Category: 36640-53-6

On June 30, 2015, Kamal, Raj; Kumar, Vipan; Bhardwaj, Vikas; Kumar, Vikas; Aneja, Kamal Rai published an article.Computed Properties of 36640-53-6 The title of the article was Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles. And the article contained the following:

In the present investigation, ten new 2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)-1-(4,6-dimethylpyrimidin-2-yl)hydrazines [I; Ar = (un)substituted Ph, 2-naphthyl] having pyrimidinyl and pyrazolyl moieties were synthesized. Structures of all compounds were confirmed by their spectral and elemental data. Most of the tested compounds were found to be significantly more effective against bacterial strains Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa than the reference drug ciprofloxacin. All the newly synthesized compounds were found to be more potent antifungal agents than reference drug against Candida albicans, whereas except I (Ar = 4-nitrophenyl) all other compounds also shown good activity against Saccharomyces cerevisiae. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Computed Properties of 36640-53-6

The Article related to pyrimidinyl pyrazolyl hydrazone preparation bactericide fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On June 30, 2015, Kamal, Raj; Kumar, Vipan; Bhardwaj, Vikas; Kumar, Vikas; Aneja, Kamal Rai published an article.Computed Properties of 36640-53-6 The title of the article was Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles. And the article contained the following:

In the present investigation, ten new 2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)-1-(4,6-dimethylpyrimidin-2-yl)hydrazines [I; Ar = (un)substituted Ph, 2-naphthyl] having pyrimidinyl and pyrazolyl moieties were synthesized. Structures of all compounds were confirmed by their spectral and elemental data. Most of the tested compounds were found to be significantly more effective against bacterial strains Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa than the reference drug ciprofloxacin. All the newly synthesized compounds were found to be more potent antifungal agents than reference drug against Candida albicans, whereas except I (Ar = 4-nitrophenyl) all other compounds also shown good activity against Saccharomyces cerevisiae. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Computed Properties of 36640-53-6

The Article related to pyrimidinyl pyrazolyl hydrazone preparation bactericide fungicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kamal, Raj; Kumar, Vipan; Kumar, Ravinder; Kumar, Vikas; Sharma, Prabodh C.; Bansal, Kushal K. published an article in 2019, the title of the article was Chloramine-T Mediated Facile One Pot Synthesis of Pyrazolyltriazolobenzothiazole Hybrids as Potent Anti-Infective Agents.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde And the article contains the following content:

An expedient and facile one pot synthesis of 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b]-1,3-benzothiazole derivatives I (R = 4-methoxyphenyl, 3-nitrophenyl, 2-naphthyl, etc.) through in situ oxidative cyclization of corresponding N-heteroarylhydrazone promoted by environmentally benign chloramines-T trihydrate at room temperature has been accomplished. All synthesized pyrazolyltriazolobenzothiazole hybrids I were also evaluated for their antibacterial and anthelmintic potentials and found to be moderate to significant anti-infective agents. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazolyl triazolobenzothiazole preparation green chem antibacterial anthelmintic activity, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On November 30, 2016, Ashok, Dongamanti; Rangu, Kavitha; Gundu, Srinivas; Rao, Velagapuri Hanumantha published an article.Application In Synthesis of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Synthesis of pyrazolylfuro[2,3-f]chromenes and evaluation of their antimicrobial activity. And the article contained the following:

A new series of furochromene-based pyrazole derivatives were synthesized from their chalcone precursors upon reaction with 2-bromo-1-(4-bromophenyl)ethanone in the presence of anhydrous K2CO3 under conventional, ultrasound and microwave irradiation The shorter reaction times and high yields render the microwave irradiation approach as an advanced method to synthesize the title compounds All obtained compounds were evaluated for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and few compounds emerged as prospective antimicrobial agents by displaying promising microbial inhibitory potency. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Application In Synthesis of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to bromobenzoyl aryl phenylpyrazolylvinyl furochromene diastereoselective preparation antibacterial antifungal sar, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Application In Synthesis of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Ali, Sahar A.; Awad, Samir Mohamed; Said, Ahmed Mohammed; Mahgoub, Shahenda; Taha, Heba; Ahmed, Naglaa Mohamed published an article in 2020, the title of the article was Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors.Safety of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde And the article contains the following content:

Oxidative stress is one of the main causes of significant severe diseases. The discovery of new potent antioxidants with high efficiency and low toxicity is a great demand in the field of medicinal chem. Herein, we report the design, synthesis mol. modeling and biol. evaluation of novel hybrids containing pyrazole, naphthalene and pyrazoline/isoxazoline moiety. Chalcones were synthesized efficiently and were used as starting materials for synthesis of a variety of heterocycles. A novel series of pyrazoline , phenylpyrazoline , isoxazoline and pyrazoline carbothioamide derivatives were synthesized and screened for in vitro antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO) and superoxide radical scavenging assay as well as 15-lipoxygenase (15-LOX) inhibition activity. Compounds and showed excellent radical scavenging activity in all three methods in comparison with ascorbic acid and 15-LOX inhibition potency using quercetin as standard then were subjected to in vivo study. Catalase (CAT) activity, glutathione (GSH) and malondialdehyde (MDA) levels were assayed in liver of treated rats. Compounds and showed significant in vivo antioxidant potentials compared to control group at dose of 100 mg/kg B. W. Mol. docking of compound endorsed its proper binding at the active site pocket of the human 15-LOX which explains its potent antioxidant activity in comparison with standard ascorbic acid. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Safety of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to naphthyl phenyl pyrazole derivative preparation antioxidants lipoxygenase inhibitor, 15-lipoxygenase inhibitors, pyrazole, antioxidant activity, hybrids, scavenging activity and other aspects.Safety of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On March 31, 2016, Ashok, Dongamanti; Rangu, Kavitha; Hanumantha Rao, Velagapuri; Gundu, Srinivas; Srilata, Ballu; Vijjulatha, Manga published an article.COA of Formula: C20H14N2O The title of the article was Microwave-assisted synthesis, molecular docking and antimicrobial activity of novel 2-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones. And the article contained the following:

A series of pyrano[2,3-f]chromenones I [Ar = C6H5, 4-BrC6H4, 3,4-(MeO)2C6H3, 2-naphthyl, etc.] was synthesized via microwave-assisted cyclization of chalcones II in the presence of iodine in DMSO. Precursor chalcones II were prepared by Claisen-Schmidt condensation of 1-(5-hydroxy-2H-chromen-6-yl)ethanone and substituted pyrazole aldehydes using KOH under microwave irradiation This approach for the preparation of pyrano[2,3-f]chromenones I offers the advantages of short reaction time (3-5 min), mild reaction conditions and high yields of products. The newly synthesized compounds I and II were tested in vitro for their antibacterial and antifungal activities. Among the tested compounds, compounds I [Ar = 4-ClC6H4, 4-HOC6H4, 3,4-(MeO)2C6H3] and II [Ar = 3-EtOC6H4] were found to be potent against tested bacterial strains whereas compounds I [Ar = 4-ClC6H4, 3,4-(MeO)2C6H3] and II [Ar = 4-EtOC6H4] were found to be potent against tested fungal strains. Furthermore, the synthesized compounds were subjected to mol. docking studies for the inhibition of enzyme DNA gyrase and compounds I [Ar = 4-HOC6H4, 4-EtOC6H4] showed promising dock score values. The in silico mol. docking results of compounds I and II were in accordance with the in vitro antimicrobial studies and they may be considered as good inhibitor of DNA gyrase. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).COA of Formula: C20H14N2O

The Article related to pyranochromenone pyrazolyl preparation antibacterial antifungal mol docking, hydroxychromenyl pyrazolyl propenone preparation oxidative cyclization microwave irradiation, pyrazole aldehyde hydroxychromenyl ethanone claisen schmidt condensation microwave irradiation, pyrazolyl hydroxychromenyl propenone antibacterial antifungal mol docking and other aspects.COA of Formula: C20H14N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On December 31, 2007, Shelke, S. N.; Dalvi, N. R.; Gill, C. H.; Karale, B. K. published an article.Synthetic Route of 36640-53-6 The title of the article was Synthesis of various heterocycles from 3-(2-naphthalenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde. And the article contained the following:

Condensation of the title compound (I) with 2′-hydroxyacetophenones gave propenones II (R1 = H, Cl, Me; R2, R4 = H, Me; R3 = H, Cl, Me, Et, Br, F), which reacted with hydrazine to give pyrazolines III and with iodine in DMSO to give chromones IV. Reaction of IV with hydrazine gave bipyrazoles V. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Synthetic Route of 36640-53-6

The Article related to pyrazolecarboxaldehyde condensation hydroxyacetophenone, pyrazolylpyrazoline aryl derivative preparation, pyrazolylchromone aryl derivative preparation, bipyrazole aryl derivative preparation and other aspects.Synthetic Route of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On December 31, 2012, Ablajan, Keyume; Wang, Liju published an article.Synthetic Route of 36640-53-6 The title of the article was Convenient synthesis and characterization of hydrazone derivatives of 3-(2-naphthyl)-1-phenyl-pyrazole-4-carbaldehyde. And the article contained the following:

In order to obtain novel hydrazone derivatives containing pyrazole and thiazole rings which possess certain biol. activity, a series of 1-(3-β-naphthyl-1-phenylpyrazole-4-methylene)-2-(4-arylthiazol-2-yl)hydrazones I(R = Ph, 4-Me-C6H4, 4-MeO-C6H4, 4-Cl-C6H4, 4-NO2-C6H4, 4-Br-C6H4, 2-naphthyl) were synthesized via two different methods including multi step reactions and one-pot synthetic route using 3-β-naphthyl-1-phenyl-pyrazole-4-carbaldehyde as a starting intermediate. The products were obtained in good yield under ultrasonic irradiation condition rather than heating. The structures of products were characterized by 1H NMR, MS and elemental anal. The preliminary bioassay showed that compounds I(R = 4-Me-C6H4, 4-Cl-C6H4) possess obvious protective effects on the PC12 cells injury induced by H2O2. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Synthetic Route of 36640-53-6

The Article related to naphthylphenylpyrazolemethyleneaiylthiazolylhydrazone preparation pc12 cell protection, naphthylphenylpyrazole carbaldehyde preparation hydrazinecarbothioamide arylcarbonylmethyl bromide cyclocondensation and other aspects.Synthetic Route of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Rajashakar, V.; Saisree, K.; Sikender, M.; Naveen, S.; Madhava Reddy, B.; Harinadha Babu, V. published an article in 2016, the title of the article was Synthesis of pyrazolyl thiobarbituric acids and their cytotoxic and antimicrobial evaluation.HPLC of Formula: 36640-53-6 And the article contains the following content:

Synthesis, cytotoxic and anti-microbial screening of novel thiobarbituric acid incorporated pyrazole derivatives I [Ar = Ph, 4-H3CC6H4, 4-HOC6H4, 4-ClC6H4 and 2-naphthyl] were performed. Vilsmeier-Haack reaction of different Ph hydrazones afforded pyrazole-4-carbaldehydes in good yields. Knoevenagel condensation of compounds with thiobarbituric acid gave a series of 5-ylidene derivatives I in reasonable yields. The synthesized compounds were characterized with the help of IR, 1H-NMR and mass spectral data. The compounds were tested for cytotoxic activity against Vero, MCF-7 and HCT-116 cell lines. Among the tested compounds, compound I [Ar = 4-HOC6H4] was found to be most active mol. with the activity against both MCF-7 and HCT-116 cell lines with IC50 values of 14.0 μM and 18.12 μM. In anti-microbial screening, none of the compounds exhibited anti-bacterial activity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).HPLC of Formula: 36640-53-6

The Article related to arylethylideneamino aniline preparation vilsmeir haack reaction, aryl phenylpyrazolyl carboxaldehyde preparation thiobarbituric acid knoevenagel condensation, phenyl arylpyrazolylmethylene thioxopyrimidine dione preparation antibacterial antitumor activity sar and other aspects.HPLC of Formula: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On March 31, 2007, Jagadhani, S. G.; Kale, S. B.; Chaudhari, C. S.; Sangle, M. D.; Randhavane, P. V.; Karale, B. K. published an article.SDS of cas: 36640-53-6 The title of the article was Knoevenagel reactions of 3-formyl chromones and 4-formyl pyrazoles with pyrazolone by conventional and non-conventional methods. And the article contained the following:

3-Formyl chromones when heated with 1,2-dihydro-1-phenyl-3-propylpyrazol-5-one (I) in presence of acetic acid afforded the compounds 4-(4-oxo-4H-chromon-3-yl)methylene-1-phenyl-3-propyl-1H-pyrazol-5-(4H)-ones. 4-Formyl pyrazoles on treatment with compound I in presence of acetic acid gave compounds (4)-1-phenyl-4-((1-phenyl-1H-pyrazol-4-yl)methylene)-3-propyl-1H-pyrazol-5-(4H)-ones. These compounds are synthesized by traditional, microwave, and ultrasonic irradiations. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).SDS of cas: 36640-53-6

The Article related to formyl chromone condensation pyrazolone microwave ultrasonic irradiation, pyrazole formyl condensation pyrazolone microwave ultrasonic irradiation, chromonyl methylene pyrazolone preparation microwave ultrasonic irradiation, pyrazolyl methylene pyrazolone preparation and other aspects.SDS of cas: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics