Category: 52096-24-9

Pu, Jun; Kreft, Anthony F.; Aschmies, Suzan H.; Atchison, Kevin P.; Berkowitz, Joshua; Caggiano, Thomas J.; Chlenov, Micheal; Diamantidis, George; Harrison, Boyd L.; Hu, Yun; Huryn, Donna; Steven Jacobsen, J.; Jin, Mei; Lipinski, Kerri; Lu, Peimin; Martone, Robert L.; Morris, Koi; Sonnenberg-Reines, June; Riddell, Dave R.; Sabalski, Joan; Sun, Shaiu-Ching; Wagner, Erik; Wang, Yiqun; Xu, Zheng; Zhou, Hua; Resnick, Lynn published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors》.Recommanded Product: 52096-24-9 The author mentioned the following in the article:

γ-Secretase inhibitors have been shown to reduce the production of β-amyloid, a component of the plaques that are found in brains of patients with Alzheimer’s disease. A novel series of heterocyclic sulfonamide γ-secretase inhibitors that reduce β-amyloid levels in cells is reported. Several examples of compounds within this series demonstrate a higher propensity to inhibit the processing of amyloid precursor protein compared to Notch, an alternative γ-secretase substrate. The results came from multiple reactions, including the reaction of 1-Butyl-1H-pyrazole(cas: 52096-24-9Recommanded Product: 52096-24-9)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Recommanded Product: 52096-24-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chen, Lin Zhi; Flammang, Robert; Maquestiau, Andre; Taft, Robert W.; Catalan, Javier; Cabildo, Pilar; Claramunt, Rosa M.; Elguero, Jose published an article on January 4 ,1991. The article was titled 《Thermodynamic basicity vs. kinetic basicity of diazoles (imidazoles and pyrazoles)》, and you may find the article in Journal of Organic Chemistry.Electric Literature of C7H12N2 The information in the text is summarized as follows:

The intrinsic basicity of 24 azoles (pyrazoles, indazoles, imidazoles, benzimidazoles) and 7-methylazaindole was determined by mass spectrometry techniques, ion cyclotron resonance (ICR), and/or chem. ionization (CI) in conjunction with tandem mass spectrometry (MS/MS). A reasonably good agreement (r2 = 0.967) is found between both methods (15 compounds). Thus, it is possible to use CI/MS/MS to determine the intrinsic basicity of compounds not measurable by ICR for purity or volatility reasons. Some anomalies are interpreted in terms of entropy and steric effects. The basicity data are also discussed by using empirical models (σα, σR) and chelation and annelation effects. The results came from multiple reactions, including the reaction of 1-Butyl-1H-pyrazole(cas: 52096-24-9Electric Literature of C7H12N2)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Electric Literature of C7H12N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Electric Literature of C7H12N2On September 30, 2016 ,《Sonochemical heating profile for solvents and ionic liquid doped solvents, and their application in the N-alkylation of pyrazoles》 was published in Ultrasonics Sonochemistry. The article was written by Frizzo, Clarissa P.; Bacim, Carolini; Moreira, Dayse N.; Rodrigues, Leticia V.; Zimmer, Georgia C.; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A. P.. The article contains the following contents:

The heating profile for 25 solvents was determined in ultrasonic probe equipment at amplitudes of 20%, 25%, and 30%. Each solvent was heated in accordance with its b.p. The effect of vapor pressure, surface tension, and viscosity of the solvents in dissipated ultrasonic power (Up) was evaluated. Multiple regression anal. of these solvent properties and dissipated Up revealed that solvent viscosity was the property that most strongly affected dissipated Up. Experimentation involving acetonitrile doped with [BMIM][BF4] indicated faster heating than MeCN. Aprotic polar solvents such as DMSO, DMF, and MeCN were tested in the N-alkylation of pyrazoles under ultrasonic conditions. After 5 min at 90°, the reactants were totally converted into product in these solvents. Solvents, with low dissipated Up (e.g., toluene) were tested. Conversions were lower compared to those of aprotic polar solvents. When the reactions were done in hexane, no conversion to product was observed To check the effect of doping in solvents with low Up, [BMIM][BF4], DMSO, and DMF were selected. The conversions for toluene doped with [BMIM][BF4], DMSO, and DMF were 100%, 59%, and 25%, resp. These conversions were greater than when done in just toluene (46%). Thus, [BMIM][BF4] was the best polar doping solvent, followed by DMSO. DMF was not considered to be a satisfactory doping solvent. No conversion was observed for reactions in the absence of base performed in DMSO, DMF, and MeCN doped with [BMIM][BF4]. The experimental process involved the reaction of 1-Butyl-1H-pyrazole(cas: 52096-24-9Electric Literature of C7H12N2)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Electric Literature of C7H12N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application In Synthesis of 1-Butyl-1H-pyrazoleOn October 22, 2018 ,《Pyrazolium Ionic Liquid Co-catalysts for the Electroreduction of CO2》 was published in ACS Applied Energy Materials. The article was written by Vasilyev, Dmitry; Shirzadi, Erfan; Rudnev, Alexander V.; Broekmann, Peter; Dyson, Paul J.. The article contains the following contents:

Pyrazolium ionic liquids (Pz ILs) were employed as co-catalysts for electrochem. conversion of CO2 to CO on a Ag disk electrode, leading to a significant decrease in the onset potential for the reduction (∼500 mV). The electrochem. conversion of CO2 to CO proceeds in MeCN-based electrolytes containing Pz IL co-catalysts with faradaic efficiencies (FEs) of nearly 100% over a range of at least 0.5 V, and the Pz cations remain intact over prolonged CO2 electrolysis. The impact of alkyl substituents on the Pz ring and the influence of H2O on the process are also discussed. After reading the article, we found that the author used 1-Butyl-1H-pyrazole(cas: 52096-24-9Application In Synthesis of 1-Butyl-1H-pyrazole)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Application In Synthesis of 1-Butyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Product Details of 52096-24-9On November 25, 2020 ,《Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor》 appeared in Journal of Medicinal Chemistry. The author of the article were Szlavik, Zoltan; Csekei, Marton; Paczal, Attila; Szabo, Zoltan B.; Sipos, Szabolcs; Radics, Gabor; Proszenyak, Agnes; Balint, Balazs; Murray, James; Davidson, James; Chen, Ijen; Dokurno, Pawel; Surgenor, Allan E.; Daniels, Zoe Marie; Hubbard, Roderick E.; Le Toumelin-Braizat, Gaetane; Claperon, Audrey; Lysiak-Auvity, Gaelle; Girard, Anne-Marie; Bruno, Alain; Chanrion, Maia; Colland, Frederic; Maragno, Ana-Leticia; Demarles, Didier; Geneste, Olivier; Kotschy, Andras. The article conveys some information:

Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resistance to chemotherapy. Here we report the discovery of our clin. candidate S64315, a selective small mol. inhibitor of Mcl-1. Starting from a fragment derived lead compound, we have conducted structure guided optimization that has led to a significant (3 log) improvement of target affinity as well as cellular potency. The presence of hindered rotation along a biaryl axis has conferred high selectivity to the compounds against other members of the Bcl-2 family. During optimization, we have also established predictive PD markers of Mcl-1 inhibition and achieved both efficient in vitro cell killing and tumor regression in Mcl-1 dependent cancer models. The preclin. candidate has drug-like properties that have enabled its development and entry into clin. trials. In addition to this study using 1-Butyl-1H-pyrazole, there are many other studies that have used 1-Butyl-1H-pyrazole(cas: 52096-24-9Product Details of 52096-24-9) was used in this study.

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Product Details of 52096-24-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Esters of phosphorus oxy-acids as alkylating agents. II. N-Alkylation of imidazole and related heterocyclic compounds with trialkyl phosphates》 was written by Yamauchi, Kiyoshi; Kinoshita, Masayoshi. Formula: C7H12N2 And the article was included in Journal of the Chemical Society in 1973. The article conveys some information:

Imidazole, benzimidazole, pyrazole, 1,2,4-triazole, and benzotriazole reacted with (RO)3PO (R = Me, Et, Bu) to give N-alkyl derivatives (41-90%). Predominant N-1 alkylation was observed in the triazoles. In the part of experimental materials, we found many familiar compounds, such as 1-Butyl-1H-pyrazole(cas: 52096-24-9Formula: C7H12N2)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Formula: C7H12N2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Quaternization and dequaternization of pyrazoles in solvent-free conditions: conventional heating versus microwave irradiation》 was written by Diez-Barra, Enrique; De la Hoz, Antonio; Sanchez-Migallon, Ana; Elguero, Jose. Reference of 1-Butyl-1H-pyrazole And the article was included in Journal of Heterocyclic Chemistry on August 31 ,1999. The article conveys some information:

A study on the quaternization and dequaternization of pyrazoles by conventional heating and microwave irradiation in solvent-free conditions is reported. Microwave irradiation produces an acceleration in the quaternization rate and a rapid equilibration between quaternized and non-quaternized products. Dequaternization is also more rapid and a change in the selectivity is observed using sym. pyrazolium salts. The experimental process involved the reaction of 1-Butyl-1H-pyrazole(cas: 52096-24-9Reference of 1-Butyl-1H-pyrazole)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Reference of 1-Butyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Wang, Tengfei; Zheng, Danning; Zhang, Jingshun; Fan, Baowan; Ma, Yuan; Ren, Tiegang; Wang, Li; Zhang, Jinglai published an article on February 5 ,2018. The article was titled 《Protic Pyrazolium Ionic Liquids: An Efficient Catalyst for Conversion of CO2 in the Absence of Metal and Solvent》, and you may find the article in ACS Sustainable Chemistry & Engineering.Safety of 1-Butyl-1H-pyrazole The information in the text is summarized as follows:

A series of novel protic pyrazolium ionic liquids are firstly synthesized and utilized as catalysts for cycloaddition of carbon dioxide and epoxides to form cyclic carbonates under metal- and solvent-free conditions. The new developed protic pyrazolium ionic liquids present excellent catalytic activity towards the fixation of carbon dioxide. More importantly, they would be prepared by a facile two-step reaction from cheap raw starting materials with a total yield more than 90%. The influence of catalyst dosage, reaction temperature, carbon dioxide pressure, and reaction time on the synthesis of cyclic carbonates is studied to identify the optimal reaction conditions. Under the optimum condition, the catalyst suitability is studied. Addnl., the possible reaction mechanism is studied by the Double-IL model to elucidate the synergistic effects of electrostatic and weak interaction in catalytic process. The experimental process involved the reaction of 1-Butyl-1H-pyrazole(cas: 52096-24-9Safety of 1-Butyl-1H-pyrazole)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazoles and their related multiring analogs are common elements of a wide variety of bioactive compounds. These ring structures are rare in nature. A consequence of this is that they have previously been thought to be poor moieties to include in potential new drugs. Safety of 1-Butyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《Ligand-controlled Regiodivergent C-H Alkenylation of Pyrazoles and its Application to the Synthesis of Indazoles》 was published in Angewandte Chemie, International Edition in 2017. These research results belong to Kim, Hyun Tae; Ha, Hyeri; Kang, Geunhee; Kim, Og Soon; Ryu, Ho; Biswas, Abul Kalam; Lim, Sang Min; Baik, Mu-Hyun; Joo, Jung Min. HPLC of Formula: 52096-24-9 The article mentions the following:

Regioselective C4-, C5-, and di-alkenylations of pyrazoles were achieved. An electrophilic Pd catalyst generated by trifluoroacetic acid (TFA) and 4,5-diazafluoren-9-one (DAF) leads to C4-alkenylation, whereas KOAc and mono-protected amino acid (MPAA) ligand Ac-Val-OH give C5-alkenylation. A combination of palladium acetate, silver carbonate, and pivalic acid affords dialkenylation products. Annulation through sequential alkenylation, thermal 6π-electrocyclization, and oxidation gives functionalized indazoles. This comprehensive strategy greatly expands the range of readily accessible pyrazole and indazole derivatives, enabling useful regiodivergent C-H functionalization of pyrazoles and other heteroaromatic systems. After reading the article, we found that the author used 1-Butyl-1H-pyrazole(cas: 52096-24-9HPLC of Formula: 52096-24-9)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.HPLC of Formula: 52096-24-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

《A General Method for Copper-Catalyzed Arene Cross-Dimerization》 was written by Do, Hien-Quang; Daugulis, Olafs. Product Details of 52096-24-9 And the article was included in Journal of the American Chemical Society on August 31 ,2011. The article conveys some information:

A general method for a highly regioselective copper-catalyzed cross-coupling of two aromatic compounds using iodine as an oxidant has been developed. The reactions involve an initial iodination of one arene followed by arylation of the most acidic C-H bond of the other coupling component. Cross-coupling of electron-rich arenes, electron-poor arenes, and five- and six-membered heterocycles is possible in many combinations. Typically, a 1/1.5 to 1/3 ratio of coupling components is used, in contrast to existing methodol. that often employs a large excess of one of the arenes. Common functionalities such as ester, ketone, aldehyde, ether, nitrile, nitro, and amine are well-tolerated. In the part of experimental materials, we found many familiar compounds, such as 1-Butyl-1H-pyrazole(cas: 52096-24-9Product Details of 52096-24-9)

1-Butyl-1H-pyrazole(cas: 52096-24-9) belongs to pyrazoles. Pyrazole derivatives have been reported to exhibit a wide range of applications in medicinal chemistry and pharmacology. A large number of drugs incorporating pyrazole structure have been utilized as partial agonists for nicotinic acid receptors, antidepressants, antimicrobial agents, antiviral agents, and antifungal agents solely or along with the combination of other structural motifs.Product Details of 52096-24-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics