Category: 2654-57-1

Synthetic Route of 2654-57-1, These common heterocyclic compound, 2654-57-1, name is 4-Methyl-1-phenylpyrazolidin-3-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Methyl-1-phenyl-1,2-dihydro-3H-pyrazol-3-one (5) was synthesized in a similar way from 0.17 g (1 mmol) of 4-methyl-1-phenylpyrazolidin-3-one (3) in 1 mL of methylene chloride and 0.19 g (1.01 mmol) of 1 in 1 mL of methylene chloride at room temperature. Yield 0.15 g (88%), yellow powder, mp 209 C [5, 6]. 1H NMR spectrum, delta, ppm: 1.90 s (3H, CH3), 7.12 t (1H, p-H, J = 7.3 Hz), 7.38 t (2H, m-H, J =8.1 Hz), 7.60 d (2H, o-H, J = 7.8 Hz), 8.01 s (1H,=CH), 10.14 (1H, NH). 13C NMR spectrum, deltaC, ppm:7.0, 103.3, 116.2, 123.9, 126.5, 129.3, 139.9, 161.4. The spectral parameters of 5 coincided with those given in [5, 6].

The synthetic route of 2654-57-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shainyan; Tolstikova; Russian Journal of Organic Chemistry; vol. 53; 4; (2017); p. 632 – 633; Zh. Org. Khim.; vol. 53; 4; (2017); p. 624 – 625,2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2654-57-1, name is 4-Methyl-1-phenylpyrazolidin-3-one, A new synthetic method of this compound is introduced below., Quality Control of 4-Methyl-1-phenylpyrazolidin-3-one

General procedure: 1a (0.5?mmol), Pd(OAc)2 (5?mol%), AMS (20?mol%), K2CO3 (0.4 equiv.), and dry chlorobenzene (1?mL) were added in a test tube. The reaction mixture was allowed to stir vigorously at 110?C for 6?h. After cooling at room temperature, the mixture was concentrated and the residue was purified by column chromatography on Al2O3 (mobile phase: dichloromethane/methanol or petroleum ether/ethyl acetate) to afford the pure product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhu, Ye-Fu; Wei, Bo-Le; Wei, Jiao-Jiao; Wang, Wen-Qiong; Song, Wei-Bin; Xuan, Li-Jiang; Tetrahedron Letters; vol. 60; 17; (2019); p. 1202 – 1205;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 2654-57-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2654-57-1, name is 4-Methyl-1-phenylpyrazolidin-3-one belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

(a) 3-hydroxy-4-methyl-1-(4-nitro-phenyl)-1H-pyrazole 8.00 g (45.4 mmol) 4-methyl-1-phenyl-1H-pyrazolidin-3-one are added to 80 ml conc. sulphuric acid at -5 C. with stirring and stirred for another 5 min. Then 3.8 ml (54.5 mmol) 65% nitric acid are added with cooling such that the temperature remains between -15 and -10 C. The reaction mixture is stirred for 1 h between -20 and -5 C., then poured into ice water and suction filtered. The filter cake is washed with water, dried at 55 C. and further reacted without any further purification. Yield: 8.00 g (approx. 40%), approx. 50% C10H9N3O3 (219.20) Rf value: 0.70 (silica gel; cyclohexane/ethyl acetate=1:1)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-1-phenylpyrazolidin-3-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dahmann, Georg; Gerlach, Kai; Pfau, Roland; Priepke, Henning; Wienen, Wolfgang; Schuler-Metz, Annette; Nar, Herbert; US2008/51578; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics