion. And the article was included in Revue Roumaine de Chimie in 1994.Quality Control of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

Various N-arylpyrazoles can be prepared by a condensation reaction of pyrazoles and activated aryl ethers, such as 2,4-dinitrophenyl Ph ether and 2,4,6-trinitrophenyl Ph ether, in DMSO as solvent at 155-165鎺?for 1-3 h. The basicity of the pyrazoles and the reactivity of activated aryl ethers are important factors in this reaction. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Quality Control of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Barriers to internal rotation in 1-(N,N-dimethylthiocarbamoyl)pyrazoles. Hammett correlation and complete lineshape study was written by Carlsson, Lars O.. And the article was included in Acta Chemica Scandinavica (1947-1973) in 1972.Related Products of 15953-73-8 This article mentions the following:

The barriers to rotation of the Me2N group in twelve 1-(N,N-dimethylthiocarbamoyl)pyrazoles are determined by the NMR technique at the coalescence temperature For one of the compounds the rate constant is determined at 15 temperatures in an interval of 40鎺?by the complete lineshape method, and the entropy and enthalpy of activation are calculated A good relation between rate constants and Hammett 锜絧-values is observed for one of the series of compounds investigated, with a 锜?value of -1.98. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Related Products of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Related Products of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reactions of N-aminopyrazoles with halogenating reagents and synthesis of 1,2,3-triazines was written by Osawa, Akio;Kaiho, Terumitsu;Ito, Takashi;Okada, Mamiko;Kawabata, Chikako;Yamaguchi, Kentaro;Igeta, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1988.Synthetic Route of C5H7ClN2 This article mentions the following:

Reactions of N-aminopyrazoles with halogenating reagents (Cl₂, Br₂, I₂, BrCl, ICl, IBr, N-chlorosuccinimide, and N-bromosuccinimide) were examined Some of these reagents preferentially leas to oxidation of the amino group to give the corresponding 1,2,3-triazines as major products, while others mainly gave either or both of 1-amino-4-halopyrazoles and 5-halo-1,2,3-triazines as the result of halogenation of the 4-position of the pyrazole ring prior to the oxidation of the amino group. In some cases, the oxidation of the amino group and the halogenation of the pyrazole ring proceeded concurrently to form not only the unhalogenated triazines but also the 1-amino-4-halopyrazines and the 5-halotriazines. Various reagents and reaction conditions were explored to utilize the reaction for the synthesis of halogenated and unhalogenated 1,2,3-triazines. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Synthetic Route of C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Synthetic Route of C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Transition metal azolates from metallocenes. Part 3: polymeric manganese(II) and nickel(II) pyrazolates; synthesis, characterization, and magnetochemistry was written by Storr, Alan;Summers, David A.;Thompson, Robert C.. And the article was included in Canadian Journal of Chemistry in 1998.Recommanded Product: 15953-73-8 This article mentions the following:

Direct reactions of nickelocene and manganocene with molten pyrazoles in an inert atm. or under vacuum gave the following metal pyrazolate compounds: [Ni(4-Xpz)₂]_x (X = H, Cl and pz = pyrazolate); [M(4-Xdmpz)₂]_x (X = Cl, Br and pzH = pyrazole). On the bases of indirect evidence all compounds are considered to have extended chain structures with metal ions linked in chains by double bridging pyrazolates. The two [Ni(4-Xpz)₂]_x compounds are diamagnetic compounds while all others are paramagnetic and reveal antiferromagnetic coupling between neighboring metal ions. Analyses of the magnetic data (Hamiltonian H = -2J 鍗?S_i-S_j) yields values of the exchange coupling compounds and -0.41 cm^-1 for the [Mn(4-Xpz)₂(4-XpzH)]_x compounds In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Recommanded Product: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Thiophene isosteres: synthesis and pharmacological study of 3-(azol-1-yl)thienoisothiazole 1,1-dioxides was written by Vega, Salvador;Madronero, Ramon;Diaz, J. Antonio;Junquera, Francisco;Alonso, Javier;Darias, Victoriano;Bravo, Luis;Abdalah, Suzanne. And the article was included in European Journal of Medicinal Chemistry in 1988.Product Details of 15953-73-8 This article mentions the following:

Three series of new 3-(azol-1-yl)thienoisothiazole 1,1-dioxides, e.g., I (X = S, X¹ = CH; X = CH, CPh, X¹ = S: R, R¹, R² = H, Cl, Me) were synthesized and tested for antiinflammatory, analgesic and antipyretic activity as well as for acute toxicity. Acetylsalicylic acid was used as the reference standard In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Product Details of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Gas-Chromatographic Study of Hydrazine Reaction with Metal 灏?Diketonates was written by Svistunova, I. V.;Shapkin, N. P.;Nikolaeva, O. V.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 2002.Name: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

When treated with hydrazine, metal 灏?diketonates undergo decomposition to form the corresponding pyrazoles, irresp. of the kinetic stability of the chelates. With substituted metal chelates, the main reaction products are pyrazoles bearing in position 4 the 绾?substituent of the complex. Other products are formed when the substituent has centers sensitive to nucleophilic substitution and/or elimination. The reaction can be used for structural assessment of the starting 灏?diketonate. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Name: 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Name: 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Floral Biosynthesis of Mn₃O₄ and Fe₂O₃ Nanoparticles Using Chaenomeles sp. Flower Extracts for Efficient Medicinal Applications was written by Karunakaran, Gopalu;Jagathambal, Matheswaran;Kolesnikov, Evgeny;Dmitry, Arkhipov;Ishteev, Artur;Gusev, Alexander;Kuznetsov, Denis. And the article was included in JOM in 2017.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

Manganese oxide (Mn3O4) and iron oxide (Fe2O3) nanoparticles were successfully synthesized with the flower extracts of Chaenomeles sp. This is the first ever approach to synthesize nanoparticles from Chaenomeles sp. flower extracts The organic mols. present in the flower extracts actively converted the nitrate precursor into its corresponding nanoparticles. The organic mols. that are involved in the synthesis of nanoparticles are identified using different phytochem. and gas chromatog.-mass spectrometry analyses. The identified components are glycosides, alkaloids, terpenoids, saponins, flavonoids, quinines, and steroids. The x-ray powder diffraction anal. revealed that the particles show tetragonal and rhombohedral crystalline phases. The Fourier transform IR spectroscopy anal. showed the functional groups that are involved in the reduction of nitrates into the corresponding nanoparticles. Energy-dispersive x-ray spectroscopy anal. confirmed the presence of the elements in the synthesized nanoparticles. Transmission electron microscopy images showed the formation of spherical nanoparticles with an average size of 30-100 nm. Antioxidant anal. showed that the synthesized nanoparticles had excellent antioxidant potential. The antibacterial study showed that they inhibit the growth of harmful bacteria such as Pseudomonas aeruginosa and Streptococcus pyogenes. Thus, this study proposes a new eco-friendly and nontoxic method to synthesize nanoparticles for medicinal applications. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor閳ユ徆onor motifs, whether as a monocyclic ring or as a fused indazole ring. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Application In Synthesis of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Enhanced Catalytic Activity of Aluminum Complexes for the Ring-Opening Polymerization of ε-Caprolactone was written by Kosuru, Someswara Rao;Sun, Ting-Han;Wang, Li-Fang;Vandavasi, Jaya Kishore;Lu, Wei-Yi;Lai, Yi-Chun;Hsu, Sodio C. N.;Chiang, Michael Y.;Chen, Hsuan-Ying. And the article was included in Inorganic Chemistry in 2017.SDS of cas: 15953-73-8 This article mentions the following:

A series of dinuclear aluminum (Al₂Pyr₂) complexes bridged by two ligands were synthesized, and their catalytic activity toward ring-opening polymerization of ε-caprolactone (CL) was investigated. Different types of the Al-N-N-Al-N-N skeletal ring were found among these Al₂Pyr₂ complexes. The butterfly form, L^Thio₂Al₂Me₄, exerted the highest catalytic activity for CL polymerization κ²-2-CL coordination with both Al centers within the butterly form L^Thio₂Al₂Me₄ facilitates the initiation process. Generally speaking, the Al₂Pyr₂ complexes exhibited substantially higher catalytic activity for CL polymerization than literature examples such as β-diketiminate- or traiaza-bearing aluminum complexes. In fact, the Al₂Pyr₂ complexes can even carry out CL polymerization at 25°. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8SDS of cas: 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Evaluating hydrogen-bond propensity, hydrogen-bond coordination and hydrogen-bond energy as tools for predicting the outcome of attempted co-crystallisations was written by Sarkar, Nandini;Aakeroy, Christer B.. And the article was included in Supramolecular Chemistry in 2020.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

Two different structure-informatics based methods and one approach based on hydrogen-bond interaction energies were evaluated for their abilities to predict the exptl. outcomes of attempted co-crystallisations between two known drug mols., Nevirapine and Diclofenac, and a series of potential co-formers. The hydrogen-bond propensity (HBP) tool gave the correct result in 26 out of 30 cases, whereas a hydrogen-bond coordination (HBC) method predicted the correct outcome in 22 out of 30 cases. Finally, calculated hydrogen-bond energies (HBE) using a simple electrostatic model, gave the correct result in 23 out of 30 experiments In those cases, where the crystal structure of a co-crystal of either Nevirapine or Diclofenac was known, we also examined how well the three methods predicted which primary hydrogen-bond interactions were present in the crystal structure. HBP correctly predicted 6 out of 6 cases, HBC could not predict any of the synthon formations correctly, and HBE successfully predicted 1 out of 6 cases. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Safety of 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics