Category: 17190-29-3

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Huang, Yaozeng; Liao, Yi researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Application of 17190-29-3.They published the article 《Synthetic applications of elementoorganic compounds of group 15 and 16. 85. Pentaalkyl stiboranes. 1. Synthesis of homobenzylic alcohols, homoallylic alcohols, homoallylic alcohols, ethyl 5-aryl-5-hydroxy-2-pentenoates, and β-hydroxypropionic acid derivatives via pentaalkylstiboranes》 about this compound( cas:17190-29-3 ) in Journal of Organic Chemistry. Keywords: stiborane alkyl preparation reaction aldehyde; alc homobenzylic homoallylic; pentenoate hydroxy; aldehyde aromatic reaction pentaalkylstiborane. We’ll tell you more about this compound (cas:17190-29-3).

Although pentaalkylstiboranes have long been known, their applications in organic synthesis have not been exploited. Treating [Bu3SbCH2E]+ X- (E = Ph, vinyl, CH:CHCO2Et, CO2Et, cyano; X = Br, iodo, BPh4) with RLi (R = Bu, Me3C, Ph) give pentaalkylstiboranes, Bu3Sb(R)CH2E, which react with aromatic aldehydes to give, after subsequent hydrolysis, homobenzylic and homoallylic alcs., Et 5-aryl-5-hydroxy-2-pentenoates, Et β-aryl-β-hydroxypropionates, and β-aryl-β-hydroxypropionitriles, resp., in good-to-excellent yields. The reaction is chemoselective for aldehydes.

This compound(3-Hydroxy-3-phenylpropanenitrile)Application of 17190-29-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about P(RNCH2CH2)3N-Catalyzed Synthesis of β-Hydroxy Nitriles, the main research direction is proazaphosphatrane catalyst reaction nitrile aldehyde ketone; hydroxy nitrile preparation.Product Details of 17190-29-3.

Successful synthesis of β-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type is reported. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced. E.g., reaction of MeCN with acetone in presence of a proazaphosphatrane and MgSO4 gave 94% HOCMe2CH2CN.

This compound(3-Hydroxy-3-phenylpropanenitrile)Product Details of 17190-29-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Formula: C9H9NO.Koenig, Thomas M.; Mitchell, David published the article 《A convenient method for preparing enantiomerically pure norfluoxetine, fluoxetine and tomoxetine》 about this compound( cas:17190-29-3 ) in Tetrahedron Letters. Keywords: norfluoxetine enantiomeric preparation; fluoxetine enantiomeric preparation; tomoxetine enantiomeric preparation. Let’s learn more about this compound (cas:17190-29-3).

A convenient synthesis for enantiomers of norfluoxetine (I; R = 4-F3C, R1 = H), fluoxetine (I; R = F3C, R1 = Me) and tomoxetine (I: R = R1 = Me) is described. All final products were derived from 3-phenyl-3-hydroxypropylamine, prepared in 2 steps from PhCHO and acetonitrile.

This compound(3-Hydroxy-3-phenylpropanenitrile)Formula: C9H9NO was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Kawano, Yoshikazu; Kaneko, Nobuya; Mukaiyama, Teruaki published the article 《Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile》. Keywords: Lewis base catalyzed cyanomethylation carbonyl compound trimethylsilyl acetonitrile; lithium acetate catalyzed cyanomethylation carbonyl compound silyl acetonitrile.They researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Category: pyrazoles-derivatives. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17190-29-3) here.

Catalytic cyanomethylation of various carbonyl compounds with (trimethylsilyl)acetonitrile (TMSCH2CN) in the presence of Lewis bases such as cesium or lithium acetate proceeded smoothly to afford the corresponding cyanomethylated adducts in good yields. Thus, AcOLi catalyzed cyanomethylation of PhCHO with Me3SiCH2CN in DMF at 0° to room temperature followed by acid hydrolysis gave 98% PhCHOHCH2CN.

《Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 17190-29-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about P(i-PrNCH2CH2)3N as a Lewis Base Catalyst for the Synthesis of β-Hydroxynitriles Using TMSAN. Author is Wadhwa, Kuldeep; Verkade, John G..

The title proazaphosphatrane was found to be an efficient catalyst for synthesis of β-hydroxynitriles via the reaction of trimethylsilylacetonitrile (TMSAN) with aldehydes under mild reaction conditions and typically low catalyst loading (ca. 2 mol %). A variety of functional groups were tolerated, and good to excellent product yields were obtained.

《P(i-PrNCH2CH2)3N as a Lewis Base Catalyst for the Synthesis of β-Hydroxynitriles Using TMSAN》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Product Details of 17190-29-3.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about A high throughput screening strategy for the assessment of nitrile-hydrolyzing activity towards the production of enantiopure β-hydroxy acids. Author is Coady, Tracey M.; Coffey, Lee V.; O’Reilly, Catherine; Owens, Erica B.; Lennon, Claire M..

Nitrile hydrolyzing enzymes have found wide use in the pharmaceutical industry for the production of fine chems. This work presents a strategy that facilitates the rapid identification of bacterial isolates demonstrating nitrile hydrolyzing activity. The strategy incorporates toxicity, starvation and induction studies along with subsequent colorimetric screening for activity, further focusing the assessment towards the substrates of interest. This high-throughput strategy uses a 96 well plate system, and has enabled the rapid biocatalytic screening of 256 novel bacterial isolates towards β-hydroxynitriles. Results demonstrate the strategy’s potential to rapidly assess a variety of β-hydroxynitriles including aliphatic, aromatic and dinitriles. A whole cell catalyst Rhodococcus erythropolis SET1 was identified and found to catalyze the hydrolysis of 3-hydroxybutyronitrile with remarkably high enantioselectivity under mild conditions, to afford (S)-3-hydroxybutyric acid in 42% yield and >99.9% ee. The biocatalytic capability of this strain including the variation of parameters such as temperature and time were further investigated and all results indicate the presence of a highly enantioselective if not enantiospecific nitrilase enzyme within the microbial whole cell.

《A high throughput screening strategy for the assessment of nitrile-hydrolyzing activity towards the production of enantiopure β-hydroxy acids》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Azizi, Najmedin; Rahimi, Zahra; Alipour, Masoumeh researched the compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ).Name: 3-Hydroxy-3-phenylpropanenitrile.They published the article 《A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent》 about this compound( cas:17190-29-3 ) in RSC Advances. Keywords: magnetic iron oxide catalyst aldehyde epoxide cyanation green chem. We’ll tell you more about this compound (cas:17190-29-3).

Magnetic Fe3O4 nanoparticles in deep eutectic solvents (DESs) have been regard as excellent catalysts for highly efficient cyanosilylation of various aldehydes and epoxides using trimethylsilyl cyanide TMSCN in high yields with excellent selectivity. Fe3O4 nanoparticles were synthesized and applied as a catalyst for the preparation of a wide variety of cyanohydrins (α-hydroxy nitriles and β-hydroxy nitriles) in readily available urea-choline chloride deep eutectic solvent DES as the most promising environmentally benign and cost-effective green solvent. Magnetic DES operates at very mild reaction conditions and can be easily recycled without significant loss of its catalytic activity.

《A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Name: 3-Hydroxy-3-phenylpropanenitrile.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Hydroxy-3-phenylpropanenitrile( cas:17190-29-3 ) is researched.Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.Ma, Da-You; Wang, De-Xian; Pan, Jie; Huang, Zhi-Tang; Wang, Mei-Xiang published the article 《Nitrile biotransformations for the synthesis of enantiomerically enriched β2-, and β3-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity》 about this compound( cas:17190-29-3 ) in Tetrahedron: Asymmetry. Keywords: Rhodococcus nitrile hydratase biotransformation enantiomeric. Let’s learn more about this compound (cas:17190-29-3).

Rhodococcus erythropolis AJ270, a nitrile hydratase/amidase-containing microbial whole cell catalyst, is able to catalyze the hydrolysis of a number of β-hydroxy and β-alkoxy nitriles under very mild conditions. Both the efficiency and enantioselectivity of the biocatalysis, however, were strongly dependent upon the structures of both nitrile and amide substrates. When biotransformations of racemic 3-hydroxy-3-phenylpropionitrile and 2-hydroxymethyl-3-phenylpropionitrile gave low enantioselectivity, their O-methylated isomers underwent highly efficient and enantioselective biocatalytic reactions to afford highly enantioenriched β2- and β3-hydroxy amide and acid derivatives in excellent yield. The study has provided an example of simple and very convenient substrate engineering method to increase the enantioselectivity of the biocatalytic reaction.

《Nitrile biotransformations for the synthesis of enantiomerically enriched β2-, and β3-hydroxy and -alkoxy acids and amides, a dramatic O-substituent effect of the substrates on enantioselectivity》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Hydroxy-3-phenylpropanenitrile)Application In Synthesis of 3-Hydroxy-3-phenylpropanenitrile.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of C9H9NO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Hydroxy-3-phenylpropanenitrile, is researched, Molecular C9H9NO, CAS is 17190-29-3, about A new facile chemoenzymatic synthesis of levamisole.

An efficient and facile chemoenzymic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-(phenyl)propanenitrile followed by its conversion to β-amino alc. as the key intermediate is described. The resolution of β-(acetyloxy)benzenepropanenitrile using diatomite-immobilized Pseudomonas cepacia (Burkholderia cepacia) lipase gave (+)-(βR)-β-(hydroxy)benzenepropanenitrile. The resolution of β-(hydroxy)benzenepropanenitrile using immobilized lipase gave (βR)-β-(acetyloxy)benzenepropanenitrile. Both intermediates were used for the synthesis of (6S)-2,3,5,6-tetrahydro-6-(phenyl)imidazo[2,1-b]thiazole (levamisole).

Different reactions of this compound(3-Hydroxy-3-phenylpropanenitrile)Synthetic Route of C9H9NO require different conditions, so the reaction conditions are very important.

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Canadian Journal of Chemistry called Metal(II) Schiff base complexes as catalysts for the high-regioselective conversion of epoxides to β-hydroxy nitriles in glycol solvents, Author is Naeimi, Hossein; Moradian, Mohsen, the main research direction is regioselective preparation hydroxy nitrile; metal Schiff base catalyst ring opening epoxide potassium cyanide.Formula: C9H9NO.

A facile preparation of 3-hydroxy propanenitrile derivatives is described involving ring opening of epoxides with potassium cyanide in glycol solvents in the presence of Schiff base complexes as catalysts. This method occurs under neutral and mild conditions with high yields and high regioselectivity. Thus, several β-hydroxy nitriles, useful intermediates toward biol.-active mols., are easily obtained at room temperature

The article 《Metal(II) Schiff base complexes as catalysts for the high-regioselective conversion of epoxides to β-hydroxy nitriles in glycol solvents》 also mentions many details about this compound(17190-29-3)Formula: C9H9NO, you can pay attention to it, because details determine success or failure

Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics