Category: 53355-55-8

Peterson, L. K. published the artcileMechanism of the transition metal-catalyzed reaction of 1,1′-carbonyldipyrazoles with aldehydes and ketones, Recommanded Product: 1H-Pyrazole-1-carbonyl chloride, the publication is Canadian Journal of Chemistry (1974), 52(13), 2367-74, database is CAplus.

The metal-catalyzed reaction of 1,1′-carbonyldipyrazoles with aldehydes or ketones to give 1,1′-alkylidenedipyrazoles and CO2, the latter being derived from the amide carbonyl group as shown by labeling experiments, is sensitive to electronic and steric substituent effects. Under comparable reaction conditions, 1,1′-carbonyldiimidazole, N-acetylpyrazole, and 1-pyrazole-N,N-diethylcarbonamide do not react with acetone while pyrazole-1-carbo(N’-phenylhydrazide) yields an anilino isocyanate dimer. These results are interpreted in terms of a mechanism that involves coordination of the metal ion at the 2,2′-N atoms of the pyrazole rings and heterolytic cleavage of an amide bond, followed by formation of a carbamate intermediate, decarboxylation, and metal ion exchange. Unsym. substituted 1,1′-carbonyldipyrazoles equilibrate thermally with their resp. sym. analogs by an intermol. exchange mechanism.

Canadian Journal of Chemistry published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Recommanded Product: 1H-Pyrazole-1-carbonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Brzozowski, Zdzislaw published the artcileDerivatives of pyrazole-1-carboxylic acid. II. Synthesis of certain 4-[2-(1-pyrazolecarboxamido)ethyl]benzenesulfonamides, Synthetic Route of 53355-55-8, the publication is Acta Poloniae Pharmaceutica (1981), 38(4), 399-405, database is CAplus.

Fifteen title compounds (I, R = H, Me, Et; R¹ = H, Me, Et, Pr, Bu, PhCH₂, Cl; R² = H, Me) were prepared in 55-91% yields from the corresponding 1-pyrazolecarbonyl chlorides and 4-H₂NSO₂C₆H₄(CH₂)₂NH₂ in Et₃N (or NaOH in aqueous Me₂CO). Some I were also obtained in the reaction of 4-H₂NSO₂C₆H₄(CH₂)₂NHCONHNH₂ (II) with BzOCH:CR¹COR in AcOH. I (R = Me, R¹ = R² = H) was addnl. prepared also from II and MeCOCH₂CH(OEt)₂. To prepare II, I (R = R² = Me, R¹ = H) was heated with N₂H₄ in EtOH.

Acta Poloniae Pharmaceutica published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Synthetic Route of 53355-55-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Brzozowski, Zdzislaw published the artcileDerivatives of 1-pyrazole carboxylic acid. I. Synthesis of certain 1-pyrazolecarbonyl chlorides, Name: 1H-Pyrazole-1-carbonyl chloride, the publication is Acta Poloniae Pharmaceutica (1981), 38(4), 393-8, database is CAplus.

Fifteen acid chlorides I (R = H, Me, Et; R¹ = H, Me, Et, Pr, Bu, PhCH₂ Cl; R² = H and Me) were prepared in 87-98% yield from the corresponding 1H– pyrazoles and COCl₂ in PhMe. Three I were converted into the corresponding amides by reaction with NH₃(g) in Et₂O. The mass spectral fragmentation of 3-ethyl-4-methyl-1-pyrazole carboxamide is presented.

Acta Poloniae Pharmaceutica published new progress about 53355-55-8. 53355-55-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,acyl chloride,Amide, name is 1H-Pyrazole-1-carbonyl chloride, and the molecular formula is C4H3ClN2O, Name: 1H-Pyrazole-1-carbonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics