Category: 423768-52-9

Related Products of 423768-52-9,Some common heterocyclic compound, 423768-52-9, name is 3-(Aminomethyl)-1,5-dimethylpyrazole, molecular formula is C6H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under argon, a solution of 3-chloro-5-(2,6-dimethoxyphenyl)-1,2,4-triazine (6.85 mg, 0.027 mmol, prepared as in example 41), (1,5-dimethyl-1H-pyrazol-3-yl)methylamine (8 mg, 0.064 mmol) and potassium carbonate (3.8 mg, 0.028 mmol) in anhydrous acetonitrile (0.7 mL) was stirred at 85C overnight. The solution was evaporated. The residue was purified by preparative TLC (silica gel, dichloromethane/methanol 95/5) to afford 5-(2,6-dimethoxyphenyl)-N-[(1,5-dimethyl-1H-pyrazol-3-yl)methyl]-1,2,4-triazin-3-amine (5.5 mg, 59%) as an off-white solid. ESI-MS m/z 341 (M+H)+. 1H NMR (CDCl3), delta (ppm): 8.45 (s, 1H), 7.40 (t, J = 8.4 Hz, 1H), 6.64 (d, J = 8.4 Hz, 2H), 6.06 (s, 1H), 4.70 (d, J = 5.2 Hz, 2H), 3.77 (s, 6H), 3.73 (s, 3H), 2.23 (s, 3H).

The synthetic route of 423768-52-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mutabilis; EP2141164; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Reference of 423768-52-9,Some common heterocyclic compound, 423768-52-9, name is 3-(Aminomethyl)-1,5-dimethylpyrazole, molecular formula is C6H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of ethyl 2-(2-amino-4,6-dichloropyrimidin-5-yl)acetate (200 mg, 0.80 mmol) in EtOH (30 mL) was added (l,5-dimethyl-lH-pyrazol-3-yl)methanamine (300 mg, 2.40 mmol) and Et3N (400 mg, 3.96 mmol). The resulting solution was refluxed for 3 hours. The reaction mixture was concentrated under vacuum. The residue was purified on a silica gel column with DCMrMeOH (50:1), resulted in 0.25 g (31%) of ethyl 2-(2-amino-4-chloro- 6-((l,5-dimethyl-lH-pyrazol-3-yl) methylamino)pyrimidin-5-yl)acetate as a yellow solid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Aminomethyl)-1,5-dimethylpyrazole, its application will become more common.

Reference:
Patent; PONIARD PHARMACEUTICALS, INC.; WO2009/139834; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics