Category: 114474-26-9

The author of 《Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates》 were Meador, Rowan I. L.; Mate, Nilamber A.; Chisholm, John D.. And the article was published in Organics in 2022. Safety of 4-(4-Nitrophenyl)-1H-pyrazole The author mentioned the following in the article:

A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles C(Cl)3C=(NH)OR1 (R1 = 1-phenylethyl, 1-(naphthalen-2-yl)ethyl, benzyl, 2H-1,3-benzodioxol-5-yl(phenyl)methyl, etc.) and a Bronsted acid catalyst. These reactions provide ready access to N-alkyl pyrazoles, e.g., I, which are present in a variety of medicinally relevant lead structures. Benzylic, phenethyl and benzhydryl trichloroacetimidates provide good yields of the N-alkyl pyrazole products. Unsym. pyrazoles provide a mixture of the two possible regioisomers, with the major product being controlled by sterics. This methodol. provides an alternative to other alkylation methods that require strong base or high temperature In addition to this study using 4-(4-Nitrophenyl)-1H-pyrazole, there are many other studies that have used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Safety of 4-(4-Nitrophenyl)-1H-pyrazole) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Safety of 4-(4-Nitrophenyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Synthesis and solid-state structure of thermally stable linear bi-pyrazoles》 was written by Maspero, Angelo; Cernuto, Giuseppe; Galli, Simona; Palmisano, Giovanni; Tollari, Stefano; Masciocchi, Norberto. Electric Literature of C9H7N3O2 And the article was included in Solid State Sciences on August 31 ,2013. The article conveys some information:

The long and rigid bi-pyrazolyl-based ligands 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone, , and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole, were isolated in pure form, with satisfying yields, as very insoluble polycrystalline materials. Their thermal behavior was studied by coupling thermal analyses and variable-temperature x-ray powder diffraction measurements. Their crystal structures were unraveled from powder diffraction data by a rather unconventional structure determination approach, without the a priori knowledge of the unit cell parameters. Inline with shorter analogs, successfully employed in the formation of porous MOFs with intriguing functional properties, 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole are promising to construct higher-porosity materials, potentially capable of hosting nano-sized guests.4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Electric Literature of C9H7N3O2) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Electric Literature of C9H7N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Monitoring the hydrogen bond net configuration and the dimensionality of aniline and phenyloxamate by adding 1H-pyrazole and isoxazole as substituents for molecular self-recognition》 were Oliveira, Willian X. C.; do Pim, Walace D.; Pinheiro, Carlos B.; Journaux, Yves; Julve, Miguel; Pereira, Cynthia L. M.. And the article was published in CrystEngComm in 2019. Quality Control of 4-(4-Nitrophenyl)-1H-pyrazole The author mentioned the following in the article:

This work describes the synthesis and characterization of a new class of oxamic acid derivatives containing pyrazole and isoxazole as substituents to investigate their ability to form hydrogen bonds aiming at applying them in crystal engineering and mol. self-recognition. In this respect, we report a new synthesis of 2-(4-nitrophenyl)-1,3-propanedial (1) in high yield using SOCl2 as a chlorinating agent. The new oxamic esters 4-(1H-pyrazol-4-yl)phenylene-N-(ethyloxamate) (2d) and 4-(1,2-oxazol-4-yl)phenylene-N-(ethyloxamate) (3d) were prepared from 1. The synthetic route consists of the cyclisation of 1 either with hydrazine to afford 4-(-aminophenyl)-1H-pyrazole (2a) or with hydroxylamine to obtain the isoxazole-based mol. 4-(4-nitrophenyl)-1,2-oxazole (3a). The reduction of 2a and 3a was carried out in an acidic/tin solution to yield 4-(4-ammoniophenyl)-1H-pyrazol-2-ium trichlorostannate(II) chloride monohydrate (2b) and 4-(4-ammoniophenyl)-1,2-oxazole hexachlorostannate(IV) (3b). Basic extraction of 3b provided 4-(4-aminophenyl)-1,2-oxazole (3c). The reduction of 2a to 4-(4-aminophenyl)-1H-pyrazole (2c) was achieved by means of hydrazine associated with supported palladium on carbon. The condensation of 2c and 3c with Et chlorooxoacetate delivers oxamic esters 2d and 3d. In n-tetrabutylammonium hydroxide solution 2d is fully hydrolyzed, obtaining the n-tetrabutylammonium salt of 4-(1H-pyrazole-4-yl)phenylene-N-oxamate as a hemihydrate (2e). The low stability of isoxazole mols. in basic solutions was proved by crystallizing the n-tetrabutylammonium salt of 1-cyano-1-(4-nitrophenyl)-2-oxoethanide (3f) (obtained by cleavage of 3d with n-Bu4NOH) and preparing its conjugated acid 2-(4-nitrophenyl-3-oxopropanenitrile) (3e). The structures of 2b, 3b, 3d and 2e were solved by single crystal X-ray diffraction techniques. The anal. of their crystal packing reveals hydrogen bond features compatible for all compounds as well as some differences depending on the pH of the crystallization solution and the presence or absence of the oxamate group due to the increase of hydrogen bond donors and acceptors. In the experimental materials used by the author, we found 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Quality Control of 4-(4-Nitrophenyl)-1H-pyrazole)

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Quality Control of 4-(4-Nitrophenyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Synthesis and solid-state structure of thermally stable linear bi-pyrazoles》 was written by Maspero, Angelo; Cernuto, Giuseppe; Galli, Simona; Palmisano, Giovanni; Tollari, Stefano; Masciocchi, Norberto. Electric Literature of C9H7N3O2 And the article was included in Solid State Sciences on August 31 ,2013. The article conveys some information:

The long and rigid bi-pyrazolyl-based ligands 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone, , and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole, were isolated in pure form, with satisfying yields, as very insoluble polycrystalline materials. Their thermal behavior was studied by coupling thermal analyses and variable-temperature x-ray powder diffraction measurements. Their crystal structures were unraveled from powder diffraction data by a rather unconventional structure determination approach, without the a priori knowledge of the unit cell parameters. Inline with shorter analogs, successfully employed in the formation of porous MOFs with intriguing functional properties, 2,6-bis[4-(1H-pyrazol-4-yl)phenyl]pyrrolo[3,4-f]isoindole-1,3,5,7(2H,6H)-tetrone and 2,5-bis[4-(1H-pyrazol-4-yl)phenyl]thiazolo[5,4-d]thiazole are promising to construct higher-porosity materials, potentially capable of hosting nano-sized guests.4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Electric Literature of C9H7N3O2) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. Electric Literature of C9H7N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The author of 《Monitoring the hydrogen bond net configuration and the dimensionality of aniline and phenyloxamate by adding 1H-pyrazole and isoxazole as substituents for molecular self-recognition》 were Oliveira, Willian X. C.; do Pim, Walace D.; Pinheiro, Carlos B.; Journaux, Yves; Julve, Miguel; Pereira, Cynthia L. M.. And the article was published in CrystEngComm in 2019. Quality Control of 4-(4-Nitrophenyl)-1H-pyrazole The author mentioned the following in the article:

This work describes the synthesis and characterization of a new class of oxamic acid derivatives containing pyrazole and isoxazole as substituents to investigate their ability to form hydrogen bonds aiming at applying them in crystal engineering and mol. self-recognition. In this respect, we report a new synthesis of 2-(4-nitrophenyl)-1,3-propanedial (1) in high yield using SOCl2 as a chlorinating agent. The new oxamic esters 4-(1H-pyrazol-4-yl)phenylene-N-(ethyloxamate) (2d) and 4-(1,2-oxazol-4-yl)phenylene-N-(ethyloxamate) (3d) were prepared from 1. The synthetic route consists of the cyclisation of 1 either with hydrazine to afford 4-(-aminophenyl)-1H-pyrazole (2a) or with hydroxylamine to obtain the isoxazole-based mol. 4-(4-nitrophenyl)-1,2-oxazole (3a). The reduction of 2a and 3a was carried out in an acidic/tin solution to yield 4-(4-ammoniophenyl)-1H-pyrazol-2-ium trichlorostannate(II) chloride monohydrate (2b) and 4-(4-ammoniophenyl)-1,2-oxazole hexachlorostannate(IV) (3b). Basic extraction of 3b provided 4-(4-aminophenyl)-1,2-oxazole (3c). The reduction of 2a to 4-(4-aminophenyl)-1H-pyrazole (2c) was achieved by means of hydrazine associated with supported palladium on carbon. The condensation of 2c and 3c with Et chlorooxoacetate delivers oxamic esters 2d and 3d. In n-tetrabutylammonium hydroxide solution 2d is fully hydrolyzed, obtaining the n-tetrabutylammonium salt of 4-(1H-pyrazole-4-yl)phenylene-N-oxamate as a hemihydrate (2e). The low stability of isoxazole mols. in basic solutions was proved by crystallizing the n-tetrabutylammonium salt of 1-cyano-1-(4-nitrophenyl)-2-oxoethanide (3f) (obtained by cleavage of 3d with n-Bu4NOH) and preparing its conjugated acid 2-(4-nitrophenyl-3-oxopropanenitrile) (3e). The structures of 2b, 3b, 3d and 2e were solved by single crystal X-ray diffraction techniques. The anal. of their crystal packing reveals hydrogen bond features compatible for all compounds as well as some differences depending on the pH of the crystallization solution and the presence or absence of the oxamate group due to the increase of hydrogen bond donors and acceptors. In the experimental materials used by the author, we found 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Quality Control of 4-(4-Nitrophenyl)-1H-pyrazole)

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Quality Control of 4-(4-Nitrophenyl)-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 114474-26-9On November 30, 2013 ,《Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents》 appeared in Medicinal Chemistry Research. The author of the article were Xu, Shengjie; Li, Shenghui; Tang, Yonghe; Zhang, Jinchao; Wang, Shuxiang; Zhou, Chuanqi; Li, Xiaoliu. The article conveys some information:

A novel series of N-arylpyrazole derivatives I(R = 4-CF3, 3,5-(CF3)2, 4-NO2), II, III and IV(R = H, OC8H17) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4-fluoronitrobenzene in the presence of base. The structures of these compounds were established on the basis of elemental (C, H, and N) and spectral anal. (1H NMR, 13C NMR, HRMS, and FT-IR). All the compounds were tested for their cytotoxic activity in vitro against four human tumor cell lines: carcinoma (Bel-7402), nasopharyngeal carcinoma (KB), immature granulocyte leukemia (HL-60), and gastrocarcinoma (BGC-823) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The results showed that most of the obtained compounds exhibited promising cytotoxicity against tested carcinoma cell lines with low IC50 values. The bis-pyrazole derivative IV(R = OC8H17), bearing alkoxy group on the 5-position of Ph ring, was the most effective one. It is inhibition of cell growth of Bel-7402 cells was 1.5-fold higher than that found for cisplatin. And, also mono-pyrazole derivatives I(R = 4-CF3, 3,5-(CF3)2) decorated with trifluoromethyl group on the Ph ring, displayed better cytotoxicity than that of cisplatin against Bel-7402 cell line. After reading the article, we found that the author used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Application of 114474-26-9)

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities. Application of 114474-26-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In 2019,New Journal of Chemistry included an article by Kandel, Shambhu; Sathish, Veerasamy; Mathivathanan, Logesh; Morozov, Alexander N.; Mebel, Alexander M.; Raptis, Raphael G.. Application of 114474-26-9. The article was titled 《Aggregation induced emission enhancement (AIEE) of tripodal pyrazole derivatives for sensing of nitroaromatics and vapor phase detection of picric acid》. The information in the text is summarized as follows:

Five pyrazole-based tripodal ligands, compounds1-5 (I,II,III,IV,V), based on a 1,3,5-triethylbenzene scaffold, show aggregation-induced emission enhancement (AIEE) and their application as fluorescent probes for detection of nitroaroms. is investigated. All five compounds are weakly fluorescent in THF, but their fluorescence intensity increases with the addition of a poor solvent (water), causing nanoaggregation, as confirmed by the changes in the UV-vis and emission spectra, and light scattering techniques. The nanoaggregates exhibit time-dependent emission characteristics and can serve as sensors for the detection of nitroarom. compounds The selective detection of picric acid (PA) over other nitroarom. compounds by 1-3 (I-III) is attributed to the photoinduced electron transfer from the trispyrazole to the quencher, as confirmed by TD-DFT calculations Furthermore, compounds 1(I) and 2 (II) were tested for sensing of PA in the vapor and solid phases by means of changes in the emission spectra observable by the naked eye. The supramol. assemblies of 1(I) and 3(III) with PA were structurally characterized by X-ray crystallog. In addition to this study using 4-(4-Nitrophenyl)-1H-pyrazole, there are many other studies that have used 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9Application of 114474-26-9) was used in this study.

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, monoamine oxidase inhibitory, anti-inflammatory, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, antidiabetic and antibacterial activities. Application of 114474-26-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Krishnan, R.; Seshadri, S. published an article in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. The title of the article was 《Synthesis of aryltriazolyl derivatives》.COA of Formula: C9H7N3O2 The author mentioned the following in the article:

Amino azo compounds I (R1 = H, Ph) were treated with Cu(OAc)2 in DMF to give naphthotriazoles II. I were prepared from the resp. 4-(4-pyrazolyl)anilines and 2-amino-1-naphthalenesulfonic acid. In the experiment, the researchers used many compounds, for example, 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9COA of Formula: C9H7N3O2)

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. COA of Formula: C9H7N3O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Cerrada, Luisa; Cudero, Jose; Elguero, Jose; Pardo, Carmen published their research in Journal of the Chemical Society, Chemical Communications on December 7 ,1993. The article was titled 《Azolyl substituted Troeger’s Bases》.HPLC of Formula: 114474-26-9 The article contains the following contents:

Troeger’s bases I [R = 1-imidazolyl, 1-(diphenylmethyl)-3-pyrazolyl, 2-(1,3,4-trazol-1-yl)phenyl] were synthesized for the first time. In the experimental materials used by the author, we found 4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9HPLC of Formula: 114474-26-9)

4-(4-Nitrophenyl)-1H-pyrazole(cas: 114474-26-9) belongs to pyrazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, antipyretic, neuroleptic, anticonvulsant, antiarrhythmic, sedative, muscle relaxant, monoamine oxidase inhibitory, anti-inflammatory, antidiabetic and antibacterial activities. HPLC of Formula: 114474-26-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics