Category: 61453-49-4

1,3-Dipolar cycloaddition of ethyl diazoacetate to alkynes in the pores of zeolite NaY was written by Kobayashi, Keijiro;Igura, Yuta;Imachi, Shouhei;Masui, Yoichi;Onaka, Makoto. And the article was included in Chemistry Letters in 2007.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

Zeolite NaY promotes 1,3-dipolar cycloaddition of Et diazoacetate to alkynes having an electron-withdrawing group to afford the corresponding functionalized pyrazoles in high yields. The activation of the dipolarophile inside the pores of NaY is proposed based on the ¹³C MAS NMR anal. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.Recommanded Product: Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of isomeric pyrazoles by the reaction of propargyl acetate with alkyl diazoacetates was written by Akhrem, A. A.;Kvasyuk, E. I.;Mikhailopulo, I. A.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1976.HPLC of Formula: 61453-49-4 The following contents are mentioned in the article:

Isomeric pyrazoles I, II (R = Et, Me) were obtained by cyclization of HCCCH2OAc with N2CHCO2R. Hydrolysis of I, II (R = Et) led to the corresponding deacetylated esters. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4HPLC of Formula: 61453-49-4).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. The pyrazole ring is resistant to oxidation and reduction but the groups, such as alkyl and formyl attached to the ring, are oxidized to respective acids. Only electrolytic oxidation, ozonolysis, and a strong base cause ring opening.HPLC of Formula: 61453-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reaction of diazoacetic ester with propargyl acetate was written by Akhrem, A. A.;Kvasyuk, E. I.;Mikhailopulo, I. A.. And the article was included in Zhurnal Obshchei Khimii in 1975.Product Details of 61453-49-4 The following contents are mentioned in the article:

Cyclization of HCCCH2OAc and N2CHCO2Et in refluxing toluene gave the isomeric pyrazolecarboxylates I and II. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Product Details of 61453-49-4).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.Product Details of 61453-49-4

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A facile synthesis of pyrazoles with multi-point structural diversity by 1,3-dipolar cycloaddition was written by Cheung, Kwai Ming J.;Reynisson, Johannes;McDonald, Edward. And the article was included in Tetrahedron Letters in 2010.Category: pyrazoles-derivatives The following contents are mentioned in the article:

We describe the synthesis of diverse pyrazoles by 1,3-dipolar cycloaddition of Et diazoacetate with various acetylenes in refluxing toluene. The product pyrazoles are useful starting points for preparing a diverse collection of trisubstituted pyrazole carboxamides. For aryl and heteroaryl alkynes a single product is obtained while alkyl alkynes afford a ca. 6:1 mixture of regioisomers. The observed regioselectivity for the cycloaddition step and the ease of reaction are consistent with predictions derived from computing the HOMO-LUMO energies of the reactants. This study involved multiple reactions and reactants, such as Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4Category: pyrazoles-derivatives).

Ethyl 4-(hydroxymethyl)-1H-pyrazole-3-carboxylate (cas: 61453-49-4) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics