Category: 25956-17-6

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.COA of Formula: C18H14N2Na2O8S2.Dinc-Zor, Sule; Donmez, Ozlem Aksu; Asci, Burge; Pingo, Evridiki published the article 《Chemometric optimization of an HPLC method for the simultaneous analysis of a multi component drug product by the help of central composite design》 about this compound( cas:25956-17-6 ) in Microchemical Journal. Keywords: syrup paracetamol doxylamine succinate saccharine HPLC chemometrics CCD. Let’s learn more about this compound (cas:25956-17-6).

In this study, a simple, accurate, precise and rapid HPLC method was developed for the simultaneous quantification of paracetamol (PAR), pseudoephedrine hydrochloride (PSE), dextromethorphan hydrobromide (DEX) and doxylamine succinate (DOX) along with colorants; allura red (AR) and brilliant blue (BB) and sweetener; saccharine (SAC) in a syrup sample. Three indepented variables considered and their levels in Central Composite Design in order to optimize chromatog. separation conditions were as follows: Phosphate buffer ratio in mobile phase in the first gradient elution (GR1; 67, 70, 75, 80 and 83%), phosphate buffer ratio in mobile phase in the second gradient elution (GR2; 27, 30, 35, 40 and 43%) and flow rate of the mobile phase (FR; 0.9, 1.0, 1.2, 1.4 and 1.5 mL/min). Critical resolution values between SAC, PAR and PSE along with between AR and BB were used as a response. Chromatog. separation was achieved using reversed phase C18 column (4.6 mm × 250 mm × 5μm particle size) and the six analytes were detected with a diode array detector at 210 nm. As per the results of the optimization procedure, these optimum variables were found to be flow rate, 1.4 mL/min, phosphate buffer ratios in mobile phase in the first and second gradient elution, 75 and 40%, resp. After optimization step, the developed method was validated in compliance with ICH guideline. Finally, the method was successfully applied to the simultaneous quantification of PAR, PSE, DEX, DOX, AR, BB and SAC in a com. syrup sample.

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Pyrazole – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Development of three-dimensional nickel-cobalt oxide nanoflowers for superior photocatalytic degradation of food colorant dyes: Catalyst properties and reaction kinetic study, published in 2021-11-09, which mentions a compound: 25956-17-6, Name is Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, Molecular C18H14N2Na2O8S2, Category: pyrazoles-derivatives.

In this work, we present three-dimensional flower-like nickel-cobalt oxide (F-NCO) nanosheets developed in a facile, eco-friendly hydrothermal route to apply as photocatalysts for food colorant Allura Red AC dye removal under light illumination. Using Brunauer-Emmett-Teller anal., it was found that the F-NCO nanosheets displayed a surface area of ∼53.65 m2/g and a Barrett-Joyner-Halenda pore size of ∼14 nm, which was also confirmed by the calculated crystallite size of ∼15 nm using powder X-ray diffraction (XRD) anal. From Williamson-Hall anal. of XRD spectra, F-NCO nanosheets revealed a crystal-lattice strain of ∼3.42 × 10-3 and a dislocation d. of ∼4.397 × 1015 lines/m2 in the crystal structure. Transmission electron microscopy anal. revealed that F-NCO nanosheets accumulated to form flower-like nanostructures of <100 nm length with a d-spacing of ∼2.6 Å, which is attributed to the (311) crystallog. plane (α = γ = β = 90°, a = b = c = 8.110 Å, JCPDS Number 00-020-0781) of the cubic phase. The F-NCO nanosheets exhibited an excellent photocatalytic efficiency of ∼94.75% in ∼10 min with sodium borohydride under UV light. The Langmuir-Hinshelwood model determined pseudo-first-order reaction kinetics of dye degradation using the vs. time plot. The kinetic study produced a first-order rate constant (k) of ~0.219 min-1, resulting in ∼3.16 min half-life (t1/2) for the F-NCO-catalyzed degradation reaction. Thus outstanding photocatalytic performance of F-NCO nanosheets would display their huge potential for organic-pollutant removal from water with exceptional recyclability for wide research applications in the future. Here is just a brief introduction to this compound(25956-17-6)Category: pyrazoles-derivatives, more information about the compound(Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate) is in the article, you can click the link below.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Tiered intake assessment for food colors, published in 2020, which mentions a compound: 25956-17-6, Name is Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, Molecular C18H14N2Na2O8S2, Reference of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate.

A tiered intake assessment approach, ranging from the conservative default, refined budget method to refined dietary exposure assessments using national food consumption surveys is presented and applied to derive maximum potential global color intake estimates Industry-reported global use levels were assigned as the maximum level. Conservative intake assessments for food colors used in non-alc. beverages were estimated for the general population 2 + y, toddlers, children 3-9 y, adolescents 10-17 y, adults 18-64 y, elderly 65-74 y, very elderly 75 + y based on assumed uses in high intake markets. Refined dietary exposures were estimated using either the 2-day food consumption data from the 2013-2016 US National Health and Nutrition Examination Survey or the 4-day food consumption data from the 2008-2016 U. K. National Diet and Nutrition Survey Rolling Program. Strong concordance between the refined budget method, the brand-loyal deterministic approach was shown, in which the latter assumes that the maximum use level of the color is present in 100% of non-alc. beverages. This study shows that safety of colors – both synthetic and natural – in beverages at proposed use levels can be supported for any geog., with all intake estimates falling below the acceptable daily intake in refined assessments. Importantly, this study demonstrates that the refined budget method is a valid first-tier screening assessment to prioritise food colors that may benefit from more refined intake assessments when warranted.

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Synthetic Route of C18H14N2Na2O8S2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about An Eco-Friendly RP-HPLC Method for the Separation and Trace Determination of Selected Food Colorant Residues in Foodstuffs Utilizing Superheated Water. Author is Lateefa A. Al-Khateeb.

A simple and precise RP-HPLC method has been developed and validated for the separation and trace determination of selected food colorant residues, namely, Tartrazine (E102), Sunset Yellow (E110) and Allura Red (E129), in water samples. The colorants were separated in less than five minutes using buffered distilled water as a mobile phase on a superheated hybrid ODS X-Bridge RP-C18 column (150 x 3.5μm, 4.6 mm i.d.). Van’t Hoff plots were linear for all the tested colorants at different mobile phases and without any significant changes in their retention factors or the transition stage of the stationary phase. The lower limits of detection for E102 and E110 were found to be 0.5 and 0.016 mg/mL, resp., whereas for E129 it was 0.0004 mg/mL. The proposed method was checked for its accuracy and precision and was applied to determine the selected colorants in soft drinks and environmental water samples with acceptable recoveries in the range from 83.5 ± 1.9 to 114 ± 3%.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zou, Ling; Pottel, Joshua; Khuri, Natalia; Ngo, Huy X.; Ni, Zhanglin; Tsakalozou, Eleftheria; Warren, Mark S.; Huang, Yong; Shoichet, Brian K.; Giacomini, Kathleen M. researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).Computed Properties of C18H14N2Na2O8S2.They published the article 《Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP》 about this compound( cas:25956-17-6 ) in Molecular Pharmaceutics. Keywords: BCRP excipient; BCRP; drug−excipient interaction; excipient. We’ll tell you more about this compound (cas:25956-17-6).

Mechanistic-understanding-based selection of excipients may improve formulation development strategies for generic drug products and potentially accelerate their approval. Our study aimed at investigating the effects of mol. excipients present in orally administered FDA-approved drug products on the intestinal efflux transporter, BCRP (ABCG2), which plays a critical role in drug absorption with potential implications on drug safety and efficacy. We determined the interactions of 136 oral mol. excipients with BCRP in isolated membrane vesicles and identified 26 excipients as BCRP inhibitors with IC50 values less than 5 μM using 3H-cholecystokinin octapeptide (3H-CCK8). These BCRP inhibitors belonged to three functional categories of excipients: dyes, surfactants, and flavoring agents. Compared with noninhibitors, BCRP inhibitors had significantly higher mol. weights and SLogP values. The inhibitory effects of excipients identified in membrane vesicles were also evaluated in BCRP-overexpressing HEK293 cells at similar concentrations Only 1 of the 26 inhibitors of BCRP identified in vesicles inhibited BCRP-mediated 3H-oxypurinol uptake by more than 50%, consistent with the notion that BCRP inhibition depends on transmembrane or intracellular availability of the inhibitors. Collectively, the results of this study provide new information on excipient selection during the development of drug products with active pharmaceutical ingredients that are BCRP substrates.

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Pliuta, Konstantin; Chebotarev, Alexander; Pliuta, Anastasia; Snigur, Denys published an article about the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6,SMILESS:O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+] ).Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:25956-17-6) through the article.

In current study the carbon-paste electrode modified by silica with embedded cetylpyridinium chloride for determination of Allura Red AC have been developed. The optimal conditions were determined to be for the square-wave voltammetric quantification: pH=2, Eads=300 mV, tads=300 s, amplitude – 40 mV, frequency – 25 Hz and potential scan rate is 250 mV sec-1. The calibration plot has linearity in the concentration ranges 0.04-0.2μM and 0.2-1.00μM. The LOD and LOQ are equal to 0.005μM and 0.015μM resp. The crafted sensor has been applied successfully to model solutions and in jelly candies anal. with RSD no more than 10%.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Self-assembly of TiO2/Fe3O4/SiO2 microbeads: A green approach to produce magnetic photocatalysts》. Authors are Brossault, David F. F.; McCoy, Thomas M.; Routh, Alexander F..The article about the compound:Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonatecas:25956-17-6,SMILESS:O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+]).SDS of cas: 25956-17-6. Through the article, more information about this compound (cas:25956-17-6) is conveyed.

A green approach for producing magnetic photocatalysts via direct agglomeration of com. nanoparticles in emulsion is shown. Aggregation is attributed to charge screening by salt addition which reduces stabilizing repulsive forces between particles, and different nanoparticles (TiO2, Fe3O4 and SiO2) serve to imbue the final agglomerates with desired adsorption, photodegradation and magnetic properties. Titania doped magnetic silica microbeads (TiO2/Fe3O4/SiO2) were produced at room temperature by CaCl2-induced aggregation of nanoparticles in a reverse emulsion template. The beads were characterized using optical microscopy, SEM, STEM, EDX and zeta potential measurements. The adsorption and photocatalytic properties of the system as well as its reusability were investigated using Rhodamine B and Methylene Blue as model pollutants. Magnetically responsive beads approx. 3-9μm in diameter incorporating SiO2, TiO2 and Fe3O4 nanoparticles were produced. Adsorption and photodegradation properties of the beads were confirmed by bleaching solutions of Rhodamine B, Methylene Blue as well as mixtures of both dyes. Reusability of the beads after magnetic separation was demonstrated, exhibiting a dye removal efficiency greater than 93% per cycle for three consecutive cycles of UV-light irradiation This method is simpler than conventional sol-gel methods and offers a green and easy to implement approach for producing structured functional materials.

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Pyrazole – Wikipedia,
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Zou, Ling; Spanogiannopoulos, Peter; Pieper, Lindsey M.; Chien, Huan-Chieh; Cai, Wenlong; Khu, Natalia; Pottel, Joshua; Vora, Bianca; Ni, Zhanglin; Tsakalozou, Eleftheria; Zhangc, Wenjun; Shoichet, Brian K.; Giacomini, Kathleen M.; Turnbaugh, Peter J. published an article about the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6,SMILESS:O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+] ).Formula: C18H14N2Na2O8S2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:25956-17-6) through the article.

Food and drug products contain diverse and abundant smallmol. additives (excipients) with unclear impacts on human physiol., drug safety, and response. Here, we evaluate their potential impact on intestinal drug absorption. By screening 136 unique compounds for inhibition of the key intestinal transporter OATP2B1 we identified and validated 24 potent OATP2B1 inhibitors, characterized by higher mol. weight and hydrophobicity compared to poor or noninhibitors. OATP2B1 inhibitors were also enriched for dyes, including 8 azo (R-N=N-R′) dyes. Pharmacokinetic studies in mice confirmed that FD′C Red Number 40, a common azo dye excipient and a potent inhibitor of OATP2B1, decreased the plasma level of the OATP2B1 substrate fexofenadine, suggesting that FD′C Red Number 40 has the potential to block drug absorption through OATP2B1 inhibition in vivo. However, the gut microbiomes of multiple unrelated healthy individuals as well as diverse human gut bacterial isolates were capable of inactivating the identified azo dye excipients, producing metabolites that no longer inhibit OATP2B1 transport. These results support a beneficial role for the microbiome in limiting the unintended effects of food and drug additives in the intestine and provide a framework for the data-driven selection of excipients. Furthermore, the ubiquity and genetic diversity of gut bacterial azoreductases coupled to experiments in conventionally raised and gnotobiotic mice suggest that variations in gut microbial community structure may be less important to consider relative to the high concentrations of azo dyes in food products, which have the potential to saturate gut bacterial enzymic activity.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Titania/electro-reduced graphene oxide nanohybrid as an efficient electrochemical sensor for the determination of allura red, published in 2020, which mentions a compound: 25956-17-6, Name is Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, Molecular C18H14N2Na2O8S2, Synthetic Route of C18H14N2Na2O8S2.

Titania/electro-reduced graphene oxide nanohybrids (TiO2/ErGO) were synthesized by the hydrolysis of titanium sulfate in graphene oxide suspension and in situ electrochem. reduction It provides a facile and efficient method to obtain nanohybrids with TiO2 nanoparticles (TiO2 NPs) uniformly coated by graphene nanoflakes. TiO2/ErGO nanohybrids were characterized by transmission electron microscopy, X-ray diffraction, cyclic voltammogram, and electrochem. impedance spectroscopy in detail. Compared with pure ErGO and TiO2 NPs, TiO2/ErGO nanohybrids greatly enhanced the electrocatalytic activity and voltammetric response of Allura Red. In the concentration range of 0.5-5.0μM, the anodic peak currents of Allura Red were linearly correlated to their concentrations However, the linear relationship was changed to the semilogarithmic relationship at a higher concentration region (5.0-800μM). The detection limit (LOD) was 0.05μM at a signal-to-noise ratio of 3. The superior sensing performances of the proposed sensor can be ascribed to the synergistic effect between TiO2 NPs and ErGO, which provides a favorable microenvironment for the electrochem. oxidation of Allura Red. The proposed TiO2/ErGO/GCE showed good reproducibility and stability both in determination and in storage, and it can accurately detect the concentration of Allura Red in milk drinks, providing an efficient platform for the sensitive determination of Allura Red with high reliability, simplicity, and rapidness.

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Reference:
Pyrazole – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Certified food dyes in over the counter medicines and supplements marketed for children and pregnant women, the main research direction is pregnancy food cosmetic dye medicine diet supplement; FD&C dyes; Gummies; High performance liquid chromatography; Over-the-counter medicine; Vitamins.Safety of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate.

Food, Drug, & Cosmetic (FD&C) dyes are synthetic color additives used in food, prescription drugs and over-the-counter medicines (OTCs). Consumption of FD&C dyes has been associated with neurobehavioral behavior in some children. The amount of dye used in com. products is proprietary, making it difficult to assess dietary intake and determine exposure in children. To date, no studies have examined FD&C dyes in OTCs or vitamins in the United States. To address this, FD&C Red Number 40, Yellow Number 5, Yellow Number 6, Blue Number 1, and Blue Number 2 levels were measured in prenatal vitamin tablets, children’s chewable and gummy vitamins, pain reliever tablets and syrups, and cough/cold/allergy tablets and syrups. Dyes were isolated using solid phase extraction (SPE) and quantified by high performance liquid chromatog. (HPLC). Dye levels varied between products with highest levels in pain reliever and cough/cold/allergy syrups. Significant variability was observed within some brands. Degradation of Red Number 40, Blue Number 1, and Yellow Number 6 was observed in the vitamin gummies. Intake of FD&C Red Number 40 is two times the US FDA ADI (accepted daily intake) for some children’s pain reliever syrups and almost three times the US FDA ADI for some cough/cold/allergy syrups.

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Pyrazole – Wikipedia,
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