Category: 3528-58-3

Rimland, Joseph et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2010 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. SDS of cas: 3528-58-3

The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist was written by Rimland, Joseph;Dunne, Angela;Hunjan, Suchete S.;Sasse, Rosemary;Uings, Iain;Montanari, Dino;Caivano, Matilde;Shah, Poonam;Standing, David;Gray, David;Brown, David;Cairns, William;Trump, Ryan;Smith, Paul W.;Bertheleme, Nicolas;D’Alessandro, Pier;Gul, Sheraz;Vimal, Mythily;Smith, David N.;Watson, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.SDS of cas: 3528-58-3 This article mentions the following:

The identification of novel, potent, non-steroidal/small mol. functional GR antagonist GSK1564023A (I) selective over PR is described. Associated structure-activity relationships and the process of optimization of an initial HTS hit are also described. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3SDS of cas: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. SDS of cas: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Nitulescu, George Mihai et al. published their research in International Journal of Molecular Sciences in 2013 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.HPLC of Formula: 3528-58-3

New potential antitumor pyrazole derivatives: synthesis and cytotoxic evaluation was written by Nitulescu, George Mihai;Draghici, Constantin;Olaru, Octavian Tudorel. And the article was included in International Journal of Molecular Sciences in 2013.HPLC of Formula: 3528-58-3 This article mentions the following:

New pyrazole derivatives I (R1 = Cl, CH3; R2 = H, CH3; R3 = C2H5, C6H5; etc.) were designed and synthesized as potential protein kinase inhibitors in the view to develop specific antitumor therapies. The antitumor potential was estimated using wheat seeds and the general toxicity was evaluated by alternative methods, using invertebrate animals. One 3-aminopyrazole derivative II emerged as a potential candidate for the development of future cytotoxic compounds In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3HPLC of Formula: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The 1H-pyrazole provides an excellent means by which to provide the requisite hydrogen bond acceptor–donor motifs, whether as a monocyclic ring or as a fused indazole ring. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.HPLC of Formula: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Liu, Fei et al. published their research in Chaye Kexue in 2016 | CAS: 3528-58-3

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Category: pyrazoles-derivatives

Study on effect of fungal-fermentation process on flavor quality in white tea was written by Liu, Fei;Xue, Zhihui;Ye, Qianlin;Sun, Weijiang. And the article was included in Chaye Kexue in 2016.Category: pyrazoles-derivatives This article mentions the following:

Baimudan and Shoumei were utilized to study the effect of fungal-fermentation process on flavor quality. Sensory evaluation found new flavors in white tea after fermentation The quality of Shoumei was improved significantly after fermentation The aroma of white tea changed from clean and fresh to pure and mellow during fermentation, which was due to the decrease of fresh odorants and increase of aged fragrant. The taste changed from astringent and harsh to aged and soft, which was attributing to the decrease of esters-catechins by 2.3 and 0.69 percent, resp., and theaflavin by 33% and 43% in Baimudan and Shoumei, resp. The taste of fermented Baimudan was a little bitter because caffeine increased significantly. The ratio of essential amino acids to nonessential amino acids increased from 36.10% to 39.84% in Baimudan and 42.16% to 62.32% in Shoumei. Therefore, fungal fermentation could largely improve the value of low or middle-grade white tea. In summary, the impacts of fungal fermentation on quality of Shoumei were larger than that of Baimudan, which was of great significance to improve the quality of low grade white tea. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Category: pyrazoles-derivatives).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics