Category: 36640-53-6

Ashok, Dongamanti; Kavitha, Rangu; Gundu, Srinivas; Sarasija, Madderla published an article in 2019, the title of the article was Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′-yl]–2H-chromen-5-ols.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde And the article contains the following content:

A new series of 6-[3-aryl-1-phenyl-4′,5′-dihydro[4,5′-bi-1H-pyrazol]-3′- -yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chal- cones 5a-j with hydrazine hydrate in presence of sodium acetate under con- ventional heating and microwave irradiation Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and anal. data. All the synthesized compounds 6a-j were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c-f and 6i showed promising antimicrobial potency. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazole pyrazoline derivative microwave irradiation conventional heating antimicrobial, Pharmaceuticals: Drug Standards and other aspects.Quality Control of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kamal, Raj; Kumar, Vipan; Kumar, Ravinder; Bhardwaj, Jitender K.; Saraf, Priyanka; Kumari, Priya; Bhardwaj, Vikas published an article in 2017, the title of the article was Design, Synthesis, and Screening of Triazolopyrimidine-Pyrazole Hybrids as Potent Apoptotic Inducers.HPLC of Formula: 36640-53-6 And the article contains the following content:

An efficient synthesis of novel 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-5,7-dimethyl-[1,2,4]triazolo[4,3-a]-pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in the testicular germ cells of goat (Capra hircus). This study aimed at assessing the cytol. and biochem. changes in testicular germ cells after the exposure to triazolopyrimidines in a dose- and time-dependent manner. Histomorphol. anal., fluorescence assays, apoptosis quantification, and terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling (TUNEL) assays were performed to determine cytol. changes, whereas thiobarbituric acid-reactive substance (TBARS) and ferric reducing antioxidant power (FRAP) assays were carried out to measure the oxidative stress in triazolopyrimidines treated germ cells. The parallel use of these methods enabled us to determine the role of triazolopyrimidines in inducing apoptosis as a consequence of cytogenetic damage and oxidative stress generated in testicular germ cells of goat. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).HPLC of Formula: 36640-53-6

The Article related to screening triazolopyrimidine pyrazole apoptosis inducer, cytotoxic activity, pyrazole, synthesis, triazole, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On April 3, 2018, Naim, Mohd. Javed; Alam, Ozair; Alam, Jahangir Md.; Shaquiquzzaman, Mohammad; Alam, Mumtaz Md.; Naidu, Vegi Ganga Modi published an article.Recommanded Product: 36640-53-6 The title of the article was Synthesis, docking, in vitro and in vivo antidiabetic activity of pyrazole-based 2,4-thiazolidinedione derivatives as PPAR-γ modulators. And the article contained the following:

The design, synthesis, structure-activity relationship, and biol. activity of 2,4-thiazolidinedione derivatives as peroxisome proliferator-activated receptor-γ (PPAR-γ) modulators for antidiabetic activity are reported. Fifteen 2,4-thiazolidinedione derivatives clubbed with pyrazole moiety were docked into the ligand binding domain of PPAR-γ by the Glide XP module of Schrodinger. Eight derivatives (5a (5-((3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione), 5b (5-((1-phenyl-3-(thien-2-yl)-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione), 5d, 5f, 5i, 5l, 5n, 5o) having Glide XP scores > -8 as compared to the standard drug, rosiglitazone (Glide XP score = -9.165), showed almost similar interaction with the amino acids such as HIS 449, TYR 473, TYR 327, HIS 323, and SER 289 in the mol. docking studies. These eight derivatives were further screened for PPAR-γ transactivation and in vivo blood glucose lowering activity in the streptozotocin-induced diabetic rat model. Compounds 5o, 5n, 5a, 5i, and 5b showed 52.06, 51.30, 48.65, 43.13, and 40.36% PPAR-γ transactivation as compared to the reference drugs rosiglitazone and pioglitazone with 85.30 and 65.22% transactivation, resp. The data anal. showed significant blood glucose lowering effects (hypoglycemia) of compounds 5o, 5n, and 5a (140.1±4.36, 141.4±6.15, and 150.7±4.15, resp.), along with reference drugs pioglitazone (135.2±4.91) and rosiglitazone (141.1±5.88) as compared to the diabetic control. Furthermore, the most potent compound 5o also elevated the PPAR-γ gene expression by 2.35-fold as compared to rosiglitazone (1.27-fold) and pioglitazone (1.6-fold). It also significantly lowered the AST, ALT, and ALP levels and caused no damage to the liver. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Recommanded Product: 36640-53-6

The Article related to pyrazole thiazolidinedione preparation ppar gamma modulator docking antidiabetic diabetes, ppar-γ, diabetes, molecular docking, thiazolidinedione, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On August 31, 2017, Naim, Mohd. Javed; Alam, Jahangir Md.; Nawaz, Farah; Naidu, V. G. M.; Aaghaz, Shams; Sahu, Meeta; Siddiqui, Nadeem; Alam, Ozair published an article.SDS of cas: 36640-53-6 The title of the article was Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives. And the article contained the following:

A series of thiazolidinedione based amide derivatives were designed, synthesized and docked against the PPARγ receptor target. 11 Compounds from the series with good glide scores were selected for in vivo antidiabetic study based on streptozotocin induced diabetic rat model. It was observed that 4 compounds (I, II, III & IV) showed significantly good antidiabetic activity in comparison to rosiglitazone and pioglitazone as reference drugs. Compound I appeared as the most potent derivative in lowering blood glucose level and showed excellent interaction with SER 342, ILE 281, pi-pi interaction with ARG 288 and halogen bond interaction with LYS 367. Further, PPARγ transactivation and gene expression studies of compound I were carried out to investigate the possible mechanism of action through PPARγ modulation. Compound I exhibited 53.65% transactivation and elevated PPARγ gene expression by 2.1 folds. The biochem. parameters (AST, ALT and ALP levels) were found within the range with no noteworthy damage to liver. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).SDS of cas: 36640-53-6

The Article related to thiazolidinedione amide derivative synthesis sar antidiabetic pharmacokinetics toxicity, antidiabetic, molecular docking, pparγ, thiazolidinedione, Pharmacology: Structure-Activity and other aspects.SDS of cas: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Verma, Anil; Kumar, Vinod; Khare, Rajshree; Singh, Joginder published an article in 2019, the title of the article was Synthesis of some hippuric acid substrate linked novel pyrazoles as antimicrobial agents.Category: pyrazoles-derivatives And the article contains the following content:

Escalating resistance of microorganisms to the currently accessible antimicrobial drugs has forced to synthesize some novel biol. active compounds as efficient alternates via economical substrates. Hence, hippuric acid was used as one of the starting materials to synthesize pyrazole derivatives All the synthesized compounds were characterized by IR, NMR (1H & 13C) and mass spectral data. The antimicrobial potential of synthesized compounds has been explored against four bacterial and two fungal strains. Among the 12 compounds, 3 compounds 8j, 8k and 8l were found to exhibit prominent antimicrobial potential as compared with the standards ciprofloxacin and amphotericin-B. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Category: pyrazoles-derivatives

The Article related to hippuric acid antimicrobial pyrazoles, Placeholder for records without volume info and other aspects.Category: pyrazoles-derivatives

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 7, 2021, Cho, Won Je published a patent.Name: 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the patent was Preparation of pyrazolecarboxamide for preventing or treating metabolic disease. And the patent contained the following:

The present invention relates to a novel pyrazolecarboxamide carboxamide compound I [R1 = H, 3-OMe, 3,4-(OMe)2, 4-Me; R2 = H, CF3, NH2; OR3 = meta-(3-pyridinyloxy), para-(4-isopropylphenyl), para-(2-methoxy-4-methylphenyl), etc.] and a composition for preventing or treating metabolic diseases, wherein the composition is a potent and selective estrogen-related receptor (ERR) γ inverse agonist with excellent selectivity and since it shows affinity, it can be effectively used for treatment of metabolic diseases. For example, II was prepared and exhibited IC50 of 1.33μM against estrogen-related receptor (ERR) γ. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Name: 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to preparation pyrazolecarboxamide treatment metabolic disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Name: 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On February 4, 2020, Wang, Renxiao; Liu, Hong; Yu, Biao; Li, Yangfeng; Li, Chunpiao; Li, Yan; Zhou, Mi; Li, Qing; Su, Minyi published a patent.Application of 36640-53-6 The title of the patent was Phenyl pyrazole compound, its pharmaceutical composition, preparing method and application. And the patent contained the following:

The invention relates to Ph pyrazole compounds of formula I and II, their preparation and application as Bcl inhibitor. Compounds I and II, wherein Ra is R1(O)n(CH2)m; R1 is C6-14 aryl or substituted C6-14 aryl; m is 0-6; n is 0 or 1; R is H or C1-C4 alkyl; Rb and Rc are independently H, C3-C8 cycloalkyl, C1-C6 alkyl, etc.; their stereoisomers, or pharmaceutically acceptable salts, are claimed. The inventive compound can be applied in preparing the drugs for preventing and/or treating Bcl-related diseases or preparing Bcl inhibitor, with high activity and low toxicity. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Application of 36640-53-6

The Article related to phenyl pyrazole preparation bcl inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On February 24, 1972, Rainer, Georg; Riedel, Richard published a patent.Formula: C20H14N2O The title of the patent was 4-(Hydroxymethyl)- and 4-formyl-1-arylpyrazoles. And the patent contained the following:

Thirty title compounds [I, R = CHO or CH2OH; R1 = (substituted) phenyl, 3-pyridyl, 2-furyl, or 2-naphthyl; R2 = H, F, Cl, Br, Me, or MeO], useful as intermediates for pharmaceutical 4-(carboxymethyl)- or 4-(cyanomethyl)-1-arylpyrazoles, were prepared by reacting R1CMe:NNHC6H4R2-p with DMF and POCl3 via I (R = CH:N+Me2ClO4-) (Ia). Saponifying Ia gave I (R = CHO), which on reduction gave I (R = CH2OH). Thus, POCl3 was stirred 1 hr with DMF and treated with p-ClC6H4CMe:NNHPh 6 hr at 70°. The mixture was treated 5 hr with aqueous NaOH at pH 7 to give 99% I (R = CHO, R1 = C6H4Cl-p, R2 = H) (II). II was treated in EtOH and DMF with NaBH4 1 hr at 20-5° to give 93% I (R = CH2OH, R1 = C6H4Cl-p, R2 = H). The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Formula: C20H14N2O

The Article related to pyrazolecarboxaldehyde, hydroxymethylpyrazole, benzenes pyrazolyl, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Formula: C20H14N2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On May 21, 2019, Sun, Liangpeng; Piao, Huri; Xu, Lili published a patent.Recommanded Product: 36640-53-6 The title of the patent was 1,3-Diarylpyrazole PTP1B inhibitor containing carboxyalkyl rhodamine structure and preparation and application thereof. And the patent contained the following:

The invention provides a compound of 1,3-diarylpyrazole PTP1B inhibitor containing carboxyalkyl rhodamine structure as shown in the formula or a pharmaceutically acceptable salt thereof as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor. Studies show that the inhibitor can effectively inhibit the activity of PTP1B and can be used as an insulin sensitizer for preventing and/or treating diseases related to insulin resistance mediated by PTP1B, particularly type II diabetes and obesity. The invention also provides a preparation method of the inhibitor. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Recommanded Product: 36640-53-6

The Article related to diarylpyrazole carboxyalkyl rhodamine preparation ptp1b inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Recommanded Product: 36640-53-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

On September 30, 2014, Ashok, D.; Ganesh, Arram; Ravi, S.; Lakshmi, B. Vijaya published an article.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde The title of the article was Solvent-free microwave assisted synthesis and antimicrobial activity of new 2-{4-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-acryloyl]-phenyl}-isoindole-1,3-diones. And the article contained the following:

A series of new 2-(4-(3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-acryloyl)-phenyl)-isoindole-1,3-diones I (Ar = C6H5, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, 2-naphthyl, etc.) have been synthesized by Claisen-Schmidt condensation of 2-(4-acetylphenyl)-isoindole-1,3-dione with 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehydes in the presence of basic alumina under solvent-free microwave irradiation and conventional heating methods. All the synthesized compounds were screened for their antimicrobial activity. The activity was determined using cup plate agar diffusion method by measuring the zone of inhibition in mm. From the screening studies it is evident that the synthesized compounds I (Ar = Ph, 4-MeC6H4, 2-naphthyl) showed good antibacterial activity and compounds I (Ar = 4-MeOC6H4, 2-naphthyl) showed good antifungal activity against all the tested organisms. The experimental process involved the reaction of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde(cas: 36640-53-6).Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

The Article related to pyrazolyl acryloyl phenylisoindoledione preparation green chem microwave irradiation, solvent free antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Reference of 3-(Naphthalen-2-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics