Category: 116228-41-2

You, Hyun published the artcileDesign, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents, Computed Properties of 116228-41-2, the main research area is benzoylpeperidinylbutylarylacrylamide preparation NAmPRTase inhibitory anticancer crystal XRD.

NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD+ biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD+ level. In this report, a series of structural analogs of FK866 I, a known NAmPRTase inhibitor, was synthesized and tested for inhibitory activities against the proliferation of cancer cells and human NAmPRTase. Among them, compound II showed similar anti-cancer and enzyme inhibitory activities to compound I. Further investigation of compound II with X-ray anal. revealed a co-crystal structure in complex with human NAmPRTase, suggesting that Asp219 in the active site of the enzyme could contribute to an addnl. interaction with the pyrrole nitrogen of compound II.

European Journal of Medicinal Chemistry published new progress about Amidation. 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Computed Properties of 116228-41-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Allin, Steven M. published the artcileBu3SnH-Mediated radical cyclization onto azoles, Safety of 4-Bromo-1-tosyl-1H-pyrazole, the main research area is bicyclic pyrrole imidazole pyrazole preparation.

Alkyl radicals have been cyclized onto pyrroles, imidazoles and pyrazoles, and acyl radicals cyclized onto pyrroles, using Bu3SnH-, (Me3Si)3SiH- and Bu3GeH-mediated aromatic homolytic substitution for the synthesis of bicyclic N-heterocycles. The reactions yield intermediate π-radicals that lose hydrogen in the rearomatization step of the aromatic homolytic substitution. Mechanistic studies of these rearomatization steps indicate aromatic homolytic substitution in which the initiator or breakdown products from the inhibitor are responsible for the H-abstraction step.

Tetrahedron published new progress about Crystal structure. 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Safety of 4-Bromo-1-tosyl-1H-pyrazole.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Fu, Lili published the artcileSynthesis of sulfonamides from azoles and sodium sulfinates at ambient temperature, Name: 4-Bromo-1-tosyl-1H-pyrazole, the main research area is oxidative amination azole sodium sulfinate NBS NIS sulfonamide synthesis; sulfur nitrogen bond formation azole sodium sulfinate.

NBS or NIS mediated direct S-N bond formation between azoles and sodium sulfinates is described. The reaction shows good substrate scope and tolerates a wide range of functionalities in both azoles and sodium sulfinate substrates. Pyrazoles are also suitable for this method, various 4-halopyrazoles derivatives were obtained by using N-halosuccinimide (NXS) as the halogen source. Thus, e.g., oxidative amination of benzimidazole with sodium p-tolylsulfinate using NBS as oxidant in 1,4-dioxane afforded 1-tosylbenzimidazole (93%).

Tetrahedron published new progress about Atom economy. 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Name: 4-Bromo-1-tosyl-1H-pyrazole.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Holzer, Wolfgang published the artcileN-substituted bromopyrazoles: synthesis and 13C NMR study, Application of 4-Bromo-1-tosyl-1H-pyrazole, the main research area is bromopyrazole preparation NMR; substituent effect bromopyrazole preparation NMR.

The synthesis of N-1 substituted 4-bromo-, 3,4-dibromo- and 3,4,5-tribromopyrazoles starting from the NH-pyrazoles is described. 13C Nmr spectroscopic studies with the title compounds are presented, investigating the influence of substituents on 13C-chem. shifts and 13C, 1H spin coupling constants

Heterocycles published new progress about NMR (nuclear magnetic resonance). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Application of 4-Bromo-1-tosyl-1H-pyrazole.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Perkins, Robert J. published the artcileElectrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides, Product Details of C10H9BrN2O2S, the main research area is electrochem nickel catalysis electrophile coupling reaction alkyl halide.

A constant-current electrochem. method for reducing catalytic Ni complexes in sp2-sp3 cross-electrophile coupling reactions was developed. The electrochem. reduction provides reliable Ni catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochem. reactions give yields (i.e., 51-86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.

Organic Letters published new progress about Coupling reaction catalysts (electrochem.). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Product Details of C10H9BrN2O2S.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Heinisch, Gottfried published the artcilePyrazoles. 3. N-1 Protected 4-substituted pyrazoles – synthesis and NMR investigation, SDS of cas: 116228-41-2, the main research area is benzylpyrazole preparation carbon NMR; pyrazole benzyl preparation carbon NMR; benzenesulfonylpyrazole preparation carbon NMR.

Pyrazoles I (R1 = cyano, CO2Et, H; R2 = cyano, CO2Et, CO2H, Ph) and II (R1 = Me, NO2; R2 = H, NO2; R3 = Me, NO2) were prepared, and 13C NMR for I and II were obtained. 1-Benzyl-4-pyrazolecarboxyldehyde was treated with CH2(CO2H)2 to give I (R1 = H, R2 = CO2H). 13C NMR were also obtained for III (R4 = PhCO, PhSO2, tosyl; R5 = H, Br, iodo, substituted ethanyl, Me, NO2; R6 = H, Br).

Heterocycles published new progress about NMR (nuclear magnetic resonance). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, SDS of cas: 116228-41-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Anka-Lufford, Lukiana L. published the artcileNickel-Catalyzed Cross-Electrophile Coupling with Organic Reductants in Non-Amide Solvents, SDS of cas: 116228-41-2, the main research area is nickel catalyst cross electrophilic coupling aryl alkyl halide; cross-coupling; green chemistry; heterocycles; homogeneous catalysis; nickel.

Cross-electrophile coupling of aryl halides with alkyl halides has thus far been primarily conducted with stoichiometric metallic reductants in amide solvents. This report demonstrates that the use of tetrakis(dimethylamino)ethylene (TDAE) as an organic reductant enables the use of non-amide solvents, such as acetonitrile or propylene oxide, for the coupling of benzyl chlorides and alkyl iodides with aryl halides. Furthermore, these conditions work for several electron-poor heterocycles that are easily reduced by manganese. Finally, the authors demonstrate that TDAE addition can be used as a control element to ‘hold’ a reaction without diminishing yield or catalyst activity.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, SDS of cas: 116228-41-2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Choi, Young Lok published the artcileDirect Synthesis of Pyrazolo[5,1-a]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation, Related Products of pyrazoles-derivatives, the main research area is halobenzylpyrazole preparation palladium intramol carbon hydrogen activation; pyrazoloisoindole derivative preparation.

An efficient, direct synthesis of pyrazolo[5,1-a]isoindoles, e.g., I, employing a palladium-catalyzed intramol. C-H bond activation of 1-(2-halobenzyl)pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermol. C-H bond activation.

Advanced Synthesis & Catalysis published new progress about Arylation (intramol.). 116228-41-2 belongs to class pyrazoles-derivatives, name is 4-Bromo-1-tosyl-1H-pyrazole, and the molecular formula is C10H9BrN2O2S, Related Products of pyrazoles-derivatives.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics