Category: 3528-58-3

Analysis of volatile constituents of Baimaohou (Camellia sinensis L.) by gas chromatography-mass spectrum was written by Zhuang, Wuyoung;Cai, Jibao;Su, Qingde. And the article was included in Asian Journal of Chemistry in 2005.Application of 3528-58-3 This article mentions the following:

Volatile oil of Baimaohou (Camellia sinensis L.) was obtained by simultaneous distillation-solvent extraction Following, the essential oil was analyzed by gas chromatog.-mass spectrum. 48 Components at least were identified, constituting approx. 74% of the oil. The main constituents of the essential oil were phytol (16.4%) and 5,6,7,7a-tetrahydro-4,4,7a-trimethyl-2(4H)-benzofuranone (10.6%), a very expensive flavor material. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Application of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Flavor evolution in raw Pu-erh tea during manufacturing using different processing types was written by Su, Dan;Xu, Tengsheng;Li, Yali;Zhou, Hongjie. And the article was included in LWT–Food Science and Technology in 2022.Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine This article mentions the following:

This study aimed to explore the relationship between the processing type and the flavor in raw Pu-erh tea (RPT). Liquid chromatog.-mass, gas chromatog.-mass spectrometry, and multivariate analyses were employed to measure the component of RPT and to determine the changes in the flavor evolution of RPT at processing type. Sensory evaluation indicated that the processing type enhanced the flavor of the RPT. Based on 12 detected taste-active compounds, PCA and heat map anal. showed the average content of 4 catechins (ECG,EGCG, EC, EGC) in RPTs was 132.27 mg/g, which was 21.19 mg/g less than sun-dried tea (SDT). Astringency and bitterness of RPT can be reduced by processing type. A total of 52 volatile compounds were perceived and 4 volatile components were identified as essential compounds related to PLS-DA (VIP >1, P < 0.05), including phytol, linalool, cis-geraniol, and trans-geraniol, which increased from 62.27% in SDT to 66.25% in brick tea, which significantly contributes to the floral flavor of brick tea. The findings presented in this thesis add to our understanding of the relationship between the processing type and the flavor of RPT. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Recommanded Product: 1-Ethyl-1H-pyrazol-5-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Expedited Palladium-Catalyzed Amination of Aryl Nonaflates through the Use of Microwave-Irradiation and Soluble Organic Amine Bases was written by Tundel, Rachel E.;Anderson, Kevin W.;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2006.Application of 3528-58-3 This article mentions the following:

Microwave-assisted, palladium-catalyzed C-N bond-forming reactions with aryl/heteroaryl nonaflates and amines using the soluble amine bases DBU or MTBD and ligands 2,4,6-(Me₂CH)₃C₆H₂C₆H₄PR₂-2 [R = cyclohexyl, CMe₃] and XantPhos resulted in good to excellent yields (71-99%) of arylamines in short reaction times (1-45 min). In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Application of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Application of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

5-Aminopyrazoles synthesis was written by Hoehn, Hans. And the article was included in Zeitschrift fuer Chemie in 1970.HPLC of Formula: 3528-58-3 This article mentions the following:

1-(R-Substituted)-5-aminopyrazoles and their 3-methyl and 4-methyl derivatives (57 compounds where R = aliphatic, cycloaliphatic, aralkyl, 2-furylmethyl, or 2-thienylmethyl) were prepared by treating CHR1:CR2CN (R1 = H, Me, etc., R2 = H, Me, Et) with N2H4 to give NH2NHCHR1CHR2CN, adding aldehyde or ketone R3R4CO to give R3CR4:NNHCHR1CHR2CN and treating the hydrazone with BuONa for 2-5 hr at 90-130°. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3HPLC of Formula: 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Overall Synthesis of GSK356278: Quick Delivery of a PDE4 Inhibitor Using a Fit-for-Purpose Approach was written by Guercio, Giuseppe;Castoldi, Damiano;Giubellina, Nicola;Lamonica, Alessandro;Ribecai, Arianna;Stabile, Paolo;Westerduin, Pieter;Dams, Riet;Nicoletti, Anna;Rossi, Sara;Bismara, Claudio;Provera, Stefano;Turco, Lucilla. And the article was included in Organic Process Research & Development in 2010.Computed Properties of C5H9N3 This article mentions the following:

The family of phosphodiesterase (PDE) enzymes hydrolyze cyclic nucleotides, cAMP and cGMP, leading to their inactivation as intracellular second messengers. Inhibition of these enzymes leads to an elevation of levels of cyclic nucleotides in the cell and prolongs their action on downstream signaling pathways. PDE4, of which there are four subtypes, is widely expressed throughout the brain but is also abundant in the periphery in inflammatory and immune cells, in the gastrointestinal tract, and in cardiac myocytes. GSK356278 (I) is a potent, selective, and competitive inhibitor of PDE4 enzymes currently under investigation for the treatment of CNS disorders. The initial synthetic route developed by Medicinal Chem. Department, used several hazardous and/or expensive reagents and harsh conditions and gave relatively low yields. By targeted process of research and development plus application of anal. techniques to identify byproduct and extensive route scouting, a novel synthetic route for I has been developed. This contribution reports the optimization of the chem. synthesis of I to develop a large-scale process suitable for its synthesis. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Computed Properties of C5H9N3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Computed Properties of C5H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

5-Aminopyrazoles as Dienophiles in the Inverse Electron Demand Diels-Alder Reactions of 2,4,6-Tris(ethoxycarbonyl)-1,3,5-triazine: Syntheses of Pyrazolopyrimidines was written by Dang, Qun;Brown, Brian S.;Erion, Mark D.. And the article was included in Journal of Organic Chemistry in 1996.Safety of 1-Ethyl-1H-pyrazol-5-amine This article mentions the following:

[4 + 2] Cycloaddition reactions of 2,4,6-tris(ethoxycarbonyl)-1,3,5-triazine with 5-aminopyrazoles are reported. This methodol. is suitable for the one-step synthesis of highly substituted pyrazolo[3,4-d]pyrimidines. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Safety of 1-Ethyl-1H-pyrazol-5-amine).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Safety of 1-Ethyl-1H-pyrazol-5-amine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Design of Potent, Selective, and Orally Bioavailable Inhibitors of Cysteine Protease Cathepsin K was written by Tavares, Francis X.;Boncek, Virginia;Deaton, David N.;Hassell, Anne M.;Long, Stacey T.;Miller, Aaron B.;Payne, Alan A.;Miller, Larry R.;Shewchuk, Lisa M.;Wells-Knecht, Kevin;Willard, Derril H. Jr.;Wright, Lois L.;Zhou, Hui-Qiang. And the article was included in Journal of Medicinal Chemistry in 2004.Reference of 3528-58-3 This article mentions the following:

Osteoclast-mediated bone matrix resorption has been attributed to cathepsin K, a cysteine protease of the papain family that is abundantly and selectively expressed in osteoclast. Inhibition of cathepsin K could potentially be an effective method to prevent osteoporosis. Structure-activity studies on a series of reversible ketoamides based inhibitors of cathepsin K have led to identification of potent and selective compounds Crystallog. studies have given insights into the mode of binding of these inhibitors. A series of ketoamides with varying P1 moieties were first synthesized to find an optimum group that would fit into the S1 subsite of the cysteine protease, cathepsin K. With a desired P1 group in place a variety of heterocyclic analogs in the P’ region were synthesized to study their steric and electronic effects. In the process of exploring these P’ heterocyclic variations, excellent selectivity was gained over other highly homologous cysteine proteases, including cathepsins L, S, and V. The favorable pharmacokinetic properties of some of these cathepsin K inhibitors in rats make them suitable for evaluation in rodent osteoporosis models. A representative cathepsin K inhibitor was shown to attenuate PTH-stimulated hypercalcemia in the TPTX rat model. These inhibitors provide a viable lead series in the discovery of new therapies for the prevention and treatment of osteoporosis. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Reference of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Reference of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones was written by Raffa, Demetrio;Edler, Michael C.;Daidone, Giuseppe;Maggio, Benedetta;Merickech, Mourad;Plescia, Salvatore;Schillaci, Domenico;Bai, Ruoli;Hamel, Ernest. And the article was included in European Journal of Medicinal Chemistry in 2004.Synthetic Route of C5H9N3 This article mentions the following:

In order to study the influence of 3-substituents on the cytotoxic activity of 2-styrylquinazolinones, a series of 6-chloro-2-styryl-3-(heteroaryl)-4(3H)-quinazolinones, e.g. I, were synthesized by refluxing equimolar amounts of the corresponding 2-methyl-quinazolinones and benzaldehyde in glacial acetic acid. At 1 μg ml^-1 concentration, almost all the synthesized compounds showed some cytotoxic activity against the L1210 and K562 leukemia cell lines. However, only compound I inhibited the growth of these cells by over 50%. It was also found to be the only member of the series that inhibited tubulin polymerization, with an IC₅₀ value of 5.8 vs. 3.2 μM for control drug colchicine. I was further examined for effects on the growth of human MCF7 breast carcinoma cells and Burkitt lymphoma CA46 cells, which had IC₅₀ values of 0.34 and 1.0 μM, resp. At 10 μM, I induced G2/M arrest (66%) in Burkitt cells, with a mitotic index of 20%. At 3.4 μM, it caused disruption of the cellular microtubule system of the MCF7 cells. Both these cellular effects are consistent with its mechanism of action resulting from its inhibitory effect on tubulin assembly. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Synthetic Route of C5H9N3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Synthetic Route of C5H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Volatile components in mycelia and fruiting bodies of the artificial culture of Ophiocordyceps longissima was written by Zhang, Yingyu;Liu, Yang;Li, Yangmei;Zhang, Longwa;Li, Chunru. And the article was included in Anhui Nongye Daxue Xuebao in 2014.Formula: C5H9N3 This article mentions the following:

The volatile compounds were extracted from the mycelia and fruiting bodies of the artificial culture of Ophiocordyceps longissima using simultaneous distillation and extraction (SDE) method. Their volatile components were analyzed using gas chromatog.-mass spectrometry (GC-MS). The results showed that culture conditions had great influence on the content and number of volatile components; however, little impact on component classes was observed The main volatile substances in mycelia were ketones, alcs., alkenes, phenols and ethers, while alcs., aldehydes, and phenols are main volatile compounds in fruiting bodies. Twenty compounds were detected in the mycelia liquid in which the content of 1-octene-3-alc. (37.70%) was the highest. Six compounds were identified from the artificial culture of the fruiting bodies with the content of 1-octene-3-alc.(51.93%) and butylated hydroxytoluene (38.37%) being relatively high. The compounds of 1-octen-3-ol and butylated hydroxytoluene are two common constituents in both artificial cultures and their contents were accounted for 51.66% and 90.30% of the total volatile components in mycelia and fruiting body, resp. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Formula: C5H9N3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Formula: C5H9N3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors was written by Meng, Wei;Brigance, Robert P.;Chao, Hannguang J.;Fura, Aberra;Harrity, Thomas;Marcinkeviciene, Jovita;O’Connor, Stephen P.;Tamura, James K.;Xie, Dianlin;Zhang, Yaqun;Klei, Herbert E.;Kish, Kevin;Weigelt, Carolyn A.;Turdi, Huji;Wang, Aiying;Zahler, Robert;Kirby, Mark S.;Hamann, Lawrence G.. And the article was included in Journal of Medicinal Chemistry in 2010.Related Products of 3528-58-3 This article mentions the following:

Continued structure-activity relation (SAR) exploration within our previously disclosed azolopyrimidine containing dipeptidyl peptidase-4 (DPP4) inhibitors led us to focus on an imidazolopyrimidine series in particular. Further study revealed that by replacing the aryl substitution on the imidazole ring with a more polar carboxylic ester or amide, these compounds displayed not only increased DPP4 binding activity but also significantly reduced human ether-a-go-go related gene (hERG) and sodium channel inhibitory activities. Addnl. incremental adjustment of polarity led to permeable mols. which exhibited favorable pharmacokinetic (PK) profiles in preclin. animal species. The active site binding mode of these compounds was determined by x-ray crystallog. as exemplified by amide 24c. A subsequent lead mol. from this series, (+)-6-(aminomethyl)-5-(2,4-dichlorophenyl)-N-(1-ethyl-1H-pyrazol-5-yl)-7-me3 thylimidazo[1,2-a]pyrimidine-2-carboxamide (24s), emerged as a potent, selective DPP4 inhibitor that displayed excellent PK profiles and in vivo efficacy in ob/ob mice. In the experiment, the researchers used many compounds, for example, 1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3Related Products of 3528-58-3).

1-Ethyl-1H-pyrazol-5-amine (cas: 3528-58-3) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Related Products of 3528-58-3

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics