Category: 36640-53-6

On December 31, 2012, Zheng, Chang-Ji; Xu, Li-Li; Sun, Liang-Peng; Miao, Jing; Piao, Hu-Ri published an article.Application In Synthesis of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Synthesis and antibacterial activity of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanines. And the article contained the following:

In the present study, a series of novel 1,3-diphenyl-1H-pyrazoles functionalized with phenylalanine-derived rhodanine derivatives were synthesized and evaluated for their antibacterial activity. Several of these compounds, e.g. I, exhibited stronger activity than the standard drugs, norfloxacin and oxacillin, with MIC values of 1 μg/mL against methicillin-resistant Staphylococcus aureus and quinolone-resistant S. aureus. None of the compounds showed any activity against Gram-neg. bacteria. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Application In Synthesis of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazole diphenyl phenylalanine rhodanine preparation antibacterial activity, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On March 27, 1979, Rainer, Georg published a patent.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the patent was 4-Pyrazoleacetic acid derivatives. And the patent contained the following:

Pyrazoleacetic acid derivatives I (R = CO2H, alkoxycarbonyl, CONH2; R1, R2 = optionally substituted Ph, furyl, thienyl, naphthyl; R3 = H, Ph, furyl) were prepared Thus, CH2Ac2 was treated with BrCH2CO2Et to give Ac2CHCH2CO2Et which was cyclized with PhNHNH2 to give I (R = CO2Et, R1 = Ph, R2 = R3 = Me), which was hydrolyzed to the acid. I had antiinflammatory and analgesic activity. Thus, I (R = CO2H, R1 = Ph, R2 = R3 = 2-furyl) had antiinflammatory ED50 in the UV erythema test of 1.5 mg/kg orally and then analgesic ED40 50 mg/kg orally. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazoleacetic acid, antiinflammatory pyrazoleacetic acid, analgesic pyrazoleacetic acid, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Verma, Anil; Kumar, Vinod; Kataria, Ramesh; Singh, Joginder published an article in 2019, the title of the article was Novel acetohydrazide pyrazole derivatives, design, synthesis, characterization and antimicrobial activity.Computed Properties of 36640-53-6 And the article contains the following content:

Eleven acetohydrazide linked pyrazole derivatives I [R = Ph, thiophen-2-yl, 1-naphthyl, etc.] were designed and synthesized via condensation of acetohyadrazide with different substituted formyl pyrazole derivatives under mild reaction conditions. Synthesized compounds I were characterized on the basis of IR, NMR (1H & 13C) and mass spectrometry. The antimicrobial activities of all the compounds I were screened against four bacterial and two fungal strains. Among the synthesized compounds, three compounds viz. I [R = 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl] were found as efficient antimicrobial agents in reference to the standard drugs viz. ciprofloxacin and amphotericin-B. Further, structure-activity relationship (SAR) study revealed that electron-withdrawing group enhances the antimicrobial potential of synthesized derivatives I as compared to other groups present in the ring. Hence, among compounds I [R = 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl] could be explored further against other microbes to prove its vitality. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Computed Properties of 36640-53-6

The Article related to diphenyl pyrazolylmethylene acetohydrazide preparation antibacterial antifungal activity sar, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Computed Properties of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 2012, Siddhartha, Tarun; Mithilesh; Sharma, Raju; Chawla, Pooja; Saraf, S. K. published an article.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Syntheses and antioxidant screening of pyrazole-4-carboxaldehyde derivatives. And the article contained the following:

Pyrazole-4-carboxaldehydes were synthesized by AcOH-mediated condensation of aryl Me ketones with phenylhydrazines in EtOH to afford the corresponding phenylhydrazones. Subsequent reaction with 2 equiv DMF-POCl3 adduct (Vilsmeier Haack reagent) in DMF at 60-70° for 6 h afforded immonium perchlorates. Further, alk. hydrolysis (NaOH) afforded pyrazole-4-carboxaldehydes. All the synthesized compounds were screened for antioxidant activity. In a ferric reducing power assay, increased absorbance of the compounds with concentration indicates increased reducing power. Compounds with higher concentrations showed a higher reducing power. The reducing power showed good linear relation (R2) in both standard as well as in the newly prepared compounds Thus, the compounds have antioxidant activity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to phenylhydrazone vilsmeier haack cyclization formylation, pyrazolecarboxaldehyde preparation antioxidant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 2002, Vovk, M. V.; Mel’nichenko, N. V.; Chornous, V. A.; Bratenko, M. K. published an article.Formula: C20H14N2O The title of the article was Intramolecular cyclization of 4-isocyanato-3-(2-naphthyl)-1-phenylpyrazole under friedel-crafts reaction conditions. And the article contained the following:

4-Isocyanato-3-(2-naphthyl)-1-phenylpyrazole cyclized under the influence of AlCl3 to give 2H-benzo-[h]pyrazolo[4,3-c]isoquinoline. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Formula: C20H14N2O

The Article related to isocyanatonaphthylphenylpyrazole intramol cyclization friedel crafts condition, benzopyrazoloisoquinoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C20H14N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackusa, Algirdas published an article in 2011, the title of the article was Synthesis of 3-substituted 1-phenyl-1H-pyrazole-4-carbaldehydes and the corresponding ethanones by Pd-catalyzed cross-coupling reactions.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde And the article contains the following content:

An efficient synthetic route to construct substituted 1-phenyl-1H-pyrazole-4-carboxaldehydes and the corresponding ethanones was described and the synthesis of the target compounds was achieved using 1-phenyl-1H-pyrazol-3-ol as a starting material. Carbon-carbon bond-forming palladium-catalyzed cross-coupling reactions were applied for the functionalization of the intermediate pyrazole triflates [i.e., trifluoromethanesulfonic acid 1-phenyl-1H-pyrazol-3-yl ester derivatives]. The target compounds thus formed included imidazo[4,3-c]pyridine derivatives, 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde, 1-phenyl-3-(3-thienyl)-1H-pyrazole-4-carboxaldehyde, 1-(1,3-diphenyl-1H-pyrazol-4-yl)ethanone, etc. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazolol triflate preparation palladium catalyzed cross coupling, pyrazolecarboxaldehyde preparation, ethanone pyrazolyl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Xu, Li-Li; Zheng, Chang-Ji; Sun, Liang-Peng; Miao, Jing; Piao, Hu-Ri published an article in 2012, the title of the article was Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents.Electric Literature of 36640-53-6 And the article contains the following content:

In the present study, a series of 1,3-diarylpyrazole derivatives I [R = (un)substituted Ph, n = 1-5] bearing rhodanine-3-fatty acid moieties were synthesized and their antimicrobial activities were tested against various Gram-pos. and Gram-neg. bacteria. 1,3-Diaryl-4-formylpyrazoles were synthesized as key intermediates following a Vilsmeier-Haack strategy. Several compounds with an MIC of 2 μg/mL exhibited stronger antibacterial activity against the methicillin-resistant Staphylococcus aureus (MRSA) than the controls. None of the compounds showed any activity against Gram-neg. bacteria. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Electric Literature of 36640-53-6

The Article related to pyrazole aryl rhodanine derivative preparation antibacterial, thiazolidinone thioxodiarylpyrazolylmethylene preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Electric Literature of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On December 31, 2014, Goel, Neelima; Drabu, Sushma; Afzal, Obaid; Bawa, Sandhya published an article.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Antimicrobial screening and one-pot synthesis of 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives. And the article contained the following:

A series of 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives (4a-4k) were synthesized through direct reductive amination of 3-(naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde with various substituted aromatic amines using NaBH4 in the presence of I2 as reducing agent. The reaction was carried out in anhydrous methanol under neutral conditions at room temperature All 4-(substituted-anilinomethyl)-3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives (4a-4k) were tested in vitro for antifungal and antibacterial activities against different fungal and bacterial strains. Most of the compounds exhibited considerable antifungal activity, but poor antibacterial activity against the test strains. In the series compound 4e, 4g, 4j, and 4k, showed excellent antifungal activity against the fungal strain Aspergillus niger (MTCC) 281 and Aspergillus flavus MTCC 277 (% inhibition in the range of 47.7-58.9). The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazole naphthyl anilinomethyl preparation antibacterial antifungal, antimicrobial activity, naphthalene, pyrazole, reductive amination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On August 13, 2009, Hirokawa, Takatsugu; Takemura, Shunji; Shibazaki, Manabu; Ishiwatari, Hiroyuki published a patent.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the patent was 3-naphthylpyrazole compounds, histamine H4 receptor antagonists containing them, their use for treatment for inflammatory disorders, and pharmaceutical compositions containing them. And the patent contained the following:

Claimed are title compounds I [ring A = C6-10 aryl; X = (CH2)n (n = 1-6), CH:N; Y = O, S, NR8; Z = direct bond, CHR7; R1-R7 = H, halo, OH, NO2, carboxy, carbamoyl, C1-6 alkyl, C2-6 acyl, C6-10-aryl-C1-6 alkyl, C5-10-heteroaryl-C2-6 alkenyl, etc.; R8 = H, OH, C1-6 alkyloxy], their salts, or their solvates [exclusive of (E)-2-[[3-(2-Naphthyl)-1-phenyl-1H-pyrazol-4-yl]methylene]hydrazinecarboxamide] and histamine H4 receptor antagonists containing I, their salts, or their solvates. Also claimed are prophylactic and/or therapeutic agents and pharmaceutical compositions containing I, their salts, or their solvates. Thus, (S)-2-amino-N-[[3-(2-naphthyl)-1-phenyl-1H-pyrazol-4-yl]methyl]-3-phenylpropanamide at 10 μM (preparation given) showed 86% inhibition against histamine binding to human recombinant H4 receptor expressed on CHO cells. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to naphthylpyrazole compound preparation histamine h4 receptor antagonist inflammation inhibitor, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On May 15, 2019, Sun, Liangpeng; Wang, Peipei; Xu, Lili; Gao, Lixin; Li, Jia; Piao, Huri published an article.SDS of cas: 36640-53-6 The title of the article was Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors. And the article contained the following:

Two series of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors. Among the compounds studied, IIIv was found to have the best in vitro inhibition activity against PTP1B (IC50 = 0.67 ± 0.09 μM) and the best selectivity (9-fold) between PTP1B and T-cell protein tyrosine phosphatase (TCPTP). Mol. docking studies demonstrated that compounds IIIm, IIIv and IVg could occupy simultaneously at both the catalytic site and the adjacent pTyr binding site. These results provide novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).SDS of cas: 36640-53-6

The Article related to inhibition activity ptp1b inhibitor sar mol docking, 1,3-diphenyl-1h-pyrazole, ptp1b inhibitor, rhodanine-3-alkanoic acid, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.SDS of cas: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics