Category: 1300746-79-5

Category: pyrazoles-derivatives. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors. Author is Ouvry, Gilles; Clary, Laurence; Tomas, Loic; Aurelly, Michele; Bonnary, Laetitia; Borde, Emilie; Bouix-Peter, Claire; Chantalat, Laurent; Defoin-Platel, Claire; Deret, Sophie; Forissier, Mathieu; Harris, Craig S.; Isabet, Tatiana; Lamy, Laurent; Luzy, Anne-Pascale; Pascau, Jonathan; Soulet, Catherine; Taddei, Alessandro; Taquet, Nathalie; Thoreau, Etienne; Varvier, Emeric; Vial, Emmanuel; Hennequin, Laurent F..

Minor structural modifications (sometimes single atom changes) can have a dramatic impact on the properties of compounds This is illustrated here on structures related to known mTOR inhibitor Sapanisertib. Subtle changes in the hinge binder lead to strikingly different overall profiles with changes in phys. properties, metabolism, and kinase selectivity.

This compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Category: pyrazoles-derivatives was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Wehn, Paul M.; Rizzi, James P.; Dixon, Darryl D.; Grina, Jonas A.; Schlachter, Stephen T.; Wang, Bin; Xu, Rui; Yang, Hanbiao; Du, Xinlin; Han, Guangzhou; Wang, Keshi; Cao, Zhaodan; Cheng, Tzuling; Czerwinski, Robert M.; Goggin, Barry S.; Huang, Heli; Halfmann, Megan M.; Maddie, Melissa A.; Morton, Emily L.; Olive, Sarah R.; Tan, Huiling; Xie, Shanhai; Wong, Tai; Josey, John A.; Wallace, Eli M. published the article 《Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)》. Keywords: indene preparation HIF2 inhibitor renal cell carcinoma treatment.They researched the compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5 ).Electric Literature of C13H8CuF3N2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1300746-79-5) here.

HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature feature of these cancers is the overaccumulation of HIF-2α protein, often by inactivation of the E3 ligase VHL (von Hippel-Lindau). Herein the authors disclose their structure based drug design (SBDD) approach that culminated in the identification of PT2385, the first HIF-2α antagonist to enter clin. trials. Highlights include the use of a putative n → π*Ar interaction to guide early analog design, the conformational restriction of an essential hydroxyl moiety, and the remarkable impact of fluorination near the hydroxyl group. Evaluation of select compounds from two structural classes in a sequence of PK/PD, efficacy, PK, and metabolite profiling identified I (PT2385, luciferase EC50 = 27 nM) as the clin. candidate. Finally, a retrospective crystallog. anal. describes the structural perturbations necessary for efficient antagonism.

This compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Electric Literature of C13H8CuF3N2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Journal of the American Chemical Society called Aqueous Benzylic C-H Trifluoromethylation for Late-Stage Functionalization, Author is Guo, Shuo; AbuSalim, Deyaa I.; Cook, Silas P., which mentions a compound: 1300746-79-5, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2, Electric Literature of C13H8CuF3N2.

The installation of trifluoromethyl groups has become an essential step across a number of industries such as agrochems., drug discovery, and materials. Consequently, the rapid introduction of this critical functional group in a predictable fashion would benefit current practitioners in those fields. This communication describes a mild trifluoromethylation of benzylic C-H bonds with high selectivity for the least hindered hydrogen atom. The reaction provides monotrifluoromethylation and proceeds in an environmentally friendly acetone/water solvent system. The method can be used to install benzylic trifluoromethyl groups on highly functionalized drug mols.

This compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Electric Literature of C13H8CuF3N2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1300746-79-5, is researched, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2Journal, Article, European Journal of Medicinal Chemistry called Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine “”bio-oxidizable”” prodrugs: Synthesis, biological evaluation and structure-activity relationship, Author is Azzouz, Rabah; Peauger, Ludovic; Gembus, Vincent; Tintas, Mihaela-Liliana; Sopkova-de Oliveira Santos, Jana; Papamicael, Cyril; Levacher, Vincent, the main research direction is benzylpyridinium salt dihydropyridine preparation antialzheimer mol docking; AChEIs; Alzheimer; Donepezil analogues; “Bio-oxidizable” prodrug.Category: pyrazoles-derivatives.

A total of fifty one N-benzylpyridinium quaternary donepezil analogs B1-3 I [R = Ph, 2,3-dihydro-1,3-benzoxazol-2-yl, cyclohexyl, etc.; R1 = H, F, OH, OCH3; R2 = H, OCH3; R1, R2 = -OCH2O-; EWG = H, CN, CF3, C(O)NH2, etc.; X = Br, I; n = 0, 1, 2] and twenty two prodrugs A1-3 II was synthesized and evaluated for their inhibitory activities against hAChE and eqBuChE. While most prodrugs A1-3 were demonstrated to be inactive against AChE (IC50 >10 μM), a large number of the corresponding N-benzylpyridinium salt B1-3 exhibited appealing three-to-one-digit nanomolar hAChE inhibitory activities and even reaching subnanomolar activity (IC50 = 0.36 nM). In addition, in silico docking studies were conducted for several compounds to explain the more relevant in vitro results. Lastly, the influence of the two stereogenic centers in prodrugs A was also evaluated, highlighting not only marked differences in residual AChE inhibitory activity of the four separated isomers of prodrug II [R = 3-chlorophenyl; R1 = H, F, OH, OCH3; R2 = OCH3; EWG = C(O)NH2;n = 1] (IC50 ranging from 173 nM to 10 μM) but also significant variations of the oxidation rate between two separated diastereoisomers of prodrug II [R = phenyl; R1 = R2 = OCH3; EWG = C(O)CH3; n = 2]. This work provides useful information in the search of a preclin. candidate to conduct further development of this attractive “”bio-oxidizable”” prodrug strategy.

Different reactions of this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))Category: pyrazoles-derivatives require different conditions, so the reaction conditions are very important.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)(SMILESS: F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F,cas:1300746-79-5) is researched.SDS of cas: 52287-51-1. The article 《Catalytic Enantioselective Boryl and Silyl Substitution with Trifluoromethyl Alkenes: Scope, Utility, and Mechanistic Nuances of Cu-F β-Elimination》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:1300746-79-5).

Catalytic enantioselective methods are introduced that allow access to a variety of allyl boronates and silanes that contain a difluoroalkene unit; the resulting products may be used for the preparation of organofluorine compounds in high enantiomeric purity. Also, a number of key mechanistic aspects of the transformations were studied and analyzed. Thus, 1st, an NHC-Cu-catalyzed method for boryl substitution with F3C-substituted alkenes is introduced. These processes, unlike the previously reported strategies, are applicable to alkyl as well as aryl substituted substrates, afford allyl boronates bearing a difluoroalkene moiety (up to 98% yield and 95:5 er). Second, the corresponding silyl substitutions, the 1st reported cases of their kind, are presented (up to 94% yield and 97:3 er). Third, exptl. and computational (DFT) studies are described that shed light on key mechanistic aspects of the catalytic processes. Evidence (x-ray structures of Cu-alkyl intermediates and kinetic studies) is put forth illustrating that the initial Cu-boryl and Cu-silyl addition is significantly faster than the ensuing Cu-F elimination, and that the latter step can be facilitated by either a mild Lewis acid (e.g., a Li or Na cation) or a nucleophilic promoter (e.g., an alkoxide). These findings together with DFT studies demonstrate that Cu-F β-elimination probably proceeds with anti-stereochem. Representative cases of ways through which the new mechanistic understanding may be used to rationalize previously disclosed findings, significantly improve a transformation, or develop new diastereo- and enantioselective catalytic methods are provided. For example, an explanation is provided regarding why bisphosphine-Cu complexes do not efficiently promote boryl substitutions with aryl-substituted substrates, but the corresponding silyl substitutions are facile, and how the size of a ligand can impact regioselectivity and efficiency.

Different reactions of this compound((1,10-Phenanthroline)(trifluoromethyl)copper(I))HPLC of Formula: 1300746-79-5 require different conditions, so the reaction conditions are very important.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 1300746-79-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Author is Rai, Ganesha; Brimacombe, Kyle R.; Mott, Bryan T.; Urban, Daniel J.; Hu, Xin; Yang, Shyh-Ming; Lee, Tobie D.; Cheff, Dorian M.; Kouznetsova, Jennifer; Benavides, Gloria A.; Pohida, Katie; Kuenstner, Eric J.; Luci, Diane K.; Lukacs, Christine M.; Davies, Douglas R.; Dranow, David M.; Zhu, Hu; Sulikowski, Gary; Moore, William J.; Stott, Gordon M.; Flint, Andrew J.; Hall, Matthew D.; Darley-Usmar, Victor M.; Neckers, Leonard M.; Dang, Chi V.; Waterson, Alex G.; Simeonov, Anton; Jadhav, Ajit; Maloney, David J..

The authors report the discovery and medicinal chem. optimization of a novel series of pyrazole-based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quant. high-throughput screening paradigm facilitated hit identification, while structure-based design and multiparameter optimization enabled the development of compounds with potent enzymic and cell-based inhibition of LDH enzymic activity. Lead compounds such as 63 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells. Moreover, robust target engagement of LDHA by lead compounds was demonstrated using the cellular thermal shift assay (CETSA), and drug-target residence time was determined via SPR. Anal. of these data suggests that drug-target residence time (off-rate) may be an important attribute to consider for obtaining potent cell-based inhibition of this cancer metabolism target.

After consulting a lot of data, we found that this compound(1300746-79-5)Application of 1300746-79-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Trifluoromethyl/Perfluoroalkyl Corannulenes: Directed Synthesis and Photophysical Characterization, Author is Xia, Yeqing; Guo, TianJian; Baldridge, Kim K.; Siegel, Jay S., which mentions a compound: 1300746-79-5, SMILESS is F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F, Molecular C13H8CuF3N2, Application of 1300746-79-5.

Cu-mediated methods for the synthesis of perfluoroalkyl-substituted corannulene derivatives were developed, including long-chain derivatives such as perfluorooctyl. The moderate to high yields of these mild and selective methods enable the production of sufficient amounts of material to conduct extensive electrochem. and photophys. measurements on a cognate series of compounds The electrochem. measurements reproduce well previous measurements. The optical measurements display a constant set of electronic transitions across the series.

The article 《Trifluoromethyl/Perfluoroalkyl Corannulenes: Directed Synthesis and Photophysical Characterization》 also mentions many details about this compound(1300746-79-5)Application of 1300746-79-5, you can pay attention to it, because details determine success or failure

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chu, Lingling; Qing, Feng-Ling published an article about the compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5,SMILESS:F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F ).Reference of (1,10-Phenanthroline)(trifluoromethyl)copper(I). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1300746-79-5) through the article.

This article describes the copper-catalyzed oxidative trifluoromethylation of heteroarenes and highly electron-deficient arenes with CF3SiMe3 through direct C-H activation. In the presence of catalyst Cu(OAc)2, ligand 1,10-phenanthroline, and cobases tert-BuONa/NaOAc, oxidative trifluoromethylation of 1,3,4-oxadiazoles with CF3SiMe3 proceeded smoothly using either air or di-tert-Bu peroxide as an oxidant to give the corresponding trifluoromethylated 1,3,4-oxadiazoles in high yields. Di-tert-Bu peroxide was chosen as the suitable oxidant for oxidative trifluoromethylation of 1,3-azoles and perfluoroarenes. Cu(OH)2 and Ag2CO3 were the best catalyst and oxidant for direct oxidative trifluoromethyaltion of indoles. The optimum reaction conditions enable oxidative trifluoromethylation of a range of heteroarenes that bear numerous functional groups. The prepared trifluoromethylated heteroarenes are of importance in the areas of pharmaceuticals and agrochems. The preliminary mechanistic studies of these oxidative trifluoromethylations are also reported.

The article 《Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes》 also mentions many details about this compound(1300746-79-5)Reference of (1,10-Phenanthroline)(trifluoromethyl)copper(I), you can pay attention to it, because details determine success or failure

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 1300746-79-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I), is researched, Molecular C13H8CuF3N2, CAS is 1300746-79-5, about A Concise Synthesis of Asymmetrically 4,5-Disubstituted 9,9-Dimethyl-9H-xanthenes. Author is Matsubara, Ryosuke; Koide, Miki; Shin, Yong-Soon; Shimada, Toshiyuki; Hayashi, Masahiko.

A concise synthesis of asym. 4,5-disubstituted 9,9-dimethyl-9H-xanthenes was developed. The monolithiation of 4,5-dibromo-9H-xanthene, subsequent zincation, and the Negishi coupling with diverse electrophiles afforded the corresponding 4-aryl- or 4-vinyl-9H-xanthenes in good yields and with high selectivity. The second substitution reactions were performed under mild reaction conditions, thus providing a convenient synthetic route to functionalized mols. based on the 9H-xanthene skeleton.

After consulting a lot of data, we found that this compound(1300746-79-5)Application of 1300746-79-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cheng, Chen; Hartwig, John F. researched the compound: (1,10-Phenanthroline)(trifluoromethyl)copper(I)( cas:1300746-79-5 ).Related Products of 1300746-79-5.They published the article 《Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol》 about this compound( cas:1300746-79-5 ) in Science (Washington, DC, United States). Keywords: rhodium catalyzed intermol carbon hydrogen silylation arene steric regiocontrol. We’ll tell you more about this compound (cas:1300746-79-5).

Regioselective C-H functionalization of arenes has widespread applications in synthetic chem. The regioselectivity of these reactions is often controlled by directing groups or steric hindrance ortho to a potential reaction site. Here, authors report a catalytic intermol. C-H silylation of unactivated arenes that manifests very high regioselectivity through steric effects of substituents meta to a potential site of reactivity. The silyl moiety can be further functionalized under mild conditions but is also inert toward many common organic transformations, rendering the silylarene products useful building blocks. The remote steric effect that we observe results from the steric properties of both the rhodium catalyst and the silane.

Although many compounds look similar to this compound(1300746-79-5)Related Products of 1300746-79-5, numerous studies have shown that this compound(SMILES:F[C-](F)([Cu+]1[N]2=C3C4=[N]1C=CC=C4C=CC3=CC=C2)F), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics