Category: 401-73-0

Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3-one nucleosides was written by Abdou, Ibrahim M.;Saleh, Ayman M.;Zohdi, Hussein F.. And the article was included in Molecules in 2004.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one This article mentions the following:

2,4-Dihydropyrazole glucosides were prepared and tested for their antitumor activity. The structures of these compounds were established by ¹H and ¹³C- NMR spectroscopy. The para-fluoro glucoside shows an in vitro IC₅₀ value of 16.4 娓璏 against proliferation of the human promyelotic leukemia (HL60) cell line. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Name: 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and fungicidal activity of methyl N-methoxy-N-[2-(3-trifluoromethyl-1-substituted pyrazole-5-yloxymethylene)] phenylcarbamates was written by Liu, Weidong;Li, Jiangsheng;Li, Zhongying;Wang, Xiaoguang;Gao, Bida. And the article was included in Nongyaoxue Xuebao in 2004.Computed Properties of C4H3F3N2O This article mentions the following:

A series of novel Me N-methoxy-N-[2-(3-trifluoromethyl)-1-substituted pyrazole-5-yloxymethylene] phenylcarbamates I (R = Ph, 4-ClPh, 4-FPh, 2-MePh, 2,4-diMePh, 2,4-diClPh, 2-F-4-BrPh, 3,5-DiClPh, 3,4-diClPh, 2,4,5-triClPh, t-Bu, CH₂CO₂Et, Bn) were synthesized from 3-trifluoromethyl-1-substituted pyrazole-5-one and Me N-methoxy-N-(2-bromomethylphenyl) carbamates. All compounds were confirmed by ¹H NMR, IR and LC/MS. The preliminary bioassays showed that some compounds had fungicidal activities to Pyricularia oryzae, Botrytis cinerea, and Erysiphe graminis under 50 mg/L, for example, the inhibitory ratio of compound I (R = Bn) to P. oryzae was 94%. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Computed Properties of C4H3F3N2O).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Computed Properties of C4H3F3N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes was written by Bingi, Chiranjeevi;Emmadi, Narender Reddy;Chennapuram, Madhu;Nanubolu, Jagadeesh Babu;Atmakur, Krishnaiah. And the article was included in RSC Advances in 2014.Reference of 401-73-0 This article mentions the following:

A series of novel aryl and heteroaryl fused 2,8-dioxabicyclo[3.3.1]nonanes I (R = 4-Cl, 4-MeO, 4-Br, etc.; R¹ = C₆H₅, 2-BrC₆H₄, 4-CNC₆H₄, etc.; R² = H, Ph) was accomplished by one pot, catalyst free reaction of 2-hydroxy chalcones with 3-trifluoromethyl substituted pyrazolones in xylene at reflux temperature The role of the trifluoromethyl functional group in formation of I was confirmed by comparative studies with 3-Me substituted pyrazolones and the outcome is presented. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Reference of 401-73-0).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Reference of 401-73-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one was written by Zohdi, Hussein;Rateb, Nora M.;Haikal, A. Z.. And the article was included in Molecules [online computer file] in 2001.COA of Formula: C4H3F3N2O This article mentions the following:

4-(3-Nitrophenylazo)-5-trifluoromethyl-2,4-dihydropyrazol-3-one (I) was synthesized by adding 5 mmol of 3-nitrobenzenediazonium chloride dropwise to a cold solution of 5-trifluoromethyl-2,4-dihydropyrazol-3-one (0.76 g, 5 mmol) in 25 mL of ethanol containing sodium acetate (0.82 g, 10 mol). The reaction mixture was stirred at room temperature for 3 h and the precipitated crude product was filtered, washed with water, dried and crystallized from ethanol to give 1.2 g (80%) of I as orange crystals. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0COA of Formula: C4H3F3N2O).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C4H3F3N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics