Category: 299930-70-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 299930-70-4 as follows. Product Details of 299930-70-4

3-Chloro-1-methyl-4-nitro-1H-pyrazole (Stage K.2, 1 0 g 6 19 mmol) was shacked in MeOH/THF 1.1 (62 ml) under 1.1 bar H2 in presence of Raney nickel (0.35 g) as catalyst for 24 h at rt. The RM was filtered over Celite, the catalyst was washed several times with MeOH/THF and the filtrate was evaporated to dryness to give the title compound as a blue oil (HPLC tR 0.89 mm (Method A), M+H = 132 MS-ES).

According to the analysis of related databases, 299930-70-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; FURET, Pascal; KALTHOFF, Frank Stephan; MAH, Robert; RAGOT, Christian; STAUFFER, Frederic; WO2010/139731; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 299930-70-4, A common heterocyclic compound, 299930-70-4, name is 3-Chloro-1-methyl-4-nitro-1H-pyrazole, molecular formula is C4H4ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: Into a 100 mL round bottom flask containing a solution of 3-chloro-l-methyl-4-nitro- lH-pyrazole (2.0 g) in ethyl acetate (50 mL) was added Raney Ni (1.0 g) and the reaction mixture was stirred under hydrogen atmosphere for 24 h. The reaction mixture was filtered through celite and washed with ethyl acetate. The filtrate was concentrated under reduced pressure and purified by flash chromatography eluting with ethyl acetate in petroleum ether (40- 50%) to afford 3 -chloro-1 -methyl-1H-pyrazol-4-amine as an oil. *H NMR (CD3OD, 400 MHz): 5 7.17 (s, 1H), 3.73 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; GIBEAU, Craig, R.; (84 pag.)WO2016/144849; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics