Category: 19959-71-8

Davoren, Jennifer E.’s team published research in Bioorganic & Medicinal Chemistry Letters in 26 | CAS: 19959-71-8

Bioorganic & Medicinal Chemistry Letters published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Application In Synthesis of 19959-71-8.

Davoren, Jennifer E. published the artcileDesign and optimization of selective azaindole amide M1 positive allosteric modulators, Application In Synthesis of 19959-71-8, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(2), 650-655, database is CAplus and MEDLINE.

Selective activation of the M1 receptor via a pos. allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer’s disease. A novel series of azaindole amides and their key pharmacophore elements are described. The nitrogen of the azaindole core is a key design element as it forms an intramol. hydrogen bond with the amide N-H thus reinforcing the bioactive conformation predicted by published SAR and the authors’ homol. model. Representative compound 25 is a potent and selective M1 PAM that has well aligned physicochem. properties, adequate brain penetration and pharmacokinetic (PK) properties, and is active in vivo. These favorable properties indicate that this series possesses suitable qualities for further development and studies.

Bioorganic & Medicinal Chemistry Letters published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Application In Synthesis of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Katane, Masumi’s team published research in Journal of Medicinal Chemistry in 56 | CAS: 19959-71-8

Journal of Medicinal Chemistry published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Category: pyrazoles-derivatives.

Katane, Masumi published the artcileIdentification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, Category: pyrazoles-derivatives, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1894-1907, database is CAplus and MEDLINE.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Yun’s team published research in Crystal Growth & Design in 20 | CAS: 19959-71-8

Crystal Growth & Design published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Computed Properties of 19959-71-8.

Li, Yun published the artcileA Metal-Ligand Layer Compatible with Various Types of Pillars for New Porous Coordination Polymers, Computed Properties of 19959-71-8, the publication is Crystal Growth & Design (2020), 20(10), 7021-7026, database is CAplus.

Pillared-layer structures are classic for porous coordination polymers (PCPs), but suitable metal-ligand layers for such structures are rare. Here, the authors report a cationic {Zn2(pzdc)}+ (H3pzdc = 3,5-pyrazoledicarboxylic acid) layer compatible with various types of pillar ligands. Solvothermal reactions of Zn(NO3)2·6H2O and H3pzdc with 4-(pyridin-4-yl)-1H-pyrazole (Hpypz), 1,4-benzenedicarboxylic acid (H2bdc), or 2-amino-1,4-benzenedicarboxylic acid (H2abdc) in a mixed solvent of H2O and N,N-dimethylformamide (DMF) produced three pillared-layer PCPs, namely [Zn4(pzdc)2(pypz)2]·guest (1), [Zn4(pzdc)2(bdc)(H2O)1.53(DMF)0.47]·guest (2), and [Zn4(pzdc)2(abdc)(H2O)1.52(DMF)0.48]·guest (3), resp. Single-crystal X-ray analyses revealed that the {Zn2(pzdc)}+ layers are fully pillared by pypz– in 1 and half pillared by bdc2- and abdc2- in 2 and 3, because the anionic pillars possess different charges. Consequently, 1 shows one-dimensional (1D) channels with a small porosity and 2 and 3 show 2D channels with large porosities, both of which were verified by N2 and CO2 adsorption isotherms. While 1 has no coordinated solvent mols. and exhibits a high water stability, 2 and 3 possess coordinated solvent mols. and quickly transform to crystals of 2D coordination networks in water, [Zn4(pzdc)2(OH)2(H2O)6]·H2bdc·4H2O (4) and [Zn4(pzdc)2(H2abdc)(OH)2(H2O)5]·2H2O (5), resp., which can be further exfoliated into ultrathin nanosheets in an ammonia solution A new metal-ligand layer can adopt various types of pillars to give a series of pillared-layer PCPs with tunable pillar densities, porosities, and water stabilities. The water-instable ones can be exfoliated to ultrathin nanosheets with intermediates suitable for single-crystal diffraction characterization.

Crystal Growth & Design published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Computed Properties of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Yun’s team published research in Crystal Growth & Design in 20 | CAS: 19959-71-8

Crystal Growth & Design published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Computed Properties of 19959-71-8.

Li, Yun published the artcileA Metal-Ligand Layer Compatible with Various Types of Pillars for New Porous Coordination Polymers, Computed Properties of 19959-71-8, the publication is Crystal Growth & Design (2020), 20(10), 7021-7026, database is CAplus.

Pillared-layer structures are classic for porous coordination polymers (PCPs), but suitable metal-ligand layers for such structures are rare. Here, the authors report a cationic {Zn2(pzdc)}+ (H3pzdc = 3,5-pyrazoledicarboxylic acid) layer compatible with various types of pillar ligands. Solvothermal reactions of Zn(NO3)2·6H2O and H3pzdc with 4-(pyridin-4-yl)-1H-pyrazole (Hpypz), 1,4-benzenedicarboxylic acid (H2bdc), or 2-amino-1,4-benzenedicarboxylic acid (H2abdc) in a mixed solvent of H2O and N,N-dimethylformamide (DMF) produced three pillared-layer PCPs, namely [Zn4(pzdc)2(pypz)2]·guest (1), [Zn4(pzdc)2(bdc)(H2O)1.53(DMF)0.47]·guest (2), and [Zn4(pzdc)2(abdc)(H2O)1.52(DMF)0.48]·guest (3), resp. Single-crystal X-ray analyses revealed that the {Zn2(pzdc)}+ layers are fully pillared by pypz– in 1 and half pillared by bdc2- and abdc2- in 2 and 3, because the anionic pillars possess different charges. Consequently, 1 shows one-dimensional (1D) channels with a small porosity and 2 and 3 show 2D channels with large porosities, both of which were verified by N2 and CO2 adsorption isotherms. While 1 has no coordinated solvent mols. and exhibits a high water stability, 2 and 3 possess coordinated solvent mols. and quickly transform to crystals of 2D coordination networks in water, [Zn4(pzdc)2(OH)2(H2O)6]·H2bdc·4H2O (4) and [Zn4(pzdc)2(H2abdc)(OH)2(H2O)5]·2H2O (5), resp., which can be further exfoliated into ultrathin nanosheets in an ammonia solution A new metal-ligand layer can adopt various types of pillars to give a series of pillared-layer PCPs with tunable pillar densities, porosities, and water stabilities. The water-instable ones can be exfoliated to ultrathin nanosheets with intermediates suitable for single-crystal diffraction characterization.

Crystal Growth & Design published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Computed Properties of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Mulyana, Yanyan’s team published research in Dalton Transactions in | CAS: 19959-71-8

Dalton Transactions published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Category: pyrazoles-derivatives.

Mulyana, Yanyan published the artcileNew cobalt(II) and zinc(II) coordination frameworks incorporating a pyridyl-pyrazole ditopic ligand, Category: pyrazoles-derivatives, the publication is Dalton Transactions (2005), 1598-1601, database is CAplus and MEDLINE.

The metal-directed assembly of new mol. frameworks incorporating 4-(4-pyridyl)pyrazole (HL), containing non-linear coordination vectors, is presented. Three metallo-arrays of types [Co(LH2)2(NO3)4], [Co(LH2)2(H2O)4][NO3]4·H2O and [Zn2(L)2Cl2]·2EtOH. The cobalt(II) in [Co(LH2)2(NO3)4] displays distorted octahedral geometry with the two protonated pyridylpyrazole ligands coordinated through their pyrazole nitrogen atoms in a trans-orientation and the remaining four coordination sites occupied by nitrate anions. Two internal hydrogen bonds occur between each pyrazole NH and the oxygens of adjacent coordinated nitrato ligands. Short intermol. hydrogen bonds also occur between the two pyridinium hydrogens and bound nitrate ligands on different mols. to yield a two-dimensional hydrogen-bonded array. Two of these arrays interpenetrate to form an extended two dimensional layer. The two-dimensional layers stack throughout the crystal structure. A second product of type [Co(LH2)2(H2O)4][NO3]4·H2O exists as two crystallog. independent forms that are chem. similar. In each form, the two protonated pyridylpyrazole ligands occupy trans positions about the cobalt with the remaining four coordination sites being filled by water mols. to yield a distorted octahedral coordination geometry. Intramol. hydrogen-bonding is observed between the two non-coordinated pyrazoyl nitrogen atoms and bound water oxygen atoms. The third complex, [Zn2(L)2Cl2]·2EtOH, contains dimer units consisting of two zinc(II) ions bridged by two pyrazoylate groups in which the coordination geometry of each zinc approximates a tetrahedron. Each zinc is bound to two deprotonated pyridylpyrazolato ligands, one pyridyl group (from a different dimeric unit) and one chloro ligand. Each pyridyl nitrogen thus connects each of these zinc dimers to an adjacent dimer unit, forming a three-dimensional network containing small voids. The latter are occupied by ethanol mols. which form hydrogen bonds to the chloro ligands.

Dalton Transactions published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Fang’s team published research in Inorganic Chemistry Frontiers in 1 | CAS: 19959-71-8

Inorganic Chemistry Frontiers published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Quality Control of 19959-71-8.

Li, Fang published the artcileMetal-ion controlled solid-state reactivity and photoluminescence in two isomorphous coordination polymers, Quality Control of 19959-71-8, the publication is Inorganic Chemistry Frontiers (2014), 1(2), 172-177, database is CAplus.

Reactions of [M(NH3)2]OH (M = Ag and Cu) and 4-(1H-pyrazol-4-yl)pyridine (Hpypz), using p-xylene (C8H10) as the template, gave isomorphous two-dimensional porous metal azolate frameworks [Ag2(pypz)2]·0.5C8H10 (MAF-36(Ag), 1·g) and [Cu2(pypz)2]·0.5C8H10 (MAF-36(Cu), 2·g). Powder and single-crystal x-ray diffraction studies showed that, upon guest removal, 1·g transformed into a three-dimensional nonporous framework [Ag6(pypz)6] (1‘), while 2·g can retain its porous two-dimensional structure. Depending on the metal ion, framework flexibility/rigidity, and/or porosity, 1·g and 2·g, as well as their guest-free derivatives, showed distinctly different photoluminescence and guest-responsive behaviors.

Inorganic Chemistry Frontiers published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Quality Control of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Xu, Sheng-jie’s team published research in Guangzhou Huagong in 40 | CAS: 19959-71-8

Guangzhou Huagong published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C13H10O2, Name: 4-(1H-Pyrazol-4-yl)pyridine.

Xu, Sheng-jie published the artcileSynthesis and cytotoxicity of some pyrazolic compounds, Name: 4-(1H-Pyrazol-4-yl)pyridine, the publication is Guangzhou Huagong (2012), 40(24), 47-48, database is CAplus.

Seven pyrazole compounds were synthesized and characterized by 1H NMR and MS, and the cytotoxicity of the compounds on Bel-7402, KB, HL-60, and BGC-823 was tested by MTT assay. The results showed that compound 4f exhibited higher cytotoxicity against Bel-7402 and BGC-823 cell lines.

Guangzhou Huagong published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C13H10O2, Name: 4-(1H-Pyrazol-4-yl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Xu, Shengjie’s team published research in Medicinal Chemistry Research in 22 | CAS: 19959-71-8

Medicinal Chemistry Research published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C18H10F3NO3S2, Application In Synthesis of 19959-71-8.

Xu, Shengjie published the artcileDesign, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents, Application In Synthesis of 19959-71-8, the publication is Medicinal Chemistry Research (2013), 22(11), 5610-5616, database is CAplus.

A novel series of N-arylpyrazole derivatives I(R = 4-CF3, 3,5-(CF3)2, 4-NO2), II, III and IV(R = H, OC8H17) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4-fluoronitrobenzene in the presence of base. The structures of these compounds were established on the basis of elemental (C, H, and N) and spectral anal. (1H NMR, 13C NMR, HRMS, and FT-IR). All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines: carcinoma (Bel-7402), nasopharyngeal carcinoma (KB), immature granulocyte leukemia (HL-60), and gastrocarcinoma (BGC-823) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The results showed that most of the obtained compounds exhibited promising cytotoxicity against tested carcinoma cell lines with low IC50 values. The bis-pyrazole derivative IV(R = OC8H17), bearing alkoxy group on the 5-position of Ph ring, was the most effective one. It is inhibition of cell growth of Bel-7402 cells was 1.5-fold higher than that found for cisplatin. And, also mono-pyrazole derivatives I(R = 4-CF3, 3,5-(CF3)2) decorated with trifluoromethyl group on the Ph ring, displayed better cytotoxicity than that of cisplatin against Bel-7402 cell line.

Medicinal Chemistry Research published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C18H10F3NO3S2, Application In Synthesis of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Lin, Jiao-Min’s team published research in Angewandte Chemie, International Edition in 55 | CAS: 19959-71-8

Angewandte Chemie, International Edition published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Formula: C8H7N3.

Lin, Jiao-Min published the artcileA Metal-Organic Framework with a Pore Size/Shape Suitable for Strong Binding and Close Packing of Methane, Formula: C8H7N3, the publication is Angewandte Chemie, International Edition (2016), 55(15), 4674-4678, database is CAplus and MEDLINE.

Much effort has been devoted to develop new porous structures for methane storage. We report a new porous coordination framework showing exceptional methane uptakes (e.g. 263 volume/volume at 298 K and 65 bar) and adsorption enthalpies (21.6 kJ mol-1) as high as current record holders functionalized by open metal sites. Computational simulations demonstrated that the hierarchical pore structure consisting of single-wall nanocages has suitable sizes/shapes and organic binding sites to enforce not only strong host-methane and methane-methane interactions but also dense packing of methane mols.

Angewandte Chemie, International Edition published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Formula: C8H7N3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Lin, Jiao-Min’s team published research in Science China: Chemistry in 59 | CAS: 19959-71-8

Science China: Chemistry published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Application In Synthesis of 19959-71-8.

Lin, Jiao-Min published the artcileA novel pillared-layer-type porous coordination polymer featuring three-dimensional pore system and high methane storage capacity, Application In Synthesis of 19959-71-8, the publication is Science China: Chemistry (2016), 59(8), 970-974, database is CAplus.

Solvothermal reaction of Zn(NO3)2, 4-(1H-pyrazol-4-yl)pyridine (Hpypz) and 1,3,5-benzenetricarboxylic acid (H3btc) in N,N-dimethylacetamide (DMA) produced a new porous coordination polymer [Zn5(pypz)4(btc)2] (1). Single-crystal x-ray diffraction study of 1 showed that deprotonated pypz– ligands served as 1,2,4-triazolate-like ligands, linking Zn(II) ions to form porous 2D sql-a layers {Zn(pypz)}+, which were further connected by eight-legged pillars {Zn2(btc)4(H2O)2}8- based on the typical paddlewheel dinuclear Zn2(RCOO)4(H2O)2 cluster to form a novel type of noninterpenetrated pillared-layer framework with 3D intersecting pore system and large pore volume Gas sorption measurements revealed that 1 possesses a large BET surface area of 2061 m2 g-1 and very high methane total uptake of 245 cm3(STP) cm-3 at 298 K and 65 bar.

Science China: Chemistry published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Application In Synthesis of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics