Category: 17190-29-3

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Facile synthesis of an organic-inorganic nanocomposite, PEG-silica, by sol-gel method; its characterization and application as an efficient catalyst in regioselective nucleophilic ring opening of epoxides: Preparation of β-azido alcohols and β-cyanohydrins, the main research direction is polyethyleneglycol silica hybrid catalyst regioselective nucleophilic ring opening epoxide; soluble gel method polyethyleneglycol silica hybrid preparation catalyst; cyanohydrin azido alc preparation polyethyleneglycol silica hybrid catalyst.Related Products of 17190-29-3.

The sol-gel method was used for the synthesis of a PEG-silica hybrid. In order to introduce PEG into the cavities of silica gel, first, the bis(3-trimethoxysilylpropyl)-polyethylene glycol precursor was synthesized by the reaction of (3-chloropropyl)trimethoxysilane with alkoxides formed on the PEG terminals. The organic-inorganic hybrid silica was then synthesized by hydrolysis and polycondensation of the precursor under mild acidic conditions. The characteristics results of FT-IR, XRD and TGA confirmed the coexistence of silica and PEG networks. The catalytic ability of this heterogeneous catalyst to the regioselective ring opening of epoxides by azide and cyanide anions in H2O was also investigated.

From this literature《Facile synthesis of an organic-inorganic nanocomposite, PEG-silica, by sol-gel method; its characterization and application as an efficient catalyst in regioselective nucleophilic ring opening of epoxides: Preparation of β-azido alcohols and β-cyanohydrins》,we know some information about this compound(17190-29-3)Related Products of 17190-29-3, but this is not all information, there are many literatures related to this compound(17190-29-3).

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Recommanded Product: 17190-29-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Synthesis and reactivity of open-chain and cyclic 2-cyano zinc and copper organometallics. Author is Majid, Tahir N.; Yeh, Ming Chang P.; Knochel, Paul.

Various open-chain and cyclic β-cyano zinc and copper organometallics, e.g., PrCH(MLn) and I [MLn = ZnI, Cu(CN)ZnI for both, R = H, Me3C, n = 1,0], can be prepared by the reaction of the corresponding organic halides with zinc and subsequent transmetalation with CuCN·2LiCl. They react in fair to good yields with various organic electrophiles (enones, allylic bromides and benzoyl chloride) affording highly functionalized nitriles. High diastereoselectivities have been observed in coupling reactions with the cyclic 2-cyano organocopper derivatives The x-ray structure of cyanoethylzinc iodide is also reported.

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Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Highly regioselective conversion of epoxides to β-hydroxy nitriles with cyanide exchange resin. Author is Tamami, B.; Iranpoor, N.; Rezaei, R..

A simple and regioselective method is described for the efficient conversion of epoxides to β-hydroxy nitriles using Amberlite IRA-400-supported cyanide. The reactions occur in the absence of catalyst and furnish the corresponding β-hydroxy nitriles in high yields.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Category: pyrazoles-derivatives.Kalvoda, Jaroslav; Kaufmann, Heinz published the article 《Cleavage of carbon-carbon double bonds by a novel cycloaddition-cycloreversion sequence》 about this compound( cas:17190-29-3 ) in Journal of the Chemical Society, Chemical Communications. Keywords: cycloaddition dipolar ethoxycarbonylformonitrile alkene; decarboxylation isoxazolinecarboxylate; androstane methylene cycloaddition ethoxycarbonylformonitrile; styrene cycloaddition ethoxycarbonylformonitrile; stilbene cycloaddition ethoxycarbonylformonitrile. Let’s learn more about this compound (cas:17190-29-3).

Carbon-carbon double bonds are cleaved with simultaneous generation of a carbonyl compound and a nitrile by a sequence involving 1,3-dipolar cycloaddition of EtO2CCNO to the alkene, followed by hydrolysis of the 3-ethoxycarbonylisoxazoline, which is formed, to give the free acid, and subsequent thermal decarboxylation. Thus treatment of the 3-methylene steroid I (RR1 = CH2, R2 = Ac) with EtO2CCNO gave 39% spiroisoxazoline II (R = Et, R2 = Ac) which on saponification with KOH-MeOH-H2O at 20° gave the free acid II (R = R2 = H). Subsequent thermal decarboxylation of II (R = R2 = H) at 130° in DMF for 1 hr gave 90-2% hydroxynitrile I (R = OH, R1 = CH2CN, R2 = H). Styrene and stilbene underwent similar reactions.

There is still a lot of research devoted to this compound(SMILES：N#CCC(O)C1=CC=CC=C1)Category: pyrazoles-derivatives, and with the development of science, more effects of this compound(17190-29-3) can be discovered.

Reference:
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.COA of Formula: C5H7Br. The article 《Nucleophilic ring opening of cyclic sulfites – a convenient method for selective functionalization of 1,2-diols》 in relation to this compound, is published in Acta Chemica Scandinavica. Let’s take a look at the latest research on this compound (cas:17190-29-3).

Regioselective nucleophilic ring cleavage of cyclic sulfites I (e.g, R1 = Ph: R2 = H, Me, Ph) with Nu-M+ (e.g., NaN3, sodiodimethylmalonate, Et4N+CN-) afforded R1CHNuCH(OH)R2 in the case of e.g., NaN3, sodiodimethylmalonate, and R1CH(OH)CHNuR2 in the case of Et4N+CN-. Regioselectivity breaks down with Nu- = Cl-.

If you want to learn more about this compound(3-Hydroxy-3-phenylpropanenitrile)Category: pyrazoles-derivatives, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17190-29-3).

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Iridium-catalyzed efficient reduction of ketones in water with formic acid as a hydride donor at low catalyst loading.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.

A highly efficient and chemoselective transfer hydrogenation of ketones in water has been successfully achieved with our newly developed catalyst. Simple ketones, as well as α- or β-functionalized ketones, are readily reduced. Formic acid is used as a traceless hydride source. At very low catalyst loading (S/C = 10 000 in most cases; S/C = 50 000 or 100 000 in some cases), the iridium catalyst is impressively efficient at reducing ketones in good to excellent yields. The TOF value can be as high as up to 26 000 mol mol-1 h-1. A variety of functional groups are well tolerated, for example, heteroaryl, aryloxy, alkyloxy, halogen, cyano, nitro, ester, especially acidic methylene, phenol and carboxylic acid groups.

If you want to learn more about this compound(3-Hydroxy-3-phenylpropanenitrile)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17190-29-3).

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.Safety of 4-(Piperazin-1-yl)phenol. The article 《Synthetic application of elemento-organic compounds of the 15th and 16th Groups. 92. Novel reaction of dibutyl(cyanomethyl)telluronium chloride with carbonyl compounds mediated by organolithium reagents: highly efficient synthesis of β-hydroxy nitriles》 in relation to this compound, is published in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Let’s take a look at the latest research on this compound (cas:17190-29-3).

Dibutyl(cyanomethyl)telluronium chloride, a precursor of stabilized telluronium ylides, after being treated with organolithium reagents reacted with carbonyl compounds to afford β-hydroxy nitriles instead of α,β-unsaturated nitriles in excellent yields. Thus, reaction of Bu2Te+CH2CNCl- with BuLi in THF-hexane followed by treatment with PhCHO and hydrolysis gave 95% PhC(OH)CH2CN.

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Name: 3-Hydroxy-3-phenylpropanenitrile. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about Additions of anionic nucleophiles to carbonyl compounds: cation and electrophile nature influence on ionic association vs. carbonyl complexation control. Author is Loupy, A.; Roux-Schmitt, M. C.; Seyden-Penne, J..

The mechanism of the addition of anionic nucleophiles to CO compounds was examined by studying the reaction in the presence and absence of cryptand complexing agents. The addition of LiCH2CN to PhCHO in THF (-80°) is controlled by CO complexation [reaction time (r.t.) for >90% yield with [2.1.1]-cryptand is 60 min and is 5 min without cryptand]; the addition of KCH2CN is controlled by ionic association [r.t. for >80% yield with [2.2.2]-cryptand is 30 min and is 150 min without cryptand]. In the reaction of 3-ClC6H4C-HCN Li+ with benzaldehydes, CO complexation prevails with 4-MeOC6H4CHO and ionic association dominates with PhCHO and 4-NCC6H4CHO.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Synthesis called An epoxide ring-opening reaction via hypervalent silicate intermediate: Synthesis of statine, Author is Konno, Hiroyuki; Toshiro, Emi; Hinoda, Naoyuki, which mentions a compound: 17190-29-3, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NO, SDS of cas: 17190-29-3.

The azide- and cyanide-opening reaction of epoxide with TBAF and TMSN3 in THF or TBAF and TMSCN in MeCN occurred regioselectively to afford β-hydroxy azides and cyanides in good yield. These hypervalent silicates are highly effective as nucleophilic azide and cyanide donors under mild conditions. This methodol. was applied to the preparation of statine.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Condensation of benzaldehyde with bromoacetonitrile》. Authors are Vul’fson, N. S.; Vinograd, L. Kh..The article about the compound:3-Hydroxy-3-phenylpropanenitrilecas:17190-29-3,SMILESS:N#CCC(O)C1=CC=CC=C1).Computed Properties of C9H9NO. Through the article, more information about this compound (cas:17190-29-3) is conveyed.

To a refluxing solution of 21.3 g. BzH, 32 ml. C6H6, and 8 ml. Et2O containing 18 g. activated Zn dust there was added in 0.5 hr. 24 g. BrCH2CN. After refluxing 2 hrs. the cooled mixture was stirred 1 hr. with 120 ml. 10% H2SO4, filtered, separated, the organic layer extracted with 10% H2SO4 and H2O, and the combined aqueous layers extracted with C6H6 and combined with the original organic layer. Distillation gave 14.2 g. PhCH(OH)CH2CN, b4-5 147-51°. This shaken with 12% H2O2 in the presence of 1 drop of NaOH and little EtOH gave the corresponding amide, m. 120° (from EtOH). Refluxing the nitrile with 4N NaOH gave 63.6% PhCH:CHCO2H.

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