Category: 741717-60-2

Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles. [Erratum to document cited in CA141:207140] was written by Antilla, Jon C.;Baskin, Jeremy M.;Barder, Timothy E.;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2004.Reference of 741717-60-2 The following contents are mentioned in the article:

On page 5578, an important reference describing the copper-catalyzed N-arylation of pyrazoles was left out of the manuscript: Cristau, H.-J., Cellier, P. P.; Spindler, J.-F.; Taillefer, M. Eur. J. Organic Chem. 2004, 695-709. This study involved multiple reactions and reactants, such as Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate (cas: 741717-60-2Reference of 741717-60-2).

Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate (cas: 741717-60-2) belongs to pyrazole derivatives. An alternative way to synthesize multisubstituted pyrazoles is the Csingle bondH arylation of simple pyrazoles. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Reference of 741717-60-2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles was written by Antilla, Jon C.;Baskin, Jeremy M.;Barder, Timothy E.;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2004.Application In Synthesis of Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate The following contents are mentioned in the article:

A copper-catalyzed N-arylation reaction of π-excessive nitrogen heterocycles is presented. The coupling of either aryl iodides or aryl bromides with common nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. General conditions that tolerate functional groups such as aldehydes, ketones, alcs., primary amines, and nitriles on the aryl halide or heterocycle, were found. Hindered aryl halides or heterocycles were also found to be suitable substrates using the conditions reported herein. This study involved multiple reactions and reactants, such as Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate (cas: 741717-60-2Application In Synthesis of Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate).

Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate (cas: 741717-60-2) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Application In Synthesis of Ethyl 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics