Category: 40711-33-9

Electric Literature of 40711-33-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40711-33-9, name is Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of ethyl 5-oxo-2,5-dihydro-1 H-pyrazole-3-carboxylate (0.6 g, 3.84 mmol, which may be prepared as described in Synthesis 2003, 15, 2353-2357), 1 ,1- dimethylethyl 4-hydroxy-1-piperidinecarboxylate (1.160 g, 5.76 mmol) and TPP (1.774 g, 6.76 mmol) in THF (8.4 ml), at 0 0C and under a nitrogen atmosphere, a solution of bis(1 ,1-dimethylethyl) (E)- 1 ,2-diazenedicarboxylate (DBAD) (1.59 g, 6.92 mmol) in THF (2.4 ml) was added. After 5 min the ice-bath was removed and the reaction mixture was stirred at RT. After 2h additional amount of 1 ,1-dimethylethyl 4-hydroxy-i-piperidinecarboxylate (150 mg), TPP (160 mg) and DBAD (140 mg) were added and the reaction mixture was stirred overnight. The reaction mixture was concentrated under vacuum and the residue was purified by FC on silica (eluting with Cy/EA from 1/0 to 7/3) to give 0.32 g of the title product .MS(m/z): 340.12 [MH]+.Following the above procedure, starting from ethyl 5-oxo-2,5-dihydro-1 H-pyrazole-3- carboxylate (0.8 g, 5.12 mmol) and 1 ,1-dimethylethyl 4-hydroxy-1-piperidinecarboxylate (1.65 g, 8.20 mmol) a further amount of the title compound (0.49 g) was prepared.MS(m/z): 340.12 [MH]+.

The chemical industry reduces the impact on the environment during synthesis Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/130232; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 40711-33-9, name is Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40711-33-9, Application In Synthesis of Ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

To a suspension of ethyl 5-oxo-2,5-dihydro-1 H-pyrazole-3-carboxylate (1.5 g, prepared with an analogous procedure to that described in Preparation 1 ) and Na2CO3 (1.22 g) in dry DMF (20 ml_), [(3-bromoethyl)oxy](1 ,1-dimethylethyl)dimethylsilane (1.11 ml.) was added drop wise and the mixture was stirred at 60 0C overnight. The reaction mixture was cooled down to rt and filtered to remove the Na2CO3. The filtrate was diluted with DMF and Na2CO3 (1.22g) and [(3-bromoethyl)oxy](1 ,1-dimethylethyl)dimethylsilane (2.1 ml.) were added and the mixture was stirred at 60 0C for additional 36h. After cooling, the mixture was diluted with Et2O, washed with chilly water, dried, filtered and evaporated under reduced pressure. The crude was dissolved in DCM (15 ml.) and 2,6-lutidine (1.08 ml.) and [(3-bromoethyl)oxy](1 ,1-dimethylethyl)dimethylsilane (0.86 ml.) were added at 0 0C and the mixture was stirred at rt for 1 h. The mixture was diluted in DCM, washed with NaHCO3sat and then with HCI 0.25N. The organic layer was dried and the solvent evaporated under reduced pressure. The crude was purified by flash chromatography on silica column eluting with Cy/AcOEt with a gradient of Cy from 100% to 80% to give the title compound as colourless oil (0.63 g).MS (m/z): 315 [MH]+.

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Reference:
Patent; GLAXO GROUP LIMITED; WO2009/130232; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics