Category: 1072-91-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-91-9, name is 1,3,5-Trimethylpyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1,3,5-Trimethylpyrazole

1,3, 5-Trimethyl-lH-pyrazole (630 mg, 5.71 mmol) cooled to [0 oC] was treated with oxalyl chloride (7.0 mL). The reaction was then warmed to [25 oC] and then heated to reflux for 4 h. At this time, the reaction was cooled to [25 oC] and was stirred at [25 oC] for 24 h. At this time, the excess oxalyl chloride was removed by distillation. The resulting residue was cooled to [0 oC] and treated with ice/water (15 mL). The mixture was slowly warmed to [25 oC] over 4 h. At this time, the resulting solids were collected by filtration, washed with water, and dried in vacuo to afford [OXO- (1,] 3,5- [TRIMETHYL-LH-PYRAZOL-4-YL)-ACETIC] acid (700 mg, 70%) as brown solid

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2003/106459; (2003); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

1072-91-9, name is 1,3,5-Trimethylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1,3,5-Trimethylpyrazole

General procedure: SOCl2 (5 mL) was added to a round-bottom flask, and then 1a-i(1.0 mmol) and a catalytic amount of DMF (0.1 mmol) were added. Themixture was heated to reflux for 4 h (reaction monitored by HPLC),then excess SOCl2 was evaporated under reduced pressure. The residuewas dispersed in H2O (200 mL) and extracted with AcOEt. The organicphase was separated, dried, and concentrated. It was then purified byflash column chromatography (eluent: ethyl acetate/petroleum ether,1 : 10 v/v) to afford 2a-i.

The synthetic route of 1072-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Yi; Liu, Yuanyuan; Xu, Guanghui; Chen, Kai; He, Guangke; Huang, Bin; Journal of Chemical Research; vol. 38; 11; (2014); p. 658 – 661;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics