Fernandes, Celia published the artcileRe(I) and 99mTc(I) tricarbonyl complexes with ether-containing pyrazolyl-based chelators: Chemistry, biodistribution and metabolism, Application of 4-(methoxymethyl)-1H-pyrazole, the publication is Journal of Organometallic Chemistry (2014), 138-148, database is CAplus.
Tris(pyrazolyl)methane chelators, L1-L3, containing one or two ether groups at different positions of the azole rings, were synthesized and fully characterized. These chelators enabled the synthesis of fac-[99mTc(CO)3{HC[4-(ROCH2)pz]3}]+ (R = Me (Tc1), Et (Tc2)) and fac-[99mTc(CO)3{HC[3,5-(EtOCH2)2pz]3}]+ (Tc3) which were identified by HPLC in comparison with the rhenium counterparts. The evaluation of Tc1-Tc3 in CD-1 mice showed that the number and/or nature of the ether groups greatly influence the biodistribution profile, pharmacokinetics and metabolic stability of these complexes. Tc1 and Tc2, bearing a unique ether substituent at the 4-position of the pyrazolyl ring, undergo metabolic transformation in vivo while Tc3 is not metabolized. The metabolization of Tc1 and Tc2 enhanced their rate of excretion but, most probably, also justify their negligible heart uptake in contrast with the high heart uptake of congener non-metabolizable complexes (99mTc-DMEOP and 99mTc-TMEOP), which have recently emerged as potential myocardial imaging agents. The attempts made to identify the metabolites of Tc1 and Tc2 showed that the metabolization of these compounds must involve the ether functions with probable formation of carboxylic acid derivatives A comparative study with the congener fac-[99mTc(CO)3{[4-(MeOCH2)pz](CH2)2NH(CH2)2NH2}]+ (Tc6) led the authors to confirm the formation of such type of metabolites. In fact, Tc6 is also metabolized in mice with formation of fac-[99mTc(CO)3{[4-(HOCH2)pz](CH2)2NH(CH2)2NH2}]+ (Tc7) and fac-[99mTc(CO)3{[4-(HOOC)pz](CH2)2NH(CH2)2NH2}]+ (Tc8), which were chem. identified by HPLC in comparison with the Re congeners (Re7 and Re8).
Journal of Organometallic Chemistry published new progress about 37599-34-1. 37599-34-1 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Ether, name is 4-(methoxymethyl)-1H-pyrazole, and the molecular formula is C5H8N2O, Application of 4-(methoxymethyl)-1H-pyrazole.
Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics