Category: 22600-77-7

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ) is researched.Computed Properties of C4H9Cl2N3.Casagrande, Manolo; Barteselli, Anna; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Sparatore, Anna published the article 《Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline》 about this compound( cas:22600-77-7 ) in Bioorganic & Medicinal Chemistry. Keywords: quinoline heteroarylmethylamino heteroarylamino preparation antiplasmodial activity; antimalarial aminoquinoline chloro preparation. Let’s learn more about this compound (cas:22600-77-7).

With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-4-(heteroarylmethylamino)quinoline and 7-chloro-4-(heteroarylamino)quinoline derivatives was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited from moderate to high antiplasmodial activities. The activity was strongly influenced both by the presence of a methylenic group, as a spacer between the 4-aminoquinoline and the heterocyclic ring, and by the presence of a basic head. The most potent mols. inhibited the growth of both CQ-S and CQ-R strains of P. falciparum with IC50 < 30 nM and were not toxic against human endothelial cells. These results confirm that the presence of an heteroaryl moiety in the side chain of 7-chloro-4-aminoquinoline is useful for the design and development of new powerful antimalarial agents. This compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments, published in 2002-09-20, which mentions a compound: 22600-77-7, mainly applied to azathiaalkaneone azidofluorophenyl functionalized preparation; rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex preparation photolysis amine; human serum albumin labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex; antibody labeling rhenium triazathiaalkanetrione azidofluorophenyl functionalized complex, Computed Properties of C4H9Cl2N3.

Functionalization of perfluoro aryl azides by bifunctional chelating agents (BFCAs) capable of forming high specific activity complexes with 99mTc (for γ-imaging) and 188Re (for radiotherapy) is described. The synthesis of multidonor BFCAs containing N2S2, N4, and N3S donor groups containing imidazole, pyridine, and pyrazine functionalities that may be important for tuning the pharmacokinetic parameters is also described. Functionalization of perfluoro aryl azides at various sites on BFCAs yields novel bifunctional photolabile chelating agents (BFPCAs) that are useful for covalent attachment to biomols. A representative Re-BFPCA I as the Me4N+ salt in a model solvent, diethylamine, proceeded to give a high yield of intermol. NH insertion product without the decomplexation of the metal ion from I. All products originated from the photolysis of I in diethylamine were characterized by anal. techniques, and a plausible mechanism of formation of different photolytic products is suggested. The high yield of intermol. NH insertion of I is extended to labeling of human serum albumin (HSA) and Fab fragments under aqueous conditions. The photolabeling technol. developed here offers a new way to attach diagnostically and therapeutically useful radiotracers (e.g., 99mTc, 188Re) to Fab fragments for potential noninvasive imaging and therapy of cancer.

《Chemistry of Bifunctional Photoprobes. 6. Synthesis and Characterization of High Specific Activity Metalated Photochemical Probes: Development of Novel Rhenium Photoconjugates of Human Serum Albumin and Fab Fragments》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((1H-Imidazol-2-yl)methanamine dihydrochloride)Computed Properties of C4H9Cl2N3.

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Walther, Martin; Matterna, Madlen; Juran, Stefanie; Faehnemann, Silke; Stephan, Holger; Kraus, Werner; Emmerling, Franziska published the article 《Imidazole-containing bispidine ligands: synthesis, structure and Cu(II) complexation》. Keywords: copper imidazole bispidine complex preparation crystal structure.They researched the compound: (1H-Imidazol-2-yl)methanamine dihydrochloride( cas:22600-77-7 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:22600-77-7) here.

The preparation and characterization of tris-pyridyl bispidine (3,7-diazabicyclo[3.3.1]nonane) derivatives with benzimidazole and imidazole donor groups at the N-3 position of the bispidine skeleton and their copper(II) complexes are reported. The impact of the hetaryl substituents on the configurational isomerism of piperidones and their corresponding bispidones was studied by NMR spectroscopy, revealing the exclusive appearance in the enol form for the piperidones in solution and the trans-configuration regarding the two pyridyl substituents, as well as the sole formation of the unsym. exo-endo isomers for the corresponding bispidones. Thus, the bispidones are preorganized ligands for building pentacoordinated complexes, confirmed by the preparation and characterization of the corresponding Cu(II) complexes. Of the di-pyridyl piperidones with benzimidazole and imidazole substituents, and of the Cu(II) complex of the benzimidazole-containing bispidone, crystals have become available for the anal. by x-ray diffraction, showing that the piperidones form the enol tautomers also in the solid state.

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Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about NMR Characterization of Hydrate and Aldehyde Forms of Imidazole-2-carboxaldehyde and Derivatives. Author is Lazaro Martinez, Juan Manuel; Romasanta, Pablo Nicolas; Chattah, Ana Karina; Buldain, Graciela Yolanda.

The existence and stability of the aldehyde-hydrate form of imidazole-2-carboxaldehyde (4) were studied using FTIR together with solution- and solid-state NMR experiments The results allowed us to conclude that the hydrate form was stable and precipitated at pH = 8.0 and that the aldehyde form was isolated at pH = 6.5 and 9.5. Moreover, the presence of the aldehyde-hydrate form was studied through NMR experiments in D2O at both alk. and acidic pH. In addition, the tautomeric forms of the 2-substituted imidazole compounds were also analyzed to investigate the influence of the hybridization on the carbon adjacent to the imidazole ring, by 13C NMR in DMSO-d6, acetone-d6, and CDCl3. The presence of the syn- and anti-isomers of oxime 8 obtained from 4 were characterized by solid-state NMR and variable-temperature NMR experiments in acetone-d6.

The article 《NMR Characterization of Hydrate and Aldehyde Forms of Imidazole-2-carboxaldehyde and Derivatives》 also mentions many details about this compound(22600-77-7)Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride, you can pay attention to it, because details determine success or failure

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Recommanded Product: 22600-77-7. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. Author is ElHady, Ahmed K.; Abdel-Halim, Mohammad; Abadi, Ashraf H.; Engel, Matthias.

In cancer cells, kinases of the Clk family control the supply of full-length, functional mRNAs coding for a variety of proteins essential to cell growth and survival. Thus, inhibition of Clks might become a novel anticancer strategy, leading to a selective depletion of cancer-relevant proteins after turnover. On the basis of a Weinreb amide hit compound, the authors designed and synthesized a diverse set of methoxybenzothiophene-2-carboxamides, of which the N-benzylated derivative showed enhanced Clk1 inhibitory activity. Introduction of a m-fluorine in the benzyl moiety eventually led to the discovery of compound 21b (5-methoxybenzo[b]thiophene-2-carboxylic acid (3-fluorobenzyl)methylamide), a potent inhibitor of Clk1 and -4 (IC50 = 7 and 2.3 nM, resp.), exhibiting an unprecedented selectivity over Dyrk1A. Compound 21b triggered the depletion of EGFR, HDAC1, and p70S6 kinase from the cancer cells, with potencies in line with the measured GIC50 values. In contrast, the cellular effects of congener 21a (5-methoxybenzo[b]thiophene-2-carboxylic acid 3-fluorobenzylamide), which inhibited Clk1 only weakly, were substantially lower.

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COA of Formula: C4H9Cl2N3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about (8,9-Dihydro-7H-imidazo[1,2-c][1,3]diazepine-5-yl)cyanamide and imidazo-bicyclic homologs. Author is Buschauer, A.; Schunack, W..

The reaction of the 2-(ω-aminoalkyl)imidazoles I [n = 1, 3, 4; R, R1 = H, Me, RR1 = (CH2)4] with (PhO)2C:NCN gave imidazo[1,5-a]imidazoles, imidazo[1,2-c]diazepines and imidazo[1,2-c]diazocines II, which are similar to (7,8-dihydroimidazo[1,2-c]pyrimidin-5-yl)cyanamides with respect to their chem. and spectroscopic properties.

After consulting a lot of data, we found that this compound(22600-77-7)COA of Formula: C4H9Cl2N3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
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Formula: C4H9Cl2N3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about 2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships. Author is Deaton, David N.; Haffner, Curt D.; Henke, Brad R.; Jeune, Michael R.; Shearer, Barry G.; Stewart, Eugene L.; Stuart, J. Darren; Ulrich, John C..

Starting from 4-amino-8-quinoline carboxamide lead 1a and scaffold hopping to the chem. more tractable quinazoline, a systematic exploration of the 2-substituents of the quinazoline ring, utilizing structure activity relationships and conformational constraint, resulted in the identification of 39 novel CD38 inhibitors. Eight of these analogs were 10-100-fold more potent human CD38 inhibitors, including the single digit nanomolar inhibitor 1am (2-(3′-Amino-1’H-spiro[cyclopropane-1,6′-pyrrolo[3,4-c]pyrazol]-5(4H)-yl)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)quinazoline-8-carboxamide). Several of these mols. also exhibited improved therapeutic indexes relative to hERG activity. A representative analog 1r ((R)-4-((2-fluoro-6-(trifluoromethyl)benzyl)amino)-2-(6-methylpyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)quinazoline-8-carboxamide) exhibited suitable pharmacokinetic parameters for in vivo animal studies, including moderate clearance and good oral bioavailability. These inhibitor compounds will aid in the exploration of the enzymic functions of CD38, as well as furthering the study of the therapeutic implications of NAD enhancement in metabolic disease models.

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Electric Literature of C4H9Cl2N3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about Structure-Guided Screening for Functionally Selective D2 Dopamine Receptor Ligands from a Virtual Chemical Library. Author is Maennel, Barbara; Jaiteh, Mariama; Zeifman, Alexey; Randakova, Alena; Moeller, Dorothee; Huebner, Harald; Gmeiner, Peter; Carlsson, Jens.

Functionally selective ligands stabilize conformations of G protein-coupled receptors (GPCRs) that induce a preference for signaling via a subset of the intracellular pathways activated by the endogenous agonists. The possibility to fine-tune the functional activity of a receptor provides opportunities to develop drugs that selectively signal via pathways associated with a therapeutic effect and avoid those causing side effects. Animal studies have indicated that ligands displaying functional selectivity at the D2 dopamine receptor (D2R) could be safer and more efficacious drugs against neuropsychiatric diseases. In this work, computational design of functionally selective D2R ligands was explored using structure-based virtual screening. Mol. docking of known functionally selective ligands to a D2R homol. model indicated that such compounds were anchored by interactions with the orthosteric site and extended into a common secondary pocket. A tailored virtual library with close to 13 000 compounds bearing 2,3-dichlorophenylpiperazine, a privileged orthosteric scaffold, connected to diverse chem. moieties via a linker was docked to the D2R model. Eighteen top-ranked compounds that occupied both the orthosteric and allosteric site were synthesized, leading to the discovery of 16 partial agonists. A majority of the ligands had comparable maximum effects in the G protein and β-arrestin recruitment assays, but a subset displayed preference for a single pathway. In particular, compound I stimulated β-arrestin recruitment (EC50 = 320 nM, Emax = 16%) but had no detectable G protein signaling. The use of structure-based screening and virtual libraries to discover GPCR ligands with tailored functional properties will be discussed.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain, published in 2015-05-15, which mentions a compound: 22600-77-7, Name is (1H-Imidazol-2-yl)methanamine dihydrochloride, Molecular C4H9Cl2N3, Application In Synthesis of (1H-Imidazol-2-yl)methanamine dihydrochloride.

A series of imidazole based platinum(II) complexes (I-IV) were synthesized and evaluated for their cytotoxicity in HCT-116 cancer cell line, known for being partially resistant to cisplatin but sensitive to oxaliplatin. Lipophilicity was modulated by introducing differently long saturated and unsaturated chains at the N1 of the imidazole moiety. Pt-I displayed the higher cytotoxic effect achieving a IC50 = 38.0 ± 14.1 μM, comparable to the oxaliplatin value. The interaction between the imidazole platinum(II) complexes and the octapeptide called Mets7, the methionine-rich motif mimicking the N-terminal domain of the yCtr-1, was evaluated in order to have a major insight of the uptake and the eventual resistance mechanisms for the so-synthesized novel platinum compounds

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (1H-Imidazol-2-yl)methanamine dihydrochloride, is researched, Molecular C4H9Cl2N3, CAS is 22600-77-7, about Model reactions for enzymic catalysis. I. Nonenzymic transamination between α-amino acids and 2-formylimidazoles.Application of 22600-77-7.

2-Formylimidazole and 1-benzyl-2-formylimidazole transaminated, in the presence of Ni2+, Co2+, and Cu2+, α-amino acids into α-keto acids. The pH optimum was 8.5 for the Ni2+- and Co2+-catalyzed reactions, while the Cu2+-catalyzed reactions showed no pH dependence.

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