Category: 17190-29-3

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Benzenesulfonylnitrile oxide: a useful intermediate for the syn-cyanohydroxylation of alkenes.SDS of cas: 17190-29-3.

A general procedure allowing the syn-cyanohydroxylation of alkenes is presented. Generation of PhSO2CNO (I) in the presence of alkenes affords 3-(phenylsulfonyl)isoxazolines. Even Me2C:CMe2 undergoes cycloaddition Treatment of the cycloadducts with 2% Na amalgam results in ring fragmentation completing the syn-cyanohydroxylation process. Treatment of the cycloadducts with strong nucleophiles (LiOMe, NaCN or NaBH4) results in substitution of the phenylsulfonyl group. This latter process, in conjunction with the initial cycloaddition, allows the use of I as a synthetic equivalent of other nitrile oxides.

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Safety of 3-Hydroxy-3-phenylpropanenitrile. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Connecting Neutral and Cationic Pathways in Nickel-Catalyzed Insertion of Benzaldehyde into a C-H Bond of Acetonitrile. Author is Smith, Jacob B.; Miller, Alexander J. M..

Nickel catalysts supported by diethylamine- or aza-crown ether-containing aminophosphinite (NCOP) pincer ligands catalyze the insertion of benzaldehyde into a C-H bond of acetonitrile. The catalytic activity of neutral (NCOP)Ni(OtBu) and cationic [(NCOP)Ni(NCCH3)]+ are starkly different. The neutral tert-butoxide precatalysts are active without any added base and give good yields of product after 24 h, while the cationic precatalysts require a base cocatalyst and still operate much more slowly (120 h in typical runs). A series of in situ spectroscopic studies identified several intermediates, including a nickel cyanoalkoxide complex that was observed in all of the reactions regardless of the choice of precatalyst. Reaction monitoring also revealed that the neutral tert-butoxide precatalysts decompose to form the cationic acetonitrile complex during catalysis; this deactivation involves alkoxide abstraction and can be hastened by the addition of lithium salts. While the deactivated cationic species is inactive under standard base-free conditions, catalysis can be re-initiated by the addition of catalytic amounts of base.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tsuruoka, Akihiko; Negi, Shigeto; Yanagisawa, Manabu; Nara, Kazumasa; Naito, Toshihiko; Minami, Norio researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Synthetic Route of C9H9NO.They published the article 《Practical oxirane ring opening with in situ prepared LiCN; synthesis of (2S, 3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)-1-butanenitrile》 about this compound( cas:17190-29-3 ) in Synthetic Communications. Keywords: oxirane regioselective ring cleavage lithium cyanide; cyanation haloalkylbenzene lithium cyanide. We’ll tell you more about this compound (cas:17190-29-3).

The title compound was obtained in 73% yield by regiospecific opening of an oxirane ring with LiCN, prepared in situ from acetone cyanohydrin and LiH, providing this key intermediate for a new antifungal agent on a multi-kg scale. Ring opening of other oxiranes and nucleophilic substitution are also described.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.Application of 882562-40-5. The article 《Additions of acetonitrile and chloroform to aromatic aldehydes in the presence of tetrabutylammonium fluoride》 in relation to this compound, is published in Bulletin of the Korean Chemical Society. Let’s take a look at the latest research on this compound (cas:17190-29-3).

When the reaction of 4-substituted benzaldehyde with MeCN took place in the presence TBAF, cyanomethylation competed with oxidation depending on the electronic effect of the substituent, while the reaction in CHCl3 gave chloromethylated products only. Generally, cyanomethylation and trichloromethylation proceeded faster, as the electronic withdrawing effect increase, unless oxidation took place. To complete the reaction, excess of TBAF was needed in case of cyanomethylation, while excess of CHCl3 was needed in trichloromethylation.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition-Metal/NHC Complexes, Author is Sureshkumar, Devarajulu; Ganesh, Venkataraman; Kumagai, Naoya; Shibasaki, Masakatsu, the main research direction is beta hydroxynitrile enantioselective diastereoselective preparation; alkylnitrile aldehyde rhodium heterocyclic carbene catalyst addition reaction; N-heterocyclic carbenes; alkylnitriles; asymmetric catalysis; cooperative catalysis; rhodium.Recommanded Product: 17190-29-3.

Direct catalytic addition of alkylnitriles to aldehydes allowed for an atom-economical access to β-hydroxynitriles under proton transfer conditions. Direct use of alkylnitriles as pronucleophiles was hampered due to their low acidity resulting in an inability to generate α-cyano carbanions in a catalytic manner. A transition metal/N-heterocyclic carbene (NHC) complex prepared from [{Rh(OMe)(cod)}2] and an imidazolium-based carbene was identified as an effective catalyst to promote the reaction with as little as 1.25 mol % of catalyst loading. The corresponding Rh complex, derived from chiral triazolium salt, rendered the reaction enantioselective, albeit with moderate enantioselectivity.

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Fan, Ye-Cheng; Du, Guang-Fen; Sun, Wan-Fu; Kang, Wei; He, Lin published an article about the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3,SMILESS:N#CCC(O)C1=CC=CC=C1 ).Quality Control of 3-Hydroxy-3-phenylpropanenitrile. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17190-29-3) through the article.

N-Heterocyclic carbenes (NHCs) have served as efficient catalysts for cyanomethylation of carbonyl compounds In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give β-hydroxynitriles in moderate to high yields.

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Formula: C9H9NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Synthesis of β-hydroxy nitriles and 1,3-amino alcohols from epoxides using acetone cyanohydrin as a LiCN precursor.

The reaction of acetone cyanohydrin with MeLi affords a LiCN·acetone complex that can be made to react with epoxides in THF, either in one-pot or using isolated samples of the cyanide complex, to cleanly afford β-hydroxy nitriles upon aqueous workup; in situ hydride reduction of nitriles affords 1,3-amino alcs.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Regioselective nucleophilic opening of epoxides and aziridines under neutral conditions in the presence of β-cyclodextrin in water, the main research direction is epoxide regioselective nucleophilic opening sodium cyanide cyclodextrin catalyst water; aziridine regioselective nucleophilic opening cyclodextrin catalyst water; hydroxy nitrile preparation; amino alc preparation.Quality Control of 3-Hydroxy-3-phenylpropanenitrile.

A variety of β-hydroxy nitriles and β-amino alcs. were synthesized by the regioselective ring opening of epoxides and aziridines under neutral and aqueous conditions in the presence of β-cyclodextrin in good yields.

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Kumagai, Naoya; Matsunaga, Shigeki; Shibasaki, Masakatsu published the article 《Cooperative catalysis of a cationic ruthenium complex, amine base, and Na salt: catalytic activation of acetonitrile as a nucleophile》. Keywords: aldehyde acetonitrile addition ruthenium DBU sodium fluorophosphate; aryl hydroxypropanenitrile preparation; aminopropanenitrile preparation; ruthenium DBU sodium fluorophosphate addition catalyst.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Formula: C9H9NO. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.

Cooperative catalysis of a cationic Ru complex, DBU, and NaPF6 is described. An exquisite combination of the catalytic triad enabled catalytic activation of acetonitrile as a nucleophile under mild amine-basic conditions. Addition of in situ-generated, Ru-bound, metalated nitrile to aldehydes and imines proceeded smoothly with catalytic amounts of Ru complex and DBU in the presence of a catalytic amount of NaPF6. Preliminary mechanistic studies suggested a role for each of the three catalytic components.

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Application of 17190-29-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Ring opening of epoxides with sodium cyanide catalyzed with Ce(OTf)4. Author is Iranpoor, N.; Shekarriz, M..

Efficient and regioselective conversion of epoxides I [R = Ph, Bu, Me2CHOCH2, H2C:CHCH2OCH2, ClCH2, PhOCH2; R1 = H; RR1 = (CH2)4] to β-hydroxy nitriles II with sodium cyanide in the presence of catalytic amounts of Ce(OTf)4 is described under solvent free conditions.

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