Category: 1269293-48-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1269293-48-2, name is Ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H9BrN2O2

Step 2b. A solution of compound form step 2a (400 mg, 1.44 mmol), 1,3,5-trichloro- l,3,5-triazinane-2,4,6-trione (700 mg, 3.14 mmol) in MeCN/AcOH/water 15ml (80/3/2) was stirred for 1 hour at -5C before was partitioned (EtOAc-brine). The organic was dried (Na2S04), filtered and concentrated to give the desired compound (500 mg) as a yellow oil. ESI-MS m/z =253.00 [M+H]+. This material was used directly in the next step without further purification.

The synthetic route of 1269293-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; QIU, Yao-ling; LI, Wei; CAO, Hui; JIN, Meizhong; GAO, Xuri; PENG, Xiaowen; KASS, Jorden; OR, Yat, Sun; (84 pag.)WO2016/183266; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1269293-48-2, name is Ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1269293-48-2

STEP A: 5-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid [0180] Lithium hydroxide (8.58 mL, 17.16 mmol) was added to a mixture of ethyl 5- bromo-1 -methyl- lH-pyrazole-3-carboxylate (1 g, 4.29 mmol) in THF (10 mL) and water (2 mL). The reaction mixture was stirred for 5 hours at room temperature and was subsequently concentrated, acidified with concentrated HC1, and extracted into EtOAc. The organic layer was dried over Na2S04 and concentrated to give the title compound as a white solid (0.72 g, 82%).

The synthetic route of 1269293-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; CHERUVALLATH, Zacharia; KOMANDLA, Mallareddy; LAWSON, John David; MCBRIDE, Christopher; TANG, Mingnam; WO2014/39831; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

1269293-48-2, name is Ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H9BrN2O2

A mixture of ethyl 5-bromo-1-methyl-pyrazole-3-carboxylate (300 mg, 1.29 mmol) and methanamine in MeOH (10 mL, 12.87 mmol) was heated to 80 C. and stirred overnight. The reaction solution was concentrated to give the product 5-bromo-N,1-dimethyl-pyrazole-3-carboxamide (280 mg, 99% yield) as a colorless oil. LCMS (ESI) [M+H]+=218.2

The synthetic route of 1269293-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Lainchbury, Michael; Gancia, Emanuela; Seward, Eileen; Madin, Andrew; Favor, David; Fong, Kin Chiu; Hu, Yonghan; Good, Andrew; US2018/282282; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics