Category: 25956-17-6

Quality Control of Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes. Author is Pham, Nathalie; Miller, Mark D.; Marty, Melanie.

There is growing evidence from human and animal studies indicating an association between exposure to synthetic food dyes and adverse neurobehavioral outcomes in children. However, data gaps persist for potential mechanisms by which the synthetic food dyes could elicit neurobehavioral impacts. We developed an approach to evaluate seven US FDA-batch-certified food dyes using publicly available high-throughput screening (HTS) data from the US EPA’s Toxicity Forecaster to assess potential underlying mol. mechanisms that may be linked to neurol. pathway perturbations. The dyes were screened through 270 assays identified based on whether they had a neurol.-related gene target and/or were mapped to neurodevelopmental processes or neurobehavioral outcomes, and were conducted in brain tissue, targeted specific hormone receptors, or targeted oxidative stress and inflammation. Some results provided support for neurol. impacts found in human and animal studies, while other results showed a lack of correlation with in vivo findings. The azo dyes had a range of activity in assays mapped to G-protein-coupled receptors and were active in assays targeting dopaminergic, serotonergic, and opioid receptors. Assays mapped to nuclear receptors (androgen, estrogen, and thyroid hormone) also exhibited activity with the food dyes. Other mol. targets included the aryl hydrocarbon receptor, acetylcholinesterase, and monoamine oxidase. The Toxicol. Prioritization Index tool was used to visualize the results of the Novascreen assays. Our results highlight certain limitations of HTS assays but provide insight into potential underlying mechanisms of neurobehavioral effects observed in in vivo animal toxicol. studies and human clin. studies.

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Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Staples, Jack W.; Stine, Jessica M.; Maki-Lohiluoma, Eero; Steed, Emily; George, Kathleen M.; Thompson, Charles M.; Woodahl, Erica L. published the article 《Food dyes as P-glycoprotein modulators》. Keywords: allurared carmoisine ponceau4R sunset quinolone yellow tartrazine AtPase Pglycoprotein; Drug transporter; Food dye; P-glycoprotein.They researched the compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ).SDS of cas: 25956-17-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25956-17-6) here.

The drug transporter P-glycoprotein (P-gp) is often investigated in drug-interaction studies because the activity is modulated by a wide variety of xenobiotics including drugs, herbal products, and food components. In this study, we tested six common arylsulfonate food dyes-allura red, carmoisine, ponceau 4R, quinolone yellow, sunset yellow, and tartrazine-as activators and inhibitors of P-gp activity in vitro. The dyes were studied as P-gp activators by measuring ATPase activity in P-gp-expressing membranes. Compared to verapamil, a known activator of P-gp, the six food dyes showed no stimulatory activity. The potential for these six food dyes to act as P-gp inhibitors was tested in an intracellular efflux assay with P-gp-expressing cells. Compared to GF120918, a known P-gp inhibitor, there was no inhibitory activity for these six food dyes. The six food dyes tested do not interact with P-gp in vitro and, therefore, are unlikely cause clin. drug-food dye interactions. Further investigation is necessary to determine whether these food dyes could interact with other drug transporters.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vortex-assisted dispersive liquid-liquid microextraction based on hydrophobic deep eutectic solvent for the simultaneous identification of eight synthetic dyes in jellies and drinks using HPLC-PDA》. Authors are Gholami, Zahra; Marhamatizadeh, Mohammad Hossein; Yousefinejad, Saeed; Rashedinia, Marzieh; Mazloomi, Seyed Mohammad.The article about the compound:Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonatecas:25956-17-6,SMILESS:O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+]).Recommanded Product: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate. Through the article, more information about this compound (cas:25956-17-6) is conveyed.

Food dye quantity as well as their permitted limit and type, is of particular importance in the food industry. Hence, it is imperative to develop alternative methods to measure them in food quality control laboratories For the first time, deep eutectic solvents was utilized in the concurrent extraction and separation of eight common synthetic dyes of Tartrazine, Quinoline Yellow, Sunset Yellow, Brilliant Blue, Ponceau 4R, Indigo Carmine, Allura Red, and Carmoisine in jellies and drinks. The results revealed that deep eutectic solvent was prepared from benzyltriethylammonium chloride, which is a hydrogen bonding acceptor. This combination with thymol as a hydrogen bonding donor can have better efficiency in extracting the dyes than the deep eutectic solvent, such as choline chloride combined with thymol. The enrichment factor was between 18.6 and 27.2 in the eight determined dyes. The limit of detection and limit of quantitation, ranged from 0.02 to 0.05μg L-1 and from 0.04 to 0.15μg L-1, resp. Within a day and between days relative standard deviations was calculated for the two levels of concentration (10 and 100μg L-1), which was equal to 0.9-3.3% and 2.5-7.3%, resp. The relative recoveries for the eight synthetic dyes was for the three levels of concentration (10, 100 and 500μg L-1), between 87.2 and 107.4% in jelly samples and 89.1 to 104% in the drink samples, which was comparable to solid phase extraction method. As a result, the deep eutectic solvents -based dispersive liquid-liquid microextraction method can be announced as a powerful, fast, sensitive and easy method to measure dyes in jellies and drinks.

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Pyrazole – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate( cas:25956-17-6 ) is researched.Synthetic Route of C18H14N2Na2O8S2.Hidalgo, Asuncion Maria; Leon, Gerardo; Gomez, Maria; Murcia, Maria Dolores; Gomez, Elisa; Macario, Jose Antonio published the article 《Removal of different dye solutions: a comparison study using a polyamide NF membrane》 about this compound( cas:25956-17-6 ) in Membranes (Basel, Switzerland). Keywords: acid brown sunset yellow polyamide nanofiltration wastewater treatment; characterization; dyes; molecular structure; nanofiltration; physico-chemical properties. Let’s learn more about this compound (cas:25956-17-6).

The removal of organic dyes in aquatic media is, nowadays, a very pressing environmental problem. These dyes usually come from industries, such as textiles, food, and pharmaceuticals, among others, and their harm is produced by preventing the penetration of solar radiation in the aquatic medium, which leads to a great reduction in the process of photosynthesis, therefore damaging the aquatic ecosystems. The feasibility of implementing a process of nanofiltration in the purification treatment of an aqueous stream with small size dyes has been studied. Six dyes were chosen: Acid Brown-83, Allura Red, Basic Fuchsin, Crystal Violet, Methyl orange and Sunset Yellow, with similar mol. volume (from 250 to 380 Å). The nanofiltration membrane NF99 was selected. Five of these mols. with different sizes, shapes and charges were employed in order to study the behavior of the membrane for two system characteristic parameters: permeate flux and rejection coefficient Furthermore, a microscopy study and a behavior anal. of the membrane were carried out after using the largest mol. Finally, the Spiegler-Kedem-Katchalsky model was applied to simulate the behavior of the membrane on the elimination of this group of dyes.

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Reference:
Pyrazole – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 25956-17-6, is researched, SMILESS is O=S(C1=CC=C2C(/N=N/C3=CC(C)=C(S(=O)([O-])=O)C=C3OC)=C(O)C=CC2=C1)([O-])=O.[Na+].[Na+], Molecular C18H14N2Na2O8S2Journal, Chemical Data Collections called Development of electrochemical sensor for adrenaline at poly (allura red) modified carbon paste electrode: A voltammetric study, Author is chandra H D, Madhu; Kumara Swamy, B. E., the main research direction is adrenaline allura red voltammetry carbon paste electrode electrochem sensor.Computed Properties of C18H14N2Na2O8S2.

Poly (allura red) modified carbon paste electrode (MCPE) sensor is developed for the electrochem. determination of Adrenaline (AD) in the presence of Uric acid (UA), by cyclic voltammetric and differential pulse voltammetric techniques. Developed Poly (allura red) MCPE is more sensitive and selective. The effect of pH, scan rate and concentration on the oxidation of adrenaline were studied, LOD 6.8μM, LOQ 22μM for AD and LOD 17μM, LOQ 54μM for UA resp. and the poly (allura red) modified carbon paste electrode is applied for the simultaneous determination of adrenaline and Uric acid, the Poly (allura red) MCPE has capable of determining both AD and UA individually with two identical different oxidation peaks for AD and UA. This method can be used for some other bioactive mols.

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Pyrazole – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Electrochemical sensor based on ionic liquid and carbon black for voltammetric determination of Allura red colorant at nanomolar levels in soft drink powders.Recommanded Product: 25956-17-6.

The ionic liquid (IL) 1-butyl-3-methylimidazolium tetrafluoroborate and carbon black (CB) nanoparticles were incorporated within a crosslinked chitosan film over the surface of a glassy carbon electrode, and the obtained architecture explored to the sensitive voltammetric sensing of Allura red colorant in soft drinking powders. The different electrodic surfaces were morphol. and electrochem. characterized. From the modification of glassy carbon electrode with IL and CB, a significantly enhanced voltammetric response was achieved toward the Allura red irreversible oxidation reaction. The type and amount of IL employed in the electrode modification step as well as all the others exptl. parameters affecting the sensor response by square-wave adsorptive anodic stripping voltammetry (SWAdASV) were systematically optimized. Under the optimum exptl. conditions, the proposed SWAdASV procedure provided a linear anal. curve in the concentration range of 3.98 × 10-8 to 9.09 × 10-7 mol L-1 and a low limit of detection of 9.1 × 10-10 mol L-1 (0.91 nmol L-1). The proposed sensor presented good precision and no matrice effects as shown from repeatability tests, concomitant studies and addition/recovery assays. The developed SWAdASV procedure was applied successfully in the determination of Allura red content in com. soft drink powder samples, and the results were in close agreement with those obtained using a comparative spectrophotometric method at a confidence level of 95%.

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Pyrazole – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 25956-17-6, is researched, Molecular C18H14N2Na2O8S2, about Development and Optimization of Asenapine Sublingual Film Using QbD Approach, the main research direction is asenapine sublingual film QbD approach; In vivo absorption; asenapine; critical quality attributes; quality by design; quality target product profile; sublingual film.Product Details of 25956-17-6.

Asenapine, an atypical antipsychotic agent, has been approved for the acute and maintenance treatment of schizophrenia and manic episodes of bipolar disorder. However, the extensive hepatic metabolism limits its oral bioavailability. Therefore, the objective of the current investigation was to develop sublingual film containing asenapine to enhance the therapeutic efficacy. Sublingual films containing asenapine were fabricated using polyethylene oxide and hydroxypropyl methylcellulose by solvent casting method. Design of experiment was used as a statistical tool to optimize the proportion of the film-forming polymers in order to establish the critical quality attributes of the drug formulation. The process was studied in detail by assessing risk of each step as well as parameters and material attributes to reduce the risk to a min. A control strategy was defined to ensure manufacture of films according to the target product profile by evaluation of intermediate quality attributes at the end of each process step. Results of optimized formulations showed rapid disintegration, adequate folding endurance, good percentage elongation, tensile strength, and viscosity. Besides, the results from the in vitro dissolution/ex vivo permeation studies showed rapid dissolution (100% in 6 min) and higher asenapine permeation (∼ 80% in 90 min) through the sublingual epithelium. In vivo study indicates greater asenapine absorption (31.18 ± 5.01% of administered dose) within 5 min and was comparable with marketed formulation. In summary, the designing plan to develop asenapine formulation was successfully achieved with desired characteristics of the delivery tool for sublingual administration.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Improved solid phase extraction for selective and efficient quantification of sunset yellow in different food samples using a novel molecularly imprinted polymer reinforced by Fe3O4@UiO-66-NH2, published in 2021-09-30, which mentions a compound: 25956-17-6, mainly applied to sunset yellow molecularly imprinted polymer food safety; Adsorption; Magnetic molecularly imprinted polymer; Metal organic framework; Sunset yellow, Application of 25956-17-6.

The overuse of synthetic dyes in food products has gradually increased in recent years, resulting food safety and human health has become a global issue. An innovative design of a magnetic molecularly imprinted polymer (Fe3O4@UiO-66-NH2@MIP) for efficient, fast, and selective determination of sunset yellow (SY) from different food products was described in this study. The absorption properties of Fe3O4@UiO-66-NH2@MIP were elucidated by adsorption kinetics, isotherms, reusability, and selectivity experiments Because of the incorporation of porous Fe3O4@UiO-66-NH2 nanocomposite into molecularly imprinted polymer an efficient nanosorbent with a short equilibrium time, a high adsorption capacity, and a good imprinting factor was finally obtained. The porous Fe3O4@UiO-66-NH2@MIP are also used for quantification of the SY. Under optimal conditions, good linearity (R2 0.9964) in the range of 1.0-120 mg L-1 and a low limit of detection (0.41 mg L-1) was observed with satisfactory recoveries (92.50-106.1%) and excellent reusability (RSD ≤ 6.6% after 12 cycles).

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Pyrazole – Wikipedia,
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Related Products of 25956-17-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about MoS2 quantum dots for on-line fluorescence determination of the food additive allura red. Author is Coloma, Alicia; del Pozo, Maria; Martinez-Moro, Rut; Blanco, Elias; Atienzar, Pedro; Sanchez, Lorenzo; Petit-Dominguez, Maria Dolores; Casero, Elena; Quintana, Carmen.

This work presents an online fluorescence method for the allura red (AR) determination The method is based on the fluorescence quenching of dots of MoS2 because of their interaction with the non-fluorescence dye. MoS2-dots were synthesized and characterized by spectroscopic techniques and High Resolution Transmission Electronic Microscopy (HR-TEM). The simultaneous injection of the nanomaterial and the dye in a flow injection anal. system allows the determination of allura red at 1.7 x 10-6 M concentration level with a very good accuracy and precision (Er minor than 10% and RSD lower than 8%) and a sampling frequency of 180 samples per h. Moreover, the interaction fluorophore-quencher results a dynamic inhibition mechanism. The proposed methodol. was applied to the AR anal. in soft beverages and powders for gelatine preparation Colorant concentrations of 63 ± 2 mg/L (n = 3) and 0.30 ± 0.01 mg/g (n = 3) were found, resp. These results were validated by high performance liquid chromatog. technique.

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Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of C18H14N2Na2O8S2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium 6-hydroxy-5-((2-methoxy-5-methyl-4-sulfonatophenyl)diazenyl)naphthalene-2-sulfonate, is researched, Molecular C18H14N2Na2O8S2, CAS is 25956-17-6, about Dietary intake of artificial food color additives containing food products by school-going children.

Nutritional risk in children is associated with food safety. This is the first study to identify the food type consumed by 6-17-yr-old school-going children in Saudi Arabia. Eight permitted artificial food color additives, including Tartrazine (E102), Sunset Yellow (E110), Carmoisine (E122), Allura Red (E129), Indigo Carmine (E132), Brilliant Blue (E133), Fast Green (E143), and Black PN (E151), and two non-permitted ones, Erythrosine (E127) and Red 2G (E128), were determined using 24-h dietary recall questionnaires. Artificial color additives in 839 food products were divided into nine categories, including biscuits, cakes, chocolates, chips, ice cream, juices and drinks, candy, jelly, and chewing gum, are determined using high performance liquid chromatog. and diode array detector. The results indicated a high intake of juices and drinks, ice cream, and cakes, but low consumption of chewing gum among school-going children. Among the permitted artificial food color additives, Brilliant Blue (E133) (54.1%) and Tartrazine (E102) (42.3%) were the most commonly used. Sunset Yellow (E110) in one chocolate sample, Tartrazine (E102) and Sunset Yellow (E110) in one and two juice and drink samples, resp., and Brilliant Blue (E133) in two candy samples exceeded the permitted level. Therefore, further investigations are needed to provide insights into the possible adverse health effects of high intake of these additives in artificial food coloring on the test population are warranted.

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